Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential

Gene Expression

Volumn 8, Issue 5-6, 1999, Pages 273-286

  Kumar, Mohan B ^a   Perdew, Gary H ^a,b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b 115 Henning Building ^*  (United States)

Author keywords

Ary hydrocarbon receptor (AhR); Coactivator; Dioxin; SRC 1

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CELL NUCLEUS RECEPTOR; DIOXIN; MUTANT PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; GENE ACTIVITY; GENE INDUCTION; NONHUMAN; PROTEIN DOMAIN; PROTEIN INTERACTION; RECEPTOR BINDING; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BINDING SITES; CELL LINE; COS CELLS; DNA-BINDING PROTEINS; GREEN FLUORESCENT PROTEINS; HISTONE ACETYLTRANSFERASES; HUMANS; LUMINESCENT PROTEINS; MUTATION; NUCLEAR PROTEINS; RECEPTORS, ARYL HYDROCARBON; RECOMBINANT PROTEINS; TETRACHLORODIBENZODIOXIN; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0033324251     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Abbott, B. D.; Schmid, J. E.; Pitt, J. A.; Buckalew, A. R.; Wood, C. R.; Held, G. A.; Diliberto, J. J. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. Toxicol. Appl. Pharmacol. 155:62-70; 1999.
2. Abnet, C. C.; Tanguay, R. L.; Heideman, W.; Peterson, R. E. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners. Toxicol. Appl. Pharmacol. 159:41-51; 1999.
3. Andreola, F.; Fernandez-Salguero, P. M.; Chiantore, M. V.; Petkovich, M. P.; Gonzalez, F. J.; De Luca, L. M. Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism. Cancer Res. 57:2835-2838; 1997.
4. Bourguet, W.; Ruff, M.; Chambon, P.; Gronemeyer, H.; Moras, D. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature 375:377-382; 1995.
5. Carver, L. A.; Bradfield, C. A. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. J. Biol. Chem. 272: 11452-11456; 1997.
6. Chan, W. K.; Yao, G.; Gu, Y. Z.; Bradfield, C. A. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation. J. Biol. Chem. 274:12115-12123; 1999.
7. Darimont, B. D.; Wagner, R. L.; Apriletti, J. W.; Stallcup, M. R.; Kushner, P. J.; Baxter, J. D.; Fletterick, R. J.; Yamamoto, K. R. Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 12: 3343-3356; 1998.
8. Ding, X. F.; Anderson, C. M.; Ma, H.; Hong, H.; Uht, R. M.; Kushner, P. J.; Stallcup, M. R. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): Multiple motifs with different binding specificities. Mol. Endocrinol. 12:302-313; 1998.
9. Gradin, K.; Wilhelmsson, A.; Poellinger, L.; Berghard, A. Nonresponsiveness of normal human fibroblasts to dioxin correlates with the presence of a constitutive xenobiotic response element-binding factor. J. Biol. Chem. 268:4061-4068; 1993.
10. Hankinson, O.; Andersen, R. D.; Birren, B. W.; Sander, F.; Negishi, M.; Nebert, D. W. Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line. J. Biol. Chem. 260:1790-1795; 1985.
11. Hayashi, Y.; Ohmori, S.; Ito, T.; Seo, H. A splicing variant of steroid receptor coactivator-1 (SRC-1E): The major isoform of SRC-1 to mediate thyroid hormone action. Biochem. Biophys. Res. Commun. 236:83-87; 1997.
12. Heery, D. M.; Kalkhoven, E.; Hoare, S.; Parker, M. G. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733-736; 1997.
13. Henry, E. C.; Gasiewicz, T. A. Transformation of the aryl hydrocarbon receptor to a DNA-binding form is accompanied by release of the 90 kDa heat-shock protein and increased affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. J. 294:95-101; 1993.
14. Henttu, P. M.; Kalkhoven, E.; Parker, M. G. AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors. Mol. Cell. Biol. 17: 1832-1839; 1997.
15. Htun, H.; Barsony, J.; Renyi, I.; Gould, D. L.; Hager, G. L. Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. Proc. Natl. Acad. Sci. USA 93:4845-4850; 1996.
16. Ikeda, M.; Kawaguchi, A.; Takeshita, A.; Chin, W. W.; Endo, T.; Onaya, T. CBP-dependent and independent enhancing activity of steroid receptor coactivator-1 in thyroid hormone receptor-mediated transactivation. Mol. Cell. Endocrinol. 147:103-112; 1999.
17. Ikonen, T.; Palvimo, J. J.; Janne, O. A. Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators. J. Biol. Chem. 272:29821-2988; 1997.
18. Jaiswal, A. K. Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression. J. Biol. Chem. 269:14502-14508; 1994.
19. Jana, N. R.; Sarkar, S.; Ishizuka, M.; Yonemoto, J.; Tohyama, C.; Sone, H. Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin and testosterone signal ransduction pathways in LNCaP prostate cancer cells. Biochem. Biophys. Res. Commun. 256:462-468; 1999.
20. Kalkhoven, E.; Valentine, J. E.; Heery, D. M.; Parker, M. G. Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor. EMBO J. 17:232-243; 1998.
21. Kharat, I.; Saatcioglu, F. Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. Cross-talk between aryl hydrocarbon-and estrogen-mediated signaling. J. Biol. Chem. 271: 10533-10537; 1996.
22. Ko, H. P.; Okino, S. T.; Ma, Q.; Whitlock, J. P., Jr. Dioxin-induced CYP1A1 transcription in vivo: The aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure. Mol. Cell. Biol. 16:430-436; 1996.
23. Ko, H. P.; Okino, S. T.; Ma, Q.; Whitlock, J. P., Jr. Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo. Mol. Cell. Biol. 17:3497-3507; 1997.
24. Kobayashi, A.; Numayama-Tsuruta, K.; Sogawa, K.; Fujii-Kuriyama, Y. CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt). J. Biochem. (Tokyo) 122:703-710; 1997.
25. Kumar, M. B.; Tarpey, R. W.; Perdew, G. H. Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. J. Biol. Chem. 274:22155-22164; 1999.
26. Lee, C. H.; Chinpaisal, C.; Wei, L. N. Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2. Mol. Cell. Biol. 18: 6745-6755; 1998.
27. Lee, S. K.; Kim, H. J.; Na, S. Y.; Kim, T. S.; Choi, H. S.; Im, S. Y.; Lee, J. W. Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits. J. Biol. Chem. 273:16651-16654; 1998.
28. Liu, Z.; Wong, J.; Tsai, S. Y.; Tsai, M. J.; O'Malley, B. W. Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. Proc. Natl. Acad. Sci. USA 96: 9485-9490; 1999.
29. Ma, Q.; Whitlock, J. P., Jr. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Biol. Chem. 272:8878-8884; 1997.
30. McInerney, E. M.; Rose, D. W.; Flynn, S. E.; Westin, S.; Mullen, T. M.; Krones, A.; Inostroza, J.; Torchia, J.; Nolte, R. T.; Assa-Munt, N.; Milburn, M. V.; Glass, C. K.; Rosenfeld, M. G. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev. 12:3357-3368; 1998.
31. McKenna, N. J.; Nawaz, Z.; Tsai, S. Y.; Tsai, M. J.; O'Malley, B. W. Distinct steady-state nuclear receptor coregulator complexes exist in vivo. Proc. Natl. Acad. Sci. USA 95:11697-11702; 1998.
32. Meyer, B. K.; Pray-Grant, M. G.; Vanden Heuvel, J. P.; Perdew, G. H. Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol. Cell. Biol. 18:978-988; 1998.
33. Mimura, J.; Yamashita, K.; Nakamura, K.; Morita, M.; Takagi, T. N.; Nakao, K.; Ema, M.; Sogawa, K.; Yasuda, M.; Katsuki, M.; Fujii-Kuriyama, Y. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells 2:645-654; 1997.
34. Misiti, S.; Koibuchi, N.; Bei, M.; Farsetti, A.; Chin, W. W. Expression of steroid receptor coactivator-1 mRNA in the developing mouse embryo: A possible role in olfactory epithelium development. Endocrinology 140:1957-1960; 1999.
35. Misiti, S.; Schomburg, L.; Yen, P. M.; Chin, W. W. Expression and hormonal regulation of coactivator and corepressor genes. Endocrinology 139:2493-2500; 1998.
36. Nebert, D. W.; Negishi, M.; Chen, Y. T.; Tukey, R. H. Cloning genes that encode inducible forms of P-450. Biochem. Soc. Trans. 12:99-101; 1984.
37. Nguyen, T. A.; Hoivik, D.; Lee, J. E.; Safe, S. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Arch. Biochem. Biophys. 367:250-257; 1999.
38. Nolte, R. T.; Wisely, G. B.; Westin, S.; Cobb, J. E.; Lambert, M. H.; Kurokawa, R.; Rosenfeld, M. G.; Willson, T. M.; Glass, C. K.; Milburn, M. V. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 395: 137-143; 1998.
39. Ogawa, H.; Inouye, S.; Tsuji, F. I.; Yasuda, K.; Umesono, K. Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells. Proc. Natl. Acad. Sci. USA 92:11899-903; 1995.
40. Okino, S. T.; Whitlock, J. P., Jr. Dioxin induces localized, graded changes in chromatin structure: Implications for Cyp1A1 gene transcription. Mol. Cell. Biol. 15:3714-3721; 1995.
41. Onate, S. A.; Boonyaratanakornkit, V.; Spencer, T. E.; Tsai, S. Y.; Tsai, M. J.; Edwards, D. P.; O'Malley, B. W. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. J. Biol. Chem. 273: 12101-12108; 1998.
42. Onate, S. A.; Tsai, S. Y.; Tsai, M. J.; O'Malley, B. W. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270: 1354-1357; 1995.
43. Perdew, G. H. Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7. Biochem. Biophys. Res. Commun. 182:55-62; 1992.
44. Peters, J. M.; Narotsky, M. G.; Elizondo, G.; Fernandez-Salguero, P. M.; Gonzalez, F. J.; Abbott, B. D. Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice. Toxicol. Sci. 47:86-92; 1999.
45. Poland, A.; Knutson, J. C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxcol. 22:517-554; 1982.
46. Pollenz, R. S.; Sattler, C. A.; Poland, A. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy. Mol. Pharmacol. 45:428-438; 1994.
47. Qi, C.; Zhu, Y.; Pan, J.; Yeldandi, A. V.; Rao, M. S.; Maeda, N.; Subbarao, V.; Pulikuri, S.; Hashimoto, T.; Reddy, J. K. Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression. Proc. Natl. Acad. Sci. USA 96:1585-1590; 1999.
48. Reisz-Porszasz, S.; Probst, M. R.; Fukunaga, B. N.; Hankinson, O. Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Mol. Cell. Biol. 14:6075-6086; 1994.
49. Reyes, H.; Reisz-Porszasz, S.; Hankinson, O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256:1193-1195; 1992.
50. Rowlands, J. C.; McEwan, I. J.; Gustafsson, J. A. Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: Direct interactions with basal transcription factors. Mol. Pharmacol. 50:538-548; 1996.
51. Rushmore, T. H.; King, R. G.; Paulson, K. E.; Pickett, C. B. Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc. Natl. Acad. Sci. USA 87:3826-3830; 1990.
52. Schaufele, F. Regulation of estrogen receptor activation of the prolactin enhancer/promoter by antagonistic activation function-2-interacting proteins. Mol. Endocrinol. 13:935-945; 1999.
53. Schmidt, J. V.; Su, G. H.; Reddy, J. K.; Simon, M. C.; Bradfield, C. A. Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development. Proc. Natl. Acad. Sci. USA 93:6731-6736; 1996.
54. Spencer, T. E.; Jenster, G.; Burcin, M. M.; Allis, C. D.; Zhou, J.; Mizzen, C. A.; McKenna, N. J.; Onate, S. A.; Tsai, S. Y.; Tsai, M. J.; O'Malley, B. W. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389:194-198; 1997.
55. Swanson, H. I.; Yang, J. H. The aryl hydrocarbon receptor interacts with transcription factor IIB. Mol. Pharmacol. 54:671-677; 1998.
56. Takeshita, A.; Yen, P. M.; Ikeda, M.; Cardona, G. R.; Liu, Y.; Koibuchi, N.; Norwitz, E. R.; Chin, W. W. Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1. J. Biol. Chem. 273:21554-21562; 1998.
57. Tukey, R. H.; Nebert, D. W. Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone. Biochemistry 23:6003-6008; 1984.
58. Tuteja, N.; Gonzalez, F. J.; Nebert, D. W. Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes. Dev. Biol. 112:177-184; 1985.
59. Westin, S.; Kurokawa, R.; Nolte, R. T.; Wisely, G. B.; McInerney, E. M.; Rose, D. W.; Milburn, M. V.; Rosenfeld, M. G.; Glass, C. K. Interactions controlling the assembly of nuclear-receptor heterodimers and coactivators. Nature 395:199-202; 1998.
60. Whitelaw, M. L.; Gustafsson, J. A.; Poellinger, L. Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: Inducible versus constitutive modes of regulation. Mol. Cell. Biol. 14:8343-8355; 1994.
61. Wood, S. M.; Gleadle, J. M.; Pugh, C. W.; Hankinson, O.; Ratcliffe, P. J. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J. Biol. Chem. 271:15117-15123; 1996.
62. Xu, J.; Qiu, Y.; DeMayo, F. J.; Tsai, S. Y.; Tsai, M. J.; O'Malley, B. M. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science 279:1922-1925; 1998.
63. Zaher, H.; Fernandez-Salguero, P. M.; Letterio, J.; Sheikh, M. S.; Fornace, A. J., Jr.; Roberts, A. B.; Gonzalez, F. J. The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis. Mol. Pharmacol. 54:313-321; 1998.
64. Zhu, Y.; Qi, C.; Jain, S.; Rao, M. S.; Reddy, J. K. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J. Biol. Chem. 272:25500-25506; 1997.
65. Zwijsen, R. M.; Buckle, R. S.; Hijmans, E. M.; Loomans, C. J.; Bernards, R. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin Dl. Genes Dev. 12:3488-3498; 1998.