Hematopoietic cells maintain hematopoietic fates upon entering the brain

Journal of Experimental Medicine

Volumn 201, Issue 10, 2005, Pages 1579-1589

  Massengale, Mei ^a   Wagers, Amy J ^a   Vogel, Hannes ^a   Weissman, Irving L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD45 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; HOE 33342; KAINIC ACID; STEM CELL FACTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; BRAIN TISSUE; CELL DIFFERENTIATION; CELL FATE; CELL TYPE; GLIA CELL; HEMATOPOIETIC STEM CELL; IMMUNOREACTIVITY; MOUSE; NONHUMAN; OLFACTORY BULB; PARABIOSIS; PRIORITY JOURNAL; PROGENY; PURKINJE CELL;

ANIMALS; ANTIGENS, DIFFERENTIATION; BRAIN; BRAIN INJURIES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINEAGE; CRANIAL IRRADIATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MICE; NEUROGLIA; NEURONS;

EID: 19344364684     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20050030     Document Type: Article

References (48)

1. Brazelton, T.R., F.M. Rossi, G.I. Keshet, and H.M. Blau. 2000. From marrow to brain: expression of neuronal phenotypes in adult mice. Science. 290:1775-1779.
2. Mezey, E., K.J. Chandross, G. Harta, R.A. Maki, and S.R. McKercher. 2000. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science. 290:1779-1782.
3. Black, I.B., and D. Woodbury. 2001. Adult rat and human bone marrow stromal stem cells differentiate into neurons. Blood Cells Mol. Dis. 27:632-636.
4. Cogle, C.R., A.T. Yachnis, E.D. Laywell, D.S. Zander, J.R. Wingard, D.A. Steindler, and E.W. Scott. 2004. Bone marrow transdifferentiation in brain after transplantation: a retrospective study. Lancet. 363:1432-1437.
5. Kabos, P., M. Ehtesham, A. Kabosova, K.L. Black, and J.S. Yu. 2002. Generation of neural progenitor cells from whole adult bone marrow. Exp. Neurol. 178:288-293.
6. Munoz-Elias, G., D. Woodbury, and I.B. Black. 2003. Marrow stromal cells, mitosis, and neuronal differentiation: stem cell and precursor functions. Stem. Cells. 21:437-448.
7. Munoz-Elias, G., A.J. Marcus, T.M. Coyne, D. Woodbury, and I.B. Black. 2004. Adult bone marrow stromal cells in the embryonic brain: engraftment, migration, differentiation, and long-term survival. J. Neurosci. 24:4585-4595.
8. Mezey, E., S. Key, G. Vogelsang, I. Szalayova, G.D. Lange, and B. Crain. 2003. Transplanted bone marrow generates new neurons in human brains. Proc. Natl. Acad. Sci. USA. 100:1364-1369.
9. Priller, J., D.A. Persons, F.F. Klett, G. Kempermann, G.W. Kreutzberg, and U. Dirnagl. 2001. Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo. J. Cell Biol. 155:733-738.
10. Takizawa, S. 2003. Differentiation of adult bone marrow cells into neurons and endothelial cells in rat brain after stroke in the presence of cytokines. [In Japanese.] Rinsho Shinkeigaku. 43:830-831.
11. Torrente, Y., M. Belicchi, F. Pisati, S.F. Pagano, F. Fortunato, M. Sironi, M.G. D'Angelo, E.A. Parati, G. Scarlato, and N. Bresolin. 2002. Alternative sources of neurons and glia from somatic stem cells. Cell Transplant. 11:25-34.
12. Woodbury, D., E.J. Schwarz, D.J. Prockop, and I.B. Black. 2000. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61:364-370.
13. Zhao, Y., D. Glesne, and E. Huberman. 2003. A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc. Natl. Acad. Sci. USA. 100:2426-2431.
14. Eglitis, M.A., and E. Mezey. 1997. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc. Natl. Acad. Sci. USA. 94:4080-4085.
15. Sanchez-Ramos, J., S. Song, F. Cardozo-Pelaez, C. Hazzi, T. Stedeford, A. Willing, T.B. Freeman, S. Saporta, W. Janssen, N. Patel, et al. 2000. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp. Neurol. 164:247-256.
16. Corti, S., F. Locatelli, S. Strazzer, S. Salani, R. Del Bo, D. Soligo, P. Bossolasco, N. Bresolin, G. Scarlato, and G.P. Comi. 2002. Modulated generation of neuronal cells from bone marrow by expansion and mobilization of circulating stem cells with in vivo cytokine treatment. Exp. Neurol. 177:443-452.
17. Wagers, A.J., and I.L. Weissman. 2004. Plasticity of adult stem cells. Cell. 116:639-648.
18. Trowbridge, I.S., and M.L. Thomas. 1994. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu. Rev. Immunol. 12:85-116.
19. Ito, D., Y. Imai, K., Ohsawa, K. Nakajima, Y. Fukuuchi, and S. Kohsaka. 1998. Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res. Mol. Brain Res. 57:1-9.
20. Mullen, R.J., C.R. Buck, and A.M. Smith. 1992. NeuN, a neuronal specific nuclear protein in vertebrates. Development. 116:201-211.
21. van Praag, H., G. Kempermann, and F.H. Gage. 1999. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2:266-270.
22. van Praag, H., B.R. Christie, T.J. Sejnowski, and F.H. Gage. 1999. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. USA. 96:13427-13431.
23. Mizumatsu, S., M.L. Monje, D.R. Morhardt, R. Rola, T.D. Palmer, and J.R. Fike. 2003. Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 63:4021-4027.
24. Monje, M.L., and T. Palmer. 2003. Radiation injury and neurogenesis. Curr. Opin. Neurol. 16:129-134.
25. Monje, M.L., H. Toda, and T.D. Palmer. 2003. Inflammatory blockade restores adult hippocampal neurogenesis. Science. 302:1760-1765.
26. Alvarez-Dolado, M., R. Pardal, J.M. Garcia-Verdugo, J.R. Fike, H.O. Lee, K. Pfeffer, C. Lois, S.J. Morrison, and A. Alvarez-Buylla. 2003. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature. 425:968-973.
27. Weimann, J.M., C.B. Johansson, A. Trejo, and H.M. Blau. 2003. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat. Cell Biol. 5:959-966.
28. Weimann, J.M., C.A. Charlton, T.R. Brazelton, R.C. Hackman, and H.M. Blau. 2003. Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc. Natl. Acad. Sci. USA. 100:2088-2093.
29. Bunster, E., and R.K. Meyer. 1933. An improved method of parabiosis. Anat. Rec. 57:339-343.
30. Wright, D.E., A.J. Wagers, A.P. Gulati, F.L. Johnson, and I.L. Weissman. 2001. Physiological migration of hematopoietic stem and progenitor cells. Science. 294:1933-1936.
31. Wagers, A.J., R.I. Sherwood, J.L. Christensen, and I.L. Weissman. 2002. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. 297:2256-2259.
32. Vallieres, L., and P.E. Sawchenko. 2003. Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity. J. Neurosci. 23:5197-5207.
33. Priller, J., A. Flugel, T. Wehner, M. Boentert, C.A. Haas, M. Prinz, F. Fernandez-Klett, K. Prass, I. Bechmann, B.A. de Boer, et al. 2001. Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat. Med. 7:1356-1361.
34. Ling, E.A., and W.C. Wong. 1993. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia. 7:9-18.
35. Hess, D.C., T. Abe, W.D. Hill, A.M. Studdard, J. Carothers, M. Masuya, P.A. Fleming, C.J. Drake, and M. Ogawa. 2004. Hematopoietic origin of microglial and perivascular cells in brain. Exp. Neurol. 186:134-144.
36. Flugel, A., M. Bradl, G.W. Kreutzberg, and M.B. Graeber. 2001. Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy. J. Neurosci. Res. 66:74-82.
37. Hickey, W.F., and H. Kimura. 1988. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science. 239:290-292.
38. Del Rio-Hortega, P. 1932. Microglia. Cytology & Cellular Pathology of the Nervous System. Paul B. Hoeber, Inc., New York. 483-534 pp.
39. Kaur, C., A.J. Hao, C.H. Wu, and E.A. Ling. 2001. Origin of microglia. Microsc. Res. Tech. 54:2-9.
40. Yang, D.D., C.Y. Kuan, A.J. Whitmarsh, M. Rincon, T.S. Zheng, R.J. Davis, P. Rakic, and R.A. Flavell. 1997. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 389:865-870.
41. Yoshimura, S., Y. Takagi, J. Harada, T. Teramoto, S.S. Thomas, C. Waeber, J.C. Bakowska, X.O. Breakefield, and M.A. Moskowitz. 2001. FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Proc. Natl. Acad. Sci. USA. 98:5874-5879.
42. Sedgwick, J.D., S. Schwender, H. Imrich, R. Dorries, G.W. Butcher, and V. ter Meulen. 1991. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc. Natl. Acad. Sci. USA. 88:7438-7442.
43. Wright, D.E., S.H. Cheshier, A.J. Wagers, T.D. Randall, J.L. Christensen, and I.L. Weissman. 2001. Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood. 97:2278-2285.
44. Morrison, S.J., A.M. Wandycz, H.D. Hemmati, D.E. Wright, and I.L. Weissman. 1997. Identification of a lineage of multipotent hematopoietic progenitors. Development. 124:1929-1939.
45. Morrison, S.J., and I.L. Weissman. 1994. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity. 1:661-673.
46. Spangrude, G.J., S. Heimfeld, and I.L. Weissman. 1988. Purification and characterization of mouse hematopoietic stem cells. Science. 241:58-62.
47. Wagers, A.J., R.C. Allsopp, and I.L. Weissman. 2002. Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo) Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor. Exp. Hematol. 30:176-185.
48. Okabe, M., M. Ikawa, K. Kominami, T. Nakanishi, and Y. Nishimune. 1997. 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 407:313-319.