Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other

Journal of Experimental Medicine

Volumn 192, Issue 12, 2000, Pages 1707-1718

  Domen, Jos ^a,b   Weissman, Irving L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Flow cytometry; Hematopoietic stem cell; Serum free medium; Stem cell factor; Transgenic mice

Indexed keywords

GROWTH FACTOR; PROTEIN BCL 2; STEEL FACTOR; STEM CELL FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL LINEAGE; CELL PROLIFERATION; CULTURE MEDIUM; FLOW CYTOMETRY; GENE OVEREXPRESSION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL SIZE; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HISTOCYTOCHEMISTRY; INTERLEUKIN-3; MAST CELLS; MICE; MICE, TRANSGENIC; PERITONEAL CAVITY; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION; STEM CELL FACTOR; STEM CELLS; THROMBOPOIETIN;

EID: 0034684662     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.12.1707     Document Type: Article

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