Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis

Molecular and Cellular Biology

Volumn 16, Issue 10, 1996, Pages 5865-5875

  Ema, Masatsugu ^a   Morita, Masanobu ^a   Ikawa, Shuntaro ^a   Tanaka, Masahiro ^a   Matsuda, Youichi ^b   Gotoh, Osamu ^c   Saijoh, Yukio ^d   Fujii, Hideta ^d   Hamada, Hiroshi ^d   Kikuchi, Yasuo ^a   Fujii Kuriyama, Yoshiaki ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HELIX LOOP HELIX PROTEIN; REPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMOSOME 10; CHROMOSOME 6Q; DOWN SYNDROME; DROSOPHILA; EMBRYO DEVELOPMENT; GENE ISOLATION; HUMAN; HUMAN CELL; MOLECULAR CLONING; MONKEY; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

ANIMALIA; MURINAE;

EID: 10144224910     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.10.5865     Document Type: Article

References (76)

1. Ayer, D. E., L. Kretzner, and R. N. Eisenman. 1993. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72:211-222.
2. Ayer, D. E., Q. E. Lawrence, and R. N. Eisenman. 1995. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80:767-776.
3. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-kappa B in the immune system. Annu. Rev. Immnol. 12:141-179.
4. Bartel, P. L., C.-T. Chen, R. Sternglanz, and S. Fields. 1994. Using the two-hybrid system to detect protein-protein interactions, p. 153-179. In D. A. Hartley (ed.), Cellular interactions in development: a practical approach. Oxford University Press, New York.
5. Burbach, K. M., A. Poland, and C. A. Bradfield. 1992. Cloning of the AH-receptor cDNA reveals a novel ligand activated transcription factor. Proc. Natl. Acad. Sci. USA 89:8185-8189.
6. Campos-Ortega, J. A., and V. Hartenstein. 1985. The embryonic development of Drosophila melanogaster. Springer-Verlag, Heidelberg, Germany.
7. Chang, Z., D. Price, S. Bockheim, M. J. Boedighelmer, R. Smith, and A. Laughon. 1993. Molecular and genetic characterization of the Drosophila tartan gene. Dev. Biol. 160:315-332.
8. Chen, H., R. Chrast, C. Rossier, A. Gos, S. E. Antonarakisis, J. Kudoh, A. Yamaki, N. Shindoh, H. Maeda, S. Minoshima, and N. Shimizu. 1995. single-minded and Down syndrome? Nat. Genet. 10:9-10.
9. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
10. Crews, S. T., J. B. Thomas, and C. S. Goodman. 1988. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Cell 52:143-151.
11. Echelard, Y., D. J. Epstein, B. St-Jacques, L. Shen, J. Mohler, J. A. McMahon, and A. P. McMahon. 1993. sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75:1417-1430.
12. Ema, M., N. Ohe, M. Suzuki, J. Mimura, K. Sogawa, S. Ikawa, and Y. Fujii-Kuriyama. 1994. Dioxin-binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J. Biol. Chem. 269:27337-27343.
13. Ema, M., K. Sogawa, N. Watanabe, Y. Chujoh, N. Matsushita, O. Gotoh, Y. Funae, and Y. Fujii-Kuriyama. 1992. cDNA cloning and structure of mouse putative Ah receptor. Biochem. Biophys. Res. Commun. 184:246-253.
14. Ema, M., M. Suzuki, M. Morita, K. Hirose, K. Sogawa, Y. Matsuda, O. Gotoh, Y. Saijoh, H. Fujii, H. Hamada, and Y. Fujii-Kuriyama. 1996. cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development and chromosomal localization. Biochem. Biophys. Res. Commun. 218:588-594.
15. Ericson, J., J. Muhr, M. Placzek, T. Lints, T. M. Jessel, and T. Edlund. 1995. sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell 81:745-756.
16. Fan, C.-M., E. Kuwana, A. Bulfone, C. F. Fletcher, N. G. Copeland, N. A. Jenkins, S. Crews, S. Martinez, L. Ruelles, J. L. R. Rubenstein, and M. Tessier-Lavigne. 1996. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. Mol. Cell. Neurosci. 7:1-16.
17. Franks, R. G., and S. T. Crews. 1994. Transcriptional activation domains of the single-minded bHLH protein are required for CNS midline cell development. Mech. Dev. 45:269-277.
18. Gashler, A. L., S. Swaminathan, and V. P. Sukhatme. 1993. A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediately-early transcription factor Egr-1. Mol. Cell. Biol. 13:4556-4571.
19. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
20. Gotoh, O. 1995. A weighting system and algorithm for aligning many phylogenetically related sequences. Comput. Appl. Biosci. 11:543-551.
21. Han, K., and J. L. Manley. 1993. Transcriptional repression by the Drosophila Even-skipped protein: definition of a minimal repression domain. Genes Dev. 7:491-503.
22. Hirose, K., M. Morita, M. Ema, J. Mimura, H. Hamada, H. Fujii, Y. Saijoh, O. Gotoh, K. Sogawa, and Y. Fujii-Kuriyama. 1996. cDNA cloning and tissue-specific expression of a novel bHLH/PAS factor (Arnt2) with close sequence similarity to AhR nuclear translocator (Arnt). Mol. Cell. Biol. 16:1706-1713.
23. Hoffman, E. C., H. Reyes, F.-F. Chu, F. Sander, L. H. Conley, B. H. Brooks, and O. Hankinson. 1991. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252:954-958.
24. Hosoya, T., and Y. Fujii-Kuriyama. Unpublished result.
25. Hynes, M., K. Poulsen, M. Tessier-Lavigne, and A. Rosenthal. 1995. Control of neuronal diversity by the floor plate: contact-mediated induction of midbrain dopaminergic neurons. Cell 80:95-101.
26. Isaac, D. D., and D. J. Andrew. 1996. Tubulogenesis in Drosophila, a requirement for the trachealess gene product. Genes Dev. 10:103-118.
27. Jackson, R. R., T. A. Bargiello, S.-H. Sun, and M. W. Young. 1986. Product of per locus of Drosophila shares homology with proteoglycans. Nature (London) 320:185-188.
28. Jain, S., K. M. Dolwick, J. V. Schmidt, and C. A. Bradfield. 1994. Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini. J. Biol. Chem. 269:31518-31524.
29. Klämbt, C., J. R. Jacobs, and C. S. Goodman. 1991. The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance. Cell 64:801-815.
30. Kozak, M. 1989. The scanning model for translation: an update. J. Cell Biol. 108:229-241.
31. Krauss, S., J.-P. Conchodet, and P. W. Ingham. 1993. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75:1431-1444.
32. Li, H., L. Dong, and J. P. Whitlock, Jr. 1994. Transcriptional activation function of the mouse Ah receptor nuclear translocator. J. Biol. Chem. 269:28098-28105.
33. Licht, J. D., M. J. Grossel, J. Figge, and U. M. Hansen. 1990. Drosophila Krüppel protein is a transcriptional repressor. Nature (London) 346:76-79.
34. Lillie, J. W., and M. R. Green. 1989. Transcriptional activation by the adenovirus E1a protein. Nature (London) 338:39-44.
35. Lindebro, M. C., L. Poellinger, and M. L. Whitelaw. 1995. Protein-protein interaction via PAS domain: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex. EMBO J. 14:3528-3539.
36. Madden, S. L., D. M. Cook, J. F. Morris, A. Gashler, V. P. Sukhatme, and F. J. Rausher III. 1991. Transcriptional repression mediated by the WT1 Wilms tumor gene product. Science 253:1550-1553.
37. Madden, S. L., D. M. Cook, and F. J. Rausher III. 1993. A structure-function analysis of transcriptional repression mediated by the WT1, Wilms' tumor suppressor protein. Oncogene 8:1713-1720.
38. Matsuda, Y., and V. M. Chapman. 1995. Application of fluorescence in situ hybridization in genome analysis of the mouse. Electrophoresis 16:261-272.
39. Matsuda, Y., Y.-H. Harada, S. Natsume-Sakai, K. Lee, T. Shiomi, and V. M. Chapman. 1992. Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding. Cytogenet. Cell Genet. 61:282-285.
40. Matsushita, N., K. Sogawa, M. Ema, A. Yoshida, and Y. Fujii-Kuriyama. 1993. A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt. J. Biol. Chem. 268:21002-21006.
41. Mellerick, D. M., and M. Nirenberg. 1995. Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of Drosophila embryos. Dev. Biol. 171:306-316.
42. Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
43. Morita, M., and Y. Fujii-Kuriyama. Unpublished results.
44. Muenke, M., L. J. Bone, H. F. Mitchell, I. Hart, K. Walton, K. Hall-Johnson, E. F. Ippel, J. Dietz-Band, K. Kvaloy, C.-H. Fan, M. Tessier-Lavigne, and D. Patterson. 1995. Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome. Am. J. Hum. Genet. 57:1074-1079.
45. Nahmane, N., G. Charron, C. Lopes, M.-L. Yaspo, C. Maunoury, L. Decorte, P.-M. Sinet, M. Bloch, and J.-M. Delabar. 1995. Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development. Proc. Natl. Acad. Sci. USA 92:9191-9195.
46. Nambu, J. R., R. G. Franks, S. Fu, and S. T. Crews. 1990. The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline development. Cell 63:63-75.
47. Nambu, J. R., J. O. Lewis, and S. T. Crews. 1993. The development and function of the Drosophila CNS midline cells. Comp. Biochem. Physiol. 104:399-409.
48. Nambu, J. R., J. O. Lewis, K. O. Wharton, Jr., and S. T. Crews. 1991. The Drosophila single-minded gene encodes a helix-loop-helix protein which acts as a master regulator of CNS midline. Cell 67:1157-1167.
49. Numayama-Tsuruta, K., and Y. Fujii-Kuriyama. Unpublished data.
50. Nüsslein-Volhard, C., E. Wieschaus, and H. Kluding. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193:267-282.
51. Pourquie, O., C.-M. Fan, M. Coltey, E. Hirsinger, Y, Watanabe, C. Breant, P. Francis-West, P. Brickell, M. Tessier-Lavigne, and N. M. Le Douarin. 1996. Lateral and axial signals involved in avian somite patterning: a role for BMP4. Cell 84:461-472.
52. Reddy, P., A. C. Jaquier, N. Aborich, G. Petersen, and M. Roshbash. 1986. The period clock locus of D. melanogaster codes for a proteoglycan. Cell 46:53-61.
53. Reyes, H., S. Reisz-Porszasz, and O. Hankinson. 1992. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256:1193-1195.
54. Riddle, R., R. L. Johnson, E. Laufer, and C. Tabin. 1993. Sonic hedgehog mediates the ZPA of polarizing activity. Cell 75:1401-1416.
55. Roelink, H., A. Augsberger, J. Heemskerk, V. Korzh, S. Norlin, A. Ruiz i Altaba, Y. Tanabe, M. Placzek, T. T. Edlund, T. M. Jessel, and J. Dodd. 1994. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 76:761-775.
56. Rothberg, J. M., J. R. Jacobs, C. S. Goodman, and S. Artavanis-Tsakonas. 1990. slit: an extracellular protein necessary for development of midline glia and commisural axon pathways contains both EGF and LRR domains. Genes Dev. 4:2169-2187.
57. Rubenstein, J. L. R., S. Martinez, K. Shimamura, and L. Puelles. 1994. The embryonic vertebrate forebrain: the prosomeric model. Science 266:578-580.
58. Sadowski, I., and M. Ptashne. 1989. A vector for expressing GAL4 (1-147) fusions in mammalian cells. Nucleic Acids Res. 17:7539.
59. Saitou, N., and M. Nei. 1987. The neighbour-joining method: a new method for reconstructing phylogenic trees. Mol. Biol. Evol. 4:406-425.
60. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
61. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
62. Schreiber-Agus, N., L. Chin, K. Chen, R. Torres, G. Rao, P. Guida, A. I. Skoultchi, and R. A. DePinho. 1995. An amino terminal domain of Mxi mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80:1777-1786.
63. Shi, Y., E. Seto, L. S. Chang, and T. Shenk. 1991. Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67:377-388.
64. Sogawa, K., R. Nakano, A. Kobayashi, Y. Kikuchi, N. Ohe, N. Matsushita, and Y. Fujii-Kuriyama. 1995. Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation. Proc. Natl. Acad. Sci. USA 92:1936-1940.
65. Sogawa, K., K. Iwabuchi, H. Abe, and Y. Fujii-Kuriyama. 1995. Transcriptional activation domain of the Ah receptor and Arnt (Ah receptor nuclear translocator). J. Cancer Res. Clin. 121:612-620.
66. Takahashi, J. S. 1992. Circadian clock genes are ticking. Science 258:238-240.
67. Thomas, J. B., S. T. Crews, and C. S. Goodman. 1988. Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system. Cell 52:133-141.
68. Wang, G. L., B.-H. Jiang, E. A. Rue, and G. L. Semenza. 1995. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92:5510-5514.
69. Weintraub, H., R. Davis, S. Tapscott, M. Thayer, M. Krause, R. Benezra, T. K. Blackwell, D. Turner, R. Rupp, S. Hollenberg, Y. Zhuang, and A. Lassar. 1991. The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251:761-766.
70. Wharton, K. A., Jr., R. G. Franks, Y. Kasai, and S. T. Crews. 1994. Control of CNS midline transcription by asymmetric E-box-like elements: similarity to xenobiotic responsive regulation. Development 120:3563-3569.
71. Whitelaw, M. L., I. Pongratz, A. Wilhelmsson, J.-Å. Gustafsson, and L. Poellinger. 1993. Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor. Mol. Cell. Biol. 13: 2504-2514.
72. Whitelaw, M. L., J.-Å. Gustafsson, and L. Poellinger. 1994. Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation. Mol. Cell. Biol. 14:8343-8355.
73. Wieschaus, E., C. Nüsslein-Volhard, and G. Jürgens. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. III. Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193:283-295.
74. Wilk, R., I. Weizman, and B.-Z. Shilo. 1996. trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila. Genes Dev. 10:93-102.
75. Wilkinson, D. G. 1992. In situ hybridization: a practical approach. Oxford University Press, London.
76. Zervos, A. S. J. Gyuris, and R. Brent. 1993. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72:223-232.