Identification of CD19-B220+c-Kit+Flt3/Flk-2+ cells as early B lymphoid precursors before pre-B-I cells in juvenile mouse bone marrow

International Immunology

Volumn 12, Issue 3, 2000, Pages 313-324

  Ogawa, Minetaro ^a,b   Ten Boekel, Edwin ^a   Melchers, Fritz ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

D(H)J(H) recombination; IL 7; Receptor tyrosine kinase; 5

Indexed keywords

CD19 ANTIGEN; CD45 ANTIGEN; CELL ANTIGEN; FLT3 LIGAND; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 7; STEM CELL FACTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW CELL; CELL PROLIFERATION; CELL SUSPENSION; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; LYMPHOID CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROLYMPHOCYTE; STROMA CELL;

EID: 0034053013     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.3.313     Document Type: Article

References (58)

1. Visser, J. W. and van Bekkum, D. W. 1990. Purification of pluripotent hemopoietic stem cells: past and present. Exp. Hematol. 18:248.
2. Morrison, S. J., Uchida, N. and Weissman, I. L. 1995. The biology of hematopoietic stem cells. Annu. Rev. Cell Dev. Biol. 11:35.
3. Spangrude, G. J., Heimfeld, S. and Weissman, I. L. 1988. Purification and characterization of mouse hematopoietic stem cells. Science 241:58.
4. Ikuta, K. and Weissman, I. L. 1992. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc. Natl Acad. Sci. USA 89:1502.
5. Osawa, M., Hanada, K., Harnada, H. and Nakauchi, H. 1996. Long-term lympho-hematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273:242.
6. Morrison, S. J. and Weissman, I. L. 1994. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1:661.
7. Kondo, M., Weissman, I. L. and Akashi, K. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91:661.
8. Rolink, A., Karasuyama, H., Haasner, D., Grawunder, U., Martensson, I. L., Kudo, A. and Melchers, F. 1994. Two pathways of B-lymphocyte development in mouse bone marrow and the role of surrogate L chain in this development. Immunol. Rev. 137:185.
9. Melchers, F., Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H., Ghia, P. and Andersson, J. 1995. Positive and negative selection events during B lymphopoiesis. Curr. Opin. Immunol. 7:214.
10. Melchers, F., Haasner, D., Grawunder, U., Kalberer, C., Karasuyama, H., Winkler, T. and Rolink, A. 1994. Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu. Rev. Immunol. 12:209.
11. Rolink, A., Kudo, A., Karasuyama, H., Kikuchi, Y. and Melchers, F. 1991. Long-term proliferating early pre-B cell lines and clones with the potential to develop to surface Ig-positive, mitogen-reactive B cells in vitro and in vivo. EMBO J. 10:327.
12. Hardy, R. R. and Hayakawa, K. 1991. A developmental switch in B lymphopoiesis. Proc. Natl Acad. Sci. USA 88:11550.
13. Cumano, A., Paige, C. J., Iscove, N. N. and Brady, G. 1992. Bipotential precursors of B cells and macrophages in murine fetal liver Nature 356:612.
14. Petrenko, O., Beavis, A., Klaine, M., Kittappa, R., Godin, I. and Lemischka, I. R. 1999. The molecular characterization of the fetal stem cell marker AA4. Immunity 10:691.
15. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. and Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stage in normal mouse bone marrow. J. Exp. Med. 173:1213.
16. + cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J. Exp. Med. 183:187.
17. Li, Y.-S., Wasserman, R., Hayakawa, K. and Hardy, R. R. 1996 Identification of the earliest B lineage stage in mouse bone marrow. Immunity 5:527.
18. H recombination. J. Exp. Med. 189:735.
19. Ogawa, M., Matsuzaki, Y., Nishikawa, S., Hayashi, S.-I., Kunisada, T., Sudo, T., Kina, T., Nakauchi, H. and Nishikawa, S.-I. 1991. Expression and function of c-kit in hematopoietic progenitor cells. J. Exp. Med. 174:63.
20. Okada, S., Nakauchi, H., Nagayoshi, K., Nishikawa, S., Nishikawa, S.-I., Miura, Y. and Suda, T. 1991. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood 78:1706.
21. Ogawa, M. 1993. Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844.
22. Era, T., Nishikawa, S., Sudo, T., Wang, F. H., Ogawa, M., Kunisada, T., Hayashi, S. and Nishikawa, S. 1994. How B-precursor cells are driven to cycle. Immunol. Rev. 137:35.
23. Landreth, K. S., Kincade, P. W., Lee, G. and Harrison, D. E. 1984. B lymphocyte precursors in embryonic and adult W anemic mice. J. Immunol. 132:2724.
24. Takeda, S., Shimizu, T. and Rodewald, H. R. 1997. Interactions between c-kit and stem cell factor are not required for B-cell development in vivo. Blood 89:518.
25. Rodewald, H. R., Ogawa, M., Haller, C., Waskow, C. and DiSanto, J. P. 1997. Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation. Immunity 6:265.
26. Hunte, B. E., Hudak, S., Campbell, D., Xu, Y. and Rennick, D. 1995. flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors. J. Immunol. 156:489.
27. Hirayama, F., Lyman, S. D., Clark, S. C. and Ogawa, M. 1995. The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors. Blood 85:1762.
28. Namikawa, R., Muench, M. O., de Vries, J. E. and Roncarolo, M. G. 1996. The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal-cell-independent expansion and differentiation of human fetal pro-B cells in vitro. Stood 87:1881.
29. Ray, R. J., Paige, C. J., Furlonger, C., Lyman, S. D. and Rottapel, R. 1996. Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7. Eur. J. Immunol. 26:1504.
30. Hirayama, F. and Ogawa, M. 1996. Cytokine regulation of early lymphohematopoietic development. Stem Cells 14:369.
31. Lyman, S. D. and Jacobsen, E. W. 1998. c-kit ligand and fits ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood 91:1101.
32. Mackarehtschian, K., Hardin, J. D., Moore, K. A., Boast, S., Goff, S. P. and Lemischka, I. R. 1995 Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3:147.
33. Ogawa, M., Sugawara, S., Kunisada, T., Sudo, T., Hayashi, S. I., Nishikawa, S., Kodama, H. and Nishikawa, S.-I. 1998. Flt3/Flk-2 and c-Kit are not essential for the proliferation of B lymphoid progenitor cells in the bone marrow of the adult mouse, Exp. Hematol. 26:478.
34. ten Boekel, E., Melchers, F. and Relink, A. 1995. The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7:1013.
35. Mårtensson, I.-L., Melchers, F. and Winkler, T. H. 1997. A transgenic marker for mouse B lymphoid precursors. J. Exp. Med. 185:653.
36. Ogawa, M., Nishikawa, S., Ikuta, K., Yamamura, F., Naito, M., Takahashi, K. and Nishikawa, S. 1988. B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac. EMBO J. 7:1337.
37. ten Boekel, E., Melchers, F. and Rolink, A. G. 1997. Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 7:357.
38. Delassus, S. and Cumano, A. 1996. Circulation of hematopoietic progenitors in the mouse embryo. Immunity 4:97.
39. Rolink, A., Streb, M., Nishikawa, S. and Melchers, F. 1991. The c-kit-encoded tyrosine kinase regulates the proliferation of early pre-B cells. Eur. J. Immunol. 21:2609.
40. Nishikawa, S. I., Era, T., Ogawa, M., Nishikawa, S., Ohno, N., Hayashi, S. I. and Kunisada, T. 1992. Control of intramarrow B-cell genesis by stromal cell-derived molecules. Curr. Top. Microbiol. Immunol. 182:27.
41. + B precursor cells by two distinct signals derived from IL-7 receptor and c-kit in a fully defined medium. J. Exp. Med. 182:315.
42. Matthews, W., Jordan, C. T., Wiegand, G. W., Pardoll, D. and Lemischka, I. R. 1991. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations, Cell 65:1143.
43. Zeigler, F. C., Bennett, B. D., Jordan, C. T., Spencer, S. D., Baumhueter, S., Carroll, K. J., Hooley, J., Bauer, K. and Matthews, W. 1994. Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells. Blood 84:2422.
44. Rasko, J. E., Metcalf, D., Rossner, M. T., Begley, C. G. and Nicola, N. A. 1995. The flt3/flk-2 ligand: receptor distribution and action on murine haemopoietic cell survival and proliferation. Leukemia 9:2058.
45. Wasserman, R., Li, Y. S. and Hardy, R. R. 1995. Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement. J. Immunol. 155:644.
46. Rolink, A., Ghia, P., Grawunder, U., Haasner, D., Karasuyama, H., Kalberer, C., Winkler, T. and Melchers, F. 1995. In-vitro analyses of mechanisms of B-cell development. Semin. Immunol. 7:155.
47. Rappold, I., Ziegler, B. L., Kohler, I., Marchetto, S., Rosnet, O., Birnbaum, D., Simmons, P. J., Zannettino, A. C., Hill, B., Neu, S., Knapp, W., Alitalo, R., Alitalo, K., Ullrich, A., Kanz, L. and Buhring, H. J. 1997. Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase. Blood 90:111.
48. Ghia, P., ten Boekel, E., Sanz, E., de la Hera, A., Rolink, A. and Melchers, F. 1996. Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci. J. Exp. Med. 184:2217
49. Rolink, A., Haasner, D., Nishikawa, S. and Melchers, F. 1993. Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice. Stood 81:2290.
50. Moscatello, K. M., Biber, K. L., Dempsey, D. C., Chervenak, R. and Wolcott, R. M. 1998. Characterization of a B cell progenitor present in neonatal bone marrow and spleen but not in adult bone marrow and spleen. J. Immunol. 161:5391.
51. Nunez, C., Nishimoto, N., Gartland, G. L., Billips, L. G., Burrows, P. D., Kubagawa, H. and Cooper, M. D. 1996 B cells are generated throughout life in humans. J. Immunol. 156:866.
52. Kantor, A. B., Stall, A. M., Adams, S., Herzenberg, L. A. and Herzenberg, L. A. 1992. Differential development of progenitor activity for three B-cell lineages. Proc. Natl Acad. Sci. USA 89:3320.
53. Feeney, A. J. 1992. Comparison of junctional diversity in the neonatal and adult immunoglobulin repertoires. Int. Rev. Immunol. 8:113.
54. Lam, K. P. and Stall, A. M. 1994. Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny. J. Exp. Med. 180:507.
55. Hayakawa, K., Tarlinton, D. and Hardy, R. R. 1994. Absence of MHC class II expression distinguishes fetal from adult B lymphopoiesis in mice. J. Immunol. 152:4801.
56. Li, Y. S., Hayakawa, K. and Hardy, R. R. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951.
57. Karasuyama, H., Rolink, A., Shinkai, Y., Young, F., Alt, F. W. and Melchers, F. 1994. The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77:133.
58. Kitamura, D., Kudo, A., Schaal, S., Muller, W., Melchers, F. and Rajewsky, K. 1992. A critical role of lambda 5 protein in B cell development. Cell 69:823.