Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches

Science

Volumn 318, Issue 5854, 2007, Pages 1296-1299

  Czechowicz, Agnieszka ^a   Kraft, Daniel ^a   Weissman, Irving L ^a   Bhattacharya, Deepta ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY ACK2; RAG2 PROTEIN; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG;

BLOOD; CELL ORGANELLE; RODENT; TOXIC SUBSTANCE;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; CHIMERA; CONTROLLED STUDY; DRUG MECHANISM; ENGRAFTMENT; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNE DEFICIENCY; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; STEM CELL MOBILIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MICE; PROTO-ONCOGENE PROTEINS C-KIT; SPLEEN; TIME FACTORS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING;

MUS;

EID: 36448992228     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1149726     Document Type: Article

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32. We thank D. Bryder for helpful discussions and technical assistance; L. Jerabek for laboratory management; C. Richter for antibody production; L. Hidalgo, D. Escoto, and J. Dollaga for animal care; C. Park for histological expertise; and M. Longaker and D. Rossi for critical reading of the manuscript. Supported by NIH grants 5R01HL058770 and 5R01CA086065 (I.L.W.), a fellowship from the Medical Scholars Program at Stanford University School of Medicine (A.C.), a fellowship from the Cancer Research Institute and NIH grants T32AI0729022 and 5K01DK078318 (D.B.), and Hope Street Kids Award and NIH grant 5K08HL076335 (D.K.). I.L.W. owns Amgen stock, cofounded and consulted for Systemix, is a cofounder and director of Stem Cells Inc., and cofounded and is a director of Cellerant Inc.