Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment

Cell

Volumn 121, Issue 2, 2005, Pages 295-306

  Adolfsson, Jörgen ^a   Månsson, Robert ^a   Buza Vidas, Natalija ^a   Hultquist, Anne ^a   Liuba, Karina ^a   Jensen, Christina T ^a   Bryder, David ^a   Yang, Liping ^a   Borge, Ole Johan ^a   Thoren, Lina A M ^a   Anderson, Kristina ^a   Sitnicka, Ewa ^a   Sasaki, Yutaka ^a   Sigvardsson, Mikael ^a   Jacobsen, Sten Eirik W ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FLT3 LIGAND; INTERLEUKIN 7 RECEPTOR; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BLOOD CELL; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ERYTHROID CELL; GENE EXPRESSION; GRANULOCYTE; HEMATOPOIETIC STEM CELL; MEGAKARYOCYTE; MONOCYTE; MOUSE; MYELOID PROGENITOR CELL; NONHUMAN; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; T LYMPHOCYTE;

EID: 20244387299     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.02.013     Document Type: Article

References (54)

1. J. Adolfsson, O.J. Borge, D. Bryder, K. Theilgaard-Monch, I. Astrand-Grundstrom, E. Sitnicka, Y. Sasaki, and S.E. Jacobsen Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity Immunity 15 2001 659 669
2. K. Akashi, D. Traver, T. Miyamoto, and I.L. Weissman A clonogenic common myeloid progenitor that gives rise to all myeloid lineages Nature 404 2000 193 197
3. D. Bryder, and S.E. Jacobsen Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro Blood 96 2000 1748 1755
4. A.B. Cantor, and S.H. Orkin Transcriptional regulation of erythropoiesis: an affair involving multiple partners Oncogene 21 2002 3368 3376
5. J.L. Christensen, and I.L. Weissman Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells Proc. Natl. Acad. Sci. USA 98 2001 14541 14546
6. A. Cumano, and I. Godin Pluripotent hematopoietic stem cell development during embryogenesis Curr. Opin. Immunol. 13 2001 166 171
7. A. Cumano, C.J. Paige, N.N. Iscove, and G. Brady Bipotential precursors of B cells and macrophages in murine fetal liver Nature 356 1992 612 615
8. A. D'Amico, and L. Wu The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3 J. Exp. Med. 198 2003 293 303
9. S. Delassus, I. Titley, and T. Enver Functional and molecular analysis of hematopoietic progenitors derived from the aorta-gonad-mesonephros region of the mouse embryo Blood 94 1999 1495 1503
10. H. Ema, and H. Nakauchi Self-renewal and lineage restriction of hematopoietic stem cells Curr. Opin. Genet. Dev. 13 2003 508 512
11. A.L. Gurney, K. Carver-Moore, F.J. de Sauvage, and M.W. Moore Thrombocytopenia in c-mpl-deficient mice Science 265 1994 1445 1447
12. J.D. Hansen, and A.G. Zapata Lymphocyte development in fish and amphibians Immunol. Rev. 166 1998 199 220
13. D.E. Harrison, C.M. Astle, and C. Lerner Number and continuous proliferative pattern of transplanted primitive immunohematopoietic stem cells Proc. Natl. Acad. Sci. USA 85 1988 822 826
14. M. Hu, D. Krause, M. Greaves, S. Sharkis, M. Dexter, C. Heyworth, and T. Enver Multilineage gene expression precedes commitment in the hemopoietic system Genes Dev. 11 1997 774 785
15. K. Ikuta, and I.L. Weissman Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation Proc. Natl. Acad. Sci. USA 89 1992 1502 1506
16. Y. Katsura Redefinition of lymphoid progenitors Nat. Rev. Immunol. 2 2002 127 132
17. R.A. Kempf, S.A. Leibel, and E. Perlin Severe thrombocytopenia following total body irradiation Int. J. Radiat. Oncol. Biol. Phys. 6 1980 252
18. M. Kondo, I.L. Weissman, and K. Akashi Identification of clonogenic common lymphoid progenitors in mouse bone marrow Cell 91 1997 661 672
19. G. Lacaud, L. Carlsson, and G. Keller Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential Immunity 9 1998 827 838
20. C.L. Li, and G.R. Johnson Murine hematopoietic stem and progenitor cells: I. Enrichment and biologic characterization Blood 85 1995 1472 1479
21. M. Lu, H. Kawamoto, Y. Katsube, T. Ikawa, and Y. Katsura The common myelolymphoid progenitor: a key intermediate stage in hemopoiesis generating T and B cells J. Immunol. 169 2002 3519 3525
22. K. Mackarehtschian, J.D. Hardin, K.A. Moore, S. Boast, S.P. Goff, and I.R. Lemischka Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors Immunity 3 1995 147 161
23. Y. Matsuzaki, K. Kinjo, R.C. Mulligan, and H. Okano Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells Immunity 20 2004 87 93
24. H.J. McKenna, K.L. Stocking, R.E. Miller, K. Brasel, T. De Smedt, E. Maraskovsky, C.R. Maliszewski, D.H. Lynch, J. Smith, and B. Pulendran Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells Blood 95 2000 3489 3497
25. R.E. Mebius, T. Miyamoto, J. Christensen, J. Domen, T. Cupedo, I.L. Weissman, and K. Akashi The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, cd45(+)cd4(+)cd3(-) cells, as well as macrophages J. Immunol. 166 2001 6593 6601
26. D. Metcalf Hematopoietic regulators: redundancy or subtlety? Blood 82 1993 3515 3523
27. H.K. Mikkola, J. Klintman, H. Yang, H. Hock, T.M. Schlaeger, Y. Fujiwara, and S.H. Orkin Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene Nature 421 2003 547 551
28. T. Miyamoto, I.L. Weissman, and K. Akashi AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation Proc. Natl. Acad. Sci. USA 97 2000 7521 7526
29. T. Miyamoto, H. Iwasaki, B. Reizis, M. Ye, T. Graf, I.L. Weissman, and K. Akashi Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment Dev. Cell 3 2002 137 147
30. T. Na Nakorn, D. Traver, I.L. Weissman, and K. Akashi Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S J. Clin. Invest. 109 2002 1579 1585
31. T. Nakahata, A.J. Gross, and M. Ogawa A stochastic model of self-renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture J. Cell. Physiol. 113 1982 455 458
32. S.L. Nutt, D. Metcalf, A. D'Amico, M. Polli, and L. Wu Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors J. Exp. Med. 201 2005 221 231
33. M. Ogawa Differentiation and proliferation of hematopoietic stem cells Blood 81 1993 2844 2853
34. S.H. Orkin, R.A. Shivdasani, Y. Fujiwara, and M.A. McDevitt Transcription factor GATA-1 in megakaryocyte development Stem Cells 16 1998 79 83
35. M. Osawa, K. Hanada, H. Hamada, and H. Nakauchi Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell Science 273 1996 242 245
36. J.J. Peschon, P.J. Morrissey, K.H. Grabstein, F.J. Ramsdell, E. Maraskovsky, B.C. Gliniak, L.S. Park, S.F. Ziegler, D.E. Williams, and C.B. Ware Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice J. Exp. Med. 180 1994 1955 1960
37. T. Reya, S.J. Morrison, M.F. Clarke, and I.L. Weissman Stem cells, cancer, and cancer stem cells Nature 414 2001 105 111
38. T.M. Schmitt, and J.C. Zuniga-Pflucker Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro Immunity 17 2002 749 756
39. R.A. Shivdasani, and S.H. Orkin The transcriptional control of hematopoiesis Blood 87 1996 4025 4039
40. L. Siminovitch, E.A. McCulloch, and J.E. Till The distribution of colony-forming cells among spleen colonies J. Cell. Physiol. 62 1963 327 336
41. H. Singh Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates Curr. Opin. Immunol. 8 1996 160 165
42. E. Sitnicka, D. Bryder, K. Theilgaard-Monch, N. Buza-Vidas, J. Adolfsson, and S.E. Jacobsen Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool Immunity 17 2002 463 472
43. E. Sitnicka, C. Brakebusch, I.L. Martensson, M. Svensson, W.W. Agace, M. Sigvardsson, N. Buza-Vidas, D. Bryder, C.M. Cilio, and H. Ahlenius Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis J. Exp. Med. 198 2003 1495 1506
44. G.J. Spangrude, S. Heimfeld, and I.L. Weissman Purification and characterization of mouse hematopoietic stem cells Science 241 1988 58 62
45. H. Takano, H. Ema, K. Sudo, and H. Nakauchi Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs J. Exp. Med. 199 2004 295 302
46. A.V. Terskikh, T. Miyamoto, C. Chang, L. Diatchenko, and I.L. Weissman Gene expression analysis of purified hematopoietic stem cells and committed progenitors Blood 102 2003 94 101
47. J.E. Till, and E.A. McCulloch A direct measurement of the radiation sensitivity of normal mouse bone marrow cells Radiat. Res. 14 1961 213 222
48. N. Uchida, A. Tsukamoto, D. He, A.M. Friera, R. Scollay, and I.L. Weissman High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts J. Clin. Invest. 101 1998 961 966
49. O.P. Veiby, S.D. Lyman, and S.E. Jacobsen Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells Blood 88 1996 1256 1265
50. I.L. Weissman, D.J. Anderson, and F. Gage Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations Annu. Rev. Cell Dev. Biol. 17 2001 387 403
51. J.B. Whitney 3rd. Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine Biochem. Genet. 16 1978 667 672
52. P. Vieira, and A. Cumano Differentiation of B lymphocytes from hematopoietic stem cells Methods Mol. Biol. 271 2004 67 76
53. - short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated recipients Blood 105 2005 2717 2723 10.1182/blood-2004-06-2159 Published online November 30, 2004
54. J. Zhu, and S.G. Emerson Hematopoietic cytokines, transcription factors and lineage commitment Oncogene 21 2002 3295 3313