Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

Journal of Experimental Medicine

Volumn 202, Issue 11, 2005, Pages 1599-1611

  Passegué, Emmanuelle ^a   Wagers, Amy J ^a,b   Giuriato, Sylvie ^a   Anderson, Wade C ^a   Weissman, Irving L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYTOKINE;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; CELL POPULATION; CELL PROLIFERATION; CELL RENEWAL; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; STEM CELL MOBILIZATION;

ANIMALS; CELL DIFFERENTIATION; CELL SEPARATION; CELL TRANSFORMATION, NEOPLASTIC; G0 PHASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GRAFT SURVIVAL; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 28544436371     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20050967     Document Type: Article

References (36)

1. Weissman, I.L. 2000. Stem cells: units of development, units of regeneration, and units of evolution. Cell. 100:157-168.
2. Bradford, G.B., B. Williams, R. Rossi, and I. Bertoncello. 1997. Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment. Exp. Hematol. 25:445-453.
3. Cheshier, S.H., S.J. Morrison, X. Liao, and I.L. Weissman. 1999. In vivo proliferation and cell cycle kinetics of long-term hematopoietic stem cells. Proc. Natl. Acad. Sci. USA. 96:3120-3125.
4. Morrison, S.J., D.E. Wright, and I.L. Weissman. 1997. Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization. Proc. Natl. Acad. Sci. USA. 94:1908-1913.
5. Wright, D.E., S.H. Cheshier, A.J. Wagers, T.D. Randall, J.L. Christensen, and I.L. Weissman. 2001. Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood. 97:2278-2285.
6. Sherr, C.J., and J.M. Roberts. 2004. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18:2699-2711.
7. Smith, E.J., G. Leone, J. DeGregori, L. Jakoi, and J.R. Nevins. 1996. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol. Cell. Biol. 16:6965-6976.
8. Cheng, T., N. Rodrigues, H. Shen, Y. Yang, D. Dombkowski, M. Sykes, and D.T. Scadden. 2000. Hematopoietic stem cell quiescence maintained by p21CIP1/WAF1. Science. 287:1804-1808.
9. Cheng, T., N. Rodrigues, D. Dombkowski, S. Stier, and D.T. Scadden. 2000. Stem cell repopulation efficiency but not pool size is governed by p27KIP1. Nat. Med. 6:1235-1240.
10. INK4c. Nat. Cell Biol. 6:436-442.
11. Park, I.-K., D. Qian, M. Kiel, M.W. Becker, M. Pihalja, I.L. Weissman, S.J. Morrison, and M.F. Clarke. 2003. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 423:302-305.
12. Kozar, K., M.A. Ciemerych, V.I. Rebel, H. Shigematsu, A. Zagozdzon, E. Sicinska, Y. Geng, Q. Yu, S. Bhattacharya, R.T. Bronson, et al. 2004. Mouse development and cell proliferation in the absence of d-cyclins. Cell. 118:477-491.
13. Malumbres, M., R. Sotillo, D. Santamaria, J. Galan, A. Cerezo, S. Ortega, P. Dubus, and M. Barbacid. 2004. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell. 118:493-504.
14. Steinman, R.A. 2002. Cell cycle regulator and hematopoiesis. Oncogene. 21:3403-3413.
15. Venezia, T.A., A.A. Merchant, C.A. Ramos, N.L. Whitehouse, A.S. Young, C.A. Shaw, and M.A. Goodell. 2004. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2:e301.
16. Fleming, W.H., E.J. Alpern, N. Uchida, K. Ikuta, G.J. Spangrude, and I.L. Weissman. 1993. Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. J. Cell Biol. 122:897-902.
17. Glimm, H., J.H. Oh, and C.J. Eaves. 2000. Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G(2)/M transit and do not reenter G(0). Blood. 96:4185-4193.
18. Cashman, J., B. Dykstra, I. Clark-Lewis, A. Eaves, and C. Eaves. 2002. Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors. J. Exp. Med. 196:1141-1149.
19. Christensen, J.L., and I.L. Weissman. 2001. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Natl. Acad. Sci. USA. 98:14541-14546.
20. Morrison, S.J., and I.L. Weissman. 1994. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity. 1:661-673.
21. Akashi, K., D. Traver, T. Miyamoto, and I.L. Weissman. 2000. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 404:193-197.
22. Kondo, M., I.L. Weissman, and K. Akashi. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 91:661-672.
23. Forster, I., P. Vieira, and K. Rajewsky. 1989. Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse. Int. Immunol. 1:321-331.
24. Domen, J. 2000. The role of apoptosis in regulating hematopoiesis and hematopoietic stem cells. Immunol. Res. 22:83-94.
25. Sicinska, E., I. Aifantis, L. Le Cam, W. Swat, C. Borowski, Q. Yu, A.A. Ferrando, S.D. Levin, Y. Geng, H. von Boehmer, and P. Sicinski. 2003. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 4:451-461.
26. Neben, S., K. Marcus, and P. Mauch. 1993. Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor. Blood. 81:1960-1967.
27. Sage, J. 2004. Cyclin C makes an entry into the cell cycle. Dev. Cell. 6:607-616.
28. Yamaguchi, M., K. Ikebuchi, F. Hirayama, N. Sato, Y. Mogi, J. Ohkawara, Y. Yoshikawa, K. Sawada, T. Koike, and S. Sekiguchi. 1998. Different adhesive characteristics and VLA-4 expression of CD34(+) progenitors in G0/G1 versus S+G2/M phases of the cell cycle. Blood. 92:842-848.
29. + cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J. Exp. Med. 175:175-184.
30. Uchida, N., A.M. Friera, D. He, M.J. Reitsma, A.S. Tsukamoto, and I.L. Weissman. 1997. Hydroxyurea can be used to increase mouse c-kit+Thy-1.1(lo)Lin-/ loSca-1(+) hematopoietic cell number and frequency in cell cycle in vivo. Blood. 90:4354-4362.
31. Sharpless, N.E., N. Bardeesy, K.H. Lee, D. Carrasco, D.H. Castrillon, A.J. Aguirre, E.A. Wu, J.W. Horner, and R.A. DePinho. 2001. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 413:86-91.
32. Zindy, F., J. van Deursen, G. Grosveld, C.J. Sherr, and M.F. Roussel. 2000. INK4d-deficient mice are fertile despite testicular atrophy. Mol. Cell. Biol. 20:372-378.
33. KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature. 387:151-158.
34. Lipinski, M.M., and T. Jacks. 1999. The retinoblastoma gene family in differentiation and development. Oncogene. 18:7873-7882.
35. Cip1/Waf1 permits relative expansion of human hematopoietic stem cells. Blood. 102:1260-1266.
36. Reya, T., S.J. Morrison, M.F. Clarke, and I.L. Weissman. 2001. Stem cells, cancer, and cancer stem cells. Nature. 414:105-111.