Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

Human Molecular Genetics

Volumn 9, Issue 12, 2000, Pages 1853-1864

  Chrast, Roman ^a   Scott, Hamish S ^a   Madani, Rime ^b   Huber, Lars ^b   Wolfer, David P ^b   Prinz, Marco ^c   Aguzzi, Adriano ^c   Lipp, Hans Peter ^b   Antonarakis, Stylianos E ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CHROMOSOME 21; CLONING VECTOR; CONTROLLED STUDY; DEVELOPMENT; DOWN SYNDROME; DROSOPHILA; EXPLORATORY BEHAVIOR; FEMALE; FERTILITY; GENE MAPPING; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HYPOTHESIS; IN VIVO STUDY; MALE; MOLECULAR CLONING; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NOCICEPTION; NONHUMAN; PARTIAL TRISOMY; PHENOTYPE; PRIORITY JOURNAL; TRANSGENE; TRANSGENIC MOUSE; VALIDATION PROCESS;

ANIMALIA; BACTERIA (MICROORGANISMS); DROSOPHILA; INSECTA; MUS MUSCULUS;

EID: 0033852958     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.12.1853     Document Type: Article

References (39)

1. Etude des chromosome somatique des neufs enfants Mongoliens
2. Molecular genetic approach to the characterization of the 'Down syndrome region' of chromosome 21
3. Molecular mapping of twenty-four features of Down syndrome on chromosome 21
4. 10 years of Genomics, chromosome 21, and Down syndrome
5. Single-minded and Down syndrome?
6. Cloning of 559 potential exons of genes of human chromosome 21 by exon trapping
7. Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region
8. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product
9. Molecular genetics of the single-minded locus: A gene involved in the development of the Drosophila nervous system
10. cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization
11. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome
12. Characterization of msim, a murine homologue of the Drosophila sim transcription factor
13. The mammalian single-minded (SIM) gene: Mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome
14. Control of cell lineage-specific development and transcription by bHLH-PAS proteins
15. Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis
16. The murine Sim-2 gene product inhibits transcription by active repression and functional interference
17. Down's syndrome: Abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase
18. Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of Down syndrome
19. A mouse model for Down syndrome exhibits learning and behavior deficits
20. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities
21. Mouse autosomal trisomy: Two's company, three's a crowd
22. Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome
23. Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: An animal model of Down's syndrome
24. Linearization and purification of BAC DNA for the development of transgenic mice
25. Opioid and nonopioid swim stress-induced analgesia: A parametric analysis in mice
26. A murine model for Down syndrome shows reduced responsiveness to pain
27. Developmental abnormalities and perinatal lethality resulting from targeted disruption of the murine Sim2 gene [abstract]
28. Gene dosage in mice-BAC to the future
29. BAC-mediated gene-dosage analysis reveals a role for Ziprol (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin
30. Overexpression of liver-type phosphofructokinase (PFKL) in transgenic-PFKL mice: Implication for gene dosage in trisomy 21
31. Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice
32. Deletion of theryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning
33. Essential role for TrkB receptors in hippocampus-mediated learning
34. Behavioral and pharmacological characterisation of the elevated 'zero-maze' as an animal model of anxiety
35. Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin
36. Clozapine promotes approach-oriented behavior in male mice
37. Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure