Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 2, 2009, Pages 450-455

  Scheuermann, Thomas H ^a   Tomchick, Diana R ^a   Machius, Mischa ^a   Guo, Yan ^a,b   Bruick, Richard K ^a   Gardner, Kevin H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Hypoxia; Internal cavity; NMR; Protein ligand interactions; X ray crystallography

Indexed keywords

HETERODIMER; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; LIGAND; PROTEIN SUBUNIT;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GROWTH; IN VITRO STUDY; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN;

ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HUMANS; LIGANDS; PROTEIN BINDING; PROTEIN CONFORMATION;

METAZOA;

EID: 58849141619     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808092106     Document Type: Article

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