-
1
-
-
0030272140
-
Development of the hematopoietic system
-
Orkin SH. Development of the hematopoietic system. Curr Opin Genet Dev. 6:1996;597-602.
-
(1996)
Curr Opin Genet Dev
, vol.6
, pp. 597-602
-
-
Orkin, S.H.1
-
2
-
-
0029876726
-
The transcriptional control of hematopoiesis
-
Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis. Blood. 87:1996;4025-4039.
-
(1996)
Blood
, vol.87
, pp. 4025-4039
-
-
Shivdasani, R.A.1
Orkin, S.H.2
-
3
-
-
0030838280
-
The lineage commitment of haemopoietic progenitor cells
-
Cross MA, Enver T. The lineage commitment of haemopoietic progenitor cells. Curr Opin Genet Dev. 7:1997;609-613.
-
(1997)
Curr Opin Genet Dev
, vol.7
, pp. 609-613
-
-
Cross, M.A.1
Enver, T.2
-
4
-
-
0030854907
-
Transcription factors, normal myeloid development, and leukemia
-
Tenen DG, Hromas R, Licht JD, Zhang DE. Transcription factors, normal myeloid development, and leukemia. Blood. 90:1997;489-519.
-
(1997)
Blood
, vol.90
, pp. 489-519
-
-
Tenen, D.G.1
Hromas, R.2
Licht, J.D.3
Zhang, D.E.4
-
5
-
-
0030993348
-
Transcription factors required for lymphoid lineage commitment
-
Georgopoulos K. Transcription factors required for lymphoid lineage commitment. Curr Opin Immunol. 9:1997;222-227.
-
(1997)
Curr Opin Immunol
, vol.9
, pp. 222-227
-
-
Georgopoulos, K.1
-
6
-
-
0344734109
-
Transcriptional regulation of B-cell differentiation
-
Reya T, Grosschedl R. Transcriptional regulation of B-cell differentiation. Curr Opin Immunol. 10:1998;158-165.
-
(1998)
Curr Opin Immunol
, vol.10
, pp. 158-165
-
-
Reya, T.1
Grosschedl, R.2
-
7
-
-
0031466610
-
Genetics of erythropoiesis: Induced mutations in mice and zebrafish
-
Orkin SH, Zon Ll. Genetics of erythropoiesis: induced mutations in mice and zebrafish. Annu Rev Genet. 31:1997;33-60.
-
(1997)
Annu Rev Genet
, vol.31
, pp. 33-60
-
-
Orkin, S.H.1
Zon, Ll.2
-
8
-
-
0027971744
-
Vintage reds and whites: Combinatorial transcription factor utilization in hematopoietic differentiation
-
Ness SA, Engel JD. Vintage reds and whites: combinatorial transcription factor utilization in hematopoietic differentiation. Curr Opin Genet Dev. 4:1994;718-724.
-
(1994)
Curr Opin Genet Dev
, vol.4
, pp. 718-724
-
-
Ness, S.A.1
Engel, J.D.2
-
9
-
-
0030986188
-
The hardwiring of development: Organization and function of genomic regulatory systems
-
Arnone MI, Davidson EH. The hardwiring of development: organization and function of genomic regulatory systems. Development. 124:1997;1851-1864.
-
(1997)
Development
, vol.124
, pp. 1851-1864
-
-
Arnone, M.I.1
Davidson, E.H.2
-
10
-
-
0032498230
-
The enhanceosome and transcriptional synergy
-
Carey M. The enhanceosome and transcriptional synergy. Cell. 92:1998;5-8.
-
(1998)
Cell
, vol.92
, pp. 5-8
-
-
Carey, M.1
-
11
-
-
18144444807
-
DNA binding of the glucocorticoid receptor is not essential for survival
-
of outstanding interest. Using a 'knock-in' approach, the authors analyze mice bearing a glucocorticoid receptor (GR) with a point mutation that abolishes dimerization and DNA binding. As a majority of the physiological roles attributed to GR are unaffected by the mutation, this study indicates that essential parts of GR functions are probably mediated by protein interactions rather than DNA binding.
-
Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schutz G. DNA binding of the glucocorticoid receptor is not essential for survival. of outstanding interest Cell. 93:1998;531-541 Using a 'knock-in' approach, the authors analyze mice bearing a glucocorticoid receptor (GR) with a point mutation that abolishes dimerization and DNA binding. As a majority of the physiological roles attributed to GR are unaffected by the mutation, this study indicates that essential parts of GR functions are probably mediated by protein interactions rather than DNA binding.
-
(1998)
Cell
, vol.93
, pp. 531-541
-
-
Reichardt, H.M.1
Kaestner, K.H.2
Tuckermann, J.3
Kretz, O.4
Wessely, O.5
Bock, R.6
Gass, P.7
Schmid, W.8
Herrlich, P.9
Angel, P.10
Schutz, G.11
-
12
-
-
0028799441
-
Association of erythroid transcription factors: Complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1
-
Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH. Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc Natl. Acad Sci USA. 92:1995;9585-9589.
-
(1995)
Proc Natl. Acad Sci USA
, vol.92
, pp. 9585-9589
-
-
Osada, H.1
Grutz, G.2
Axelson, H.3
Forster, A.4
Rabbitts, T.H.5
-
13
-
-
0030999645
-
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NL1 proteins
-
of outstanding interest. Using immunoprecipitations and binding-site selection protocols, this report demonstrates that GATA-1, LMO-2, Ldb1, SCL/tal-1 and E47 - for some of which individual interactions had been reported before - are assembled in a functional complex in erythroid cells. Immunoprecipitations directed against different components of the complex and binding-site selection from random oligonucleotides consistently identified defined composite GATA/E-box elements
-
Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A, Rabbitts TH. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NL1 proteins. of outstanding interest EMBO J. 16:1997;3145-3157 Using immunoprecipitations and binding-site selection protocols, this report demonstrates that GATA-1, LMO-2, Ldb1, SCL/tal-1 and E47 - for some of which individual interactions had been reported before - are assembled in a functional complex in erythroid cells. Immunoprecipitations directed against different components of the complex and binding-site selection from random oligonucleotides consistently identified defined composite GATA/E-box elements.
-
(1997)
EMBO J
, vol.16
, pp. 3145-3157
-
-
Wadman, I.A.1
Osada, H.2
Grutz, G.G.3
Agulnick, A.D.4
Westphal, H.5
Forster, A.6
Rabbitts, T.H.7
-
14
-
-
0030581174
-
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
-
Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell. 86:1996;47-57.
-
(1996)
Cell
, vol.86
, pp. 47-57
-
-
Porcher, C.1
Swat, W.2
Rockwell, K.3
Fujiwara, Y.4
Alt, F.W.5
Orkin, S.H.6
-
15
-
-
0028858855
-
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
-
Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 373:1995;432-434.
-
(1995)
Nature
, vol.373
, pp. 432-434
-
-
Shivdasani, R.A.1
Mayer, E.L.2
Orkin, S.H.3
-
16
-
-
0029781248
-
The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse
-
Robb L, Elwood NJ, Elefanty AG, Kontgen F, Li R, Barnett LD, Begley CG. The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J. 15:1996;4123-4129.
-
(1996)
EMBO J
, vol.15
, pp. 4123-4129
-
-
Robb, L.1
Elwood, N.J.2
Elefanty, A.G.3
Kontgen, F.4
Li, R.5
Barnett, L.D.6
Begley, C.G.7
-
17
-
-
0029121271
-
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
-
Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey RP, Metcalf D, Begley CG. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl. Acad Sci USA. 92:1995;7075-7079.
-
(1995)
Proc Natl. Acad Sci USA
, vol.92
, pp. 7075-7079
-
-
Robb, L.1
Lyons, I.2
Li, R.3
Hartley, L.4
Kontgen, F.5
Harvey, R.P.6
Metcalf, D.7
Begley, C.G.8
-
18
-
-
0032584104
-
The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis
-
-/- mice [14,16], suggesting that the direct interaction of SCL and LMO-2 is important in early hematopoietic progenitors.
-
-/- mice [14,16], suggesting that the direct interaction of SCL and LMO-2 is important in early hematopoietic progenitors.
-
(1998)
Proc Natl. Acad Sci USA
, vol.95
, pp. 3890-3895
-
-
Yamada, Y.1
Warren, A.J.2
Dobson, C.3
Forster, A.4
Pannell, R.5
Rabbitts, T.H.6
-
19
-
-
0028278325
-
The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development
-
Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 78:1994;45-57.
-
(1994)
Cell
, vol.78
, pp. 45-57
-
-
Warren, A.J.1
Colledge, W.H.2
Carlton, M.B.3
Evans, M.J.4
Smith, A.J.5
Rabbitts, T.H.6
-
20
-
-
0028233760
-
Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells
-
Weiss MJ, Keller G, Orkin SH. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev. 8:1994;1184-1197.
-
(1994)
Genes Dev
, vol.8
, pp. 1184-1197
-
-
Weiss, M.J.1
Keller, G.2
Orkin, S.H.3
-
21
-
-
0029926485
-
Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
-
Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci USA. 93:1996;12355-12358.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12355-12358
-
-
Fujiwara, Y.1
Browne, C.P.2
Cunniff, K.3
Goff, S.C.4
Orkin, S.H.5
-
22
-
-
0028022916
-
An early haematopoietic defect in mice lacking the transcription factor GATA-2
-
Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 371:1994;221-226.
-
(1994)
Nature
, vol.371
, pp. 221-226
-
-
Tsai, F.Y.1
Keller, G.2
Kuo, F.C.3
Weiss, M.4
Chen, J.5
Rosenblatt, M.6
Alt, F.W.7
Orkin, S.H.8
-
23
-
-
0030926190
-
Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation
-
-/- ES cells [14,16,18].
-
-/- ES cells [14,16,18].
-
(1997)
Blood
, vol.89
, pp. 3636-3643
-
-
Tsai, F.Y.1
Orkin, S.H.2
-
24
-
-
0031024994
-
Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line
-
of outstanding interest. of special interest. The authors established an erythroid cell line from GATA-1 -deficient ES cells to analyze the ability of GATA-1 and various deletion mutants to restore erythroid maturation. They observed that, although transactivation domains are dispensable for this function, the amino-terminal zinc finger is required. As this finger is not essential for binding to the vast majority of GATA recognition motifs on the DNA, it is proposed to serve as an interaction site for a partner protein, which indeed was later identified [26].
-
of outstanding interest Weiss MJ, Yu C, Orkin SH. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. of special interest Mol Cell Biol. 17:1997;1642-1651 The authors established an erythroid cell line from GATA-1 -deficient ES cells to analyze the ability of GATA-1 and various deletion mutants to restore erythroid maturation. They observed that, although transactivation domains are dispensable for this function, the amino-terminal zinc finger is required. As this finger is not essential for binding to the vast majority of GATA recognition motifs on the DNA, it is proposed to serve as an interaction site for a partner protein, which indeed was later identified [26].
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1642-1651
-
-
Weiss, M.J.1
Yu, C.2
Orkin, S.H.3
-
25
-
-
0031440922
-
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation
-
of outstanding interest. of special interest. These experiments demonstrate that LMO-2 and Ldb-1 inhibit GATA-1-induced erythroid maturation. A possible mechanism could be that they keep GATA-1 in a complex with SCL [13] and prevent its interaction with partners required at later differentiation stages, such as FOG [26,27].
-
of outstanding interest Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. of special interest Proc Natl Acad Sci USA. 94:1997;13707-13712 These experiments demonstrate that LMO-2 and Ldb-1 inhibit GATA-1-induced erythroid maturation. A possible mechanism could be that they keep GATA-1 in a complex with SCL [13] and prevent its interaction with partners required at later differentiation stages, such as FOG [26,27].
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13707-13712
-
-
Visvader, J.E.1
Mao, X.2
Fujiwara, Y.3
Hahm, K.4
Orkin, S.H.5
-
26
-
-
0031472234
-
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
-
of special interest. of outstanding interest. This report describes the isolation of FOG as a cofactor for GATA-1 in erythroid maturation. FOG binds to the amino-terminal zinc finger of GATA-1, previously identified as being essential for erythroid maturation [24]. Indeed, FOG cooperates with GATA-1 in transactivation and erythroid differentiation.
-
of special interest Tsang AP, Visvader JE, Turner CA, Fujiwara Y, Yu C, Weiss MJ, Crossley M, Orkin SH. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. of outstanding interest Cell. 90:1997;109-119 This report describes the isolation of FOG as a cofactor for GATA-1 in erythroid maturation. FOG binds to the amino-terminal zinc finger of GATA-1, previously identified as being essential for erythroid maturation [24]. Indeed, FOG cooperates with GATA-1 in transactivation and erythroid differentiation.
-
(1997)
Cell
, vol.90
, pp. 109-119
-
-
Tsang, A.P.1
Visvader, J.E.2
Turner, C.A.3
Fujiwara, Y.4
Yu, C.5
Weiss, M.J.6
Crossley, M.7
Orkin, S.H.8
-
27
-
-
0032522474
-
Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG
-
of outstanding interest. Gene inactivation of FOG in mice and ES cells reveals a blockage of erythroid maturation similar to the one observed upon GATA-1 inactivation, supporting an in vivo role of FOG as a GATA-1 cofactor during late stages of erythroid maturation. In addition, however, inactivation of FOG results in a failure of megakaryocytic differentiation, pointing to a GATA-independent role of FOG in megakaryopoiesis.
-
Tsang AP, Fujiwara Y, Hom DB, Orkin SH. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. of outstanding interest Genes Dev. 12:1998;1176-1188 Gene inactivation of FOG in mice and ES cells reveals a blockage of erythroid maturation similar to the one observed upon GATA-1 inactivation, supporting an in vivo role of FOG as a GATA-1 cofactor during late stages of erythroid maturation. In addition, however, inactivation of FOG results in a failure of megakaryocytic differentiation, pointing to a GATA-independent role of FOG in megakaryopoiesis.
-
(1998)
Genes Dev
, vol.12
, pp. 1176-1188
-
-
Tsang, A.P.1
Fujiwara, Y.2
Hom, D.B.3
Orkin, S.H.4
-
28
-
-
0030926006
-
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development
-
Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 16:1997;3965-3973.
-
(1997)
EMBO J
, vol.16
, pp. 3965-3973
-
-
Shivdasani, R.A.1
Fujiwara, Y.2
McDevitt, M.A.3
Orkin, S.H.4
-
29
-
-
0028963735
-
Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF
-
Merika M, Orkin SH. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol Cell Biol. 15:1995;2437-2447.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2437-2447
-
-
Merika, M.1
Orkin, S.H.2
-
30
-
-
0029010790
-
Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene
-
Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature. 375:1995;316-318.
-
(1995)
Nature
, vol.375
, pp. 316-318
-
-
Nuez, B.1
Michalovich, D.2
Bygrave, A.3
Ploemacher, R.4
Grosveld, F.5
-
31
-
-
0028990264
-
Lethal beta-thalassaemia in mice lacking the erythroid CACCC- transcription factor EKLF
-
Perkins AC, Sharpe AH, Orkin SH. Lethal beta-thalassaemia in mice lacking the erythroid CACCC- transcription factor EKLF. Nature. 375:1995;318-322.
-
(1995)
Nature
, vol.375
, pp. 318-322
-
-
Perkins, A.C.1
Sharpe, A.H.2
Orkin, S.H.3
-
32
-
-
0028813664
-
A direct physical association between ETS and AP-1 transcription factors in normal human T cells
-
Bassuk AG, Leiden JM. A direct physical association between ETS and AP-1 transcription factors in normal human T cells. Immunity. 3:1995;223-237.
-
(1995)
Immunity
, vol.3
, pp. 223-237
-
-
Bassuk, A.G.1
Leiden, J.M.2
-
33
-
-
0029870839
-
MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation
-
Sieweke MH, Tekotte H, Frampton J, Graf T. MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. Cell. 85:1996;49-60.
-
(1996)
Cell
, vol.85
, pp. 49-60
-
-
Sieweke, M.H.1
Tekotte, H.2
Frampton, J.3
Graf, T.4
-
34
-
-
0032125697
-
Regulation of eosinophil-specific gene expression by C/EBP-Ets complex and GATA-1
-
of special interest. This study shows that a complex of Ets-1, C/EBP and possibly GATA-1 controls the eosinophil-specific expression of the EOS47 gene, giving a molecular explanation for the reprogramming into eosinophils observed upon expression of GATA-1 in myeloblasts [51] or C/EBP in MEP cells [48].
-
McNagny K, Sieweke M, Döderlein G, Graf T, Nerlov C. Regulation of eosinophil-specific gene expression by C/EBP-Ets complex and GATA-1. of special interest EMBO J. 17:1998;3669-3680 This study shows that a complex of Ets-1, C/EBP and possibly GATA-1 controls the eosinophil-specific expression of the EOS47 gene, giving a molecular explanation for the reprogramming into eosinophils observed upon expression of GATA-1 in myeloblasts [51] or C/EBP in MEP cells [48].
-
(1998)
EMBO J
, vol.17
, pp. 3669-3680
-
-
McNagny, K.1
Sieweke, M.2
Döderlein, G.3
Graf, T.4
Nerlov, C.5
-
35
-
-
0032536821
-
Cooperative interaction of Ets-1 with USF-1 required for HIV-1 enhancer activity in T cells
-
of special interest. This paper demonstrates that the interaction between Ets-1 and USF-1 is highly selective within the respective protein families. Such selective interactions might explain why transcription factors with little apparent differences in DNA-binding specificity can exert specific cellular functions. The study also shows that the two factors cooperate on a composite site of the HIV enhancer in T-cells. The association between the two factors is critical as a truncated Ets-1 molecule containing the interaction site can inhibit the activity of the enhancer without binding to DNA.
-
Sieweke MH, Tekotte H, Jarosch U, Graf T. Cooperative interaction of Ets-1 with USF-1 required for HIV-1 enhancer activity in T cells. of special interest EMBO J. 17:1998;1728-1739 This paper demonstrates that the interaction between Ets-1 and USF-1 is highly selective within the respective protein families. Such selective interactions might explain why transcription factors with little apparent differences in DNA-binding specificity can exert specific cellular functions. The study also shows that the two factors cooperate on a composite site of the HIV enhancer in T-cells. The association between the two factors is critical as a truncated Ets-1 molecule containing the interaction site can inhibit the activity of the enhancer without binding to DNA.
-
(1998)
EMBO J
, vol.17
, pp. 1728-1739
-
-
Sieweke, M.H.1
Tekotte, H.2
Jarosch, U.3
Graf, T.4
-
36
-
-
0030024112
-
CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter
-
Zhang DE, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen HM, Hiebert SW, Tenen DG. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol. 16:1996;1231-1240.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1231-1240
-
-
Zhang, D.E.1
Hetherington, C.J.2
Meyers, S.3
Rhoades, K.L.4
Larson, C.J.5
Chen, H.M.6
Hiebert, S.W.7
Tenen, D.G.8
-
37
-
-
0029793902
-
PU,1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
-
Smith LT, Hohaus S, Gonzalez DA, Dziennis SE, Tenen DG. PU,1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood. 88:1996;1234-1247.
-
(1996)
Blood
, vol.88
, pp. 1234-1247
-
-
Smith, L.T.1
Hohaus, S.2
Gonzalez, D.A.3
Dziennis, S.E.4
Tenen, D.G.5
-
38
-
-
0029886810
-
Interaction of the co-activator CBP with Myb proteins: Effects on Myb- specific transactivation and on the cooperativity with NF-M
-
Oelgeschlager M, Janknecht R, Krieg J, Schreek S, Luscher B. Interaction of the co-activator CBP with Myb proteins: effects on Myb- specific transactivation and on the cooperativity with NF-M. EMBO J. 15:1996;2771-2780.
-
(1996)
EMBO J
, vol.15
, pp. 2771-2780
-
-
Oelgeschlager, M.1
Janknecht, R.2
Krieg, J.3
Schreek, S.4
Luscher, B.5
-
39
-
-
0030012002
-
CBP as a transcriptional coactivator of c-Myb
-
Dai P, Akimaru H, Tanaka Y, Hou DX, Yasukawa T, Kanei-Ishii C, Takahashi T, Ishii S. CBP as a transcriptional coactivator of c-Myb. Genes Dev. 10:1996;528-540.
-
(1996)
Genes Dev
, vol.10
, pp. 528-540
-
-
Dai, P.1
Akimaru, H.2
Tanaka, Y.3
Hou, D.X.4
Yasukawa, T.5
Kanei-Ishii, C.6
Takahashi, T.7
Ishii, S.8
-
40
-
-
0028947450
-
Myb and Ets proteins cooperate to transactivate an early myeloid gene
-
Shapiro LH. Myb and Ets proteins cooperate to transactivate an early myeloid gene. J Biol Chem. 270:1995;8763-8771.
-
(1995)
J Biol Chem
, vol.270
, pp. 8763-8771
-
-
Shapiro, L.H.1
-
41
-
-
0030794281
-
Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb
-
Britos-Bray M, Friedman AD. Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb. Mol Cell Biol. 17:1997;5127-5135.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5127-5135
-
-
Britos-Bray, M.1
Friedman, A.D.2
-
42
-
-
0031924678
-
A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions
-
Yang C, Shapiro LH, Rivera M, Kumar A, Brindle PK. A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol Cell Biol. 18:1998;2218-2229.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2218-2229
-
-
Yang, C.1
Shapiro, L.H.2
Rivera, M.3
Kumar, A.4
Brindle, P.K.5
-
43
-
-
0032101379
-
Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
-
Kitabayashi I, Yokoyama A, Shimizu K, Ohki M. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J. 17:1998;2994-3004.
-
(1998)
EMBO J
, vol.17
, pp. 2994-3004
-
-
Kitabayashi, I.1
Yokoyama, A.2
Shimizu, K.3
Ohki, M.4
-
44
-
-
0031029557
-
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha- deficient mice
-
of special interest. See annotation [45].
-
Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha- deficient mice. of special interest Proc Natl Acad Sci USA. 94:1997;569-574 See annotation [45].
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 569-574
-
-
Zhang, D.E.1
Zhang, P.2
Wang, N.D.3
Hetherington, C.J.4
Darlington, G.J.5
Tenen, D.G.6
-
45
-
-
0030659176
-
Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice
-
-/- occurs later in maturation, indicating that the two proteins serve successive functions during the differentiation process, possibly because they replace each other as crucial components of transcription factor complexes.
-
-/- occurs later in maturation, indicating that the two proteins serve successive functions during the differentiation process, possibly because they replace each other as crucial components of transcription factor complexes.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13187-13192
-
-
Yamanaka, R.1
Barlow, C.2
Lekstrom-Himes, J.3
Castilla, L.H.4
Liu, P.P.5
Eckhaus, M.6
Decker, T.7
Wynshaw-Boris, A.8
Xanthopoulos, K.G.9
-
46
-
-
0025821494
-
A functional c-myb gene is required for normal murine fetal hepatic hematopolesis
-
Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, Pietryga DW, Scott WJ Jr, Potter SS. A functional c-myb gene is required for normal murine fetal hepatic hematopolesis. Cell. 65:1991;677-689.
-
(1991)
Cell
, vol.65
, pp. 677-689
-
-
Mucenski, M.L.1
McLain, K.2
Kier, A.B.3
Swerdlow, S.H.4
Schreiner, C.M.5
Miller, T.A.6
Pietryga, D.W.7
Scott W.J., Jr.8
Potter, S.S.9
-
47
-
-
0030061554
-
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
-
Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 84:1996;321-330.
-
(1996)
Cell
, vol.84
, pp. 321-330
-
-
Okuda, T.1
Van Deursen, J.2
Hiebert, S.W.3
Grosveld, G.4
Downing, J.R.5
-
48
-
-
0032145528
-
Distinct C/EBP functions are required for eosinophil lineage commitment and maturation
-
of special interest. When ectopically expressed in multipotent MEP progenitor cells, C/EBPα and β isoforms are shown to induce eosinophil differentiation. In addition, C/EBPβ induces myeloblast differentiation in a subset of the cells.
-
Nerlov C, McNagny KM, Döderlein G, Kowenz-Leutz E, Graf T. Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. of special interest Genes Dev. 12:1998;2413-2425 When ectopically expressed in multipotent MEP progenitor cells, C/EBPα and β isoforms are shown to induce eosinophil differentiation. In addition, C/EBPβ induces myeloblast differentiation in a subset of the cells.
-
(1998)
Genes Dev
, vol.12
, pp. 2413-2425
-
-
Nerlov, C.1
McNagny, K.M.2
Döderlein, G.3
Kowenz-Leutz, E.4
Graf, T.5
-
49
-
-
0029619087
-
NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line
-
Muller C, Kowenz-Leutz E, Grieser-Ade S, Graf T, Leutz A. NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line. EMBO J. 14:1995;6127-6135.
-
(1995)
EMBO J
, vol.14
, pp. 6127-6135
-
-
Muller, C.1
Kowenz-Leutz, E.2
Grieser-Ade, S.3
Graf, T.4
Leutz, A.5
-
50
-
-
0032478276
-
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation
-
Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci USA. 95:1998;2061-2066.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2061-2066
-
-
Blobel, G.A.1
Nakajima, T.2
Eckner, R.3
Montminy, M.4
Orkin, S.H.5
-
51
-
-
0029066359
-
GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts
-
Kulessa H, Frampton J, Graf T. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes Dev. 9:1995;1250-1262.
-
(1995)
Genes Dev
, vol.9
, pp. 1250-1262
-
-
Kulessa, H.1
Frampton, J.2
Graf, T.3
-
52
-
-
0026489910
-
GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line
-
Visvader JE, Elefanty AG, Strasser A, Adams JM. GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line. EMBO J. 11:1992;4557-4564.
-
(1992)
EMBO J
, vol.11
, pp. 4557-4564
-
-
Visvader, J.E.1
Elefanty, A.G.2
Strasser, A.3
Adams, J.M.4
-
53
-
-
0030042608
-
Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation
-
Hoang T, Paradis E, Brady G, Billia F, Nakahara K, Iscove NN, Kirsch IR. Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation. Blood. 87:1996;102-111.
-
(1996)
Blood
, vol.87
, pp. 102-111
-
-
Hoang, T.1
Paradis, E.2
Brady, G.3
Billia, F.4
Nakahara, K.5
Iscove, N.N.6
Kirsch, I.R.7
-
54
-
-
0031897459
-
C-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation
-
Hedge SP, Kumar A, Kurschner C, Shapiro LH. c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation. Mol Cell Biol. 18:1998;2729-2737.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2729-2737
-
-
Hedge, S.P.1
Kumar, A.2
Kurschner, C.3
Shapiro, L.H.4
-
55
-
-
0031437119
-
Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
-
of outstanding interest. This provoking study shows that the transcription factor Ikaros - a key regulator of lymphocyte differentiation - is localized to discrete heterochromatic subnuclear domains, where it associates with inactive but not with active genes. The colocalization of silent genes with the Ikaros domains is reversed upon gene activation during differentiation. The mechanism for this is unknown but as Ikaros forms complexes and colocalizes with other factors, such as Helios, in some cells but not others [56], changes in complex composition during differentiation could determine which genes are recruited to the subnuclear domains. Thus, the ability of particular enhancers to recruit transcription factors may be restricted by the compartmentalization of pre-existing transcription factor complexes in specific subnuclear domains.
-
Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. of outstanding interest Cell. 91:1997;845-854 This provoking study shows that the transcription factor Ikaros - a key regulator of lymphocyte differentiation - is localized to discrete heterochromatic subnuclear domains, where it associates with inactive but not with active genes. The colocalization of silent genes with the Ikaros domains is reversed upon gene activation during differentiation. The mechanism for this is unknown but as Ikaros forms complexes and colocalizes with other factors, such as Helios, in some cells but not others [56], changes in complex composition during differentiation could determine which genes are recruited to the subnuclear domains. Thus, the ability of particular enhancers to recruit transcription factors may be restricted by the compartmentalization of pre-existing transcription factor complexes in specific subnuclear domains.
-
(1997)
Cell
, vol.91
, pp. 845-854
-
-
Brown, K.E.1
Guest, S.S.2
Smale, S.T.3
Hahm, K.4
Merkenschlager, M.5
Fisher, A.G.6
-
56
-
-
15144358621
-
Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
-
Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev. 12:1998;782-796.
-
(1998)
Genes Dev
, vol.12
, pp. 782-796
-
-
Hahm, K.1
Cobb, B.S.2
McCarty, A.S.3
Brown, K.E.4
Klug, C.A.5
Lee, R.6
Akashi, K.7
Weissman, I.L.8
Fisher, A.G.9
Smale, S.T.10
-
57
-
-
0032524357
-
New twists in gene regulation by glucocorticoid receptor: Is DNA binding dispensable?
-
Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell. 93:1998;487-490.
-
(1998)
Cell
, vol.93
, pp. 487-490
-
-
Karin, M.1
-
58
-
-
0032522804
-
Autocrine growth and anchorage independence: Two complementing Jun-controlled genetic programs of cellular transformation
-
of special interest. By introducing mutations into the c-Jun leucine zipper that selectively abolish dimerization with either Fos or ATF2, the authors demonstrate that the interaction with either protein specifies a separate function of c-Jun in cell transformation.
-
van Dam H, Huguier S, Kooistra K, Baguet J, Vial E, van der Eb AJ, Herrlich P, Angel P, Castellazzi M. Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation. of special interest Genes Dev. 12:1998;1227-1239 By introducing mutations into the c-Jun leucine zipper that selectively abolish dimerization with either Fos or ATF2, the authors demonstrate that the interaction with either protein specifies a separate function of c-Jun in cell transformation.
-
(1998)
Genes Dev
, vol.12
, pp. 1227-1239
-
-
Van Dam, H.1
Huguier, S.2
Kooistra, K.3
Baguet, J.4
Vial, E.5
Van Der Eb, A.J.6
Herrlich, P.7
Angel, P.8
Castellazzi, M.9
|