-
1
-
-
0027261321
-
Suppression of apoptosis allows differentiation and development of a multipotent haemopoietic cell line in the absence of added growth factors
-
Fairbairn LJ, Cowling GJ, Reipert BM, Dexter TM. Suppression of apoptosis allows differentiation and development of a multipotent haemopoietic cell line in the absence of added growth factors. Cell. 74:1993;823-832.
-
(1993)
Cell
, vol.74
, pp. 823-832
-
-
Fairbairn, L.J.1
Cowling, G.J.2
Reipert, B.M.3
Dexter, T.M.4
-
2
-
-
0028880455
-
Generation of committed erythroid BFU-e and CFU-e does not require erythropoietin or the erythropoietin receptor
-
Wu H, Lui X, Jaenisch R, Lodish HF. Generation of committed erythroid BFU-e and CFU-e does not require erythropoietin or the erythropoietin receptor. Cell. 83:1995;59-67.
-
(1995)
Cell
, vol.83
, pp. 59-67
-
-
Wu, H.1
Lui, X.2
Jaenisch, R.3
Lodish, H.F.4
-
3
-
-
0030050404
-
Differential effects of an erythropoietin receptor disruption on primitive and definitive erythropoiesis
-
Lin CS, Lim SK, Dagati V, Costantini F. Differential effects of an erythropoietin receptor disruption on primitive and definitive erythropoiesis. Genes Dev. 10:1996;154-164.
-
(1996)
Genes Dev
, vol.10
, pp. 154-164
-
-
Lin, C.S.1
Lim, S.K.2
Dagati, V.3
Costantini, F.4
-
4
-
-
0029876726
-
The transcriptional control of hematopoiesis
-
of special interest. A comprehensive review of transcription factor gene knockouts that effect haemopoietic/lymphopoietic development.
-
Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis. of special interest Blood. 87:1996;4025-4039 A comprehensive review of transcription factor gene knockouts that effect haemopoietic/lymphopoietic development.
-
(1996)
Blood
, vol.87
, pp. 4025-4039
-
-
Shivdasani, R.A.1
Orkin, S.H.2
-
5
-
-
0027971744
-
Vintage reds and whites: Combinatorial transcriptional factor utilization in hematopoietic differentiation
-
Ness SA, Engel JD. Vintage reds and whites: combinatorial transcriptional factor utilization in hematopoietic differentiation. Curr Opin Genet Dev. 4:1994;718-724.
-
(1994)
Curr Opin Genet Dev
, vol.4
, pp. 718-724
-
-
Ness, S.A.1
Engel, J.D.2
-
6
-
-
0030999645
-
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
-
of special interest. Lmo2 (Rbtn2/Ttg2) forms a transactivating complex in erythroid cells that includes SCL (TAL-1), GATA-1, E2A, and a recently identified protein Ldb/NLI. Only in the presence of all five components does this complex bind in vivo to a bipartite DNA motif which contains a GATA site and an E box separated by ~9 bp.
-
Wadman IA, Osada H, Grütz GG, Agulnick AD, Westphal H, Forster A, Rabbitts TH. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. of special interest EMBO J. 16:1997;3145-3157 Lmo2 (Rbtn2/Ttg2) forms a transactivating complex in erythroid cells that includes SCL (TAL-1), GATA-1, E2A, and a recently identified protein Ldb/NLI. Only in the presence of all five components does this complex bind in vivo to a bipartite DNA motif which contains a GATA site and an E box separated by ~9 bp.
-
(1997)
EMBO J
, vol.16
, pp. 3145-3157
-
-
Wadman, I.A.1
Osada, H.2
Grütz, G.G.3
Agulnick, A.D.4
Westphal, H.5
Forster, A.6
Rabbitts, T.H.7
-
7
-
-
0027934267
-
Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line
-
Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR. Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line. Oncogene. 9:1994;3013-3016.
-
(1994)
Oncogene
, vol.9
, pp. 3013-3016
-
-
Cross, M.A.1
Heyworth, C.M.2
Murrell, A.M.3
Bockamp, E.O.4
Dexter, T.M.5
Green, A.R.6
-
8
-
-
0030272140
-
Development of the hematopoietic system
-
Orkin SH. Development of the hematopoietic system. Curr Opin Genet Dev. 6:1996;597-602.
-
(1996)
Curr Opin Genet Dev
, vol.6
, pp. 597-602
-
-
Orkin, S.H.1
-
9
-
-
0030954167
-
Multilineage gene expression precedes commitment in the hemopoietic system
-
of outstanding interest. Using single cell RTPCR, the authors have analysed the expression of different lineage markers seen in populations of multipotential cells. The results show that single multipotent cells co-express different lineage-affiliated programmes of gene expression prior to exclusive unilineage commitment.
-
Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C, Enver T. Multilineage gene expression precedes commitment in the hemopoietic system. of outstanding interest Genes Dev. 11:1997;774-785 Using single cell RTPCR, the authors have analysed the expression of different lineage markers seen in populations of multipotential cells. The results show that single multipotent cells co-express different lineage-affiliated programmes of gene expression prior to exclusive unilineage commitment.
-
(1997)
Genes Dev
, vol.11
, pp. 774-785
-
-
Hu, M.1
Krause, D.2
Greaves, M.3
Sharkis, S.4
Dexter, M.5
Heyworth, C.6
Enver, T.7
-
10
-
-
0029843415
-
Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells
-
of outstanding interest. A semi-quantitative RT-PCR technique was used to measure specific mRNA levels in single cells removed at various stages from macrophage, granulocyte and erythroid colonies developing from CD34+ CD38- human progenitors. In erythroid colonies, an early drop in SCL expression is followed by decreases in GATA-1 and GATA-2, whereas NFE-2 increases steadily. Purified CD34+ 38- progenitors themselves express a number of lineage-restricted transcription factors, consistent with [9].
-
Cheng T, Shen H, Giokas D, Gere J, Tenen DG, Scadden DT. Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells. of outstanding interest Proc Natl Acad Sci USA. 93:1996;13158-13163 A semi-quantitative RT-PCR technique was used to measure specific mRNA levels in single cells removed at various stages from macrophage, granulocyte and erythroid colonies developing from CD34+ CD38- human progenitors. In erythroid colonies, an early drop in SCL expression is followed by decreases in GATA-1 and GATA-2, whereas NFE-2 increases steadily. Purified CD34+ 38- progenitors themselves express a number of lineage-restricted transcription factors, consistent with [9].
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13158-13163
-
-
Cheng, T.1
Shen, H.2
Giokas, D.3
Gere, J.4
Tenen, D.G.5
Scadden, D.T.6
-
11
-
-
0031048644
-
Initiation of murine embryonic erythropoiesis: A spatial analysis
-
Silver L, Palis J. Initiation of murine embryonic erythropoiesis: a spatial analysis. Blood. 89:1997;1154-1164.
-
(1997)
Blood
, vol.89
, pp. 1154-1164
-
-
Silver, L.1
Palis, J.2
-
12
-
-
0030581174
-
The T cell leukaemia oncoprotein SCL/Tal-1 is essential for development of all hematopoietic lineages
-
Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH. The T cell leukaemia oncoprotein SCL/Tal-1 is essential for development of all hematopoietic lineages. Cell. 86:1996;47-57.
-
(1996)
Cell
, vol.86
, pp. 47-57
-
-
Porcher, C.1
Swat, W.2
Rockwell, K.3
Fujiwara, Y.4
Alt, F.W.5
Orkin, S.H.6
-
13
-
-
0029781248
-
The SCL gene product is required for the generation of all haematopoietic lineages in the adult mouse
-
Robb L, Elwood NJ, Elefanty AG, Kontgen F, Li R, Barnett LD, Begley CG. The SCL gene product is required for the generation of all haematopoietic lineages in the adult mouse. EMBO J. 15:1996;4123-4129.
-
(1996)
EMBO J
, vol.15
, pp. 4123-4129
-
-
Robb, L.1
Elwood, N.J.2
Elefanty, A.G.3
Kontgen, F.4
Li, R.5
Barnett, L.D.6
Begley, C.G.7
-
14
-
-
0029939388
-
Induction of hematopoietic commitment and erythromyeloid differentiation in embryonal stem cells constitutively expressing c-myb
-
Melotti P, Calabretta B. Induction of hematopoietic commitment and erythromyeloid differentiation in embryonal stem cells constitutively expressing c-myb. Blood. 87:1996;2221-2234.
-
(1996)
Blood
, vol.87
, pp. 2221-2234
-
-
Melotti, P.1
Calabretta, B.2
-
15
-
-
0029992843
-
The transcription factors c-myb and GATA-2 act independently in the regulation of normal hematopoiesis
-
Melotti P, Calabretta B. The transcription factors c-myb and GATA-2 act independently in the regulation of normal hematopoiesis. Proc Natl Acad Sci USA. 93:1996;5313-5318.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5313-5318
-
-
Melotti, P.1
Calabretta, B.2
-
16
-
-
0029793902
-
Pu.1 (Spi1) and C/EBP alpha regulate the granulocyte colony stimulating factor receptor promoter in myeloid cells
-
Smith LT, Hohaus S, Gonzalez DA, Dziennis SE, Tenen DG. Pu.1 (Spi1) and C/EBP alpha regulate the granulocyte colony stimulating factor receptor promoter in myeloid cells. Blood. 88:1996;1234-1247.
-
(1996)
Blood
, vol.88
, pp. 1234-1247
-
-
Smith, L.T.1
Hohaus, S.2
Gonzalez, D.A.3
Dziennis, S.E.4
Tenen, D.G.5
-
17
-
-
0029740334
-
C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter
-
Oelgeschlager M, Nuchprayoon I, Luscher B, Friedman AD. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol Cell Biol. 16:1996;4717-4725.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4717-4725
-
-
Oelgeschlager, M.1
Nuchprayoon, I.2
Luscher, B.3
Friedman, A.D.4
-
18
-
-
0029785842
-
Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification
-
of special interest. As previously shown for lymphoid (IgH, CD3δ) and erythroid (β-globin) associated genes (49), this group show that the major enhancer of the granulocyte-specific MPO gene is in an open chromatin configuration in multipotential cells prior to lineage commitment. The authors propose a model in which temporal exchange of C/EBP isoforms at the MPO enhancer mediates the transition from this primed state in multipotential cells to a transcriptionally active configuration in promyelocytes.
-
Ford AM, Bennett CA, Healy LE, Towatari M, Greaves MF, Enver T. Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification. of special interest Proc Natl Acad Sci USA. 93:1996;10838-10843 As previously shown for lymphoid (IgH, CD3δ) and erythroid (β-globin) associated genes (49), this group show that the major enhancer of the granulocyte-specific MPO gene is in an open chromatin configuration in multipotential cells prior to lineage commitment. The authors propose a model in which temporal exchange of C/EBP isoforms at the MPO enhancer mediates the transition from this primed state in multipotential cells to a transcriptionally active configuration in promyelocytes.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10838-10843
-
-
Ford, A.M.1
Bennett, C.A.2
Healy, L.E.3
Towatari, M.4
Greaves, M.F.5
Enver, T.6
-
19
-
-
0030481726
-
Regulation and function of transcription factor GATA-1 during red blood cell differentiation
-
Briegel K, Bartunek P, Steng G, Lim KC, Beug H, Engel JD, Zenke M. Regulation and function of transcription factor GATA-1 during red blood cell differentiation. Development. 122:1996;3839-3850.
-
(1996)
Development
, vol.122
, pp. 3839-3850
-
-
Briegel, K.1
Bartunek, P.2
Steng, G.3
Lim, K.C.4
Beug, H.5
Engel, J.D.6
Zenke, M.7
-
20
-
-
0029870839
-
Maf B is an interaction partner and repressor of Ets 1 that inhibits erythroid differentiation
-
of special interest. The myelomonocytic transcription factor Maf B is found to bind Ets 1 and to inhibit the expression of the transferrin receptor gene, which in turn is required for erythroid differentiation.This provides a basis for the reciprocal relationship between the activation of appropriate genes and the inactivation of inappropriate ones during lineage differentiation.
-
Sieweke MH, Tekotte H, Frampton J, Graf T. Maf B is an interaction partner and repressor of Ets 1 that inhibits erythroid differentiation. of special interest Cell. 85:1996;49-60 The myelomonocytic transcription factor Maf B is found to bind Ets 1 and to inhibit the expression of the transferrin receptor gene, which in turn is required for erythroid differentiation.This provides a basis for the reciprocal relationship between the activation of appropriate genes and the inactivation of inappropriate ones during lineage differentiation.
-
(1996)
Cell
, vol.85
, pp. 49-60
-
-
Sieweke, M.H.1
Tekotte, H.2
Frampton, J.3
Graf, T.4
-
21
-
-
0030921503
-
An SCL gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice
-
Aplan PD, Jones CA, Chervinsky DS, Zhao XF, Ellsworth MK, Wu C, McGuire EA, Gross KW. An SCL gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J. 16:1997;2408-2419.
-
(1997)
EMBO J
, vol.16
, pp. 2408-2419
-
-
Aplan, P.D.1
Jones, C.A.2
Chervinsky, D.S.3
Zhao, X.F.4
Ellsworth, M.K.5
Wu, C.6
McGuire, E.A.7
Gross, K.W.8
-
22
-
-
0030061554
-
AML-1, the target of multiple chromosomal translocations in human leukaemia, is essential for normal fetal liver hematopoiesis
-
Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML-1, the target of multiple chromosomal translocations in human leukaemia, is essential for normal fetal liver hematopoiesis. Cell. 84:1996;321-330.
-
(1996)
Cell
, vol.84
, pp. 321-330
-
-
Okuda, T.1
Van Deursen, J.2
Hiebert, S.W.3
Grosveld, G.4
Downing, J.R.5
-
23
-
-
0029918597
-
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
-
Wang Q, Stancey T, Binder M, Marin-Padilla M, Sharp AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA. 93:1996;3444-3449.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3444-3449
-
-
Wang, Q.1
Stancey, T.2
Binder, M.3
Marin-Padilla, M.4
Sharp, A.H.5
Speck, N.A.6
-
24
-
-
0029973591
-
Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta
-
Sasaki K, Yagi H, Bronson RT, Tominaga K, Matsunashi T, Deguchi K, Tani Y, Kishimoto T, Komori T. Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta. Proc Natl Acad Sci USA. 93:1996;12359-12363.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12359-12363
-
-
Sasaki, K.1
Yagi, H.2
Bronson, R.T.3
Tominaga, K.4
Matsunashi, T.5
Deguchi, K.6
Tani, Y.7
Kishimoto, T.8
Komori, T.9
-
25
-
-
0029837148
-
In vitro differentiation of embryonic stem cells: New approaches to old problems
-
Weiss MJ, Orkin SH. In vitro differentiation of embryonic stem cells: new approaches to old problems. J Clin Invest. 98:1996;13-17.
-
(1996)
J Clin Invest
, vol.98
, pp. 13-17
-
-
Weiss, M.J.1
Orkin, S.H.2
-
26
-
-
0031024994
-
Erythroid cell specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targetted cell line
-
-/-ES cells.
-
-/-ES cells.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1642-1651
-
-
Weiss, M.J.1
Yu, C.2
Orkin, S.H.3
-
27
-
-
0029919410
-
PU.1 but not Ets-2 is essential for macrophage development from embryonic stem cells
-
Henkel GW, McKercher SR, Yamamoto H, Anderson KL, Oshima RG, Maki RA. PU.1 but not Ets-2 is essential for macrophage development from embryonic stem cells. Blood. 88:1996;2917-2926.
-
(1996)
Blood
, vol.88
, pp. 2917-2926
-
-
Henkel, G.W.1
McKercher, S.R.2
Yamamoto, H.3
Anderson, K.L.4
Oshima, R.G.5
Maki, R.A.6
-
28
-
-
0242549003
-
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
-
of special interest. The PU.1 knockout mice reported in this study survive for 2-3 days after birth, or up to 17 days on antibiotics. No mature macrophages, neutrophils, B or T lymphocytes are detectable at birth but some T cells and neutrophils begin to appear by 3-5 days. The lack of macrophages does not obviously affect the development of other tissues. It is unclear why this phenotype should be less severe than the embryonic lethality (ocurring at day 18) reported previously [27]. Possible effects of the insertion cassette on neighbouring genes, or residual Pu.1 activity cannot be ruled out.
-
McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. of special interest EMBO J. 15:1996;5647-5658 The PU.1 knockout mice reported in this study survive for 2-3 days after birth, or up to 17 days on antibiotics. No mature macrophages, neutrophils, B or T lymphocytes are detectable at birth but some T cells and neutrophils begin to appear by 3-5 days. The lack of macrophages does not obviously affect the development of other tissues. It is unclear why this phenotype should be less severe than the embryonic lethality (ocurring at day 18) reported previously [27]. Possible effects of the insertion cassette on neighbouring genes, or residual Pu.1 activity cannot be ruled out.
-
(1996)
EMBO J
, vol.15
, pp. 5647-5658
-
-
McKercher, S.R.1
Torbett, B.E.2
Anderson, K.L.3
Henkel, G.W.4
Vestal, D.J.5
Baribault, H.6
Klemsz, M.7
Feeney, A.J.8
Wu, G.E.9
Paige, C.J.10
Maki, R.A.11
-
29
-
-
0028136726
-
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
-
Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 265:1994;1573-1577.
-
(1994)
Science
, vol.265
, pp. 1573-1577
-
-
Scott, E.W.1
Simon, M.C.2
Anastasi, J.3
Singh, H.4
-
30
-
-
0030933226
-
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1
-
Tondravi MM, McKercher SR, Anderson K, Erdmann JM, Quiroz M, Maki R, Teitelbaum SL. Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Nature. 385:1997;81-84.
-
(1997)
Nature
, vol.385
, pp. 81-84
-
-
Tondravi, M.M.1
McKercher, S.R.2
Anderson, K.3
Erdmann, J.M.4
Quiroz, M.5
Maki, R.6
Teitelbaum, S.L.7
-
31
-
-
0030611964
-
PU.1 functions in a cell-autonomous manner to control the differentiation of multipotent lymphoid-myeloid progenitors
-
Scott EW, Fisher RC, Olson EC, Kehrli EW, Celeste Simon M, Singh H. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotent lymphoid-myeloid progenitors. Immunity. 6:1997;437-447.
-
(1997)
Immunity
, vol.6
, pp. 437-447
-
-
Scott, E.W.1
Fisher, R.C.2
Olson, E.C.3
Kehrli, E.W.4
Celeste Simon, M.5
Singh, H.6
-
32
-
-
0030047739
-
Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: Regulation of multiple myeloid CSF receptor promoters
-
Zhang DE, Hohaus S, Voso MT, Chen HM, Smith LT, Hetherington CJ, Tenen DG. Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters. Curr Top Microbiol Immunol. 211:1996;137-147.
-
(1996)
Curr Top Microbiol Immunol
, vol.211
, pp. 137-147
-
-
Zhang, D.E.1
Hohaus, S.2
Voso, M.T.3
Chen, H.M.4
Smith, L.T.5
Hetherington, C.J.6
Tenen, D.G.7
-
34
-
-
0028355443
-
Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony forming cells
-
Whetton AD, Heyworth CM, Nicholls SE, Evans CA, Lord JM, Dexter TM, Owen-Lynch PJ. Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony forming cells. J Cell Biol. 125:1994;651-659.
-
(1994)
J Cell Biol
, vol.125
, pp. 651-659
-
-
Whetton, A.D.1
Heyworth, C.M.2
Nicholls, S.E.3
Evans, C.A.4
Lord, J.M.5
Dexter, T.M.6
Owen-Lynch, P.J.7
-
35
-
-
0029014378
-
IL-4 promotes macrophage development by rapidly stimulating lineage restriction of bipotent granulocyte macrophage colony forming cells
-
Nicholls SE, Heyworth CM, Dexter TM, Lord JM, Johnson GD, Whetton AD. IL-4 promotes macrophage development by rapidly stimulating lineage restriction of bipotent granulocyte macrophage colony forming cells. J Immunol. 155:1995;845-853.
-
(1995)
J Immunol
, vol.155
, pp. 845-853
-
-
Nicholls, S.E.1
Heyworth, C.M.2
Dexter, T.M.3
Lord, J.M.4
Johnson, G.D.5
Whetton, A.D.6
-
36
-
-
0029921175
-
Lineage commitment of transformed haematopoietic progenitors is determined by the level of PKC activity
-
of special interest. The differentiation of Myb-Ets transformed chicken progenitors (MEPs) along myelomonocytic or eosinophillic lineages is influenced by activators of protein kinase C. Low PKC activity is associated with myelomonocytic fate and high activity with eosinophillic. Transformation of progenitors with retroviruses encoding Myb-Ets-PKC (α or ζ) derivatives yielded clones with a high background of myelomonocytic differentiation, which switched to eosinophillic differentiation in the presence of PKC activators.
-
Rossi F, McNagny M, Smith G, Frampton J, Graf T. Lineage commitment of transformed haematopoietic progenitors is determined by the level of PKC activity. of special interest EMBO J. 15:1996;1894-1901 The differentiation of Myb-Ets transformed chicken progenitors (MEPs) along myelomonocytic or eosinophillic lineages is influenced by activators of protein kinase C. Low PKC activity is associated with myelomonocytic fate and high activity with eosinophillic. Transformation of progenitors with retroviruses encoding Myb-Ets-PKC (α or ζ) derivatives yielded clones with a high background of myelomonocytic differentiation, which switched to eosinophillic differentiation in the presence of PKC activators.
-
(1996)
EMBO J
, vol.15
, pp. 1894-1901
-
-
Rossi, F.1
McNagny, M.2
Smith, G.3
Frampton, J.4
Graf, T.5
-
37
-
-
0029066359
-
GATA-1 reprograms avian myelomonocytic cells into eosinpophils, thromboblasts and erythroblasts
-
Kulessa H, Frampton J, Graf T. GATA-1 reprograms avian myelomonocytic cells into eosinpophils, thromboblasts and erythroblasts. Genes Dev. 9:1995;1250-1262.
-
(1995)
Genes Dev
, vol.9
, pp. 1250-1262
-
-
Kulessa, H.1
Frampton, J.2
Graf, T.3
-
38
-
-
0029619087
-
NF-M (C/EBPbeta) induces eosinophilic differentiation and apoptosis in a haemopoietic progenitor cell line
-
Muller C, Kowenz-Leutz E, Grieser-Ade S, Graf T, Leutz A. NF-M (C/EBPbeta) induces eosinophilic differentiation and apoptosis in a haemopoietic progenitor cell line. EMBO J. 14:1995;6127-6135.
-
(1995)
EMBO J
, vol.14
, pp. 6127-6135
-
-
Muller, C.1
Kowenz-Leutz, E.2
Grieser-Ade, S.3
Graf, T.4
Leutz, A.5
-
40
-
-
0031000903
-
Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood
-
of special interest. A combination of thrombopoietin and FLT3 ligand sustains the continously increasing production of umbilical cord blood derived haemopoietic progenitors over a period of 6 months in culture. Long-term culture-initiating cells are increased 200,000-fold over the first 20 weeks.
-
Piacibello W, Sanavio L, Garetto L, Severino A, Bergandi D, Ferrario J, Fagioli F, Berger M, Aglietta M. Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood. of special interest Blood. 89:1997;2644-2653 A combination of thrombopoietin and FLT3 ligand sustains the continously increasing production of umbilical cord blood derived haemopoietic progenitors over a period of 6 months in culture. Long-term culture-initiating cells are increased 200,000-fold over the first 20 weeks.
-
(1997)
Blood
, vol.89
, pp. 2644-2653
-
-
Piacibello, W.1
Sanavio, L.2
Garetto, L.3
Severino, A.4
Bergandi, D.5
Ferrario, J.6
Fagioli, F.7
Berger, M.8
Aglietta, M.9
-
42
-
-
0029773904
-
Modulated expression of Notch 1 during thymocyte development
-
Hasserjian RP, Aster JC, Davi F, Weinberg DS, Sklar J. Modulated expression of Notch 1 during thymocyte development. Blood. 88:1996;970-976.
-
(1996)
Blood
, vol.88
, pp. 970-976
-
-
Hasserjian, R.P.1
Aster, J.C.2
Davi, F.3
Weinberg, D.S.4
Sklar, J.5
-
43
-
-
0030297895
-
An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
-
Robey E, Chang D, Itano A, Cado D, Alexander H, Lands D, Weinmaster G, Salmon P. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell. 87:1996;483-492.
-
(1996)
Cell
, vol.87
, pp. 483-492
-
-
Robey, E.1
Chang, D.2
Itano, A.3
Cado, D.4
Alexander, H.5
Lands, D.6
Weinmaster, G.7
Salmon, P.8
-
44
-
-
0028212430
-
A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors
-
Milner LA, Kopan R, Martin DI, Bernstein ID. A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors. Blood. 83:1994;2057-2062.
-
(1994)
Blood
, vol.83
, pp. 2057-2062
-
-
Milner, L.A.1
Kopan, R.2
Martin, D.I.3
Bernstein, I.D.4
-
45
-
-
0025856717
-
Tan-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
-
Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J. Tan-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 66:1991;649-661.
-
(1991)
Cell
, vol.66
, pp. 649-661
-
-
Ellisen, L.W.1
Bird, J.2
West, D.C.3
Soreng, A.L.4
Reynolds, T.C.5
Smith, S.D.6
Sklar, J.7
-
46
-
-
0029942842
-
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated notch alleles
-
Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, Baltimore D. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated notch alleles. J Exp Med. 183:1996;2283-2291.
-
(1996)
J Exp Med
, vol.183
, pp. 2283-2291
-
-
Pear, W.S.1
Aster, J.C.2
Scott, M.L.3
Hasserjian, R.P.4
Soffer, B.5
Sklar, J.6
Baltimore, D.7
-
47
-
-
0029808295
-
Frequent provirus insertional mutagenesis of notch-1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and notch-1 for oncogenesis
-
Girard L, Hanna Z, Beaulieu N, Hoemann CD, Simard C, Kozak CA, Jolicoeur P. Frequent provirus insertional mutagenesis of notch-1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and notch-1 for oncogenesis. Genes Dev. 10:1996;1930-1944.
-
(1996)
Genes Dev
, vol.10
, pp. 1930-1944
-
-
Girard, L.1
Hanna, Z.2
Beaulieu, N.3
Hoemann, C.D.4
Simard, C.5
Kozak, C.A.6
Jolicoeur, P.7
-
48
-
-
0029850324
-
Inhibition of granulocytic differentiation by Notch 1
-
of special interest. Constitutive expression of the intracellular domain of Notch 1 in 32D cells - myeloid progenitors that undergo granulocyte differentiation in response to G-CSF - inhibits their differentiation and permits expansion of undifferentiated cells.
-
Milner LA, Bigas A, Kopan R, Brashem-Stein C, Bernstein ID, Martin DIK. Inhibition of granulocytic differentiation by Notch 1. of special interest Proc Natl Acad Sci USA. 93:1996;13014-13019 Constitutive expression of the intracellular domain of Notch 1 in 32D cells - myeloid progenitors that undergo granulocyte differentiation in response to G-CSF - inhibits their differentiation and permits expansion of undifferentiated cells.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13014-13019
-
-
Milner, L.A.1
Bigas, A.2
Kopan, R.3
Brashem-Stein, C.4
Bernstein, I.D.5
Martin, D.I.K.6
-
49
-
-
0026534651
-
Immunoglobulin heavy-chain and CD3 delta-chain gene enhancers are DNasel-hypersensitive in hemopoietic progenitor cells
-
Ford AM, Bennett CA, Healy LE, Navarro E, Spooncer E, Greaves MF. Immunoglobulin heavy-chain and CD3 delta-chain gene enhancers are DNasel-hypersensitive in hemopoietic progenitor cells. Proc Natl Acad Sci USA. 89:1992;3424-3428.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 3424-3428
-
-
Ford, A.M.1
Bennett, C.A.2
Healy, L.E.3
Navarro, E.4
Spooncer, E.5
Greaves, M.F.6
-
50
-
-
0029876439
-
Tissue specific factors additively increase the probability of the all-or-none formation of a hypersensitive site
-
of special interest. The progressive deletion of NFE-2 and GATA-1 - but not NF1 or CACCC/Sp1 - sites reduces the probability of hypersensitive site formation at the chicken βA/ε globin enhancer. These results support a stochastic model of hypersensitive site formation during differentiation.
-
Boyes J, Felsenfeld G. Tissue specific factors additively increase the probability of the all-or-none formation of a hypersensitive site. of special interest EMBO J. 15:1996;2496-2507 The progressive deletion of NFE-2 and GATA-1 - but not NF1 or CACCC/Sp1 - sites reduces the probability of hypersensitive site formation at the chicken βA/ε globin enhancer. These results support a stochastic model of hypersensitive site formation during differentiation.
-
(1996)
EMBO J
, vol.15
, pp. 2496-2507
-
-
Boyes, J.1
Felsenfeld, G.2
-
51
-
-
0030028985
-
Transcriptional enhancers act in cis to suppress position-effect variegation
-
of special interest. Deletion of an enhancer from a stably integrated reporter cassette was found to have no immediate effect on the level of gene expression but to increase the rate of silencing. Similarly, stimulation of a metal-responsive enhancer slows the rate of silencing. These results support an 'on-off' rather than a continuously variable model of enhancer-mediated gene regulation.
-
Walters MC, Magis W, Fiering S, Eidemiller J, Scalzo D, Groudine M, Martin DIK. Transcriptional enhancers act in cis to suppress position-effect variegation. of special interest Genes Dev. 10:1996;185-195 Deletion of an enhancer from a stably integrated reporter cassette was found to have no immediate effect on the level of gene expression but to increase the rate of silencing. Similarly, stimulation of a metal-responsive enhancer slows the rate of silencing. These results support an 'on-off' rather than a continuously variable model of enhancer-mediated gene regulation.
-
(1996)
Genes Dev
, vol.10
, pp. 185-195
-
-
Walters, M.C.1
Magis, W.2
Fiering, S.3
Eidemiller, J.4
Scalzo, D.5
Groudine, M.6
Martin, D.I.K.7
-
52
-
-
0029912235
-
Locus control region function and heterochromatin induced position effect variegation
-
of special interest. The 3′ enhancer/LCR of the CD2 gene can be split into a part with enhancer activity and a separate part which acts to establish open chromatin, even in the normally heterochromatic pericentromeric regions of the chromosome. Part deletion of the LCR abrogates the ability to establish open chromatin domains, resulting in a bimodal pattern of transgene expression in which transcription in individual cells is either on or off. It is suggested that elements with these properties may effect binary decisions during development.
-
Festenstein R, Tolaini M, Corbella P, Mamalaki C, Parrington J, Fox M, Miliou A, Jones M, Kioussis D. Locus control region function and heterochromatin induced position effect variegation. of special interest Science. 271:1996;1123-1125 The 3′ enhancer/LCR of the CD2 gene can be split into a part with enhancer activity and a separate part which acts to establish open chromatin, even in the normally heterochromatic pericentromeric regions of the chromosome. Part deletion of the LCR abrogates the ability to establish open chromatin domains, resulting in a bimodal pattern of transgene expression in which transcription in individual cells is either on or off. It is suggested that elements with these properties may effect binary decisions during development.
-
(1996)
Science
, vol.271
, pp. 1123-1125
-
-
Festenstein, R.1
Tolaini, M.2
Corbella, P.3
Mamalaki, C.4
Parrington, J.5
Fox, M.6
Miliou, A.7
Jones, M.8
Kioussis, D.9
-
53
-
-
0030854907
-
Transcription factors normal myeloid development and leukaemia
-
Tenen DG, Hromas R, Licht JD, Zhang DE. Transcription factors normal myeloid development and leukaemia. Blood. 90:1997;489-519.
-
(1997)
Blood
, vol.90
, pp. 489-519
-
-
Tenen, D.G.1
Hromas, R.2
Licht, J.D.3
Zhang, D.E.4
|