-
2
-
-
60149091189
-
Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
-
Sonenberg, N. & Hinnebusch, A. G. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136, 731-745 (2009).
-
(2009)
Cell
, vol.136
, pp. 731-745
-
-
Sonenberg, N.1
Hinnebusch, A.G.2
-
3
-
-
35649001888
-
A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer
-
Braunstein, S. et al. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol. Cell 28, 501-512 (2007).
-
(2007)
Mol. Cell
, vol.28
, pp. 501-512
-
-
Braunstein, S.1
-
4
-
-
10044276783
-
Regulation ofmTORfunction in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
Brugarolas, J. et al. Regulation ofmTORfunction in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18, 2893-2904 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
-
5
-
-
33644852277
-
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
-
Koritzinsky, M. et al. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 25, 1114-1125 (2006).
-
(2006)
EMBO J.
, vol.25
, pp. 1114-1125
-
-
Koritzinsky, M.1
-
6
-
-
32444433450
-
Hypoxia-induced energy stress regulates mRNA translation and cell growth
-
Liu, L. et al. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol. Cell 21, 521-531 (2006).
-
(2006)
Mol. Cell
, vol.21
, pp. 521-531
-
-
Liu, L.1
-
7
-
-
17144424622
-
Translational control in stress and apoptosis
-
Holcik, M. & Sonenberg, N. Translational control in stress and apoptosis. Nature Rev. Mol. Cell Biol. 6, 318-327 (2005).
-
(2005)
Nature Rev. Mol. Cell Biol.
, vol.6
, pp. 318-327
-
-
Holcik, M.1
Sonenberg, N.2
-
8
-
-
47749141892
-
Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism
-
Young, R. M. et al. Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism. J. Biol. Chem. 283, 16309-16319 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16309-16319
-
-
Young, R.M.1
-
9
-
-
77954356006
-
Eukaryotic protein synthesis: Still a mystery
-
Merrick, W. C. Eukaryotic protein synthesis: still a mystery. J. Biol. Chem. 285, 21197-21201 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 21197-21201
-
-
Merrick, W.C.1
-
10
-
-
77950920903
-
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
-
Hafner, M. et al. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 141, 129-141 (2010).
-
(2010)
Cell
, vol.141
, pp. 129-141
-
-
Hafner, M.1
-
12
-
-
34548803430
-
Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
-
Franovic, A. et al. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc. Natl Acad. Sci. USA 104, 13092-13097 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 13092-13097
-
-
Franovic, A.1
-
13
-
-
0035917313
-
HIFa targetedforVHL-mediated destructionby proline hydroxylation: Implications for O2 sensing
-
Ivan,M. et al. HIFa targetedforVHL-mediated destructionby proline hydroxylation: implications for O2 sensing. Science 292, 464-468 (2001).
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
-
14
-
-
0035917808
-
Targeting of HIF-a to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola, P. et al. Targeting of HIF-a to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-472 (2001).
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
15
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin, W. G. Jr & Ratcliffe, P. J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402 (2008).
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
16
-
-
0033233243
-
Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
-
Semenza, G. L. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15, 551-578 (1999).
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
17
-
-
0037315337
-
Widespread hypoxia-inducible expression of HIF-2a in distinct cell populations of different organs
-
Wiesener, M. S. et al. Widespread hypoxia-inducible expression of HIF-2a in distinct cell populations of different organs. FASEB J. 17, 271-273 (2003).
-
(2003)
FASEB J.
, vol.17
, pp. 271-273
-
-
Wiesener, M.S.1
-
18
-
-
33847795858
-
Cell stress modulates the function of splicing regulatory protein RBM4 in translation control
-
Lin, J. C., Hsu, M. & Tarn, W. Y. Cell stress modulates the function of splicing regulatory protein RBM4 in translation control. Proc. Natl Acad. Sci. USA 104, 2235-2240 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 2235-2240
-
-
Lin, J.C.1
Hsu, M.2
Tarn, W.Y.3
-
19
-
-
71749110414
-
RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation
-
Lin, J. C. & Tarn, W. Y. RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation. J. Biol. Chem. 284, 34658-34665 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 34658-34665
-
-
Lin, J.C.1
Tarn, W.Y.2
-
20
-
-
78049275913
-
RNAcontext: A newmethod for learning the sequence and structure binding preferences of RNA-binding proteins
-
Kazan, H., Ray, D., Chan, E. T., Hughes, T. R.& Morris, Q.RNAcontext: a newmethod for learning the sequence and structure binding preferences of RNA-binding proteins. PLOS Comput. Biol. 6, e1000832 (2010).
-
(2010)
PLOS Comput. Biol.
, vol.6
-
-
Kazan, H.1
Ray, D.2
Chan, E.T.3
Hughes, T.R.4
Morris, Q.5
-
21
-
-
67650484984
-
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins
-
Ray, D. et al. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nature Biotechnol. 27, 667-670 (2009).
-
(2009)
Nature Biotechnol.
, vol.27
, pp. 667-670
-
-
Ray, D.1
-
22
-
-
0028034233
-
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 59-cap function
-
Pause, A. et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 59-cap function. Nature 371, 762-767 (1994).
-
(1994)
Nature
, vol.371
, pp. 762-767
-
-
Pause, A.1
-
23
-
-
13444259647
-
Regulation of cap-dependent translation by eIF4E inhibitory proteins
-
Richter, J. D. & Sonenberg, N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433, 477-480 (2005).
-
(2005)
Nature
, vol.433
, pp. 477-480
-
-
Richter, J.D.1
Sonenberg, N.2
-
24
-
-
14444274091
-
Cloning and characterization of 4EHP, a novel mammalian eIF4Erelated cap-binding protein
-
Rom, E. et al. Cloning and characterization of 4EHP, a novel mammalian eIF4Erelated cap-binding protein. J. Biol. Chem. 273, 13104-13109 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13104-13109
-
-
Rom, E.1
-
25
-
-
1842839822
-
Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1
-
Tee, A. R., Tee, J. A. & Blenis, J. Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1. FEBS Lett. 564, 58-62 (2004).
-
(2004)
FEBS Lett.
, vol.564
, pp. 58-62
-
-
Tee, A.R.1
Tee, J.A.2
Blenis, J.3
-
26
-
-
79953052296
-
MRNAhelicases: The tacticians of translational control
-
Parsyan, A. et al.mRNAhelicases: the tacticians of translational control.NatureRev. Mol. Cell Biol. 12, 235-245 (2011).
-
(2011)
Nature Rev. Mol. Cell Biol.
, vol.12
, pp. 235-245
-
-
Parsyan, A.1
-
27
-
-
77954319020
-
Sequencing of 50 human exomes reveals adaptation to high altitude
-
Yi, X. et al. Sequencing of 50 human exomes reveals adaptation to high altitude. Science 329, 75-78 (2010).
-
(2010)
Science
, vol.329
, pp. 75-78
-
-
Yi, X.1
-
28
-
-
77949326973
-
Genomics illuminates a deadly brain cancer
-
Kuehn, B. M. Genomics illuminates a deadly brain cancer. J. Am. Med. Assoc. 303, 925-927 (2010).
-
(2010)
J. Am. Med. Assoc.
, vol.303
, pp. 925-927
-
-
Kuehn, B.M.1
-
29
-
-
75849160216
-
Human cancers converge at the HIF-2a oncogenic axis
-
Franovic, A., Holterman, C. E., Payette, J. & Lee, S. Human cancers converge at the HIF-2a oncogenic axis. Proc. Natl Acad. Sci. USA 106, 21306-21311 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 21306-21311
-
-
Franovic, A.1
Holterman, C.E.2
Payette, J.3
Lee, S.4
-
30
-
-
0035503362
-
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
-
Giatromanolaki, A. et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 61, 7992-7998 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 7992-7998
-
-
Giatromanolaki, A.1
-
31
-
-
0242581718
-
Hypoxia inducible factor activates the transforming growth factor-a/epidermal growth factor receptor growth stimulatory pathway in VHL2/2 renal cell carcinoma cells
-
Gunaratnam, L. et al. Hypoxia inducible factor activates the transforming growth factor-a/epidermal growth factor receptor growth stimulatory pathway in VHL2/2 renal cell carcinoma cells. J. Biol. Chem. 278, 44966-44974 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 44966-44974
-
-
Gunaratnam, L.1
-
32
-
-
20444485232
-
Silencing of epidermal growthfactor receptorsuppresses hypoxiainducible factor-2-driven VHL2/2 renal cancer
-
Smith, K. et al. Silencing of epidermal growthfactor receptorsuppresses hypoxiainducible factor-2-driven VHL2/2 renal cancer. Cancer Res. 65, 5221-5230 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 5221-5230
-
-
Smith, K.1
|