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Volumn 423, Issue 6938, 2003, Pages 448-452

Wnt proteins are lipid-modified and can act as stem cell growth factors

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; MASS SPECTROMETRY; TISSUE;

EID: 0037737726     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01611     Document Type: Article
Times cited : (1886)

References (30)
  • 1
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan, K. & Nusse, R. Wnt signaling: a common theme in animal development. Genes Dev. 11, 3286-3305 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 3286-3305
    • Cadigan, K.1    Nusse, R.2
  • 2
    • 18644373146 scopus 로고    scopus 로고
    • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering, M. et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111, 241-250 (2002).
    • (2002) Cell , vol.111 , pp. 241-250
    • Van de Wetering, M.1
  • 3
    • 0037008478 scopus 로고    scopus 로고
    • Ectodermal Wnt function as a neural crest inducer
    • Garcia-Castro, M. I., Marcelle, C. & Bronner-Fraser, M. Ectodermal Wnt function as a neural crest inducer. Science 297, 848-851 (2002).
    • (2002) Science , vol.297 , pp. 848-851
    • Garcia-Castro, M.I.1    Marcelle, C.2    Bronner-Fraser, M.3
  • 4
    • 0025325505 scopus 로고
    • Secreted int-1 protein is associated with the cell surface
    • Papkoff, J. & Schryver, B. Secreted int-1 protein is associated with the cell surface. Mol. Cell Biol. 10, 2723-2730 (1990).
    • (1990) Mol. Cell Biol. , vol.10 , pp. 2723-2730
    • Papkoff, J.1    Schryver, B.2
  • 5
    • 23444459214 scopus 로고
    • Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells
    • Van Leeuwen, F., Harryman Samos, C. H. & Nusse, R. Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells. Nature 368, 342-344 (1994).
    • (1994) Nature , vol.368 , pp. 342-344
    • Van Leeuwen, F.1    Harryman Samos, C.H.2    Nusse, R.3
  • 6
    • 0029150726 scopus 로고
    • Biochemical analysis of murine Wnt proteins reveals both shared and distinct properties
    • Burrus, L. W. & McMahon, A. P. Biochemical analysis of murine Wnt proteins reveals both shared and distinct properties. Exp. Cell Res. 220, 363-373 (1995).
    • (1995) Exp. Cell Res. , vol.220 , pp. 363-373
    • Burrus, L.W.1    McMahon, A.P.2
  • 7
    • 0033616573 scopus 로고    scopus 로고
    • Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein
    • Hsieh J. C., Rattner, A., Smallwood, P. M. & Nathans, J. Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc. Natl Acad. Sci. USA 96, 3546-3551 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3546-3551
    • Hsieh, J.C.1    Rattner, A.2    Smallwood, P.M.3    Nathans, J.4
  • 8
    • 0029038919 scopus 로고
    • A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells
    • Bradley, R. S. & Brown, A. M. A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells. Mol. Cell Biol. 15, 4616-4622 (1995).
    • (1995) Mol. Cell Biol. , vol.15 , pp. 4616-4622
    • Bradley, R.S.1    Brown, A.M.2
  • 9
    • 0026066007 scopus 로고
    • Expression of two members of the Wnt gene family during mouse development; restricted temporal and spatial patterns in the developing neural tube
    • Roelink, H. & Nusse, R. Expression of two members of the Wnt gene family during mouse development; restricted temporal and spatial patterns in the developing neural tube. Genes Dev 5, 381-388 (1991).
    • (1991) Genes Dev. , vol.5 , pp. 381-388
    • Roelink, H.1    Nusse, R.2
  • 10
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis, P. Wnt signaling and cancer. Genes Dev. 14, 1837-1851 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 11
    • 0031792355 scopus 로고    scopus 로고
    • Cytoskeletal reorganization by soluble Wnt-3a protein signalling
    • Shibamoto, S. et al. Cytoskeletal reorganization by soluble Wnt-3a protein signalling. Genes Cells 3, 659-670 (1998).
    • (1998) Genes Cells , vol.3 , pp. 659-670
    • Shibamoto, S.1
  • 12
    • 0030601956 scopus 로고    scopus 로고
    • Activation of Siamois by the Wnt pathway
    • Brannon, M. & Kimelman, D. Activation of Siamois by the Wnt pathway. Dev. Biol. 180, 344-347 (1996).
    • (1996) Dev. Biol. , vol.180 , pp. 344-347
    • Brannon, M.1    Kimelman, D.2
  • 13
    • 18744425721 scopus 로고    scopus 로고
    • LEF-I/TCF proteins mediate wntinducible transcription from the Xenopus nodal-related 3 promoter
    • McKendry, R., Hsu, S. C., Harland, R. M. & Grosschedl, R. LEF-I/TCF proteins mediate wntinducible transcription from the Xenopus nodal-related 3 promoter. Dev. Biol. 192, 420-431 (1997).
    • (1997) Dev. Biol. , vol.192 , pp. 420-431
    • McKendry, R.1    Hsu, S.C.2    Harland, R.M.3    Grosschedl, R.4
  • 14
    • 0019887744 scopus 로고
    • Phase separation of integral membrane proteins in Triton X-114 solution
    • Bordier, C. Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol. Chem. 256, 1604-1607 (1981).
    • (1981) J. Biol. Chem. , vol.256 , pp. 1604-1607
    • Bordier, C.1
  • 15
    • 0032546946 scopus 로고    scopus 로고
    • A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)
    • Duncan, J. A. & Gilman, A. G. A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). J. Biol. Chem. 273, 15830-15837 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 15830-15837
    • Duncan, J.A.1    Gilman, A.G.2
  • 16
    • 0027097821 scopus 로고
    • Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line
    • Mason, J. O., Kitajewski, J. & Varmus, H. E. Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. Mol. Biol. Cell 3, 521-533 (1992).
    • (1992) Mol. Biol. Cell , vol.3 , pp. 521-533
    • Mason, J.O.1    Kitajewski, J.2    Varmus, H.E.3
  • 17
    • 0032960350 scopus 로고    scopus 로고
    • A Wnt signalling pathway controls hox gene expression and neuroblast migration in C. elegans
    • Maloof, J. N., Whangbo, J., Harris, J. M., Jongeward, G. D. & Kenvon, C. A Wnt signalling pathway controls hox gene expression and neuroblast migration in C. elegans. Development 126, 37-49 (1999).
    • (1999) Development , vol.126 , pp. 37-49
    • Maloof, J.N.1    Whangbo, J.2    Harris, J.M.3    Jongeward, G.D.4    Kenvon, C.5
  • 18
    • 0027996069 scopus 로고
    • Notch is required for wingless signaling in the epidermis of Drosophila
    • Couso, J. P. & Arias, A. M. Notch is required for wingless signaling in the epidermis of Drosophila. Cell 79, 259-272 (1994).
    • (1994) Cell , vol.79 , pp. 259-272
    • Couso, J.P.1    Arias, A.M.2
  • 19
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • advance online publication, 27 April (doi:10.1038/nature 01593)
    • Reya, T. et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature advance online publication, 27 April 2003 (doi:10.1038/nature01593).
    • (2003) Nature
    • Reya, T.1
  • 20
    • 0030450052 scopus 로고    scopus 로고
    • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
    • Kadowaki, T., Wilder, E., Klingensmith, J., Zachary, K. & Perrimon, N. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 10, 3116-3128 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 3116-3128
    • Kadowaki, T.1    Wilder, E.2    Klingensmith, J.3    Zachary, K.4    Perrimon, N.5
  • 21
    • 0030829387 scopus 로고    scopus 로고
    • Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos
    • Rocheleau, C. E. et al. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell 90, 707-716 (1997).
    • (1997) Cell , vol.90 , pp. 707-716
    • Rocheleau, C.E.1
  • 22
    • 0034161499 scopus 로고    scopus 로고
    • A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
    • Hofmann, K. A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Trends Biochem. Sci. 25, 111-112 (2000).
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 111-112
    • Hofmann, K.1
  • 23
    • 0037066744 scopus 로고    scopus 로고
    • Drosophila segment polarity gene product porcupine stimulates the postranslational N-glycosylation of wingless in the endoplasmic reticulum
    • Tanaka, K., Kitagawa, Y. & Kadowaki, T. Drosophila segment polarity gene product porcupine stimulates the postranslational N-glycosylation of wingless in the endoplasmic reticulum. J. Biol. Chem. 277, 12816-12823 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 12816-12823
    • Tanaka, K.1    Kitagawa, Y.2    Kadowaki, T.3
  • 24
    • 0028176875 scopus 로고
    • Dishevelled and armadillo act in the wingless signalling pathway in Drosophila
    • Noordermeer, I., Klingensmith, J., Perrimon, N. & Nusse, R. dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature 367, 80-83 (1994).
    • (1994) Nature , vol.367 , pp. 80-83
    • Noordermeer, I.1    Klingensmith, J.2    Perrimon, N.3    Nusse, R.4
  • 25
    • 15444359695 scopus 로고    scopus 로고
    • Identification of a palmitic acid-modified form of human Sonic hedgehog
    • Pepinsky, R. B. et al. Identification of a palmitic acid-modified form of human Sonic hedgehog. J. Biol. Chem. 273, 14037-14045 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 14037-14045
    • Pepinsky, R.B.1
  • 26
    • 0036830126 scopus 로고    scopus 로고
    • Ligand receptor interactions in the WNT signaling pathway in Drosophila
    • Wu, C. H. & Nusse, R. Ligand receptor interactions in the WNT signaling pathway in Drosophila. J. Biol Chem. 277, 41762-41769 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 41762-41769
    • Wu, C.H.1    Nusse, R.2
  • 27
    • 18444391517 scopus 로고    scopus 로고
    • Shotgun identification of protein modifications from protein complexes and lens tissue
    • MacCoss, M. J. et al. Shotgun identification of protein modifications from protein complexes and lens tissue. Proc. Natl Acad. Sci. USA 99, 7900-7905 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 7900-7905
    • MacCoss, M.J.1
  • 28
    • 0035106351 scopus 로고    scopus 로고
    • Large-scale analysis of the yeast proteome by multidimensional protein identification technology
    • Washburn, M. P., Wolters, D. & Yates, J. R. Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nature Biotechnol. 19, 242-247 (2001).
    • (2001) Nature Biotechnol. , vol.19 , pp. 242-247
    • Washburn, M.P.1    Wolters, D.2    Yates, J.R.3
  • 29
    • 0036393898 scopus 로고    scopus 로고
    • DTASelect and contrast: Tools for assembling and comparing protein identifications from shotgun proteomics
    • Tabb, D., McDonald, W. H. & Yates, J. R. DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics. J. Proteome Res. 1, 21-26 (2002).
    • (2002) J. Proteome Res. , vol.1 , pp. 21-26
    • Tabb, D.1    McDonald, W.H.2    Yates, J.R.3
  • 30
    • 0034684662 scopus 로고    scopus 로고
    • Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kit1/c-Kit signaling the other
    • Domen, J. & Weissman, J. L. Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kit1/c-Kit signaling the other. J. Exp. Med 192, 1707-1718 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1707-1718
    • Domen, J.1    Weissman, J.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.