Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo

Journal of Experimental Medicine

Volumn 198, Issue 2, 2003, Pages 305-313

  Karsunky, Holger ^a,d   Merad, Miriam ^a   Cozzio, Antonio ^a   Weissman, Irving L ^a   Manz, Markus G ^a,b,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^c Inst for Res in Biomedicine   (Switzerland)

^d STANFORD UNIVERSITY   (United States)

Author keywords

Dendritic cells; Development; Flt3 Flt3L; Hematopoietic progenitors

Indexed keywords

FLT3 LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL ACTIVITY; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; DOWNSTREAM PROCESSING; EPIDERMIS CELL; ERYTHROCYTE; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; LYMPHOID CELL; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; REGULATORY MECHANISM; SPLEEN CELL; STEADY STATE; STEM CELL; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CLONAL ANERGY; CROSSES, GENETIC; DENDRITIC CELLS; FLOW CYTOMETRY; FMS-LIKE TYROSINE KINASE 3; LYMPHOCYTES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SKIN; SPLEEN; THYMUS GLAND;

EID: 0042662868     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030323     Document Type: Article

References (43)

1. Matthews, W., C.T. Jordan, G.W. Wiegand, D. Pardoll, and I.R. Lemischka. 1991. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell. 65:1143-1152.
2. Small, D., M. Levenstein, E. Kim, C. Carow, S. Amin, P. Rockwell, L. Witte, C. Burrow, M.Z. Ratajczak, A.M. Gewirtz, et al. 1994. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc. Natl. Acad. Sci. USA. 91:459-463.
3. Lyman, S.D., and S.E. Jacobsen. 1998. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood. 91:1101-1134.
4. Mackarehtschian, K., J.D. Hardin, K.A. Moore, S. Boast, S.P. Goff, and I.R. Lemischka. 1995. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity. 3:147-161,
5. McKenna, H.J., K.L. Stocking, R.E. Miller, K. Brasel, T. De Smedt, E. Maraskovsky, C.R. Maliszewski, D.H. Lynch, J. Smith, B. Pulendran, et al. 2000. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood. 95:3489-3497.
6. Brasel, K., H.J. McKenna, P.J. Morrissey, K. Charrier, A.E. Morris, C.C. Lee, D.E. Williams, and S.D. Lyman. 1996. Hematologic effects of flt3 ligand in vivo in mice. Blood. 88:2004-2012.
7. Brasel, K., H.J. McKenna, K. Charrier, P.J. Morrissey, D.E. Williams, and S.D. Lyman. 1997. Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice. Blood. 90:3781-3788.
8. Maraskovsky, E., K. Brasel, M. Teepe, E.R. Roux, S.D. Lyman, K. Shortman, and H.J. McKenna. 1996. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J. Exp. Med. 184:1953-1962,
9. Juan, T.S., I.K. McNiece, G. Van, D. Lacey, C. Hartley, P. McElroy, Y. Sun, J. Argento, D. Hill, X.Q. Yan, et al. 1997. Chronic expression of murine flt3 ligand in mice results in increased circulating white blood cell levels and abnormal cellular infiltrates associated with splenic fibrosis. Blood. 90:76-84.
10. Hawley, T.S., A.Z. Fong, H. Griesser, S.D. Lyman, and R.G. Hawley. 1998. Leukemic predisposition of mice transplanted with gene-modified hematopoietic precursors expressing flt3 ligand. Blood. 92:2003-2011.
11. Kelly, L.M., Q. Liu, J.L. Kutok, I.R. Williams, C.L. Boulton, and D.G. Gilliland. 2002. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood. 99:310-318.
12. Shaw, S.G., A.A. Maung, R.J. Steptoe, A.W. Thomson, and N.L. Vujanovic. 1998. Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy. J. Immunol. 161:2817-2824.
13. O'Keeffe, M., H. Hochrein, D. Vremec, J. Pooley, R. Evans, S. Woulfe, and K. Shortman. 2002. Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice. Blood. 99:2122-2130.
14. Brasel, K., T. De Smedt, J.L. Smith, and C.R. Maliszewski. 2000. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood. 96:3029-3039.
15. Gilliet, M., A. Boonstra, C. Paturel, S. Antonenko, X.L. Xu, G. Trinchieri, A. O'Garra, and Y.J. Liu. 2002. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3 ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 195:953-958.
16. Kondo, M., I.L. Weissman, and K. Akashi. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 91:661-672.
17. Akashi, K., D. Traver, T. Miyamoto, and I.L. Weissman. 2000. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 404:193-197.
18. Traver, D., K. Akashi, M. Manz, M. Merad, T. Miyamoto, E.G. Engleman, and I.L. Weissman. 2000. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science. 290:2152-2154.
19. Manz, M.G., D. Traver, T. Miyamoto, I.L. Weissman, and K. Akashi. 2001. Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood. 97:3333-3341.
20. Wu, L., A. D'Amico, H. Hochrein, M. O'Keeffe, K. Shortman, and K. Lucas. 2001. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood. 98:3376-3382.
21. Christensen, J.L., and I.L. Weissman. 2001. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Natl. Acad. Sci. USA. 98:14541-14546.
22. Adolfsson, J., O.J. Borge, D. Bryder, K. Theilgaard-Monch, I. Astrand-Grundstrom, E. Sitnicka, Y, Sasaki, and S.E. Jacobsen. 2001. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 15:659-669.
23. Hardy, R.R., C.E. Carmack, S.A. Shinton, J.D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213-1225.
24. Asselin-Paturel, C., A. Boonstra, M. Dalod, I. Durand, N. Yessaad, C. Dezutter-Dambuyant, A. Vicari, A. O'Garra, C. Biron, F. Briere, et al. 2001. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2:1144-1150.
25. del Hoyo, G.M., P. Martin, H.H. Vargas, S. Ruiz, C.F. Arias, and C. Ardavin. 2002. Characterization of a common precursor population for dendritic cells. Nature. 415:1043-1047.
26. Merad, M., M.G. Manz, H. Karsunky, A. Wagers, W. Peters, I. Charo, I.L. Weissman, J.G. Cyster, and E.G. Engleman. 2002. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat. Immunol. 3:1135-1141.
27. Pharr, P.N., and A. Hofbauer. 1997. Loss of flk-2/flt3 expression during commitment of multipotent mouse hematopoietic progenitor cells to the mast cell lineage. Exp. Hematol. 25:620-628.
28. Manz, M.G., T. Miyamoto, K. Akashi, and I.L. Weissman. 2002. Prospective isolation of human clonogenic common myeloid progenitors. Proc. Natl. Acad. Sci. USA. 99:11872-11877.
29. Wright, D.E., A.J. Wagers, A.P. Gulati, F.L. Johnson, and I.L. Weissman. 2001. Physiological migration of hematopoietic stem and progenitor cells. Science. 294:1933-1936.
30. Bjorck, P. 2001. Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood. 98:3520-3526.
31. + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194:1171-1178.
32. Rasko, J.E., D. Metcalf, M.T. Rossner, C.G. Begley, and N.A. Nicola. 1995. The flt3/flk-2 ligand: receptor distribution and action on murine haemopoietic cell survival and proliferation. Leukemia. 9:2058-2066.
33. Wasserman, R., Y.S. Li, and R.R. Hardy. 1995. Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement. J. Immunol. 155:644-651.
34. Rappold, I., B.L. Ziegler, I. Kohler, S. Marchetto, O. Rosnet, D. Birnbaum, P.J. Simmons, A.C. Zannettino, B. Hill, S. Neu, et al. 1997. Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase. Blood. 90:111-125.
35. Tudor, K.S., K.J. Payne, Y. Yamashita, and P.W. Kincade. 2000. Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events. Immunity. 12:335-345.
36. Gotze, K.S., M. Ramirez, K. Tabor, D. Small, W. Matthews, and C.I. Civin. 1998. Flt3high and Flt3low CD34+ progenitor cells isolated from human bone marrow are functionally distinct. Blood. 91:1947-1958.
37. Wu, L., M. Antica, G.R. Johnson, R. Scollay, and K. Shortman. 1991. Developmental potential of the earliest precursor cells from the adult mouse thymus. J. Exp. Med. 174:1617-1627.
38. Randolph, G.J., K. Inaba, D.F. Robbiani, R.M. Steinman, and W.A. Muller. 1999. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity. 11:753-761.
39. Bjorck, P., and P.W. Kincade. 1998. CD19+ pro-B cells can give rise to dendritic cells in vitro. J. Immunol. 161:5795-5799.
40. Izon, D., K. Rudd, W. DeMuth, W.S. Pear, C. Clendenin, R.C. Lindsley, and D. Allman. 2001. A common pathway for dendritic cell and early B cell development. J. Immunol. 167:1387-1392.
41. Nutt, S.L., B. Heavey, A.G. Rolink, and M. Busslinger. 1999. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 401:556-562.
42. Lyman, S.D., L. James, S. Escobar, H. Downey, P. de Vries, K. Brasel, K. Stocking, M.P. Beckmann, N.G. Copeland, L.S. Cleveland, et al. 1995. Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs. Oncogene. 10:149-157.
43. Vremec, D., G.J. Lieschke, A.R. Dunn, L. Robb, D. Metcalf, and K. Shortman. 1997. The influence of granulocyte/ macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur. J. Immunol. 27:40-44.