Circadian clock feedback cycle through NAMPT-Mediated NAD+ biosynthesis

Science

Volumn 324, Issue 5927, 2009, Pages 651-654

  Ramsey, Kathryn Moynihan ^a,b   Yoshino, Jun ^e   Brace, Cynthia S ^e   Abrassart, Dana ^a   Kobayashi, Yumiko ^a,b   Marcheva, Biliana ^a   Hong, Hee Kyung ^a   Chong, Jason L ^a   Buhr, Ethan D ^a   Lee, Choogon ^c   Takahashi, Joseph S ^a,d   Imai, Shin Ichiro ^e   Bass, Joseph ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^c FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; SIRTUIN 1; TRANSCRIPTION FACTOR CLOCK; ACRYLAMIDE DERIVATIVE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL CYCLE PROTEIN; CYTOKINE; ENZYME INHIBITOR; N (4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL) 3 (PYRIDIN 3 YL)ACRYLAMIDE; N-(4-(1-BENZOYLPIPERIDIN-4-YL)BUTYL)-3-(PYRIDIN-3-YL)ACRYLAMIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, MOUSE; NUCLEAR PROTEIN; PER2 PROTEIN, MOUSE; PIPERIDINE DERIVATIVE; PROTEIN BMAL1; SIRT1 PROTEIN, MOUSE; SIRTUIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

CIRCADIAN RHYTHM; ENZYME; GENETIC ANALYSIS; METABOLISM; RODENT;

ARTICLE; BIOSYNTHESIS; CIRCADIAN RHYTHM; ENZYME INHIBITION; FEEDBACK SYSTEM; GENE; GENE EXPRESSION; NONHUMAN; PER2 GENE; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; BIOLOGICAL RHYTHM; CELL LINE; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; LIVER; LIVER CELL; METABOLISM; MOUSE; PROTEIN BINDING; TUMOR CELL LINE; WHITE ADIPOSE TISSUE;

MAMMALIA; MUS;

ACRYLAMIDES; ADIPOSE TISSUE, WHITE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL CLOCKS; CELL CYCLE PROTEINS; CELL LINE; CELL LINE, TUMOR; CIRCADIAN RHYTHM; CYTOKINES; ENZYME INHIBITORS; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; LIVER; MICE; NAD; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NUCLEAR PROTEINS; PIPERIDINES; PROTEIN BINDING; SIRTUINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 65549103855     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1171641     Document Type: Article

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27. We thank S.-H. Yoo and members of the Bass, Imai, and Takahashi laboratories for discussions. Work was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK007169) to K.M.R.; the National Institute on Aging (AG02150), the Ellison Medical Foundation, and the Longer Life Foundation to S.I.; NIH (PO1 AG011412), the Chicago Biomedical Consortium Searle Funds, and the Juvenile Diabetes Research Foundation to J.B.; and a grant from the National Institute of Mental Health (P50 MH074924) to J.S.T. J.Y. is supported by the Japan Research Foundation for Clinical Pharmacology and Keio University Medical Science Fund, J.S.T. is an Investigator in the Howard Hughes Medical Institute and a cofounder of ReSet Therapeutics, and J.S.T. and J.B. are members of its scientific advisory board. J.B. is also an adviser and receives support from Amylin Pharmaceuticals. S.I. holds a patent related to the work reported in this paper, specifically NAMPT and NMN.