Interacting molecular loops in the mammalian circadian clock

Science

Volumn 288, Issue 5468, 2000, Pages 1013-1019

  Shearman, Lauren P ^a   Sriram, Sathyanarayanan ^a   Weaver, David R ^a   Maywood, Elizabeth S ^b   Chaves, Inẽs ^c   Zheng, Binhai ^d   Kume, Kazuhiko ^a   Lee, Cheng Chi ^d   Van Der Horst, Gijsbertus T J ^c   Hastings, Michael H ^b   Reppert, Steven M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REGULATOR PROTEIN; RNA;

ANIMAL CELL; ARTICLE; CIRCADIAN RHYTHM; FEEDBACK SYSTEM; GENE EXPRESSION; GENETIC TRANSCRIPTION; INTRACELLULAR TRANSPORT; MOLECULAR BIOLOGY; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION REGULATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL CLOCKS; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEUS; CIRCADIAN RHYTHM; DIMERIZATION; DROSOPHILA PROTEINS; EYE PROTEINS; FEEDBACK; FEMALE; FLAVOPROTEINS; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MUTATION; NUCLEAR PROTEINS; PHOTORECEPTORS, INVERTEBRATE; PROTEIN BIOSYNTHESIS; RECEPTORS, G-PROTEIN-COUPLED; RNA; SUPRACHIASMATIC NUCLEUS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034640253     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5468.1013     Document Type: Article

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55. We thank S. Kay and C. Weitz for expression and reporter constructs and A. Chavda and C. Capodice for technical support. Supported by R37 HD14427 and RO1 NS39303, BBSRC 8/S09882, and a Spinoza Premium of the Netherlands Organization for Scientific Research. L.P.S. was supported in part by NIH Training Grant HL07901, K.K. by the University of Tokyo, and C.C.L. by the NIH.