-
1
-
-
77951921902
-
Mammalian Per-Arnt-SIM proteins in environmental adaptation
-
McIntosh, B. E., Hogenesch, J. B. & Bradfield, C. A. Mammalian Per-Arnt-SIM proteins in environmental adaptation. Annu. Rev. Physiol. 72, 625-645 (2010
-
(2010)
Annu. Rev. Physiol
, vol.72
, pp. 625-645
-
-
McIntosh, B.E.1
Hogenesch, J.B.2
Bradfield, C.A.3
-
2
-
-
0035393437
-
SIM1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus
-
Michaud, J. L. et al. SIM1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus. Hum. Mol. Genet. 10, 1465-1473 (2001
-
(2001)
Hum. Mol. Genet
, vol.10
, pp. 1465-1473
-
-
Michaud, J.L.1
-
3
-
-
84455171663
-
Npas4 regulates a transcriptional program in CA3 required for contextual memory formation
-
Ramamoorthi, K. et al. Npas4 regulates a transcriptional program in CA3 required for contextual memory formation. Science 334, 1669-1675 (2011
-
(2011)
Science
, vol.334
, pp. 1669-1675
-
-
Ramamoorthi, K.1
-
4
-
-
34447621808
-
The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors
-
Furness, S. G., Lees, M. J. & Whitelaw, M. L. The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Lett. 581, 3616-3625 (2007
-
(2007)
FEBS Lett
, vol.581
, pp. 3616-3625
-
-
Furness, S.G.1
Lees, M.J.2
Whitelaw, M.L.3
-
5
-
-
0345708353
-
The mammalian basic helix-loop-helix/PAS family of transcriptional regulators
-
Kewley, R. J., Whitelaw, M. L. & Chapman-Smith, A. The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int. J. Biochem. Cell Biol. 36, 189-204 (2004
-
(2004)
Int. J. Biochem. Cell Biol
, vol.36
, pp. 189-204
-
-
Kewley, R.J.1
Whitelaw, M.L.2
Chapman-Smith, A.3
-
6
-
-
0031834838
-
Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor
-
Pongratz, I., Antonsson, C., Whitelaw, M. L. & Poellinger, L. Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor. Mol. Cell. Biol. 18, 4079-4088 (1998
-
(1998)
Mol. Cell. Biol
, vol.18
, pp. 4079-4088
-
-
Pongratz, I.1
Antonsson, C.2
Whitelaw, M.L.3
Poellinger, L.4
-
7
-
-
0032990441
-
PAS domains: Internal sensors of oxygen, redox potential, and light
-
Taylor, B. L. & Zhulin, I. B. PAS domains: Internal sensors of oxygen, redox potential, and light. Microbiol. Mol. Biol. Rev. 63, 479-506 (1999
-
(1999)
Microbiol. Mol. Biol. Rev
, vol.63
, pp. 479-506
-
-
Taylor, B.L.1
Zhulin, I.B.2
-
8
-
-
84863751285
-
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex
-
Huang, N. et al. Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science 337, 189-194 (2012
-
(2012)
Science
, vol.337
, pp. 189-194
-
-
Huang, N.1
-
9
-
-
0035834762
-
Definition of a dioxin receptor mutant that is a constitutive activator of transcription: Delineation of overlapping repression and ligand binding functions within the PAS domain
-
McGuire, J., Okamoto, K., Whitelaw, M. L., Tanaka, H. & Poellinger, L. Definition of a dioxin receptor mutant that is a constitutive activator of transcription: Delineation of overlapping repression and ligand binding functions within the PAS domain. J. Biol. Chem. 276, 41841-41849 (2001
-
(2001)
J. Biol. Chem
, vol.276
, pp. 41841-41849
-
-
McGuire, J.1
Okamoto, K.2
Whitelaw, M.L.3
Tanaka, H.4
Poellinger, L.5
-
10
-
-
33750202279
-
The phosphorylation status of PAS-B distinguishes HIF-1α from HIF-2α in NBS1 repression
-
To, K. K., Sedelnikova, O. A., Samons, M., Bonner, W. M. & Huang, L. E. The phosphorylation status of PAS-B distinguishes HIF-1α from HIF-2α in NBS1 repression. EMBO J. 25, 4784-4794 (2006
-
(2006)
EMBO J.
, vol.25
, pp. 4784-4794
-
-
To, K.K.1
Sedelnikova, O.A.2
Samons, M.3
Bonner, W.M.4
Huang, L.E.5
-
11
-
-
84875201642
-
Regulating the ARNT/TACC3 axis: Multiple approaches to manipulating protein/protein interactions with small molecules
-
Guo, Y. et al. Regulating the ARNT/TACC3 axis: Multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem. Biol. 8, 626-635 (2013
-
(2013)
ACS Chem. Biol
, vol.8
, pp. 626-635
-
-
Guo, Y.1
-
12
-
-
79956370722
-
Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B
-
Partch, C. L. & Gardner, K. H. Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B. Proc. Natl Acad. Sci. USA 108, 7739-7744 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 7739-7744
-
-
Partch, C.L.1
Gardner, K.H.2
-
13
-
-
23944457372
-
Transcription factor single-minded 2 (SIM2) is ubiquitinated by the RING-IBR-RING-type E3 ubiquitin ligases
-
Okui, M. et al. Transcription factor single-minded 2 (SIM2) is ubiquitinated by the RING-IBR-RING-type E3 ubiquitin ligases. Exp. Cell Res. 309, 220-228 (2005
-
(2005)
Exp. Cell Res
, vol.309
, pp. 220-228
-
-
Okui, M.1
-
14
-
-
79956017554
-
Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR
-
Hao, N., Whitelaw, M. L., Shearwin, K. E., Dodd, I. B. & Chapman-Smith, A. Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR. Nucleic Acids Res. 39, 3695-3709 (2011
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 3695-3709
-
-
Hao, N.1
Whitelaw, M.L.2
Shearwin, K.E.3
Dodd, I.B.4
Chapman-Smith, A.5
-
15
-
-
0036261821
-
Recruitment of the NCoA/SRC-1/ p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex
-
Beischlag, T. V. et al. Recruitment of the NCoA/SRC-1/ p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol. Cell. Biol. 22, 4319-4333 (2002
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 4319-4333
-
-
Beischlag, T.V.1
-
16
-
-
77956322192
-
Roles of coactivators in hypoxic induction of the erythropoietin gene
-
Wang, F., Zhang, R., Wu, X. & Hankinson, O. Roles of coactivators in hypoxic induction of the erythropoietin gene. PLoS ONE 5, e10002 (2010
-
(2010)
PLoS ONE
, vol.5
-
-
Wang, F.1
Zhang, R.2
Wu, X.3
Hankinson, O.4
-
17
-
-
0037155908
-
Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element cross-talk between basic helix-loop-helix/per-arnt-sim homology transcription factors
-
Woods, S. L. & Whitelaw, M. L. Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-SIM homology transcription factors. J. Biol. Chem. 277, 10236-10243 (2002
-
(2002)
J. Biol. Chem
, vol.277
, pp. 10236-10243
-
-
Woods, S.L.1
Whitelaw, M.L.2
-
18
-
-
10144224910
-
Two new members of the murine SIM gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis
-
Ema, M. et al. Two new members of the murine SIM gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol. Cell. Biol. 16, 5865-5875 (1996
-
(1996)
Mol. Cell. Biol
, vol.16
, pp. 5865-5875
-
-
Ema, M.1
-
19
-
-
66449131733
-
SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor
-
Oshima, M., Mimura, J., Sekine, H., Okawa, H. & Fujii-Kuriyama, Y. SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor. J. Biol. Chem. 284, 11017-11026 (2009
-
(2009)
J. Biol. Chem
, vol.284
, pp. 11017-11026
-
-
Oshima, M.1
Mimura, J.2
Sekine, H.3
Okawa, H.4
Fujii-Kuriyama, Y.5
-
20
-
-
84155196846
-
Exactly the same but different: Promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor
-
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E. & Zhao, B. Exactly the same but different: Promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol. Sci. 124, 1-22 (2011
-
(2011)
Toxicol. Sci
, vol.124
, pp. 1-22
-
-
Denison, M.S.1
Soshilov, A.A.2
He, G.3
DeGroot, D.E.4
Zhao, B.5
-
21
-
-
84869849711
-
Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling
-
Hao, N. et al. Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Mol. Pharmacol. 82, 1082-1093 (2012
-
(2012)
Mol. Pharmacol
, vol.82
, pp. 1082-1093
-
-
Hao, N.1
-
22
-
-
38949097735
-
The search for endogenous activators of the aryl hydrocarbon receptor
-
Nguyen, L. P. & Bradfield, C. A. The search for endogenous activators of the aryl hydrocarbon receptor. Chem. Res. Toxicol. 21, 102-116 (2008
-
(2008)
Chem. Res. Toxicol
, vol.21
, pp. 102-116
-
-
Nguyen, L.P.1
Bradfield, C.A.2
-
23
-
-
0029806936
-
Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53
-
Denissenko, M. F., Pao, A., Tang, M. & Pfeifer, G. P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 274, 430-432 (1996
-
(1996)
Science
, vol.274
, pp. 430-432
-
-
Denissenko, M.F.1
Pao, A.2
Tang, M.3
Pfeifer, G.P.4
-
24
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B. et al. Cancer genome landscapes. Science 339, 1546-1558 (2013
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
-
25
-
-
0034681182
-
Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor
-
Shimizu, Y. et al. Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc. Natl Acad. Sci. USA 97, 779-782 (2000
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 779-782
-
-
Shimizu, Y.1
-
26
-
-
80054041992
-
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
-
Opitz, C. A. et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478, 197-203 (2011
-
(2011)
Nature
, vol.478
, pp. 197-203
-
-
Opitz, C.A.1
-
27
-
-
0037162529
-
A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors
-
Andersson, P. et al. A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc. Natl Acad. Sci. USA 99, 9990-9995 (2002
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 9990-9995
-
-
Andersson, P.1
-
28
-
-
3142689710
-
A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice
-
Moennikes, O. et al. A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice. Cancer Res. 64, 4707-4710 (2004
-
(2004)
Cancer Res
, vol.64
, pp. 4707-4710
-
-
Moennikes, O.1
-
29
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603-607 (2012
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
-
30
-
-
69449101827
-
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
-
Kawajiri, K. et al. Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc. Natl Acad. Sci. USA 106, 13481-13486 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 13481-13486
-
-
Kawajiri, K.1
-
31
-
-
84879556245
-
ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice
-
Ikuta, T. et al. ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice. Carcinogenesis 34, 1620-1627 (2013
-
(2013)
Carcinogenesis
, vol.34
, pp. 1620-1627
-
-
Ikuta, T.1
-
32
-
-
0038100188
-
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
-
Ohtake, F. et al. Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature 423, 545-550 (2003
-
(2003)
Nature
, vol.423
, pp. 545-550
-
-
Ohtake, F.1
-
33
-
-
34047094888
-
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase
-
Ohtake, F. et al. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 446, 562-566 (2007
-
(2007)
Nature
, vol.446
, pp. 562-566
-
-
Ohtake, F.1
-
34
-
-
47249128122
-
The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates
-
Fritz, W. A., Lin, T. M. & Peterson, R. E. The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates. Carcinogenesis 29, 1077-1082 (2008
-
(2008)
Carcinogenesis
, vol.29
, pp. 1077-1082
-
-
Fritz, W.A.1
Lin, T.M.2
Peterson, R.E.3
-
35
-
-
84880674927
-
Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor
-
Shin, J. H. et al. Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor. Proc. Natl Acad. Sci. USA 110, 12391-12396 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 12391-12396
-
-
Shin, J.H.1
-
36
-
-
84878107936
-
Selective oestrogen receptor modulators in prevention of breast cancer: An updated meta-analysis of individual participant data
-
Cuzick, J. et al. Selective oestrogen receptor modulators in prevention of breast cancer: An updated meta-analysis of individual participant data. Lancet 381, 1827-1834 (2013
-
(2013)
Lancet
, vol.381
, pp. 1827-1834
-
-
Cuzick, J.1
-
37
-
-
0035810987
-
Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt
-
Keith, B., Adelman, D. M. & Simon, M. C. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc. Natl Acad. Sci. USA 98, 6692-6697 (2001
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 6692-6697
-
-
Keith, B.1
Adelman, D.M.2
Simon, M.C.3
-
38
-
-
84878820408
-
Reciprocal regulation of the basic helix-loop-helix/Per- Arnt-SIM partner proteins, Arnt and Arnt2, during neuronal differentiation
-
Hao, N., Bhakti, V. L., Peet, D. J. & Whitelaw, M. L. Reciprocal regulation of the basic helix-loop-helix/Per- Arnt-SIM partner proteins, Arnt and Arnt2, during neuronal differentiation. Nucleic Acids Res. 41, 5626-5638 (2013
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 5626-5638
-
-
Hao, N.1
Bhakti, V.L.2
Peet, D.J.3
Whitelaw, M.L.4
-
39
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza, G. L. Hypoxia-inducible factors in physiology and medicine. Cell 148, 399-408 (2012
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
40
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick, R. K. & McKnight, S. L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340 (2001
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
41
-
-
17944375360
-
Celegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein, A. C. et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54 (2001
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
-
42
-
-
0035917313
-
HIFα targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan, M. et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 292, 464-468 (2001
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
-
43
-
-
0035917808
-
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola, P. et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-472 (2001
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
44
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson, K. S. et al. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 277, 26351-26355 (2002
-
(2002)
J. Biol. Chem
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
-
45
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando, D. et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16, 1466-1471 (2002
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
-
46
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J. & Whitelaw, M. L. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295, 858-861 (2002
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
47
-
-
82255186546
-
Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response
-
Heikkila, M., Pasanen, A., Kivirikko, K. I. & Myllyharju, J. Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response. Cell. Mol. Life Sci. 68, 3885-3901 (2011
-
(2011)
Cell. Mol. Life Sci
, vol.68
, pp. 3885-3901
-
-
Heikkila, M.1
Pasanen, A.2
Kivirikko, K.I.3
Myllyharju, J.4
-
48
-
-
0037031808
-
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3α locus
-
Makino, Y., Kanopka, A., Wilson, W. J., Tanaka, H. & Poellinger, L. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3α locus. J. Biol. Chem. 277, 32405-32408 (2002
-
(2002)
J. Biol. Chem
, vol.277
, pp. 32405-32408
-
-
Makino, Y.1
Kanopka, A.2
Wilson, W.J.3
Tanaka, H.4
Poellinger, L.5
-
49
-
-
84867420094
-
Cancer and altered metabolism: Potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases
-
Kaelin, W. G. Jr. Cancer and altered metabolism: Potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb. Symp. Quant. Biol. 76, 335-345 (2011
-
(2011)
Cold Spring Harb. Symp. Quant. Biol
, vol.76
, pp. 335-345
-
-
Kaelin Jr., W.G.1
-
50
-
-
84655161946
-
HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression
-
Keith, B., Johnson, R. S. & Simon, M. C. HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression. Nature Rev. Cancer 12, 9-22 (2012
-
(2012)
Nature Rev. Cancer
, vol.12
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
51
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza, G. L. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29, 625-634 (2010
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
52
-
-
84861944874
-
An oxygen-regulated switch in the protein synthesis machinery
-
Uniacke, J. et al. An oxygen-regulated switch in the protein synthesis machinery. Nature 486, 126-129 (2012
-
(2012)
Nature
, vol.486
, pp. 126-129
-
-
Uniacke, J.1
-
53
-
-
84875755814
-
Influence of metabolism on epigenetics and disease
-
Kaelin, W. G. Jr & McKnight, S. L. Influence of metabolism on epigenetics and disease. Cell 153, 56-69 (2013
-
(2013)
Cell
, vol.153
, pp. 56-69
-
-
Kaelin Jr., W.G.1
McKnight, S.L.2
-
54
-
-
33746930794
-
Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
-
King, A., Selak, M. A. & Gottlieb, E. Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer. Oncogene 25, 4675-4682 (2006
-
(2006)
Oncogene
, vol.25
, pp. 4675-4682
-
-
King, A.1
Selak, M.A.2
Gottlieb, E.3
-
55
-
-
0348107409
-
The TCA cycle and tumorigenesis: The examples of fumarate hydratase and succinate dehydrogenase
-
Pollard, P. J., Wortham, N. C. & Tomlinson, I. P. The TCA cycle and tumorigenesis: The examples of fumarate hydratase and succinate dehydrogenase. Ann. Med. 35, 632-639 (2003
-
(2003)
Ann. Med
, vol.35
, pp. 632-639
-
-
Pollard, P.J.1
Wortham, N.C.2
Tomlinson, I.P.3
-
56
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
-
Isaacs, J. S. et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability. Cancer Cell 8, 143-153 (2005
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
-
57
-
-
84862776918
-
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
-
Koivunen, P. et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 483, 484-488 (2012
-
(2012)
Nature
, vol.483
, pp. 484-488
-
-
Koivunen, P.1
-
58
-
-
84876889621
-
What a difference a hydroxyl makes: Mutant idh (r)-2-hydroxyglutarate and cancer
-
Losman, J. A. & Kaelin, W. G. Jr. What a difference a hydroxyl makes: Mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev. 27, 836-852 (2013
-
(2013)
Genes Dev
, vol.27
, pp. 836-852
-
-
Losman, J.A.1
Kaelin Jr., W.G.2
-
59
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
-
Selak, M. A. et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell 7, 77-85 (2005
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
-
60
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α
-
Zhao, S. et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science 324, 261-265 (2009
-
(2009)
Science
, vol.324
, pp. 261-265
-
-
Zhao, S.1
-
61
-
-
84866480031
-
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
-
Sasaki, M. et al. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev. 26, 2038-2049 (2012
-
(2012)
Genes Dev
, vol.26
, pp. 2038-2049
-
-
Sasaki, M.1
-
62
-
-
84865520089
-
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
-
Sasaki, M. et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature 488, 656-659 (2012
-
(2012)
Nature
, vol.488
, pp. 656-659
-
-
Sasaki, M.1
-
63
-
-
70350452792
-
Targeting the hypoxia-inducible factor (HIF) pathway in cancer
-
Poon, E., Harris, A. L. & Ashcroft, M. Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Rev. Mol. Med. 11, e26 (2009
-
(2009)
Expert Rev. Mol. Med
, vol.11
-
-
Poon, E.1
Harris, A.L.2
Ashcroft, M.3
-
64
-
-
79959955993
-
Cancer therapeutic agents targeting hypoxia-inducible factor- ;1
-
Wang, R., Zhou, S. & Li, S. Cancer therapeutic agents targeting hypoxia-inducible factor-1. Curr. Med. Chem. 18, 3168-3189 (2011
-
(2011)
Curr. Med. Chem.
, vol.18
, pp. 3168-3189
-
-
Wang, R.1
Zhou, S.2
Li, S.3
-
65
-
-
0346734132
-
Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor
-
Erbel, P. J., Card, P. B., Karakuzu, O., Bruick, R. K. & Gardner, K. H. Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor. Proc. Natl Acad. Sci. USA 100, 15504-15509 (2003
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 15504-15509
-
-
Erbel, P.J.1
Card, P.B.2
Karakuzu, O.3
Bruick, R.K.4
Gardner, K.H.5
-
66
-
-
58849141619
-
Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor
-
Scheuermann, T. H. et al. Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor. Proc. Natl Acad. Sci. USA 106, 450-455 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 450-455
-
-
Scheuermann, T.H.1
-
67
-
-
82355168493
-
New aryl hydrocarbon receptor homology model targeted to improve docking reliability
-
Motto, I., Bordogna, A., Soshilov, A. A., Denison, M. S. & Bonati, L. New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J. Chem. Inf. Model. 51, 2868-2881 (2011
-
(2011)
J. Chem. Inf. Model
, vol.51
, pp. 2868-2881
-
-
Motto, I.1
Bordogna, A.2
Soshilov, A.A.3
Denison, M.S.4
Bonati, L.5
-
68
-
-
84875443909
-
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
-
Scheuermann, T. H. et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nature Chem. Biol. 9, 271-276 (2013
-
(2013)
Nature Chem. Biol
, vol.9
, pp. 271-276
-
-
Scheuermann, T.H.1
-
69
-
-
37049002915
-
N and C-terminal flanking regions modulate light-induced signal transduction in the LOV2 domain of the blue light sensor phototropin 1 from Avena sativa
-
Halavaty, A. S. & Moffat, K. N- And C-terminal flanking regions modulate light-induced signal transduction in the LOV2 domain of the blue light sensor phototropin 1 from Avena sativa. Biochemistry 46, 14001-14009 (2007
-
(2007)
Biochemistry
, vol.46
, pp. 14001-14009
-
-
Halavaty, A.S.1
Moffat, K.2
-
70
-
-
70449580319
-
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
-
Lee, K. et al. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc. Natl Acad. Sci. USA 106, 17910-17915 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 17910-17915
-
-
Lee, K.1
-
71
-
-
84880359790
-
A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells
-
Miranda, E. et al. A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J. Am. Chem. Soc. 135, 10418-10425 (2013
-
(2013)
J. Am. Chem. Soc
, vol.135
, pp. 10418-10425
-
-
Miranda, E.1
-
72
-
-
80052899933
-
Genetics of circadian rhythms in mammalian model organisms
-
Lowrey, P. L. & Takahashi, J. S. Genetics of circadian rhythms in mammalian model organisms. Adv. Genet. 74, 175-230 (2011
-
(2011)
Adv. Genet
, vol.74
, pp. 175-230
-
-
Lowrey, P.L.1
Takahashi, J.S.2
-
73
-
-
84857704420
-
Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function
-
Kucera, N. et al. Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function. Proc. Natl Acad. Sci. USA 109, 3311-3316 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 3311-3316
-
-
Kucera, N.1
-
74
-
-
70450239457
-
Metabolism and cancer: The circadian clock connection
-
Sahar, S. & Sassone-Corsi, P. Metabolism and cancer: The circadian clock connection. Nature Rev. Cancer 9, 886-896 (2009
-
(2009)
Nature Rev. Cancer
, vol.9
, pp. 886-896
-
-
Sahar, S.1
Sassone-Corsi, P.2
-
75
-
-
0037711399
-
The circadian clock: Pacemaker and tumour suppressor
-
Fu, L. & Lee, C. C. The circadian clock: Pacemaker and tumour suppressor. Nature Rev. Cancer 3, 350-361 (2003
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 350-361
-
-
Fu, L.1
Lee, C.C.2
-
76
-
-
77956200571
-
Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice
-
Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D. & Fu, L. Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS ONE 5, e10995 (2010
-
(2010)
PLoS ONE
, vol.5
-
-
Lee, S.1
Donehower, L.A.2
Herron, A.J.3
Moore, D.D.4
Fu, L.5
-
77
-
-
0037020198
-
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
-
Fu, L., Pelicano, H., Liu, J., Huang, P. & Lee, C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111, 41-50 (2002
-
(2002)
Cell
, vol.111
, pp. 41-50
-
-
Fu, L.1
Pelicano, H.2
Liu, J.3
Huang, P.4
Lee, C.5
-
78
-
-
33646084831
-
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells
-
Gery, S. et al. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol. Cell 22, 375-382 (2006
-
(2006)
Mol. Cell
, vol.22
, pp. 375-382
-
-
Gery, S.1
-
79
-
-
22844451414
-
Deregulated expression of the PER1 PER2 and PER3 genes in breast cancers
-
Chen, S. T. et al. Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Carcinogenesis 26, 1241-1246 (2005
-
(2005)
Carcinogenesis
, vol.26
, pp. 1241-1246
-
-
Chen, S.T.1
-
80
-
-
84880667008
-
Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy
-
Hwang-Verslues, W. W. et al. Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. Proc. Natl Acad. Sci. USA http://dx.doi.org/10.1073/ pnas.1222684110 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
-
-
Hwang-Verslues, W.W.1
-
81
-
-
62449319445
-
Loss of cryptochrome reduces cancer risk in p53 mutant mice
-
Ozturk, N., Lee, J. H., Gaddameedhi, S. & Sancar, A. Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc. Natl Acad. Sci. USA 106, 2841-2846 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 2841-2846
-
-
Ozturk, N.1
Lee, J.H.2
Gaddameedhi, S.3
Sancar, A.4
-
82
-
-
83055184184
-
The circadian molecular clock creates epidermal stem cell heterogeneity
-
Janich, P. et al. The circadian molecular clock creates epidermal stem cell heterogeneity. Nature 480, 209-214 (2011
-
(2011)
Nature
, vol.480
, pp. 209-214
-
-
Janich, P.1
-
83
-
-
84869036539
-
Circadian topology of metabolism
-
Bass, J. Circadian topology of metabolism. Nature 491, 348-356 (2012
-
(2012)
Nature
, vol.491
, pp. 348-356
-
-
Bass, J.1
-
84
-
-
79551534130
-
Crosstalk between components of circadian and metabolic cycles in mammals
-
Asher, G. & Schibler, U. Crosstalk between components of circadian and metabolic cycles in mammals. Cell. Metab. 13, 125-137 (2011
-
(2011)
Cell. Metab
, vol.13
, pp. 125-137
-
-
Asher, G.1
Schibler, U.2
-
85
-
-
80053355301
-
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock
-
DiTacchio, L. et al. Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science 333, 1881-1885 (2011
-
(2011)
Science
, vol.333
, pp. 1881-1885
-
-
DiTacchio, L.1
-
86
-
-
33645826250
-
Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene
-
van Zutven, L. J. et al. Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. Genes Chromosomes Cancer 45, 437-446 (2006
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 437-446
-
-
Van Zutven, L.J.1
-
87
-
-
67349266612
-
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
-
Wang, G. G. et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature 459, 847-851 (2009
-
(2009)
Nature
, vol.459
, pp. 847-851
-
-
Wang, G.G.1
-
88
-
-
77952795537
-
Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase
-
Zhou, X. et al. Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Res. 70, 4214-4221 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 4214-4221
-
-
Zhou, X.1
-
89
-
-
84867877340
-
The NAD metabolome - A key determinant of cancer cell biology
-
Chiarugi, A., Dolle, C., Felici, R. & Ziegler, M. The NAD metabolome - A key determinant of cancer cell biology. Nature Rev. Cancer 12, 741-752 (2012
-
(2012)
Nature Rev. Cancer
, vol.12
, pp. 741-752
-
-
Chiarugi, A.1
Dolle, C.2
Felici, R.3
Ziegler, M.4
-
90
-
-
65549103855
-
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
-
Ramsey, K. M. et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324, 651-654 (2009
-
(2009)
Science
, vol.324
, pp. 651-654
-
-
Ramsey, K.M.1
-
91
-
-
65549118773
-
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
-
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M. & Sassone-Corsi, P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 324, 654-657 (2009
-
(2009)
Science
, vol.324
, pp. 654-657
-
-
Nakahata, Y.1
Sahar, S.2
Astarita, G.3
Kaluzova, M.4
Sassone-Corsi, P.5
-
92
-
-
0035919479
-
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
-
Rutter, J., Reick, M., Wu, L. C. & McKnight, S. L. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science 293, 510-514 (2001
-
(2001)
Science
, vol.293
, pp. 510-514
-
-
Rutter, J.1
Reick, M.2
Wu, L.C.3
McKnight, S.L.4
-
93
-
-
47549088250
-
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
-
Nakahata, Y. et al. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329-340 (2008
-
(2008)
Cell
, vol.134
, pp. 329-340
-
-
Nakahata, Y.1
-
94
-
-
47749140333
-
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
-
Asher, G. et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134, 317-328 (2008
-
(2008)
Cell
, vol.134
, pp. 317-328
-
-
Asher, G.1
-
95
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
-
Rodgers, J. T. et al. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434, 113-118 (2005
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
-
96
-
-
34249275727
-
Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism
-
Liu, C., Li, S., Liu, T., Borjigin, J. & Lin, J. D. Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism. Nature 447, 477-481 (2007
-
(2007)
Nature
, vol.447
, pp. 477-481
-
-
Liu, C.1
Li, S.2
Liu, T.3
Borjigin, J.4
Lin, J.D.5
-
97
-
-
37249053976
-
CLOCK-mediated acetylation of BMAL1 controls circadian function
-
Hirayama, J. et al. CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 450, 1086-1090 (2007
-
(2007)
Nature
, vol.450
, pp. 1086-1090
-
-
Hirayama, J.1
-
98
-
-
33646145721
-
Circadian regulator CLOCK is a histone acetyltransferase
-
Doi, M., Hirayama, J. & Sassone-Corsi, P. Circadian regulator CLOCK is a histone acetyltransferase. Cell 125, 497-508 (2006
-
(2006)
Cell
, vol.125
, pp. 497-508
-
-
Doi, M.1
Hirayama, J.2
Sassone-Corsi, P.3
-
99
-
-
77956627087
-
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
-
Asher, G. et al. Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142, 943-953 (2010
-
(2010)
Cell
, vol.142
, pp. 943-953
-
-
Asher, G.1
-
100
-
-
84863895758
-
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis
-
Geyfman, M. et al. Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc. Natl Acad. Sci. USA 109, 11758-11763 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 11758-11763
-
-
Geyfman, M.1
-
101
-
-
77950422142
-
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
-
Kang, T. H., Lindsey-Boltz, L. A., Reardon, J. T. & Sancar, A. Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. Proc. Natl Acad. Sci. USA 107, 4890-4895 (2010
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 4890-4895
-
-
Kang, T.H.1
Lindsey-Boltz, L.A.2
Reardon, J.T.3
Sancar, A.4
-
102
-
-
62449268975
-
Circadian oscillation of nucleotide excision repair in mammalian brain
-
Kang, T. H., Reardon, J. T., Kemp, M. & Sancar, A. Circadian oscillation of nucleotide excision repair in mammalian brain. Proc. Natl Acad. Sci. USA 106, 2864-2867 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 2864-2867
-
-
Kang, T.H.1
Reardon, J.T.2
Kemp, M.3
Sancar, A.4
-
103
-
-
79960587570
-
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
-
Lee, J. H. & Sancar, A. Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis. Proc. Natl Acad. Sci. USA 108, 10668-10672 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 10668-10672
-
-
Lee, J.H.1
Sancar, A.2
-
104
-
-
14744278784
-
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex
-
Gorbacheva, V. Y. et al. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc. Natl Acad. Sci. USA 102, 3407-3412 (2005
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 3407-3412
-
-
Gorbacheva, V.Y.1
-
105
-
-
84881159203
-
Small molecule modifiers of circadian clocks
-
Chen, Z., Yoo, S. H. & Takahashi, J. S. Small molecule modifiers of circadian clocks. Cell. Mol. Life Sci. 70, 2985-2998 (2013
-
(2013)
Cell. Mol. Life Sci
, vol.70
, pp. 2985-2998
-
-
Chen, Z.1
Yoo, S.H.2
Takahashi, J.S.3
-
106
-
-
84862909015
-
Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening
-
Chen, Z. et al. Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proc. Natl Acad. Sci. USA 109, 101-106 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 101-106
-
-
Chen, Z.1
-
107
-
-
84860291442
-
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
-
Solt, L. A. et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485, 62-68 (2012
-
(2012)
Nature
, vol.485
, pp. 62-68
-
-
Solt, L.A.1
-
108
-
-
84865558040
-
Identification of small molecule activators of cryptochrome
-
Hirota, T. et al. Identification of small molecule activators of cryptochrome. Science 337, 1094-1097 (2012
-
(2012)
Science
, vol.337
, pp. 1094-1097
-
-
Hirota, T.1
-
109
-
-
78650432933
-
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase
-
Hirota, T. et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 8, e1000559 (2010
-
(2010)
PLoS Biol
, vol.8
-
-
Hirota, T.1
-
110
-
-
69249110003
-
Normal And Cancer-related Functions Of The P160 Steroid Receptor Co-activator (SRC) Family
-
Xu, J., Wu, R. C. & O'Malley, B. W. Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nature Rev. Cancer 9, 615-630 (2009
-
(2009)
Nature Rev. Cancer
, vol.9
, pp. 615-630
-
-
Xu, J.1
Wu, R.C.2
O'Malley, B.W.3
-
111
-
-
0030768745
-
Steroid receptor coactivator-1 is a histone acetyltransferase
-
Spencer, T. E. et al. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389, 194-198 (1997
-
(1997)
Nature
, vol.389
, pp. 194-198
-
-
Spencer, T.E.1
-
112
-
-
0030740253
-
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
-
Chen, H. et al. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569-580 (1997
-
(1997)
Cell
, vol.90
, pp. 569-580
-
-
Chen, H.1
-
113
-
-
9144260515
-
Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain
-
Razeto, A. et al. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. J. Mol. Biol. 336, 319-329 (2004
-
(2004)
J. Mol. Biol
, vol.336
, pp. 319-329
-
-
Razeto, A.1
-
114
-
-
41949109528
-
P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain
-
Lodrini, M. et al. P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain. Nucleic Acids Res. 36, 1847-1860 (2008
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 1847-1860
-
-
Lodrini, M.1
-
115
-
-
0033305404
-
Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53
-
Lee, S. K., Kim, H. J., Kim, J. W. & Lee, J. W. Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53. Mol. Endocrinol. 13, 1924-1933 (1999
-
(1999)
Mol. Endocrinol
, vol.13
, pp. 1924-1933
-
-
Lee, S.K.1
Kim, H.J.2
Kim, J.W.3
Lee, J.W.4
-
116
-
-
0348047596
-
CoCoA a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators
-
Kim, J. H., Li, H. & Stallcup, M. R. CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol. Cell 12, 1537-1549 (2003
-
(2003)
Mol. Cell
, vol.12
, pp. 1537-1549
-
-
Kim, J.H.1
Li, H.2
Stallcup, M.R.3
-
117
-
-
1642349331
-
AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice
-
Kuang, S. Q. et al. AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res. 64, 1875-1885 (2004
-
(2004)
Cancer Res
, vol.64
, pp. 1875-1885
-
-
Kuang, S.Q.1
-
118
-
-
0036683485
-
Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes
-
Belandia, B., Orford, R. L., Hurst, H. C. & Parker, M. G. Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes. EMBO J. 21, 4094-4103 (2002
-
(2002)
EMBO J.
, vol.21
, pp. 4094-4103
-
-
Belandia, B.1
Orford, R.L.2
Hurst, H.C.3
Parker, M.G.4
-
119
-
-
82655174048
-
Steroid receptor coactivators 1 2, and 3: Critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy
-
Johnson, A. B. & O'Malley, B. W. Steroid receptor coactivators 1, 2, and 3: Critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy. Mol. Cell Endocrinol. 348, 430-439 (2012
-
(2012)
Mol. Cell Endocrinol. 348
, pp. 430-439
-
-
Johnson, A.B.1
O'Malley, B.W.2
-
120
-
-
0033324251
-
Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential
-
Kumar, M. B. & Perdew, G. H. Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential. Gene Expr. 8, 273-286 (1999
-
(1999)
Gene Expr
, vol.8
, pp. 273-286
-
-
Kumar, M.B.1
Perdew, G.H.2
-
121
-
-
0033986948
-
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1α
-
Carrero, P. et al. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1α. Mol. Cell. Biol. 20, 402-415 (2000
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 402-415
-
-
Carrero, P.1
-
122
-
-
0035110716
-
Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu
-
Bouras, T., Southey, M. C. & Venter, D. J. Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu. Cancer Res. 61, 903-907 (2001
-
(2001)
Cancer Res
, vol.61
, pp. 903-907
-
-
Bouras, T.1
Southey, M.C.2
Venter, D.J.3
-
123
-
-
4944243842
-
Expression of SRC- ;1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1
-
Fleming, F J. et al. Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1. J. Clin. Pathol. 57, 1069-1074 (2004
-
(2004)
J Clin Pathol
, vol.57
, pp. 1069-1074
-
-
Fleming, F.J.1
-
124
-
-
0242587820
-
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
-
Kamei, Y. et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403-414 (1996
-
(1996)
Cell
, vol.85
, pp. 403-414
-
-
Kamei, Y.1
-
125
-
-
0035955718
-
An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer
-
Reiter, R., Wellstein, A. & Riegel, A. T. An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer. J. Biol. Chem. 276, 9736-39741 (2001
-
(2001)
J. Biol. Chem
, vol.276
, pp. 9736-39741
-
-
Reiter, R.1
Wellstein, A.2
Riegel, A.T.3
-
126
-
-
0842308305
-
Impact of the nuclear receptor coactivator AIB1 isoform AIB1-Delta3 on estrogenic ligands with different intrinsic activity
-
Reiter, R., Oh, A. S., Wellstein, A. & Riegel, A. T. Impact of the nuclear receptor coactivator AIB1 isoform AIB1-Delta3 on estrogenic ligands with different intrinsic activity. Oncogene 23, 403-409 (2004
-
(2004)
Oncogene
, vol.23
, pp. 403-409
-
-
Reiter, R.1
Oh, A.S.2
Wellstein, A.3
Riegel, A.T.4
-
127
-
-
0030797902
-
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
-
Anzick, S. L. et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277, 965-968 (1997
-
(1997)
Science
, vol.277
, pp. 965-968
-
-
Anzick, S.L.1
-
128
-
-
0032406875
-
In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity
-
Bautista, S. et al. In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity. Clin. Cancer Res. 4, 2925-2929 (1998
-
(1998)
Clin. Cancer Res
, vol.4
, pp. 2925-2929
-
-
Bautista, S.1
-
129
-
-
4544314561
-
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene
-
Torres-Arzayus, M. I. et al. High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell 6, 263-274 (2004
-
(2004)
Cancer Cell
, vol.6
, pp. 263-274
-
-
Torres-Arzayus, M.I.1
-
130
-
-
24744446846
-
Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis
-
Kuang, S. Q. et al. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 65, 7993-8002 (2005
-
(2005)
Cancer Res
, vol.65
, pp. 7993-8002
-
-
Kuang, S.Q.1
-
131
-
-
45549110356
-
The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice
-
Fereshteh, M. P. et al. The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice. Cancer Res. 68, 3697-3706 (2008
-
(2008)
Cancer Res
, vol.68
, pp. 3697-3706
-
-
Fereshteh, M.P.1
-
132
-
-
58549097737
-
Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation
-
Wang, S. et al. Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc. Natl Acad. Sci. USA 106, 151-156 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 151-156
-
-
Wang, S.1
-
133
-
-
48549086542
-
Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression
-
Yan, J. et al. Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression. Cancer Res. 68, 5460-5468 (2008
-
(2008)
Cancer Res
, vol.68
, pp. 5460-5468
-
-
Yan, J.1
-
134
-
-
79951497419
-
The genomic complexity of primary human prostate cancer
-
Berger, M. F. et al. The genomic complexity of primary human prostate cancer. Nature 470, 214-220 (2011
-
(2011)
Nature
, vol.470
, pp. 214-220
-
-
Berger, M.F.1
-
135
-
-
84861581164
-
Exome sequencing identifies recurrent SPOP FOXA1 and MED12 mutations in prostate cancer
-
Barbieri, C. E. et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nature Genet. 44, 685-689 (2012
-
(2012)
Nature Genet
, vol.44
, pp. 685-689
-
-
Barbieri, C.E.1
-
136
-
-
77955660663
-
Diverse somatic mutation patterns and pathway alterations in human cancers
-
Kan, Z. et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 466, 869-873 (2010
-
(2010)
Nature
, vol.466
, pp. 869-873
-
-
Kan, Z.1
-
137
-
-
84876831537
-
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
-
Geng, C. et al. Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proc. Natl Acad. Sci. USA 110, 6997-7002 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 6997-7002
-
-
Geng, C.1
-
138
-
-
77954255681
-
Integrative genomic profiling of human prostate cancer
-
Taylor, B. S. et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 18, 11-22 (2010
-
(2010)
Cancer Cell
, vol.18
, pp. 11-22
-
-
Taylor, B.S.1
-
139
-
-
84861432291
-
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/ Src-2 in liver cancer
-
O'Donnell, K. A. et al. A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/ Src-2 in liver cancer. Proc. Natl Acad. Sci. USA 109, E1377-E1386 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
-
-
O'Donnell, K.A.1
-
140
-
-
0032080173
-
A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia
-
Carapeti, M., Aguiar, R. C. T., Goldman, J. M. & Cross, N. C. P. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. Blood 91, 3127-3133 (1998
-
(1998)
Blood
, vol.91
, pp. 3127-3133
-
-
Carapeti, M.1
Aguiar, R.C.T.2
Goldman, J.M.3
Cross, N.C.P.4
-
141
-
-
0032530267
-
Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2
-
Liang, J., Prouty, L., Williams, B. J., Dayton, M. A. & Blanchard, K. L. Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2. Blood 92, 2118-2122 (1998
-
(1998)
Blood
, vol.92
, pp. 2118-2122
-
-
Liang, J.1
Prouty, L.2
Williams, B.J.3
Dayton, M.A.4
Blanchard, K.L.5
-
142
-
-
0041785491
-
MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP
-
Deguchi, K. et al. MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell 3, 259-271 (2003
-
(2003)
Cancer Cell
, vol.3
, pp. 259-271
-
-
Deguchi, K.1
-
143
-
-
19944385935
-
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
-
Huntly, B. J. et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 6, 587-596 (2004
-
(2004)
Cancer Cell
, vol.6
, pp. 587-596
-
-
Huntly, B.J.1
-
144
-
-
2342457139
-
SIM2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus
-
Goshu, E. et al. SIM2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. Mol. Endocrinol. 18, 1251-1262 (2004
-
(2004)
Mol. Endocrinol
, vol.18
, pp. 1251-1262
-
-
Goshu, E.1
-
145
-
-
84860780042
-
SIM2 prevents entry into the myogenic program by repressing myod transcription during limb embryonic myogenesis
-
Havis, E. et al. SIM2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development 139, 1910-1920 (2012
-
(2012)
Development
, vol.139
, pp. 1910-1920
-
-
Havis, E.1
-
146
-
-
0033852958
-
Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (SIM2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome
-
Chrast, R. et al. Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (SIM2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Hum. Mol. Genet. 9, 1853-1864 (2000
-
(2000)
Hum. Mol. Genet
, vol.9
, pp. 1853-1864
-
-
Chrast, R.1
-
147
-
-
0037447077
-
Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors
-
DeYoung, M. P., Tress, M. & Narayanan, R. Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors. Proc. Natl Acad. Sci. USA 100, 4760-4765 (2003
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 4760-4765
-
-
DeYoung, M.P.1
Tress, M.2
Narayanan, R.3
-
148
-
-
24644525067
-
Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells
-
Aleman, M. J. et al. Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells. Proc. Natl Acad. Sci. USA 102, 12765-12770 (2005
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 12765-12770
-
-
Aleman, M.J.1
-
149
-
-
40349091380
-
Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2
-
Laffin, B. et al. Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2. Mol. Cell. Biol. 28, 1936-1946 (2008
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 1936-1946
-
-
Laffin, B.1
-
150
-
-
0141863174
-
Down's syndrome-associated Single Minded 2 gene as a pancreatic cancer drug therapy target
-
DeYoung, M. P., Tress, M. & Narayanan, R. Down's syndrome-associated Single Minded 2 gene as a pancreatic cancer drug therapy target. Cancer Lett. 200, 25-31 (2003
-
(2003)
Cancer Lett
, vol.200
, pp. 25-31
-
-
DeYoung, M.P.1
Tress, M.2
Narayanan, R.3
-
151
-
-
33847396441
-
Increased expression of SIM2-s protein is a novel marker of aggressive prostate cancer
-
Halvorsen, O. J. et al. Increased expression of SIM2-s protein is a novel marker of aggressive prostate cancer. Clin. Cancer Res. 13, 892-897 (2007
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 892-897
-
-
Halvorsen, O.J.1
-
152
-
-
70349448674
-
Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer
-
Arredouani, M. S. et al. Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer. Clin. Cancer Res. 15, 5794-5802 (2009
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 5794-5802
-
-
Arredouani, M.S.1
-
153
-
-
80052453850
-
Protein-coding and microRNA biomarkers of recurrence of prostate cancer following radical prostatectomy
-
Long, Q. et al. Protein-coding and microRNA biomarkers of recurrence of prostate cancer following radical prostatectomy. Am. J. Pathol. 179, 46-54 (2011
-
(2011)
Am. J. Pathol
, vol.179
, pp. 46-54
-
-
Long, Q.1
-
154
-
-
79953735516
-
Singleminded-2s (SIM2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFκB
-
Scribner, K. C., Wellberg, E. A., Metz, R. P. & Porter, W. W. Singleminded-2s (SIM2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFκB. Mol. Endocrinol. 25, 635-644 (2011
-
(2011)
Mol. Endocrinol.
, vol.25
, pp. 635-644
-
-
Scribner, K.C.1
Wellberg, E.A.2
Metz, R.P.3
Porter, W.W.4
-
155
-
-
84878253028
-
Regulation of DCIS to invasive breast cancer progression by Singleminded-2s (SIM2s
-
Scribner, K. C., Behbod, F. & Porter, W. W. Regulation of DCIS to invasive breast cancer progression by Singleminded-2s (SIM2s). Oncogene 32, 2631-2639 (2013
-
(2013)
Oncogene
, vol.32
, pp. 2631-2639
-
-
Scribner, K.C.1
Behbod, F.2
Porter, W.W.3
-
156
-
-
77950363603
-
The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation
-
Wellberg, E., Metz, R. P., Parker, C. & Porter, W. W. The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation. Development 137, 945-952 (2010
-
(2010)
Development
, vol.137
, pp. 945-952
-
-
Wellberg, E.1
Metz, R.P.2
Parker, C.3
Porter, W.W.4
-
157
-
-
59149086440
-
AHR signaling in prostate growth, morphogenesis, and disease
-
Vezina, C. M., Lin, T. M. & Peterson, R. E. AHR signaling in prostate growth, morphogenesis, and disease. Biochem. Pharmacol. 77, 566-576 (2009
-
(2009)
Biochem. Pharmacol
, vol.77
, pp. 566-576
-
-
Vezina, C.M.1
Lin, T.M.2
Peterson, R.E.3
-
158
-
-
33744948882
-
Differential transcriptional regulation by mouse single-minded 2s
-
Metz, R. P., Kwak, H. I., Gustafson, T., Laffin, B. & Porter, W. W. Differential transcriptional regulation by mouse single-minded 2s. J. Biol. Chem. 281, 10839-10848 (2006
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10839-10848
-
-
Metz, R.P.1
Kwak, H.I.2
Gustafson, T.3
Laffin, B.4
Porter, W.W.5
-
159
-
-
70350064297
-
The HIF1α-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element
-
Farrall, A. L. & Whitelaw, M. L. The HIF1α-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element. Oncogene 28, 3671-3680 (2009
-
(2009)
Oncogene
, vol.28
, pp. 3671-3680
-
-
Farrall, A.L.1
Whitelaw, M.L.2
-
160
-
-
0034640253
-
Interacting molecular loops in the mammalian circadian clock
-
Shearman, L. P. et al. Interacting molecular loops in the mammalian circadian clock. Science 288, 1013-1019 (2000
-
(2000)
Science
, vol.288
, pp. 1013-1019
-
-
Shearman, L.P.1
-
161
-
-
34249097203
-
Circadian mutant overtime reveals F-box protein FBXL3 regulation of Cryptochrome and Period gene expression
-
Siepka, S. M. et al. Circadian mutant overtime reveals F-box protein FBXL3 regulation of Cryptochrome and Period gene expression. Cell 129, 1011-1023 (2007
-
(2007)
Cell
, vol.129
, pp. 1011-1023
-
-
Siepka, S.M.1
-
162
-
-
84874768419
-
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
-
Yoo, S. H. et al. Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Cell 152, 1091-1105 (2013
-
(2013)
Cell
, vol.152
, pp. 1091-1105
-
-
Yoo, S.H.1
-
163
-
-
22844432019
-
SCFβ- TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period- ;1 (Per1) protein
-
Shirogane, T., Jin, J., Ang, X. L. & Harper, J. W. SCFβ- TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J. Biol. Chem. 280, 26863-26872 (2005
-
(2005)
J. Biol. Chem
, Issue.280
, pp. 26863-26872
-
-
Shirogane, T.1
Jin, J.2
Ang, X.L.3
Harper, J.W.4
-
164
-
-
34248566788
-
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
-
Busino, L. et al. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science 316, 900-904 (2007
-
(2007)
Science
, vol.316
, pp. 900-904
-
-
Busino, L.1
-
165
-
-
70350128135
-
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
-
Lamia, K. A. et al. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326, 437-440 (2009
-
(2009)
Science
, vol.326
, pp. 437-440
-
-
Lamia, K.A.1
-
166
-
-
0035966317
-
Posttranslational mechanisms regulate the mammalian circadian clock
-
Lee, C., Etchegaray, J. P., Cagampang, F. R., Loudon, A. S. & Reppert, S. M. Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107, 855-867 (2001
-
(2001)
Cell
, vol.107
, pp. 855-867
-
-
Lee, C.1
Etchegaray, J.P.2
Cagampang, F.R.3
Loudon, A.S.4
Reppert, S.M.5
-
167
-
-
84860264490
-
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β.
-
Cho, H. et al. Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature 485, 123-127 (2012
-
(2012)
Nature
, vol.485
, pp. 123-127
-
-
Cho, H.1
-
168
-
-
0037178787
-
The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator
-
Preitner, N. et al. The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110, 251-260 (2002
-
(2002)
Cell
, vol.110
, pp. 251-260
-
-
Preitner, N.1
-
169
-
-
4143142003
-
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock
-
Sato, T. K. et al. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43, 527-537 (2004
-
(2004)
Neuron
, vol.43
, pp. 527-537
-
-
Sato, T.K.1
-
170
-
-
37249086610
-
Rev-erbα, a heme sensor that coordinates metabolic and circadian pathways
-
Yin, L. et al. Rev-erbα, a heme sensor that coordinates metabolic and circadian pathways. Science 318, 1786-1789 (2007
-
(2007)
Science
, vol.318
, pp. 1786-1789
-
-
Yin, L.1
-
171
-
-
42149130265
-
Why does ARNT2 behave differently from ARNT?
-
Hankinson, O. Why does ARNT2 behave differently from ARNT? Toxicol. Sci. 103, 1-3 (2008
-
(2008)
Toxicol. Sci.
, vol.103
, pp. 1-3
-
-
Hankinson, O.1
-
172
-
-
80054705389
-
Structure of an enclosed dimer formed by the Drosophila period protein
-
King, H. A., Hoelz, A., Crane, B. R. & Young, M. W. Structure of an enclosed dimer formed by the Drosophila period protein. J. Mol. Biol. 413, 561-572 (2011
-
(2011)
J. Mol. Biol
, vol.413
, pp. 561-572
-
-
King, H.A.1
Hoelz, A.2
Crane, B.R.3
Young, M.W.4
-
173
-
-
77955499804
-
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α
-
Lim, J. H. et al. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α. Mol. Cell 38, 864-878 (2010
-
(2010)
Mol. Cell
, vol.38
, pp. 864-878
-
-
Lim, J.H.1
-
174
-
-
66749129781
-
Regulation of hypoxia-inducible factor 2α signaling by the stress-responsive deacetylase sirtuin 1
-
Dioum, E. M. et al. Regulation of hypoxia-inducible factor 2α signaling by the stress-responsive deacetylase sirtuin 1. Science 324, 1289-1293 (2009
-
(2009)
Science
, vol.324
, pp. 1289-1293
-
-
Dioum, E.M.1
-
175
-
-
75149115740
-
The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis
-
Fan, Y. et al. The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer Res. 70, 212-220 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 212-220
-
-
Fan, Y.1
-
176
-
-
33846652552
-
Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression
-
Liao, D., Corle, C., Seagroves, T. N. & Johnson, R. S. Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res. 67, 563-572 (2007
-
(2007)
Cancer Res
, vol.67
, pp. 563-572
-
-
Liao, D.1
Corle, C.2
Seagroves, T.N.3
Johnson, R.S.4
-
177
-
-
77955982276
-
HIF-2α deletion promotes Kras-driven lung tumor development
-
Mazumdar, J. et al. HIF-2α deletion promotes Kras-driven lung tumor development. Proc. Natl Acad. Sci. USA 107, 14182-14187 (2010
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 14182-14187
-
-
Mazumdar, J.1
-
178
-
-
77957350018
-
Macrophage expression of hypoxia-inducible factor-1 α suppresses T-cell function and promotes tumor progression
-
Doedens, A. L. et al. Macrophage expression of hypoxia-inducible factor-1 α suppresses T-cell function and promotes tumor progression. Cancer Res. 70, 7465-7475 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 7465-7475
-
-
Doedens, A.L.1
-
179
-
-
77955295091
-
Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
-
Imtiyaz, H. Z. et al. Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation. J. Clin. Invest. 120, 2699-2714 (2010
-
(2010)
J. Clin. Invest
, vol.120
, pp. 2699-2714
-
-
Imtiyaz, H.Z.1
-
180
-
-
56449122777
-
Period 2 mutation accelerates ApcMin/+ tumorigenesis
-
Wood, P. A. et al. Period 2 mutation accelerates ApcMin/+ tumorigenesis. Mol. Cancer Res. 6, 1786-1793 (2008
-
(2008)
Mol. Cancer Res
, vol.6
, pp. 1786-1793
-
-
Wood, P.A.1
-
181
-
-
84879391795
-
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
-
Chang, H-C. & Guarente, L. SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 153, 1448-1460 (2013
-
(2013)
Cell
, vol.153
, pp. 1448-1460
-
-
Chang, H.-C.1
Guarente, L.2
|