메뉴 건너뛰기




Volumn 28, Issue 41, 2009, Pages 3671-3680

The HIF1α-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element

Author keywords

BNIP3; Cancer; Cell death; HIF1a; Hypoxia; SIM2

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN BNIP3; SINGLE MINDED 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BNIP3 PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1BETA; MEMBRANE PROTEIN; ONCOPROTEIN; SIM2 PROTEIN, HUMAN;

EID: 70350064297     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.228     Document Type: Article
Times cited : (40)

References (50)
  • 1
    • 20444437669 scopus 로고    scopus 로고
    • 0-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death
    • Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M et al. (2005). Upregulation of BNIP3 by 5-aza-20-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. J Gastroenterol 40: 504-510.
    • (2005) J Gastroenterol , vol.40 , pp. 504-510
    • Abe, T.1    Toyota, M.2    Suzuki, H.3    Murai, M.4    Akino, K.5    Ueno, M.6
  • 2
    • 17144390205 scopus 로고    scopus 로고
    • Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer
    • Akada M, Crnogorac-Jurcevic T, Lattimore S, Mahon P, Lopes R, Sunamura M et al. (2005). Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. Clin Cancer Res 11: 3094-3101.
    • (2005) Clin Cancer Res , vol.11 , pp. 3094-3101
    • Akada, M.1    Crnogorac-Jurcevic, T.2    Lattimore, S.3    Mahon, P.4    Lopes, R.5    Sunamura, M.6
  • 3
    • 24644525067 scopus 로고    scopus 로고
    • Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells
    • Aleman MJ, DeYoung MP, Tress M, Keating P, Perry GW, Narayanan R. (2005). Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells. Proc Natl Acad Sci USA 102: 12765-12770.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12765-12770
    • Aleman, M.J.1    Deyoung, M.P.2    Tress, M.3    Keating, P.4    Perry, G.W.5    Narayanan, R.6
  • 4
    • 38949119423 scopus 로고    scopus 로고
    • Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3
    • Azad MB, Chen Y, Henson ES, Cizeau J, McMillan-Ward E, Israels SJ et al. (2008). Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy 4: 195-204.
    • (2008) Autophagy , vol.4 , pp. 195-204
    • Azad, M.B.1    Chen, Y.2    Henson, E.S.3    Cizeau, J.4    McMillan-Ward, E.5    Israels, S.J.6
  • 5
    • 33846094145 scopus 로고    scopus 로고
    • Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer
    • Bacon AL, Fox S, Turley H, Harris AL. (2007). Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer. Oncogene 26: 132-141.
    • (2007) Oncogene , vol.26 , pp. 132-141
    • Bacon, A.L.1    Fox, S.2    Turley, H.3    Harris, A.L.4
  • 6
    • 0028113218 scopus 로고
    • Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins
    • Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B et al. (1994). Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell 79: 341-351.
    • (1994) Cell , vol.79 , pp. 341-351
    • Boyd, J.M.1    Malstrom, S.2    Subramanian, T.3    Venkatesh, L.K.4    Schaeper, U.5    Elangovan, B.6
  • 7
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    • Bruick RK. (2000). Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA 97: 9082-9087.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9082-9087
    • Bruick, R.K.1
  • 8
    • 62849105988 scopus 로고    scopus 로고
    • The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death
    • Burton TR, Gibson SB. (2009). The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death. Cell Death Differ 16: 515-523.
    • (2009) Cell Death Differ , vol.16 , pp. 515-523
    • Burton, T.R.1    Gibson, S.B.2
  • 9
    • 26844467247 scopus 로고    scopus 로고
    • Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors
    • Chandran U, Dhir R, Ma C, Michalopoulos G, Becich M, Gilbertson J. (2005). Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors. BMC Cancer 5: 45.
    • (2005) BMC Cancer , vol.5 , pp. 45
    • Chandran, U.1    Dhir, R.2    Ma, C.3    Michalopoulos, G.4    Becich, M.5    Gilbertson, J.6
  • 10
    • 0030810722 scopus 로고    scopus 로고
    • Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region
    • Chrast R, Scott HS, Chen H, Kudoh J, Rossier C, Minoshima S et al. (1997). Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. Genome Res 7: 615-624.
    • (1997) Genome Res , vol.7 , pp. 615-624
    • Chrast, R.1    Scott, H.S.2    Chen, H.3    Kudoh, J.4    Rossier, C.5    Minoshima, S.6
  • 11
    • 3042562282 scopus 로고    scopus 로고
    • Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
    • Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S. (2004). Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 64: 4286-4293.
    • (2004) Cancer Res , vol.64 , pp. 4286-4293
    • Daido, S.1    Kanzawa, T.2    Yamamoto, A.3    Takeuchi, H.4    Kondo, Y.5    Kondo, S.6
  • 12
    • 2942520695 scopus 로고    scopus 로고
    • Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil
    • De Angelis PM, Fjell B, Kravik KL, Haug T, Tunheim SH, Reichelt W et al. (2004). Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. Int J Oncol 24: 1279-1288.
    • (2004) Int J Oncol , vol.24 , pp. 1279-1288
    • De Angelis, P.M.1    Fjell, B.2    Kravik, K.L.3    Haug, T.4    Tunheim, S.H.5    Reichelt, W.6
  • 14
    • 0037447077 scopus 로고    scopus 로고
    • Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors
    • DeYoung MP, Tress M, Narayanan R. (2003a). Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors. Proc Natl Acad Sci USA 100: 4760-4765.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4760-4765
    • Deyoung, M.P.1    Tress, M.2    Narayanan, R.3
  • 15
    • 0141863174 scopus 로고    scopus 로고
    • Down's syndrome-associated Single Minded 2 gene as a pancreatic cancer drug therapy target
    • DeYoung MP, Tress M, Narayanan R. (2003b). Down's syndrome-associated Single Minded 2 gene as a pancreatic cancer drug therapy target. Cancer Lett 200: 25-31.
    • (2003) Cancer Lett , vol.200 , pp. 25-31
    • Deyoung, M.P.1    Tress, M.2    Narayanan, R.3
  • 16
    • 35348904350 scopus 로고    scopus 로고
    • Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells
    • Drabsch Y, Hugo H, Zhang R, Dowhan DH, Miao YR, Gewirtz AM et al. (2007). Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. Proc Natl Acad Sci USA 104: 13762-13767.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13762-13767
    • Drabsch, Y.1    Hugo, H.2    Zhang, R.3    Dowhan, D.H.4    Miao, Y.R.5    Gewirtz, A.M.6
  • 17
    • 10144224910 scopus 로고    scopus 로고
    • Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis
    • Ema M, Morita M, Ikawa S, Tanaka M, Matsuda Y, Gotoh O et al. (1996b). Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol Cell Biol 16: 5865-5875.
    • (1996) Mol Cell Biol , vol.16 , pp. 5865-5875
    • Ema, M.1    Morita, M.2    Ikawa, S.3    Tanaka, M.4    Matsuda, Y.5    Gotoh, O.6
  • 18
    • 21744434389 scopus 로고    scopus 로고
    • Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
    • Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler MW et al. (2005). Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene 24: 4421-4432.
    • (2005) Oncogene , vol.24 , pp. 4421-4432
    • Erkan, M.1    Kleeff, J.2    Esposito, I.3    Giese, T.4    Ketterer, K.5    Buchler, M.W.6
  • 19
    • 0036261649 scopus 로고    scopus 로고
    • Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants
    • Goshu E, Jin H, Fasnacht R, Sepenski M, Michaud JL, Fan CM. (2002). Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Mol Cell Biol 22: 4147-4157.
    • (2002) Mol Cell Biol , vol.22 , pp. 4147-4157
    • Goshu, E.1    Jin, H.2    Fasnacht, R.3    Sepenski, M.4    Michaud, J.L.5    Fan, C.M.6
  • 21
    • 34249041247 scopus 로고    scopus 로고
    • 0- deoxycytidine and irinotecan on colon cancer cell line HCT-15
    • Ishiguro M, Iida S, Uetake H, Morita S, Makino H, Kato K et al. (2007). Effect of combined therapy with low-dose 5-aza-20-deoxycytidine and irinotecan on colon cancer cell line HCT-15. Ann Surg Oncol 14: 1752-1762.
    • (2007) Ann Surg Oncol , vol.14 , pp. 1752-1762
    • Ishiguro, M.1    Iida, S.2    Uetake, H.3    Morita, S.4    Makino, H.5    Kato, K.6
  • 22
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P et al. (2008). Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 23
    • 0345708353 scopus 로고    scopus 로고
    • The mammalian basic helix-loop-helix/PAS family of transcriptional regulators
    • Kewley RJ, Whitelaw ML, Chapman-Smith A. (2004). The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int J Biochem Cell Biol 36: 189-204.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 189-204
    • Kewley, R.J.1    Whitelaw, M.L.2    Chapman-Smith, A.3
  • 25
    • 40349091380 scopus 로고    scopus 로고
    • Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2
    • Laffin B, Wellberg E, Kwak HI, Burghardt RC, Metz RP, Gustafson T et al. (2008). Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2. Mol Cell Biol 28: 1936-1946.
    • (2008) Mol Cell Biol , vol.28 , pp. 1936-1946
    • Laffin, B.1    Wellberg, E.2    Kwak, H.I.3    Burghardt, R.C.4    Metz, R.P.5    Gustafson, T.6
  • 26
    • 33645730274 scopus 로고    scopus 로고
    • Regulation of BNIP3 in normal and cancer cells
    • Lee H, Paik SG. (2006). Regulation of BNIP3 in normal and cancer cells. Mol Cells 21: 1-6.
    • (2006) Mol Cells , vol.21 , pp. 1-6
    • Lee, H.1    Paik, S.G.2
  • 27
    • 34147193472 scopus 로고    scopus 로고
    • Cell biology: Autophagy and cancer
    • Levine B. (2007). Cell biology: autophagy and cancer. Nature 446: 745-747.
    • (2007) Nature , vol.446 , pp. 745-747
    • Levine, B.1
  • 28
    • 34547120221 scopus 로고    scopus 로고
    • S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer
    • Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T et al. (2007). S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer. Cancer Res 67: 6786-6795.
    • (2007) Cancer Res , vol.67 , pp. 6786-6795
    • Mahon, P.C.1    Baril, P.2    Bhakta, V.3    Chelala, C.4    Caulee, K.5    Harada, T.6
  • 29
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. (2007). Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 30
    • 36148954660 scopus 로고    scopus 로고
    • The role of the hypoxia-inducible BH3-only proteins BNIP3 and BNIP3L in cancer
    • Mellor HR, Harris AL. (2007). The role of the hypoxia-inducible BH3-only proteins BNIP3 and BNIP3L in cancer. Cancer Metastasis Rev 26: 553-566.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 553-566
    • Mellor, H.R.1    Harris, A.L.2
  • 31
    • 33744948882 scopus 로고    scopus 로고
    • Differential transcriptional regulation by mouse single-minded 2s
    • Metz RP, Kwak HI, Gustafson T, Laffin B, Porter WW. (2006). Differential transcriptional regulation by mouse single-minded 2s. J Biol Chem 281: 10839-10848.
    • (2006) J Biol Chem , vol.281 , pp. 10839-10848
    • Metz, R.P.1    Kwak, H.I.2    Gustafson, T.3    Laffin, B.4    Porter, W.W.5
  • 32
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immuno-blotting
    • Mizushima N, Yoshimori T. (2007). How to interpret LC3 immuno-blotting. Autophagy 3: 542-545.
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 33
    • 0030740207 scopus 로고    scopus 로고
    • The murine Sim-2 gene product inhibits transcription by active repression and functional interference
    • Moffett P, Reece M, Pelletier J. (1997). The murine Sim-2 gene product inhibits transcription by active repression and functional interference. Mol Cell Biol 17: 4933-4947.
    • (1997) Mol Cell Biol , vol.17 , pp. 4933-4947
    • Moffett, P.1    Reece, M.2    Pelletier, J.3
  • 34
    • 0036281211 scopus 로고    scopus 로고
    • Processing of gene expression data generated by quantitative real-time RT-PCR
    • 1376, 1378-1379
    • Muller P, Janovjak H, Miserez AR, Dobbie Z. (2002). Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32: 1372-4, 1376, 1378-1379
    • (2002) Biotechniques , vol.32 , pp. 1372-4
    • Muller, P.1    Janovjak, H.2    Miserez, A.R.3    Dobbie, Z.4
  • 36
    • 3442888541 scopus 로고    scopus 로고
    • Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer
    • Okami J, Simeone DM, Logsdon CD. (2004). Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res 64: 5338-5346.
    • (2004) Cancer Res , vol.64 , pp. 5338-5346
    • Okami, J.1    Simeone, D.M.2    Logsdon, C.D.3
  • 37
    • 0031041307 scopus 로고    scopus 로고
    • Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein
    • Probst MR, Fan CM, Tessier-Lavigne M, Hankinson O. (1997). Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. J Biol Chem 272: 4451-4457.
    • (1997) J Biol Chem , vol.272 , pp. 4451-4457
    • Probst, M.R.1    Fan, C.M.2    Tessier-Lavigne, M.3    Hankinson, O.4
  • 39
    • 0032725554 scopus 로고    scopus 로고
    • P42/ p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcrip-tional activity of HIF-1
    • Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J. (1999). p42/ p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcrip-tional activity of HIF-1. J Biol Chem 274: 32631-32637.
    • (1999) J Biol Chem , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothie, E.3    Roux, D.4    Pouyssegur, J.5
  • 40
    • 0034663989 scopus 로고    scopus 로고
    • HIF-1 and human disease: One highly involved factor
    • Semenza GL. (2000). HIF-1 and human disease: one highly involved factor. Genes Dev 14: 1983-1991.
    • (2000) Genes Dev , vol.14 , pp. 1983-1991
    • Semenza, G.L.1
  • 41
    • 0036022241 scopus 로고    scopus 로고
    • Craniofacial abnormalities resulting from targeted disruption of the murine Sim2 gene
    • Shamblott MJ, Bugg EM, Lawler AM, Gearhart JD. (2002). Craniofacial abnormalities resulting from targeted disruption of the murine Sim2 gene. Dev Dyn 224: 373-380.
    • (2002) Dev Dyn , vol.224 , pp. 373-380
    • Shamblott, M.J.1    Bugg, E.M.2    Lawler, A.M.3    Gearhart, J.D.4
  • 42
    • 0035884701 scopus 로고    scopus 로고
    • HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
    • Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. (2001). HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 61: 6669-6673.
    • (2001) Cancer Res , vol.61 , pp. 6669-6673
    • Sowter, H.M.1    Ratcliffe, P.J.2    Watson, P.3    Greenberg, A.H.4    Harris, A.L.5
  • 45
    • 27644506613 scopus 로고    scopus 로고
    • Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression
    • Varambally S, Yu J, Laxman B, Rhodes DR, Mehra R, Tomlins SA et al. (2005). Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell 8: 393-406.
    • (2005) Cancer Cell , vol.8 , pp. 393-406
    • Varambally, S.1    Yu, J.2    Laxman, B.3    Rhodes, D.R.4    Mehra, R.5    Tomlins, S.A.6
  • 46
    • 46349100861 scopus 로고    scopus 로고
    • The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence
    • Woods S, Farrall A, Procko C, Whitelaw ML. (2008). The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence. Nucleic Acids Res 36: 3716-3727.
    • (2008) Nucleic Acids Res , vol.36 , pp. 3716-3727
    • Woods, S.1    Farrall, A.2    Procko, C.3    Whitelaw, M.L.4
  • 47
    • 0037155908 scopus 로고    scopus 로고
    • Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors
    • Woods SL, Whitelaw ML. (2002). Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 277: 10236-10243.
    • (2002) J Biol Chem , vol.277 , pp. 10236-10243
    • Woods, S.L.1    Whitelaw, M.L.2
  • 48
    • 4344561557 scopus 로고    scopus 로고
    • Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy
    • Yu YP, Landsittel D, Jing L, Nelson J, Ren B, Liu L et al. (2004). Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol 22: 2790-2799.
    • (2004) J Clin Oncol , vol.22 , pp. 2790-2799
    • Yu, Y.P.1    Landsittel, D.2    Jing, L.3    Nelson, J.4    Ren, B.5    Liu, L.6
  • 49
    • 43649104579 scopus 로고    scopus 로고
    • Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    • Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB et al. (2008). Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283: 10892-10903.
    • (2008) J Biol Chem , vol.283 , pp. 10892-10903
    • Zhang, H.1    Bosch-Marce, M.2    Shimoda, L.A.3    Tan, Y.S.4    Baek, J.H.5    Wesley, J.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.