Phenotypic distinction and functional characterization of pro-B cells in adult mouse bone marrow

Journal of Immunology

Volumn 166, Issue 5, 2001, Pages 3042-3051

  Mojica, M P ^a   Perry, S S ^a   Searles, A E ^a   Elenitoba Johnson, K S J ^a   Pierce, L J ^a   Wiesmann, A ^a   Slayton, W B ^a   Spangrude, G J ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; CD24 ANTIGEN; CD45 ANTIGEN; CYTOKINE; GENE PRODUCT; INTERLEUKIN 7; LEUKOSIALIN; STEEL FACTOR; TRANSCRIPTION FACTOR PAX5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL ISOLATION; CELL LINEAGE; CELL SURFACE; CONTROLLED STUDY; LYMPHOID CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEM CELL;

EID: 0035284739     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.5.3042     Document Type: Article

References (63)

1. The biology of hematopoietic stem cells
2. Purification and characterization of mouse hematopoietic stem cells
3. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
4. Commitment to the B lymphoid lineage occurs before DH-JH recombination
5. Loss of c-kit accompanies B-lineage commitment and acquisition of CD45R by most murine B-lymphocyte precursors
6. Identification of clonogenic common lymphoid progenitors in mouse bone marrow
7. Identification of the earliest B lineage stage in mouse bone marrow
8. + cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors
9. Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events
10. Apoptosis during B lymphopoiesis in mouse bone marrow
11. Resting and activated subsets of mouse multipotent hematopoietic stem cells
12. + mouse hematopoietic stem cells separated by counterflow centrifugal elutriation
13. + hemopoietic stem cells
14. Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells
15. Primitive stem cells alone mediate rapid marrow recovery and multilineage engraftment after transplantation
16. low/- hemopoietic stem cells
17. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule
18. Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor
19. Rapid, B lymphoid-restricted engraftment mediated by a primitive bone marrow subpopulation
20. Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: In vivo expansion of stem cell phenotype but not function
21. Monocyte chemoattractant protein-1 gene is expressed in activated neutrophils and retinoic acid-induced human myeloid cell lines
22. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
23. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
24. Negative regulation of early B lymphopoiesis by interleukin 3 and interleukin 1α
25. Modulation of early B lymphopoiesis by interleukin-3
26. Cell surface antigens expressed by subsets of pre-B cells and B cells
27. B lymphocyte developmental lineages
28. Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice
29. Functional characterization of two stromal cell lines that support B lymphopoiesis
30. Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule
31. Functional heterogeneity of the hematopoietic microenvironment: Rare stromal elements maintain long-term repopulating stem cells
32. Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression
33. Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription
34. The development of B cells in the bone marrow is controlled by the balance between cell-autonomous mechanisms and signals from the microenvironment
35. Both E12 and E47 allow commitment to the B cell lineage
36. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
37. Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
38. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP
39. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12
40. Identification of BSAP (Pax-5) target genes in early B-cell development by loss-and gain-of-function experiments
41. Lymphoid-restricted development from multipotent candidate murine stem cells: Distinct and complimentary functions of the c-kit and flt3 ligands
42. Use of scid mice to identify and quantitate lymphoid-restricted stem cells in long-term bone marrow cultures
43. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
44. A comparison of long-term repopulating hematopoietic stem cells in fetal liver and adult bone marrow from the mouse
45. Dynamics of early T cells: Prothymocyte migration and proliferation in the adult mouse thymus
46. Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization
47. Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing
48. Presence of progenitors restricted to T, B, or myeloid lineage, but absence of multipotent stem cells, in the murine fetal thymus
49. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
50. hi cells coincides with commitment to the B cell lineage
51. Stromal cell-independent maturation of IL-7-responsive pro-B cells
52. The Ikaros gene is required for the development of all lymphoid lineages
53. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
54. The helix-loop-helix gene E2A is required for B cell formation
55. Failure of B-cell differentiation in mice lacking the transcription factor EBF
56. Growth factors and hematopoietic stem cells
57. Lineage commitment and maturation in hematopoietic cells: The case for extrinsic regulation
58. Do stem cells play dice?
59. In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors
60. Continued differentiation during B lymphopoiesis requires signals in addition to cell survival
61. Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow
62. Megakaryocytic and erythrocytic cell lines share a common precursor cell
63. A common precursor for hematopoietic and endothelial cells