Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 19, 2011, Pages 7739-7744

  Partch, Carrie L ^a   Gardner, Kevin H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Bifunctional interactions; Protein protein interactions; Transcriptional coactivators

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; OXYGEN; TRANSFORMING ACIDIC COILED COIL 3; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CELL FATE; CONTROLLED STUDY; DIMERIZATION; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; GLYCOLYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN TRANSPORT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTIONAL ACTIVATION;

EUKARYOTA;

EID: 79956370722     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101357108     Document Type: Article

References (43)

1. Kewley RJ, Whitelaw ML, Chapman-Smith A (2004) The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int J Biochem Cell Biol 36:189-204. (Pubitemid 37487755)
2. Chapman-Smith A, Lutwyche JK, Whitelaw ML (2004) Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators. J Biol Chem 279:5353-5362. (Pubitemid 38220557)
3. Erbel PJ, Card PB, Karakuzu O, Bruick RK, Gardner KH (2003) Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor. Proc Natl Acad Sci USA 100:15504-15509. (Pubitemid 38021019)
4. Yang J, et al. (2005) Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor. J Biol Chem 280:36047-36054. (Pubitemid 41633875)
5. Hoffman EC, et al. (1991) Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252:954-958. (Pubitemid 21917012)
6. Ko HP, Okino ST, Ma Q, Whitlock JP, Jr (1996) Dioxin-induced CYP1A1 transcription in vivo: The aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure. Mol Cell Biol 16:430-436. (Pubitemid 126506991)
7. Li H, Ko HP, Whitlock JP (1996) Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha. J Biol Chem 271:21262-21267. (Pubitemid 26292983)
8. Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL (1997) Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J Biol Chem 272:19253-19260. (Pubitemid 27337716)
9. Ruas JL, Poellinger L, Pereira T (2002) Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein. J Biol Chem 277:38723-38730. (Pubitemid 35154734)
10. Hu CJ, et al. (2006) Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol 26:3514-3526.
11. McKenna NJ, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW (1998) Distinct steady-state nuclear receptor coregulator complexes exist in vivo. Proc Natl Acad Sci USA 95:11697-11702. (Pubitemid 28460477)
12. Ravnskjaer K, et al. (2007) Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J 26:2880-2889. (Pubitemid 46975772)
13. Zelzer E, Wappner P, Shilo BZ (1997) The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins. Genes Dev 11:2079-2089. (Pubitemid 27369102)
14. Beischlag TV, et al. (2004) Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. J Biol Chem 279:54620-54628. (Pubitemid 40053205)
15. Kim JH, Stallcup MR (2004) Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription. J Biol Chem 279:49842-49848.
16. Partch CL, Card PB, Amezcua CA, Gardner KH (2009) Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT). J Biol Chem 284:15184-15192.
17. Sadek CM, et al. (2000) Isolation and characterization of AINT: A novel ARNT interacting protein expressed during murine embryonic development. Mech Dev 97:13-26.
18. McKeveney PJ, et al. (2001) Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells. Br J Haematol 112:1016-1024. (Pubitemid 32322931)
19. Peset I, Vernos I (2008) The TACC proteins: TACC-ling microtubule dynamics and centrosome function. Trends Cell Biol 18:379-388.
20. Metzen E, et al. (2003) Intracellular localisation of human HIF-1 alpha hydroxylases: Implications for oxygen sensing. J Cell Sci 116:1319-1326. (Pubitemid 36410669)
21. Tian H, McKnight SL, Russell DW (1997) Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11:72-82. (Pubitemid 27043825)
22. Dioum EM, et al. (2009) Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324(5932):1289-1293.
23. Simpson RJ, et al. (2004) A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3. J Biol Chem 279:39789-39797. (Pubitemid 39258249)
24. Ablack JN, et al. (2010) Comparison of E1A CR3 dependent transcriptional activation across six different human adenovirus subgroups. J Virol 84:12771-12781.
25. He B, et al. (2008) A repressive role for prohibitin in estrogen signaling. Mol Endocrinol 22:344-360. (Pubitemid 351185935)
26. Scheuermann TH, et al. (2009) Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci USA 106:450-455.
27. de Vries SJ, van Dijk M, Bonvin AM (2010) The HADDOCK web server for data-driven biomolecular docking. Nat Protoc 5:883-897.
28. Kaelin WG, Jr, Ratcliffe PJ (2008) Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. Mol Cell 30:393-402.
29. Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721-732.
30. Piekorz RP, et al. (2002) The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J 21:653-664. (Pubitemid 34174046)
31. Garriga-Canut M, Orkin SH (2004) Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J Biol Chem 279:23597-23605. (Pubitemid 38685674)
32. Adelman DM, Maltepe E, Simon MC (1999) Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev 13:2478-2483. (Pubitemid 29489639)
33. Iyer NV, et al. (1998) Cellular and developmental control of O2 homeostasis by hypoxia- inducible factor 1 alpha. Genes Dev 12:149-162. (Pubitemid 28060446)
34. Peng J, Zhang L, Drysdale L, Fong GH (2000) The transcription factor EPAS-1/hypoxiainducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci USA 97:8386-8391. (Pubitemid 30639682)
35. Ramirez-Bergeron DL, Runge A, Adelman DM, Gohil M, Simon MC (2006) HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev Cell 11:81-92. (Pubitemid 43960804)
36. Ryan HE, Lo J, Johnson RS (1998) HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17:3005-3015. (Pubitemid 28254373)
37. Simsek T, et al. (2010) The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 7:380-390.
38. Takubo K, et al. (2010) Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 7:391-402.
39. Wurdak H, et al. (2010) A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci USA 107:16542-16547.
40. Card PB, Erbel PJ, Gardner KH (2005) Structural basis of ARNT PAS-B dimerization: Use of a common beta-sheet interface for hetero- and homodimerization. J Mol Biol 353:664-677. (Pubitemid 41414739)
41. Delaglio F, et al. (1995) NMRPipe: A multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6:277-293.
42. Johnson BA (2004) Using NMRView to visualize and analyze the NMR spectra of macromolecules. Methods Mol Biol 278:313-352.
43. Jiang L, et al. (2008) De novo computational design of retro-aldol enzymes. Science 319:1387-1391. (Pubitemid 351354873)