Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 9, 2012, Pages 3311-3316

  Kucera, Nicole ^a,e   Schmalen, Ira ^b   Hennig, Sven ^a,e   Ol̈linger, Rupert ^d   Strauss, Holger M ^c,f   Grudziecki, Astrid ^d   Wieczorek, Caroline ^a,g   Kramer, Achim ^d   Wolf, Eva ^b,h  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c Gesellschaft für Kolloidanalytik MbH   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f NOVO NORDISK A S   (Denmark)

^g MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^h UNIVERSITY OF MUNICH   (Germany)

Author keywords

Circadian clock; Pas domains; Period proteins; Protein interactions

Indexed keywords

HELIX LOOP HELIX PROTEIN; HOMODIMER; LUCIFERASE; PER1 PROTEIN; PER2 PROTEIN; PER3 PROTEIN; PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BETA SHEET; BLEACHING; CELL FUNCTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; FLUORESCENCE; GEL FILTRATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; ULTRACENTRIFUGATION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HELIX-LOOP-HELIX MOTIFS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PERIOD CIRCADIAN PROTEINS; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SOLUTIONS; TRYPTOPHAN;

MAMMALIA;

EID: 84857704420     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113280109     Document Type: Article

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