Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53

Science

Volumn 274, Issue 5286, 1996, Pages 430-432

  Denissenko, Mikhail F ^a   Pao, Annie ^b   Tang, Moon Shong ^b   Pfeifer, Gerd P ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROXYBENZO[A]PYRENE OXIDE;

ARTICLE; BRONCHUS MUCOSA; CHEMICAL CARCINOGENESIS; CIGARETTE SMOKING; DNA DAMAGE; HELA CELL; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CARCINOGENESIS; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; BRONCHI; CARCINOGENS; CELLS, CULTURED; CODON; DINUCLEOSIDE PHOSPHATES; DNA ADDUCTS; EXONS; FIBROBLASTS; GENES, P53; HELA CELLS; HUMANS; LUNG NEOPLASMS; MUTAGENS; MUTATION; PLANTS, TOXIC; SMOKE; TOBACCO;

BRONCHUS;

EID: 0029806936     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5286.430     Document Type: Article

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28. We thank S. Bates for cell culture work. Supported by NIH grants CA65652 to G.P.P. and ES03124 to M.-s. T.