Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase

Cancer Research

Volumn 70, Issue 10, 2010, Pages 4214-4221

  Zhou, Xue ^a   Sun, Hong ^a   Chen, Haobin ^a   Zavadil, Jiri ^a   Kluz, Thomas ^a   Arita, Adriana ^a   Costa, Max ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; JARID1A DEMETHYLASE; LYSINE; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CARCINOGENESIS; CONTROLLED STUDY; DEMETHYLATION; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; LUNG CARCINOMA; OXYGEN TENSION; PRIORITY JOURNAL; PROMOTER REGION; TUMOR GROWTH;

BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRONCHI; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; HEME OXYGENASE-1; HISTONES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; LYSINE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-BINDING PROTEIN 2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 77952795537     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2942     Document Type: Article

References (36)

1. Kenneth NS, Rocha S. Regulation of gene expression by hypoxia. Biochem J 2008;414:19-29.
2. Strahl BD, Allis CD. The language of covalent histone modifications. Nature 2000;403:41-45
3. Peterson CL, Laniel MA. Histones and histone modifications. Curr Biol 2004;14:R546-51.
4. Martin C, Zhang Y. The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 2005;6:838-849 (Pubitemid 41568733)
5. Mikkelsen TS, Ku M, Jaffe DB, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007; 448:553-560
6. Heintzman ND, Stuart RK, Hon G, et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet 2007;39:311-318
7. Christensen J, Agger K, Cloos PA, et al. RBP2 belongs to a family of demethylases, specific for tri- and dimethylated lysine 4 on histone 3. Cell 2007;128:1063-1076 (Pubitemid 46427869)
8. Iwase S, Lan F, Bayliss P, et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 2007;128:1077-1088 (Pubitemid 46437259)
9. Klose RJ, Yan Q, Tothova Z, et al. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 2007;128:889-900. (Pubitemid 46341416)
10. Seward DJ, Cubberley G, Kim S, et al. Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol 2007;14:240-242 (Pubitemid 46355570)
11. Kim TD, Shin S, Janknecht R. Repression of Smad3 activity by histone demethylase SMCX/JARID1C. Biochem Biophys Res Commun 2008;366:563-567 (Pubitemid 50012656)
12. Pasini D, Hansen KH, Christensen J, Agger K, Cloos PA, Helin K. Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev 2008;22:1345-1355 (Pubitemid 351717525)
13. Defeo-Jones D, Huang PS, Jones RE, et al. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. Nature 1991;352:251-254 (Pubitemid 21912329)
14. Tu S, Teng YC, Yuan C, et al. The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif. Nat Struct Mol Biol 2008;15:419-421 (Pubitemid 351483392)
15. Benevolenskaya EV, Murray HL, Branton P, Young RA, Kaelin WG, Jr. Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. Mol Cell 2005;18:623-635
16. Lopez-Bigas N, Kisiel TA, Dewaal DC, et al. Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Mol Cell 2008;31:520-530
17. Barrett A, Madsen B, Copier J, et al. PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen? Int J Cancer 2002;101:581-588
18. Jensen LR, Amende M, Gurok U, et al. Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. Am J Hum Genet 2005;76:227-236
19. Chen H, Ke Q, Kluz T, Yan Y, Costa M. Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol 2006;26:3728-3737 (Pubitemid 43726391)
20. Zhou X, Sun H, Ellen TP, Chen H, Costa M. Arsenite alters global histone H3 methylation. Carcinogenesis 2008;29:1831-1836
21. Davidson TL, Chen H, Di Toro DM, D'Angelo G, Costa M. Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog 2006;45:479-489
22. Gothie E, Richard DE, Berra E, Pages G, Pouyssegur J. Identification of alternative spliced variants of human hypoxia-inducible factor-1α. J Biol Chem 2000;275:6922-6927 (Pubitemid 30146234)
23. Chen H, Yan Y, Davidson TL, Shinkai Y, Costa M. Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res 2006;66:9009-9016 (Pubitemid 44521119)
24. Cangul H. Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. BMC Genet 2004;5:27. (Pubitemid 41363876)
25. Ellen TP, Ke Q, Zhang P, Costa M. NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. Carcinogenesis 2008;29:2-8. (Pubitemid 351201735)
26. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci U S A 1968;61:748-755
27. Otterbein LE, Kolls JK, Mantell LL, Cook JL, Alam J, Choi AM. Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury. J Clin Invest 1999;103:1047-1054 (Pubitemid 29169613)
28. Poss KD, Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc Natl Acad Sci U S A 1997;94:10925-10930 (Pubitemid 27430837)
29. Vile GF, Basu-Modak S, Waltner C, Tyrrell RM. Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proc Natl Acad Sci U S A 1994;91:2607-2610 (Pubitemid 24139396)
30. Mikesch JH, Buerger H, Simon R, Brandt B. Decay-accelerating factor (CD55): a versatile acting molecule in human malignancies. Biochim Biophys Acta 2006;1766:42-52. (Pubitemid 44175633)
31. Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev 2008;27:253-261
32. Johnson AB, Denko N, Barton MC. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat Res 2008;640:174-179
33. Wang F, Zhang R, Beischlag TV, Muchardt C, Yaniv M, Hankinson O. Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. J Biol Chem 2004;279:46733-46741 (Pubitemid 39518321)
34. Jung JE, Lee HG, Cho IH, et al. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J 2005;19:1296-1298
35. Goldblatt H, Friedman L, Cechner RL. On the malignant transformation of cells during prolonged culture under hypoxic conditions in vitro. Biochem Med 1973;7:241-252
36. Xia X, Lemieux ME, Li W, et al. Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci U S A 2009;106:4260-4265