Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 9, 2005, Pages 3407-3412

  Gorbacheva, Victoria Y ^a   Kondratov, Roman V ^a   Zhang, Renliang ^a   Cherukuri, Srujana ^a   Gudkov, Andrei V ^a   Takahashi, Joseph S ^b   Antoch, Marina P ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Chemotherapy; Circadian clock; Drug response

Indexed keywords

CRYPTOCHROME; CRYPTOCHROME 1; CRYPTOCHROME 2; CYCLOPHOSPHAMIDE; DRUG METABOLITE; PROTEIN BMAL1; TRANSCRIPTION FACTOR CLOCK; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL SURVIVAL; CIRCADIAN RHYTHM; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ACTIVATION; DRUG DETOXIFICATION; DRUG EFFECT; DRUG RESPONSE; DRUG SENSITIVITY; GENE MUTATION; GENOTOXICITY; GENOTYPE; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; WILD TYPE;

ANIMALS; ANTINEOPLASTIC AGENTS; B-LYMPHOCYTES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CIRCADIAN RHYTHM; COCULTURE TECHNIQUES; CYCLOPHOSPHAMIDE; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 14744278784     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409897102     Document Type: Article

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