The isolation and structure elucidation of fungal metabolites

Handbook of Industrial Mycology

Volumn , Issue , 2004, Pages 187-268

  Harris, Guy H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84887869168     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9780203970553     Document Type: Chapter

References (318)

1. Ersson, B.; Ryden, L.; Janson, J.-C. Introduction to Protein Purification. In Protein Purification. Principles, High Resolution Methods, and Applications. 2nd Edition; Ryden, L., Janson, J.-C., Eds. Wiley-Liss): (New York, 1998; 3-40.
2. McGovern, S.L.; Caselli, E.; Grigorieff, N.; Shoichet, B.K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. Journal of Medicinal Chemistry 2002, 45, 1712-1722.
3. Kupchan, S.M.; Britton, R.W.; Ziegler, M.F.; Sigel, C.W. J. Org. Chem. 1973, 38, 178-179.
4. Harris, G.H. The use of CCC in the pharmaceutical industry. Countercurrent Chromatography the Support Free Liquid Stationary Phase 2002, 38, 301-330.
5. Snyder, L.R.; Kirkland, J.J. Introduction to Modern Liquid Chromatography. 1979.
6. Henke, H. and Editor Preparative Gel Chromatography on Sephadex LH-20.
7. Dufresne, C.; Jones, E.T.T.; Omstead, M.N.; Bergstrom, J.D.; Wilson, K.E. Novel zaragozic acids from Leptodontidium elatius. Journal of Natural Products 1996, 59, 52-54.
8. Bills, G.F.; Pelaez, F.; Polishook, J.D.; Diezmatas, M.T.; Harris, G.H.; Clapp, W.H.; Dufresne, C.; Byrne, K.M.; Nallinomstead, M.; Jenkins, R.G.; Mojena, M.; Huang, L.Y.; Bergstrom, J.D. Distribution of Zaragozic Acids (Squalestatins) among Filamentous Ascomycetes. Mycological Research 1994, 98 Part 7, 733-739.
9. Berthod, A. Countercurrent Chromatography: The Support-Free Liquid Phase. Elsevier): (New York, 2002.
10. Conway, W.D.; Countercurrent Chromatography: Apparatus, Theory and Applications (Wiley-VCH [Imprint]. John Wiley & Sons): Hoboken, Aug. 1990.
11. Conway, W.D.; Petroski, R.J. Modern Countercurrent Chromatography. American Chemical Society): (Washington, 1995.
12. Neue, U.D.; HPLC Columns: Theory, Technology, and Practice. John Wiley & Sons : Hoboken, July 1997.
13. Hauser, D.; Sigg, H.P. Isolation and degradation of sordarin. Helv. Chim. Acta 1971, 54, 1178-1190.
14. Sturr, M.G.; Chartrain, M.M.; Harris, G.H.; Nielsen-Kahn, J.; Heimbuch, B. Microbial transformation product. In 19 pp. Merck& Co., Inc., USA: PCT Int. Appl.
15. Coval, S.J.; Puar, M.S.; Phife, D.W.; Terracciano, J.S.; Patel, M. SCH57404, an antifungal agent possessing the rare sodaricin skeleton and a tricyclic sugar moiety. Journal of Antibiotics 1995, 48, 1171-1172.
16. Kennedy, T.C.; Webb, G.; Cannell, R.J.P.; Kinsman, O.S.; Middleton, R.F.; Sidebottom, P.J.; Taylor, N.L.; Dawson, M.J.; Buss, A.D. Novel inhibitors of fungal protein synthesis produced by a strain of Graphium putredinis: isolation, characterization and biological properties. Journal of Antibiotics 1998, 51, 1012-1018.
17. Davoli, P.; Engel, G.; Werle, A.; Sterner, O.; Anke, T. Neosordarin and hydroxysordarin, two new antifungal agents from Sordaria araneosa. Journal of Antibiotics 2002, 55, 377-382.
18. Guan, Z.; Harris, G.H.; Justice, M.C.; Nielsen-Kahn, J.; Shastry, M.S.; Basilio, A.; Collado, J.; Diez, M.T. A novel sordarin derivative isolated from culture fermentations and functions as an antifungal agent. In 27 pp. Merck& Co., Inc., USA; MerckSharp & Dohme De Espana, S. A.: PCT Int. Appl.:.
19. Harris, G.H.; Dal, P. Application of pH-zone-refining CCC to the isolation of antifungal fermentation products. Journal of Liquid Chromatography and Related Technologies 2001, 24, 1775-1790.
20. Ito, Y.; Ma, Y. pH-Zone-refining countercurrent chromatography. Journal of Chromatography A 1996, 753, 1-36.
21. VanMiddlesworth, F.; Cannell, R.J.P. Dereplication and partial identification of natural products. Natural Products Isolation 1998, 4, 279-327.
22. Nielsen, K.F.; Smedsgaard, J. Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography-UV-mass spectrometry methodology. Journal of Chromatography A 2003, 1002, 111-136.
23. Sanders, J.K.; Hunter, B.K. Modern NMR Spectroscopy: A Guide for Chemists. 1993.
24. Croasmun, W.R.; Carlson, R.M.K.; Two-Dimensional NMR Spectroscopy: Applications for Chemists and Biochemists. 2nd Edition; John Wiley & Sons: Hoboken, July 1994.
25. Reynolds, W.F.; Enriquez, R.G. Choosing the best pulse sequences, acquisition parameters, postacquisition processing strategies, and probes for natural product structure elucidation by NMR spectroscopy. Journal of Natural Products 2002, 65, 221-244.
26. Dale, J.A.; Mosher, H.S. Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, Omethylmandelate, and alpha-methoxy-alpha- trifluoromethylphenylacetate (MTPA) esters. Journal of the American Chemical Society 1973, 95, 512-519.
27. Circular Dichroism: Principles and Applications. Berova, N., Nakanishi, K., Woody, R.W., Eds. (Wiley-VCH: New York, N. Y.), 2000.
28. Kagata, T.; Shigemori, H.; Mikami, Y.; Kobayashi, J. Coruscol A, a new metabolite from the marine-derived fungus Penicillium species. Journal of Natural Products 2000, 63, 886-887.
29. Boonphong, S.; Kittakoop, P.; Isaka, M.; Pittayakhajonwut, D.; Tanticharoen, M.; ThebtarAnonth, Y. Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex. Journal of Natural Products 2001, 64, 965-967.
30. Zhang, H.; Tomoda, H.; Tabata, N.; Miura, H.; Namikoshi, M.; Yamaguchi, Y.; Masuma, R.; Omura, S. Cladospolide D, a new 12-membered macrolide antibiotic produced by Cladosporium sp. FT-0012. Journal of Antibiotics 2001, 54, 635-641.
31. Yamada, T.; Iritani, M.; Minoura, K.; Numata, A.; Kobayashi, Y.; Wang, Y.-G. Absolute stereostructures of cell adhesion inhibitors, macrosphelides H and L, from Periconia byssoides OUPS-N133. Journal of Antibiotics 2002, 55, 147-154.
32. Singh, S.B.; Herath, K.; Guan, Z.; Zink, D.L.; Dombrowski, A.W.; Polishook, J.D.; Silverman, K.C.; Lingham, R.B.; Felock, P.J.; Hazuda, D.J. Integramides A and B, two novel nonribosomal linear peptides containing nine Calpha-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase. Organic Letters 2002, 4, 1431-1434.
33. Isaka, M.; Tanticharoen, M.; Kongsaeree, P.; Thebtaranonth, Y. Structures of Cordypyridones A-D, Antimalarial N-Hydroxy- and N-Methoxy-2-pyridones from the Insect Pathogenic Fungus Cordyceps nipponica. Journal of Organic Chemistry 2001, 66, 4803-4808.
34. Sakurai, M.; Kohno, J.; Nishio, M.; Yamamoto, K.; Okuda, T.; Kawano, K.; Nakanishi, N. TMC-205 a new transcriptional up-regulator of SV40 promoter produced by an unidentified fungus. Fermentation, isolation, physico-chemical properties, structure determination and biological activities. Journal of Antibiotics 2001, 54, 628-634.
35. Arnone, A.; Nasini, G.; De Pava, O.V. Structure and absolute configuration of new acetylenic compounds isolated from cultures of Clitocybe catinus. Phytochemistry 2000, 53, 1087-1090.
36. Tomoda, H.; Ohyama, Y.; Abe, T.; Tabata, N.; Namikoshi, M.; Yamaguchi, Y.; Masuma, R.; Omura, S. Roselipins, inhibitors of diacylglycerol acyltransferase, produced by Gliocladium roseum KF-1040. Journal of Antibiotics 1999, 52, 689-694.
37. Kohno, J.; Asai, Y.; Nishio, M.; Sakurai, M.; Kawano, K.; Hiramatsu, H.; Kameda, N.; Kishi, N.; Okuda, T.; Komatsubara, S. TMC-171A, B, C and TMC-154, novel polyketide antibiotics produced by Gliocladium sp. TC 1304 and TC 1282. Journal of Antibiotics 1999, 52, 1114-1123.
38. Dai, J.R.; Carte, B.K.; Sidebottom, P.J.; Yew, A.L.S.; Ng, S.B.; Huang, Y.C.; Butler, M.S. Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus. Journal of Natural Products 2001, 64, 125-126.
39. Kimura, Y.; Mizuno, T.; Kawano, T.; Okada, K.; Shimada, A. Peniamidienone and penidilamine, plant growth regulators produced by the fungus Penicillium sp. no. 13. Phytochemistry 2000, 53, 829-831.
40. Omolo, J.O.; Anke, H.; Chhabra, S.; Sterner, O. New variotin analogues from Aspergillus viride-nutans. Journal of Natural Products 2000, 63, 975-977.
41. Schlegel, B.; Luhmann, U.; Hartl, A.; Grafe, U. Piptamine, a new antibiotic produced by Piptoporus betulinus Lu 9-1. Journal of Antibiotics 2000, 53, 973-974.
42. Watanabe, S.; Hirai, H.; Ishiguro, M.; Kambara, T.; Kojima, Y.; Matsunaga, T.; Nishida, H.; Suzuki, Y.; Sugiura, A.; Harwood, H.J., Jr.; Huang, L.H.; Kojima, N. CJ-15,183, a new inhibitor of squalene synthase produced by a fungus Aspergillus aculeatus. Journal of Antibiotics 2001, 54, 904-910.
43. Ratnayake, A.S.; Yoshida, W.Y.; Mooberry, S.L.; Hemscheidt, T. The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus. Organic Letters 2001, 3, 3479-3481.
44. Rao, K.C.S.; Divakar, S.; Karanth, N.G.; Sattur, A.P. 14-(2′,3′,5′-trihydroxyphenyl)tetradecan- 2-ol, a novel acetylcholinesterase inhibitor from Chrysosporium sp. Journal of Antibiotics 2001, 54, 848-849.
45. Singh, S.B.; Zink, D.L.; Bills, G.F.; Pelaez, F.; Teran, A.; Collado, J.; Silverman, K.C.; Lingham, R.B.; Felock, P.; Hazuda, D.J. Discovery, structure and HIV-1 integrase inhibitory activities of integracins, novel dimeric alkyl aromatics from Cytonaema sp. Tetrahedron Letters 2002, 43, 1617-1620.
46. Shigemori, H.; Komatsu, K.; Mikami, Y.; Kobayashi, J.I. Seragakinone A, a new pentacyclic metabolite from a marine-derived fungus. Tetrahedron 1999, 55, 14925-14930.
47. Onuki, H.; Miyashige, H.; Hasegawa, H.; Yamashita, S. NI15501A, a novel anthranilamide derivative from a marine fungus Penicillium sp. Journal of Antibiotics 1998, 51, 442-444.
48. Ishiyama, D.; Futamata, K.; Futamata, M.; Kasuya, O.; Kamo, S.; Yamashita, F.; Kanazawa, S. Novel selective inhibitors for human topoisomerase I, BM2419-1 and -2 derived from saintopin. Journal of Antibiotics 1998, 51, 1069-1074.
49. Eilbert, F.; Anke, H.; Sterner, O. Neobulgarones A-F from cultures of Neobulgaria pura, new inhibitors of appressorium formation of Magnaporthe grisea. Journal of Antibiotics 2000, 53, 1123-1129.
50. Kanai, Y.; Ishiyama, D.; Senda, H.; Iwatani, W.; Takahashi, H.; Konno, H.; Tokumasu, S.; Kanazawa, S. Novel human topoisomerase I inhibitors, topopyrones A, B, C and D. I. Producing strain, fermentation, isolation, physico-chemical properties and biological activity. Journal of Antibiotics 2000, 53, 863-872.
51. Asai, A.; Yamashita, Y.; Ando, K.; Kakita, S.; Kita, K.; Suzuki, Y.; Mihara, A.; Ashizawa, T.; Mizukami, T.; Nakano, H. UCT1072s, new antitumor antibiotics with topoisomerase II mediated DNA cleavage activity, from Aspergillus sp. Journal of Antibiotics 1999, 52, 1046-1049.
52. Wrigley, S.K.; Sadeghi, R.; Bahl, S.; Whiting, A.J.; Ainsworth, A.M.; Martin, S.M.; Katzer, W.; Ford, R.; Kau, D.A.; Robinson, N.; Hayes, M.A.; Elcock, C.; Mander, T.; Moore, M. A novel (6S)-4,6-dimethyldodeca-2E,4E-dienoyl ester of phomalactone and related alpha-pyrone esters from a Phomopsis sp. with cytokine production inhibitory activity. Journal of Antibiotics 1999, 52, 862-872.
53. Schlingmann, G.; Milne, L.; Carter, G.T. New alpha-pyrones produced by fungal culture LL- 11G219 function as androgen receptor ligands. Tetrahedron 1998, 54, 13013-13022.
54. Thines, E.; Anke, H.; Sterner, O. Scytalols A, B, C, and D and other modulators of melanin biosynthesis from Scytalidium sp. 36-93. Journal of Antibiotics 1998, 51, 387-393.
55. Fang, F.; Ui, H.; Shiomi, K.; Masuma, R.; Yamaguchi, Y.; Zhang, C.G.; Zhang, X.W.; Tanaka, Y.; Omura, S. Two new components of the aspochalasins produced by Aspergillus sp. Journal of Antibiotics 1997, 50, 919-925.
56. Alvi, K.A.; Pu, H.; Luche, M.; Rice, A.; App, H.; McMahon, G.; Dare, H.; Margolis, B. Asterriquinones produced by Aspergillus candidus inhibit binding of the Grb-2 adapter to phosphorylated EGF receptor tyrosine kinase. Journal of Antibiotics 1999, 52, 215-223.
57. Miljkovic, A.; Mantle, P.G.; Williams, D.J.; Rassing, B. Scorpinone: A new natural azaanthraquinone produced by a Bispora-like tropical fungus. Journal of Natural Products 2001, 64, 1251-1253.
58. Matsuzaki, K.; Tahara, H.; Inokoshi, J.; Tanaka, H.; Masuma, R.; Omura, S. New brominated and halogen-less derivatives and structure-activity relationship of azaphilones inhibiting gp120-CD4 binding. Journal of Antibiotics 1998, 51, 1004-1011.
59. Toki, S.; Tanaka, T.; Uosaki, Y.; Yoshida, M.; Suzuki, Y.; Kita, K.; Mihara, A.; Ando, K.; Lokker, N.A.; Giese, N.A.; Matsuda, Y. RP-1551s, a family of azaphilones produced by Penicillium sp., inhibit the binding of PDGF to the extracellular domain of its receptor. Journal of Antibiotics 1999, 52, 235-244.
60. Kono, K.; Tanaka, M.; Ono, Y.; Hosoya, T.; Ogita, T.; Kohama, T. S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus. Journal of Antibiotics 2001, 54, 415-420.
61. Asami, Y.; Kakeya, H.; Onose, R.; Yoshida, A.; Matsuzaki, H.; Osada, H. Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp. Organic Letters 2002, 4, 2845-2848.
62. Wrigley, S.K.; Ainsworth, A.M.; Kau, D.A.; Martin, S.M.; Bahl, S.; Tang, J.S.; Hardick, D.J.; Rawlins, P.; Sadheghi, R.; Moore, M. Novel reduced benzo[j]fluoranthen-3-ones from Cladosporium cf. cladosporioides with cytokine production and tyrosine kinase inhibitory properties. Journal of Antibiotics 2001, 54, 479-488.
63. Shen, X.Y.; Krasnoff, S.B.; Lu, S.W.; Dunbar, C.D.; J, O.N.; Turgeon, B.G.; Yoder, O.C.; Gibson, D.M.; Hamann, M.T. Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus. Journal of Natural Products 1999, 62, 895-897.
64. Rahbk, L.; Breinholt, J.; Frisvad, J.C.; Christophersen, C. Circumdatin A, B, and C: Three New Benzodiazepine Alkaloids Isolated from a Culture of the Fungus Aspergillus ochraceus. Journal of Organic Chemistry 1999, 64, 1689-1692.
65. Koyama, K.; Kuramochi, D.; Kinoshita, K.; Takahashi, K. Hypoxylonols A and B, novel reduced benzo[j]fluoranthene derivatives from the mushroom Hypoxylon truncatum. Journal of Natural Products 2002, 65, 1489-1490.
66. Kleinwachter, P.; Schlegel, B.; Dorfelt, H.; Grafe, U. Spirobenzofuran, a new bioactive metabolite from Acremonium sp. HKI 0230. Journal of Antibiotics 2001, 54, 526-527.
67. Brauers, G.; Edrada, R.A.; Ebel, R.; Proksch, P.; Wray, V.; Berg, A.; Grafe, U.; Schachtele, C.; Totzke, F.; Finkenzeller, G.; Marme, D.; Kraus, J.; Munchbach, M.; Michel, M.; Bringmann, G.; Schaumann, K. Anthraquinones and betaenone derivatives from the spongeassociated fungus Microsphaeropsis species: Novel inhibitors of protein kinases. Journal of Natural Products 2000, 63, 739-745.
68. Jaturapat, A.; Isaka, M.; Hywel-Jones, N.L.; Lertwerawat, Y.; Kamchonwongpaisan, S.; Kirtikara, K.; Tanticharoen, M.; Thebtaranonth, Y. Bioxanthracenes from the insect pathogenic fungus Cordyceps pseudomilitaris BCC 1620. I. Taxonomy, fermentation, isolation and antimalarial activity. Journal of Antibiotics 2001, 54, 29-35.
69. Brady, S.F.; Singh, M.P.; Janso, J.E.; Clardy, J. Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. Organic Letters 2000, 2, 4047-4049.
70. Silberborth, S.; Stumpf, A.; Erkel, G.; Anke, T.; Sterner, O. Gerronemins A-F, cytotoxic biscatechols from a Gerronema species. Phytochemistry 2002, 59, 643-648.
71. Whyte, A.C.; Joshi, B.K.; Gloer, J.B.; Wicklow, D.T.; Dowd, P.F. New cyclic peptide and bisindolyl benzenoid metabolites from the sclerotia of Aspergillus sclerotiorum. Journal of Natural Products 2000, 63, 1006-1009.
72. Bode, H.B.; Zeeck, A. Sphaerolone and dihydrosphaerolone, two bisnaphthyl-pigments from the fungus Sphaeropsidales sp. F-24′707. Phytochemistry 2000, 54, 597-601.
73. Kleinwachter, P.; Schlegel, B.; Dornberger, K.; Dorfelt, H. 9-hydroxyoudemansin A, a novel antifungal (E)-.beta.-methoxyacrylate from a Mycena species. Journal of Antibiotics 1999, 52, 332-334.
74. Colmenares, A.J.; Duran-Patron, R.M.; Hernandez-Galan, R.; Collado, I.G. Four new lactones from Botrytis cinerea. Journal of Natural Products 2002, 65, 1724-1726.
75. Macias, F.A.; Varela, R.M.; Simonet, A.M.; Cutler, H.G.; Cutler, S.J.; Dugan, F.M.; Hill, R.A. Novel Bioactive Breviane Spiroditerpenoids from Penicillium brevicompactum Dierckx. Journal of Organic Chemistry 2000, 65, 9039-9046.
76. Macias, F.A.; Varela, R.M.; Simonet, A.M.; Cutler, H.G.; Cutler, S.J.; Eden, M.A.; Hill, R.A. Bioactive Carotanes from Trichoderma virens. Journal of Natural Products 2000, 63, 1197-1200.
77. Sakaki, H.; Kaneno, H.; Sumiya, Y.; Tsushima, M.; Miki, W.; Kishimoto, N.; Fujita, T.; Matsumoto, S.; Komemushi, S.; Sawabe, A. A new carotenoid glycosyl ester isolated from a marine microorganism, Fusarium strain T-1. Journal of Natural Products 2002, 65, 1683-1684.
78. Qi, J.; Ojika, M.; Sakagami, Y. Termitomycesphins A-D, Novel Neuritogenic Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus. Tetrahedron 2000, 56, 5835-5841.
79. Feng, Y.J.; Blunt, J.W.; Cole, A.L.J.; Munro, M.H.G. The isolation of two new chromone derivatives from the New Zealand fungus Tolypocladium extinguens. Journal of Natural Products 2002, 65, 1681-1682.
80. Lin, Y.; Wu, X.; Feng, S.; Jiang, G.; Zhou, S.; Vrijmoed, L.L.P.; Jones, E.B.G. A novel Ncinnamoylcyclopeptide containing an allenic ether from the fungus Xylaria sp. (strain #ns2508) from the South China Sea. Tetrahedron Letters 2001, 42, 449-451.
81. Hein, S.M.; Gloer, J.B.; Koster, B.; Malloch, D. Bombardolides: New antifungal and antibacterial gamma-lactones from the coprophilous fungus Bombardioidea anartia. Journal of Natural Products 2001, 64, 809-812.
82. Tsunoo, A.; Kamijo, M.; Taketomo, N.; Sato, Y.; Ajisaka, K. Roseocardin, a novel cardiotonic cyclodepsipeptide from Trichothecium roseum TT103. Journal of Antibiotics 1997, 50, 1007-1013.
83. Cueto, M.; Jensen, P.R.; Fenical, W. N-Methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus Fusarium. Phytochemistry 2000, 55, 223-226.
84. Ishiyama, D.; Sato, T.; Honda, R.; Senda, H.; Konno, H.; Kanazawa, S. Glomosporin, a novel antifungal cyclic depsipeptide from Glomospora sp. II. Structure elucidation. Journal of Antibiotics 2000, 53, 525-531.
85. Che, Y.; Swenson, D.C.; Gloer, J.B.; Koster, B.; Malloch, D. Pseudodestruxins A and B: New cyclic depsipeptides from the coprophilous fungus Nigrosabulum globosum. Journal of Natural Products 2001, 64, 555-558.
86. Koiso, Y.; Morisaki, N.; Yamashita, Y.; Mitsui, Y.; Shirai, R.; Hashimoto, Y.; Iwasaki, S. Isolation and structure of an antimitotic cyclic peptide, ustiloxin F: chemical interrelation with a homologous peptide, ustiloxin B. Journal of Antibiotics 1998, 51, 418-422.
87. Omura, S.; Arai, N.; Yamaguchi, Y.; Masuma, R.; Iwai, Y.; Namikoshi, M.; Turberg, A.; Kolbl, H.; Shiomi, K. Argifin, a new chitinase inhibitor, produced by Gliocladium sp. FTD- 0668 I. Taxonomy, fermentation, and biological activities. Journal of Antibiotics 2000, 53, 603-608.
88. Malmstrom, J.; Ryager, A.; Anthoni, U.; Nielsen, P.H. Unguisin C, a GABA-containing cyclic peptide from the fungus Emericella unguis. Phytochemistry 2002, 60, 869-872.
89. Singh, S.B.; Zink, D.L.; Liesch, J.M.; Dombrowski, A.W.; Darkin-Rattray, S.J.; Schmatz, D.M.; Goetz, M.A. Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions. Organic Letters 2001, 3, 2815-2818.
90. Masuoka, Y.; Shin-Ya, K.; Kim, Y.-B.; Yoshida, M.; Nagai, K.; Suzuki, K.-I.; Hayakawa, Y.; Seto, H. Diheteropeptin, a new substance with TGF-.beta.-like activity, produced by a fungus, Diheterospora chlamydosporia. I. Production, isolation and biological activities. Journal of Antibiotics 2000, 53, 788-792.
91. Jiang, Z.; Barret, M.-O.; Boyd, K.G.; Adams, D.R.; Boyd, A.S.F.; Grant Burgess, J. JM47, a cyclic tetrapeptide HC-toxin analogue from a marine Fusarium species. Phytochemistry 2002, 60, 33-38.
92. Namatame, I.; Tomoda, H.; Si, S.; Yamaguchi, Y.; Masuma, R.; Omura, S. Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979. Journal of Antibiotics 1999, 52, 1-6.
93. Chu, M.; Chan, T.M.; Das, P.; Mierzwa, R.; Patel, M.; Puar, M.S. Structure of Sch 218157, a cyclodepsipeptide with neurokinin activity. Journal of Antibiotics 2000, 53, 736-738.
94. Vongvanich, N.; Kittakoop, P.; Isaka, M.; Trakulnaleamsai, S.; Vimuttipong, S.; Tanticharoen, M.; ThebtarAnonth, Y. Hirsutellide A, a new antimycobacterial cyclohexadepsipeptide from the entomopathogenic fungus Hirsutella kobayasii. Journal of Natural Products 2002, 65, 1346-1348.
95. Li, J.Y.; Strobel, G.A. Jesterone and hydroxy-jesterone antioomycete cyclohexenone epoxides from the endophytic fungus Pestalotiopsis jesteri. Phytochemistry 2001, 57, 261-265.
96. Yun, B.-S.; Kang, H.-C.; Koshino, H.; Yu, S.-H.; Yoo, I.-D. Suillusin, a unique benzofuran from the mushroom Suillus granulatus. Journal of Natural Products 2001, 64, 1230-1231.
97. Matsumoto, T.; Ishiyama, A.; Yamaguchi, Y.; Masuma, R.; Ui, H.; Shiomi, K.; Yamada, H.; Omura, S. Novel cyclopentanone derivatives pentenocins A and B, with interleukin-1.beta. converting enzyme inhibitory activity, produced by Trichoderma hamatum FO-6903. Journal of Antibiotics 1999, 52, 754-757.
98. Kogen, H.; Kiho, T.; Tago, K.; Miyamoto, S.; Fujioka, T.; Otsuka, N.; Suzuki-Konagai, K.; Ogita, T. Alutacenoic Acids A and B, Rare Naturally Occurring Cyclopropenone Derivatives Isolated from Fungi: Potent Non-Peptide Factor XIIIa Inhibitors. Journal of the American Chemical Society 2000, 122, 1842-1843.
99. Kohno, J.; Nonaka, N.; Nishio, M.; Ohnuki, T.; Kawano, K.; Okuda, T.; Komatsubara, S. TMC-169, a new antibiotic of the aspochalasin group produced by Aspergillus flavipes. Journal of Antibiotics 1999, 52, 575-577.
100. Tomoda, H.; Namatame, I.; Si, S.; Kawaguchi, K.; Masuma, R.; Namikoshi, M.; Omura, S. Phenochalasins, inhibitors of lipid droplet formation in mouse macrophages, produced by Phomopsis sp. FT-0211. Journal of Antibiotics 1999, 52, 851-856.
101. Fujii, Y.; Tani, H.; Ichinoe, M.; Nakajima, H. Zygosporin D and two new cytochalasins produced by the fungus Metarrhizium anisopliae. Journal of Natural Products 2000, 63, 132-135.
102. Wagenaar, M.M.; Corwin, J.; Strobel, G.; Clardy, J. Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. Journal of Natural Products 2000, 63, 1692-1695.
103. Evidente, A.; Andolfi, A.; Vurro, M.; Zonno, M.C.; Motta, A. Cytochalasins Z1, Z2 and Z3, three 24-oxa[14]cytochalasans produced by Pyrenophora semeniperda. Phytochemistry 2002, 60, 45-53.
104. Feng, Y.; Blunt, J.W.; Cole, A.L.J.; Munro, M.H.G. Three Novel Cytochalasins X, Y, and Z from Pseudeurotium zonatum. Journal of Natural Products 2002, 65, 1274-1277.
105. Edrada, R.A.; Heubes, M.; Brauers, G.; Wray, V.; Berg, A.; Grafe, U.; Wohlfarth, M.; Muhlbacher, J.; Schaumann, K.; Sudarsono, ; Bringmann, G.; Proksch, P. Online analysis of xestodecalactones A-C, novel bioactive metabolites from the fungus Penicillium cf. montanense and their subsequent isolation from the sponge Xestospongia exigua. Journal of Natural Products 2002, 65, 1598-1604.
106. Fujii, Y.; Asahara, M.; Ichinoe, M.; Nakajima, H. Fungal melanin inhibitor and related compounds from Penicillium decumbens. Phytochemistry 2002, 60, 703-708.
107. Namikoshi, M.; Kobayashi, H.; Yoshimoto, T.; Hosoya, T. Phomopsidin, a new inhibitor of microtubule assembly produced by Phomopsis sp. isolated from coral reef in Pohnpei. Journal of Antibiotics 1997, 50, 890-892.
108. Cao, S.G.; Lee, A.S.Y.; Huang, Y.C.; Flotow, H.; Ng, S.; Butler, M.S.; Buss, A.D. Agonodepsides A and B: Two new depsides from a filamentous fungus F7524. Journal of Natural Products 2002, 65, 1037-1038.
109. Kaida, K.; Fudou, R.; Kameyama, T.; Tubaki, K.; Suzuki, Y.; Ojika, M.; Sakagami, Y. New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica. 1. Taxonomy, fermentation, isolation, and biological properties. Journal of Antibiotics 2001, 54, 17-21.
110. Hegde, V.R.; Puar, M.S.; Dai, P.; Pu, H.; Patel, M.; Anthes, J.C.; Richard, C.; Terracciano, J.; Das, P.R.; Gullo, V. A family of depsi-peptide fungal metabolites, as selective and competitive human tachykinin receptor (NK2) antagonists: Fermentation, isolation, physico-chemical properties, and biological activity. Journal of Antibiotics 2001, 54, 125-135.
111. Sato, S.; Nakagawa, R.; Fudo, R.; Fukuda, Y.; Yoshimura, T.; Kaida, K.-I.; Ando, T.; Kameyama, T.; Tsuji, T. F390B and C, new antitumor dihydroxanthone derivatives isolated from Penicillium sp. Journal of Antibiotics 1997, 50, 614-616.
112. Fredenhagen, A.; Petersen, F.; Tintelnot-Blomley, M.; Rosel, J.; Mett, H.; Hug, P. Semicochliodinol A and B: inhibitors of HIV-1 protease and EGF-R protein tyrosine kinase related to asterriquinones produced by the fungus Chrysosporium merdarium. Journal of Antibiotics 1997, 50, 395-401.
113. Chu, M.; Truumees, I.; Mierzwa, R.; Patel, M.; Puar, M.S. Sch 56396: a new c-fos protooncogene inhibitor produced by the fungus Tolypocladium sp. Journal of Antibiotics 1997, 50, 1061-1063.
114. Suzuki, Y.; Takahashi, H.; Esumi, Y.; Arie, T.; Morita, T.; Koshino, H.; Uzawa, J.; Uramoto, M.; Yamaguchi, I. Haematocin, a new antifungal diketopiperazine produced by Nectria haematococca Berk. et Br. (880701a-1) causing nectria blight disease on ornamental plants. Journal of Antibiotics 2000, 53, 45-49.
115. Kozlovsky, A.G.; Vinokurova, N.G.; Adanin, V.M.; Burkhardt, G.; Dahse, H.-M.; Graefe, U. New Diketopiperazine Alkaloids from Penicillium fellutanum. Journal of Natural Products 2000, 63, 698-700.
116. Kwon, O.S.; Park, S.H.; Yun, B.-S.; Pyun, Y.R.; Kim, C.-J. Cyclo(dehydroala-L-Leu), an alpha-glucosidase inhibitor from Penicillium sp. F70614. Journal of Antibiotics 2000, 53, 954-958.
117. Sugie, Y.; Hirai, H.; Inagaki, T.; Ishiguro, M.; Kim, Y.-J.; Kojima, Y.; Sakakibara, T.; Sakemi, S.; Sugiura, A.; Suzuki, Y.; Brennan, L.; Duignan, J.; Huang, L.H.; Sutcliffe, J.; Kojima, N. A new antibiotic CJ-17,665 from Aspergillus ochraceus. Journal of Antibiotics 2001, 54, 911-916.
118. Yun, B.-S.; Cho, Y.; Lee, I.-K.; Cho, S.-M.; Lee, T.H.; Yoo, I.-D. Sterins A and B, new antioxidative compounds from Stereum hirsutum. Journal of Antibiotics 2002, 55, 208-210.
119. Soledade, M.; Pedras, C.; Biesenthal, C.J. Isolation, structure determination, and phytotoxicity of unusual dioxopiperazines from the phytopathogenic fungus Phoma lingam. Phytochemistry 2001, 58, 905-909.
120. Ichikawa, K.; Hirai, H.; Ishiguro, M.; Kambara, T.; Kato, Y.; Kim, Y.J.; Kojima, Y.; Matsunaga, Y.; Nishida, H.; Shiomi, Y.; Yoshikawa, N.; Huang, L.H.; Kojima, N. Cytokine production inhibitors produced by a fungus, Oidiodendron griseum. Journal of Antibiotics 2001, 54, 697-702.
121. Afiyatullov, S.S.; Kuznetsova, T.A.; Isakov, V.V.; Pivkin, M.V.; Prokof’ eva, N.G.; Elyakov, G.B. New diterpenic altrosides of the fungus Acremonium striatisporum isolated from a sea cucumber. Journal of Natural Products 2000, 63, 848-850.
122. Kita, T.; Takaya, Y.; Oshima, Y.; Ohta, T.; Aizawa, K.; Hirano, T.; Inakuma, T. Scabronines B, C, D, E, F, novel diterpenoids showing stimulating activity of nerve growth factor-synthesis, from the mushroom Sarcodon scabrosus. Tetrahedron 1998, 54, 11877-11886.
123. Hinkley, S.F.; Mazzola, E.P.; Fettinger, J.C.; Lam, Y.F.; Jarvis, B.B. Atranones A-G, from the toxigenic mold Stachybotrys chartarum. Phytochemistry 2000, 55, 663-673.
124. Kleinwachter, P.; Dahse, H.-M.; Luhmann, U.; Schlegel, B.; Dornberger, K. Epicorazine C, an antimicrobial metabolite from Stereum hirsutum HKI 0195. Journal of Antibiotics 2001, 54, 521-525.
125. Yamada, T.; Iwamoto, C.; Yamagaki, N.; Yamanouchi, T.; Minoura, K.; Yamori, T.; Uehara, Y.; Andoh, T.; Umemura, K.; Numata, A. Leptosins M-N1, cytotoxic metabolites from a Leptosphaeria species separated from a marine alga. Structure determination and biological activities. Tetrahedron 2002, 58, 479-487.
126. Ui, H.; Shiomi, K.; Yamaguchi, Y.; Masuma, R.; Nagamitsu, T.; Takano, D.; Sunazuka, T.; Namikoshi, M.; Omura, S. Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554. Journal of Antibiotics 2001, 54, 234-238.
127. Sugie, Y.; Dekker, K.A.; Inagaki, T.; Kim, Y.-J.; Sakakibara, T.; Sakemi, S.; Sugiura, A.; Brennan, L.; Duignan, J.; Sutcliffe, J.A.; Kojima, Y. A novel antibiotic CJ-17,572 from a fungus, Pezicula sp. Journal of Antibiotics 2002, 55, 19-24.
128. Sugie, Y.; Inagaki, S.; Kato, Y.; Nishida, H.; Pang, C.-H.; Saito, T.; Sakemi, S.; Dib-Hajj, F.; Mueller, J.P.; Sutcliffe, J.; Kojima, Y. CJ-21,058, a new SecA inhibitor isolated from a fungus. Journal of Antibiotics 2002, 55, 25-29.
129. Singh, M.P.; Zaccardi, J.; Greenstein, M. LL-49F233alpha, a novel antibiotic produced by an unknown fungus: biological and mechanistic activities. Journal of Antibiotics 1998, 51, 1109-1112.
130. Hirotani, M.; Sai, K.; Hirotani, S.; Yoshikawa, T. Blazeispirols B, C, E and F, des-A-ergostane- type compounds, from the cultured mycelia of the fungus Agaricus blazei. Phytochemistry 2002, 59, 571-577.
131. Mothana, R.A.A.; Jansen, R.; Juelich, W.-D.; Lindequist, U. Ganomycins A and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi. Journal of Natural Products 2000, 63, 416-418.
132. Kawagishi, H.; Miyazawa, T.; Kume, H.; Arimoto, Y.; Inakuma, T. Aldehyde dehydrogenase inhibitors from the mushroom Clitocybe clavipes. Journal of Natural Products 2002, 65, 1712-1714.
133. Sakemi, S.; Bordner, J.; DeCosta, D.L.; Dekker, K.A.; Hirai, H.; Inagaki, T.; Kim, Y.-J.; Kojima, N.; Sims, J.C.; Sugie, Y.; Sugiura, A.; Sutcliffe, J.A.; Tachikawa, K.; Truesdell, S.J.; Wong, J.W.; Yoshikawa, N.; Kojima, Y. CJ-15,696 and its analogs, new furopyridine antibiotics from the fungus Cladobotryum varium: fermentation, isolation, structural elucidation, biotransformation and antibacterial activities. Journal of Antibiotics 2002, 55, 6-18.
134. Arnone, A.; De Gregorio, C.; Nasini, G.; Vajna de Pava, O. Secondary mold metabolites. 56. Isolation and structure elucidation of tsugicolines F-H, novel furosesquiterpenes, and tsugicoline I from the fungus Laurilia tsugicola. Tetrahedron 1998, 54, 10199-10204.
135. Tomikawa, T.; Shin-Ya, K.; Furihata, K.; Kinoshita, T.; Miyajima, A.; Seto, H.; Hayakawa, Y. Rasfonin, a new apoptosis inducer in ras-dependent cells from Talaromyces sp. Journal of Antibiotics 2000, 53, 848-850.
136. Gunawardana, G.; Rasmussen, R.R.; Scherr, M.; Frost, D.; Brandt, K.D.; Choi, W.; Jackson, M.; Karwowski, J.P.; Sunga, G.; Malmberg, L.-H.; West, P.; Chen, R.H.; Kadam, S.; Clement, J.J.; McAlpine, J.B. Corynecandin: a novel antifungal glycolipid from Coryneum modonium. Journal of Antibiotics 1997, 50, 884-886.
137. Boros, C.; Katz, B.; Mitchell, S.; Pearce, C.; Swinbank, K.; Taylor, D. Emmyguyacins A and B: unusual glycolipids from a sterile fungus species that inhibit the low-pH conformational change of hemagglutinin A during replication of influenza virus. Journal of Natural Products 2002, 65, 108-114.
138. Silberborth, S.; Erkel, G.; Anke, T.; Sterner, O. The irpexans, a new group of biologically active metabolites produced by the basidiomycete Irpex sp. 93028. Journal of Antibiotics 2000, 53, 1137-1144.
139. Rasser, F.; Anke, T.; Sterner, O. Terpenoids from Bovista sp. 96042. Tetrahedron 2002, 58, 7785-7789.
140. Smith, C.J.; Abbanat, D.; Bernan, V.S.; Maiese, W.M.; Greenstein, M.; Jompa, J.; Tahir, A.; Ireland, C.M. Novel polyketide metabolites from a species of marine fungi. Journal of Natural Products 2000, 63, 142-145.
141. Nishihara, Y.; Tsujii, E.; Yamagishi, Y.; Sakamoto, K.; Tsurumi, Y.; Furukawa, S.; Ohtsu, R.; Kino, T.; Hino, M.; Yamashita, M.; Hashimoto, S. FR198248, a new anti-influenza agent isolated from Aspergillus terreus No. 13830. I. Taxonomy, fermentation, isolation, physicochemical properties and biological activities. Journal of Antibiotics 2001, 54, 136-143.
142. Kohno, J.; Hirano, N.; Sugawara, K.; Nishio, M.; Hashiyama, T.; Nakanishi, N.; Komatsubara, S. Structure of TMC-69, a new antitumor antibiotic from Chrysosporium sp. TC 1068. Tetrahedron 2001, 57, 1731-1735.
143. Takahashi, S.; Kakinuma, N.; Uchida, K.; Hashimoto, R.; Yanagisawa, T.; Nakagawa, A. Pyridovericin and pyridomacrolidin: novel metabolites from entomopathogenic fungi, Beauveria bassiana. Journal of Antibiotics 1998, 51, 596-598.
144. Takahashi, S.; Uchida, K.; Kakinuma, N.; Hashimoto, R.; Yanagisawa, T.; Nakagawa, A. The structures of pyridovericin and pyridomacrolidin, new metabolites from the entomopathogenic fungus, Beauveria bassiana. Journal of Antibiotics 1998, 51, 1051-1054.
145. Rasser, F.; Anke, T.; Sterner, O. Secondary metabolites from a Gloeophyllum species. Phytochemistry 2000, 54, 511-516.
146. Ondeyka, J.G.; Dahl-Roshak, A.M.; Tkacz, J.S.; Zink, D.L.; Zakson-Aiken, M.; Shoop, W.L.; Goetz, M.A.; Singh, S.B. Nodulisporic acid B, B1, and B2: a series of 1′-deoxy-nodulisporic acids from Nodulisporium sp. Bioorganic & Medicinal Chemistry Letters 2002, 12, 2941-2944.
147. Qian-Cutrone, J.; Huang, S.; Shu, Y.-Z.; Vyas, D.; Fairchild, C.; Menendez, A.; Krampitz, K.; Dalterio, R.; Klohr, S.E.; Gao, Q. Stephacidin A and B: two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cells. Journal of the American Chemical Society 2002, 124, 14556-14557.
148. Strobel, G.; Ford, E.; Worapong, J.; Harper, J.K.; Arif, A.M.; Grant, D.M.; Fung, P.C.W.; Chau, R.M.W. Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities. Phytochemistry 2002, 60, 179-183.
149. Inagaki, T.; Kaneda, K.; Suzuki, Y.; Hirai, H.; Nomura, E.; Sakakibara, T.; Yamauchi, Y.; Huang, L.H.; Norcia, M.; Wondrack, L.M.; Sutcliffe, J.A.; Kojima, N. CJ-12,373, a novel topoisomerase II inhibitor: fermentation, isolation, structure elucidation and biological activities. Journal of Antibiotics 1998, 51, 112-116.
150. Lee, C.H.; Chung, M.C.; Lee, H.J.; Bae, K.S.; Kho, Y.H. MR566A and MR566B, new melanin synthesis inhibitors produced by Trichoderma harzianum. I. Taxonomy, fermentation, isolation and biological activities. Journal of Antibiotics 1997, 50, 469-473.
151. Vijayakumar, E.K.S.; Roy, K.; Hiremath, C.P.; Deshmukh, S.K.; Mukhopadhyay, T.; Kogler, H. L970843 and L970844, two new antifungal metabolites from an unidentified fungal species HIL Y-903146. Journal of Antibiotics 2001, 54, 973-976.
152. Kohno, J.; Hiramatsu, H.; Nishio, M.; Sakurai, M.; Okuda, T.; Komatsubara, S. Structures of TMC-120A, B and C, novel isoquinoline alkaloids from Aspergillus ustus TC 1118. Tetrahedron 1999, 55, 11247-11252.
153. Kohno, J.; Sakurai, M.; Kameda, N.; Nishio, M.; Kawano, K.; Kishi, N.; Okuda, T.; Komatsubara, S. Production, isolation and biological properties of TMC-120A, B and C, novel inhibitors of eosinophil survival from Aspergillus ustus TC 1118. Journal of Antibiotics 1999, 52, 913-916.
154. Minagawa, K.; Kouzuki, S.; Yoshimoto, J.; Kawamura, Y.; Tani, H.; Iwata, T.; Terui, Y.; Nakai, H.; Yagi, S.; Hattori, N.; Fujiwara, T.; Kamigauchi, T. Stachyflin and acetylstachyflin, novel anti-influenza A virus substances, produced by Stachybotrys sp. RF-7260. I. Isolation, structure elucidation and biological activities. Journal of Antibiotics 2002, 55, 155-164.
155. Gonzalez, A.G.; Leon, F.; Rivera, A.; Padron, J.I.; Gonzalez Plata, J.; Zuluaga, J.C.; Quintana, J.; Estevez, F.; Bermejo, J. New lanostanoids from the fungus Ganoderma concinna. Journal of Natural Products 2002, 65, 417-421.
156. Heinze, S.; Ritzau, M.; Ihn, W.; Hulsmann, H.; Schlegel, B.; Dornberger, K.; Fleck, W.F.; Zerlin, M.; Christner, C.; Grafe, U.; Kullertz, G.; Fischer, G. Lipohexin, a new inhibitor of prolyl endopeptidase from Moeszia lindtneri (HKI-0054) and Paecilomyces sp. (HKI-0055; HKI-0096). I. Screening, isolation and structure elucidation. Journal of Antibiotics 1997, 50, 379-383.
157. Fujie, A.; Iwamoto, T.; Muramatsu, H.; Okudaira, T.; Nitta, K.; Nakanishi, T.; Sakamoto, K.; Hori, Y.; Hino, M.; Hashimoto, S.; Okuhara, M. FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties. Journal of Antibiotics 2000, 53, 912-919.
158. Abbanat, D.; Leighton, M.; Maiese, W.; Jones, E.B.G.; Pearce, C.; Greenstein, M. Cell wallactive antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL- 15G256. I. Taxonomy and fermentation. Journal of Antibiotics 1998, 51, 296-302.
159. Sugawara, T.; Tanaka, A.; Tanaka, K.; Nagai, K.; Suzuki, K.; Suzuki, T. YM-170320, a novel lipopeptide antibiotic inducing morphological change of colonies in a mutant of Candida tropicalis pK233. Journal of Antibiotics 1998, 51, 435-438.
160. Ohyama, T.; Kurihara, Y.; Ono, Y.; Ishikawa, T.; Miyakoshi, S.; Hamano, K.; Arai, M.; Suzuki, T.; Igari, H.; Suzuki, Y.; Inukai, M. Arborcandins A, B, C, D, E and F, novel 1,3- beta-glucan synthase inhibitors: Production and biological activity. Journal of Antibiotics 2000, 53, 1108-1116.
161. Dekker, K.A.; Aiello, R.J.; Hirai, H.; Inagaki, T.; Sakakibara, T.; Suzuki, Y.; Thompson, J.F.; Yamauchi, Y.; Kojima, N. Novel lactone compounds from Mortierella verticillata that induce the human low-density lipoprotein receptor gene: fermentation, isolation, structural elucidation and biological activities. Journal of Antibiotics 1998, 51, 14-20.
162. Jadulco, R.; Proksch, P.; Wray, V.; Sudarsono, ; Berg, A.; Grafe, U. New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum. Journal of Natural Products 2001, 64, 527-530.
163. Geris dos Santos, R.M.; Rodrigues-Fo, E. Meroterpenes from Penicillium sp found in association with Melia azedarach. Phytochemistry 2002, 61 (8), 907-912.
164. Stierle, A.A.; Stierle, D.B.; Bugni, T. Sequoiatones A and B: novel antitumor metabolites isolated from a redwood endophyte. Journal of Organic Chemistry 1999, 64, 5479-5484.
165. Lin, Y.; Wu, X.; Feng, S.; Jiang, G.; Luo, J.; Zhou, S.; Vrijmoed, L.L.P.; Jones, E.B.G.; Krohn, K.; Steingroever, K.; Zsila, F. Five Unique Compounds: Xyloketals from Mangrove Fungus Xylaria sp. from the South China Sea Coast. Journal of Organic Chemistry 2001, 66, 6252-6256.
166. Dabrah, T.T.; Harwood, H.J., Jr.; Huang, L.H.; Jankovich, N.D.; Kaneko, T.; Li, J.-C.; Lindsey, S.; Moshier, P.M.; Subashi, T.A.; Therrien, M.; Watts, P.C. CP-225,917 and CP-263,114, novel Ras farnesylation inhibitors from an unidentified fungus. I. Taxonomy, fermentation, isolation, and biochemical properties. Journal of Antibiotics 1997, 50, 1-7.
167. Thines, E.; Arendholz, W.-R.; Anke, H.; Sterner, O. Benesudon, a new antibiotic fungal metabolite from cultures of Mollisia benesuada (Tul.) Phill. Journal of Antibiotics 1997, 50, 13-17.
168. Tabata, Y.; Miike, N.; Hatsu, M.; Kurata, Y.; Yaguchi, T.; Someya, A.; Miyadoh, S.; Hoshiko, S.; Tsuruoka, T.; Omoto, S. PF1092A, B and C, new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum. I. Taxonomy of producing strain, fermentation, isolation and biological activities. Journal of Antibiotics 1997, 50, 304-308.
169. Engler, M.; Anke, T.; Sterner, O. Pterulinic acid and pterulone, two novel inhibitors of NADH: ubiquinone oxidoreductase (complex I) produced by a Pterula species. II. Physico-chemical properties and structure elucidation. Journal of Antibiotics 1997, 50, 330-333.
170. Lee, H.-J.; Chung, M.-C.; Lee, C.-H.; Yun, B.-S.; Chun, H.-K.; Kho, Y.-H. Gelastatins A and B, new inhibitors of gelatinase A from Westerdykella multispora F50733. Journal of Antibiotics 1997, 50, 357-358.
171. Mukhopadhyay, T.; Bhat, R.G.; Roy, K.; Vijayakumar, E.K.S.; Ganguli, B.N. Aranochlor A and aranochlor B, two new metabolites from Pseudoarachniotus roseus: production, isolation, structure elucidation and biological properties. Journal of Antibiotics 1998, 51, 439-441.
172. Alvi, K.A.; Casey, A.; Nair, B.G. Pulchellalactam: A CD45 protein tyrosine phosphatase inhibitor from the marine fungus Corollospora pulchella. Journal of Antibiotics 1998, 51, 515-517.
173. Hartl, A.; Stelzner, A.; Ritzau, M.; Heinze, S.; Grafe, U. 5-hydroxy-3,4,7-triphenyl-2,6-benzofurandione, a new xanthine oxidase inhibitor from Peniophora sanguinea. Journal of Antibiotics 1998, 51, 528-530.
174. Abbanat, D.A.; Singh, M.P.; Greenstein, M. Hongoquercins, new antibacterial agents from the fungus LL-23G227: fermentation and biological activity. Journal of Antibiotics 1998, 51, 708-714.
175. Sassa, T.; Kinoshita, H.; Nukina, M.; Sugiyama, T. Acremolactone A, a novel herbicidal epoxydihydropyranyl gamma-lactone from Acremonium roseum I4267. Journal of Antibiotics 1998, 51, 967-969.
176. Saito, T.; Aoki, F.; Hirai, H.; Inagaki, T.; Matsunaga, Y.; Sakakibara, T.; Sakemi, S.; Suzuki, Y.; Watanabe, S.; Suga, O.; Sujaku, T.; Smogowicz, A.A.; Truesdell, S.J.; Wong, J.W.; Nagahisa, A.; Kojima, Y.; Kojima, N. Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum. Journal of Antibiotics 1998, 51, 983-990.
177. Kim, S.K.; Hatori, M.; Ojika, M.; Sakagami, Y.; Marumo, S. KM-01, a brassinolide inhibitor, its production, isolation and structure from two fungi Drechslera avenae and Pycnoporus coccineus. Bioorganic and Medicinal Chemistry 1998, 6, 1975-1982.
178. Ondeyka, J.G.; Giacobbe, R.A.; Bills, G.F.; Cuadrillero, C.; Schmatz, D.; Goetz, M.A.; Zink, D.L.; Singh, S.B. Coprophilin: An anticoccidial agent produced by a dung inhabiting fungus. Bioorganic and Medicinal Chemistry Letters 1998, 8, 3439-3442.
179. Bhandari, R.; Eguchi, T.; Sekine, A.; Ohashi, Y.; Kakinuma, K.; Ito, M.; Mizoue, K. Structure of NG-061, a novel potentiator of nerve growth factor (NGF) isolated from Penicillium minioluteum F-4627. Journal of Antibiotics 1999, 52, 231-234.
180. Tabata, Y.; Ikegami, S.; Yaguchi, T.; Sasaki, T.; Hoshiko, S.; Sakuma, S.; Shin-Ya, K.; Seto, H. Diazaphilonic acid, a new azaphilone with telomerase inhibitory activity. Journal of Antibiotics 1999, 52, 412-414.
181. Uchida, R.; Tomoda, H.; Dong, Y.; Omura, S. Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436. Journal of Antibiotics 1999, 52, 572-574.
182. Hinkley, S.F.; Fettinger, J.C.; Dudley, K.; Jarvis, B.B. Memnobotrins and memnoconols: novel metabolites from Memnoniella echinata. Journal of Antibiotics 1999, 52, 988-997.
183. Chu, M.; Mierzwa, R.; He, L.; King, A.; Patel, M.; Pichardo, J.; Hart, A.; Butkiewicz, N.; Puar, M.S. Isolation and structure of Sch 351633: A novel hepatitis C virus (HCV) NS3 protease inhibitor from the fungus Penicillium griseofulvum. Bioorganic and Medicinal Chemistry Letters 1999, 9, 1949-1952.
184. Otoguro, K.; Shiomi, K.; Yamaguchi, Y.; Arai, N.; Sunazuka, T.; Masuma, R.; Iwai, Y.; Omura, S. Arisugacins C and D, novel acetylcholinesterase inhibitors and their related novel metabolites produced by Penicillium sp. FO-4259-11. Journal of Antibiotics 2000, 53, 50-57.
185. Kono, K.; Tanaka, M.; Ogita, T.; Hosoya, T.; Kohama, T. F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete. Journal of Antibiotics 2000, 53, 459-466.
186. Vertesy, L.; Burger, H.-J.; Kenja, J.; Knauf, M.; Kogler, H.; Paulus, E.F.; Ramakrishna, N.V.S.; Swamy, K.H.S.; Vijayakumar, E.K.S.; Hammann, P. Kodaistatins, novel inhibitors of glucose-6-phosphate translocase T1 from Aspergillus terreus Thom DSM 11247. Isolation and structural elucidation. Journal of Antibiotics 2000, 53, 677-686.
187. Ishii, T.; Hayashi, K.; Hida, T.; Yamamoto, Y.; Nozaki, Y. TAN-1813, a novel Ras-farnesyltransferase inhibitor produced by Phoma sp. Taxonomy, fermentation, isolation and biological activities in vitro and in vivo. Journal of Antibiotics 2000, 53, 765-778.
188. Kwon, J.-Y.; Jeong, H.-W.; Kim, H.-K.; Kang, K.-H.; Chang, Y.-H.; Bae, K.-S.; Choi, J.- D.; Lee, U.-C.; Son, K.-H.; Kwon, B.-M. cis-fumagillin, a new methionine aminopeptidase (type 2) inhibitor produced by Penicillium sp. F2757. Journal of Antibiotics 2000, 53, 799-806.
189. Puar, M.S.; Barrabee, E.; Hallade, M.; Patel, M. Sch 420789: a novel fungal metabolite with phospholipase D inhibitory activity. Journal of Antibiotics 2000, 53, 837-838.
190. Hwang, E.-I.; Yun, B.-S.; Kim, Y.-K.; Kwon, B.-M.; Kim, H.-G.; Lee, H.-B.; Jeong, W.-J.; Kim, S.-U. Phellinsin A, a novel chitin synthase inhibitor produced by Phellinus sp. PL3. Journal of Antibiotics 2000, 53, 903-911.
191. Igarashi, Y.; Kuwamori, Y.; Takagi, K.; Ando, T.; Fudou, R.; Furumai, T.; Oki, T. Xanthoepocin, a new antibiotic from Penicillium simplicissimum IFO5762. Journal of Antibiotics 2000, 53, 928-933.
192. Fukami, A.; Nakamura, T.; Kim, Y.P.; Shiomi, K.; Hayashi, M.; Nagai, T.; Yamada, H.; Komiyama, K.; Omura, S. A new anti-influenza virus antibiotic, 10-norparvulenone from Microsphaeropsis sp FO-5050. Journal of Antibiotics 2000, 53, 1215-1218.
193. Nozawa, O.; Okazaki, T.; Morimoto, S.; Chen, Z.-X.; He, B.-M.; Mizoue, K. Waol B, a new trihydrofuran derivative with cytocidal activity, isolated from Myceliophthora lutea. Journal of Antibiotics 2000, 53, 1296-1300.
194. Nam, J.Y.; Kim, H.K.; Kwon, J.Y.; Han, M.Y.; Son, K.H.; Lee, U.C.; Choi, J.D.; Kwon, B.M. 8-O-methylsclerotiorinamine, antagonist of the Grb2-SH2 domain, isolated from Penicillium multicolor. Journal of Natural Products 2000, 63, 1303-1305.
195. Minagawa, K.; Kouzuki, S.; Nomura, K.; Yamaguchi, T.; Kawamura, Y.; Matsushima, K.; Tani, H.; Ishii, K.; Tanimoto, T.; Kamigauchi, T. Bisabosquals, novel squalene synthase inhibitors. I. Taxonomy, fermentation, isolation and biological activities. Journal of Antibiotics 2001, 54, 890-895.
196. Fujimoto, H.; Nakamura, E.; Kim, Y.P.; Okuyama, E.; Ishibashi, M.; Sassa, T. Immunomodulatory constituents from an ascomycete, Eupenicillium crustaceum, and revised absolute structure of macrophorin D. Journal of Natural Products 2001, 64, 1234-1237.
197. Rho, M.C.; Lee, H.S.; Chang, K.T.; Song, H.Y.; Kwon, O.E.; Lee, S.W.; Ko, J.S.; Hong, S.G.; Kim, Y.K. Phenylpyropene C, a new inhibitor of acyl-CoA: Cholesterol acyltransferase produced by Penicillium griseofulvum F1959. Journal of Antibiotics 2002, 55, 211-214.
198. Roll, D.M.; Tischler, M.; Williamson, R.T.; Carter, G.T. The structure of V214w from an unidentified fungus. Journal of Antibiotics 2002, 55, 520-523.
199. Sekizawa, R.; Ikeno, S.; Nakamura, H.; Naganawa, H.; Matsui, S.; Iinuma, H.; Takeuchi, T. Panepophenanthrin, from a mushroom strain, a novel inhibitor of the ubiquitin-activating enzyme. Journal of Natural Products 2002, 65, 1491-1493.
200. He, H.; Yang, H.Y.; Bigelis, R.; Solum, E.H.; Greenstein, M.; Carter, G.T. Pyrrocidines A and B, new antibiotics produced by a filamentous fungus. Tetrahedron Letters 2002, 43, 1633-1636.
201. Kotoda, N.; Shin-Ya, K.; Furihata, K.; Hayakawa, Y.; Seto, H. Isolation and structure elucidation of novel neuronal cell protecting substances, carbazomadurins A and B produced by Actinomadura madurae. Journal of Antibiotics 1997, 50, 770-772.
202. Yano, H.; Nakanishi, S.; Ikuina, Y.; Ando, K.; Toshida, M.; Saitoh, Y.; Matsuda, Y. MS- 681a, b, c and d, new inhibitors of myosin light chain kinase from Myrothecium sp. KY6568. I. Characterization of producing strain and production, isolation and biological activities. Journal of Antibiotics 1997, 50, 992-997.
203. Muroi, M.; Sano, K.; Okada, G.; Koshino, H.; Oku, T.; Takatsuki, A. F13459, a new derivative of mycophenolic acid I. Taxonomy, isolation, and biological properties. Journal of Antibiotics 2001, 54, 489-493.
204. Macias, M.; Ulloa, M.; Gamboa, A.; Mata, R. Phytotoxic compounds from the new coprophilous fungus Guanomyces polythrix. Journal of Natural Products 2000, 63, 757-761.
205. Berg, A.; Gorls, H.; Dorfelt, H.; Walther, G.; Schlegel, B.; Grafe, U. Aureoquinone, a new protease inhibitor from Aureobasidium sp. Journal of Antibiotics 2000, 53, 1293-1295.
206. Fausto Rivero-Cruz, J.; Garcia-Aguirre, G.; Cerda-Garcia-Rojas, C.M.; Mata, R. Conformational Behavior and Absolute Stereostructure of Two Phytotoxic Nonenolides from the Fungus Phoma herbarum. Tetrahedron 2000, 56, 5337-5344.
207. Berg, A.; Reiber, K.; Dorfelt, H.; Walther, G.; Schlegel, B.; Grafe, U. Laccaridiones A and B, new protease inhibitors from Laccaria amethystea. Journal of Antibiotics 2000, 53, 1313-1316.
208. Brady, S.F.; Wagenaar, M.M.; Singh, M.P.; Janso, J.E.; Clardy, J. The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Organic Letters 2000, 2, 4043-4046.
209. Kuboki, H.; Tsuchida, T.; Wakazono, K.; Isshiki, K.; Kumagai, H.; Yoshioka, T. Mer-f3, 12- hydroxy-ovalicin, produced by Metarrhizium sp. f3. Journal of Antibiotics 1999, 52, 590-593.
210. Banks, R.M.; Blanchflower, S.E.; Everett, J.R.; Manger, B.R.; Reading, C. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. Journal of Antibiotics 1997, 50, 840-846.
211. Agatsuma, T.; Akama, T.; Nara, S.; Matsumiya, S.; Nakai, R.; Ogawa, H.; Otaki, S.; Ikeda, S.; Saitoh, Y.; Kanda, Y. UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species. Organic Letters 2002, 4, 4387-4390.
212. Brady, S.F.; Clardy, J. CR377, a new pentaketide antifungal agent isolated from an endophytic fungus. Journal of Natural Products 2000, 63, 1447-1448.
213. Kakeya, H.; Onose, R.; Koshino, H.; Yoshida, A.; Kobayashi, K.; Kageyama, S.; Osada, H. Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites. Journal of the American Chemical Society 2002, 124, 3496-3497.
214. Hosoe, T.; Okamoto, S.; Nozawa, K.; Kawai, K.-I.; Okada, K.; de Campos-Takaki, G.M.; Fukushima, K.; Miyaji, M. New pentanorlanostane derivatives, cladosporide B-D, as characteristic antifungal agents against Aspergillus fumigatus, isolated from Cladosporium sp. Journal of Antibiotics 2001, 54, 747-750.
215. Chikanishi, T.; Hasumi, K.; Harada, T.; Kawasaki, N.; Endo, A. Clonostachin, a novel peptaibol that inhibits platelet aggregation. Journal of Antibiotics 1997, 50, 105-110.
216. Leclerc, G.; Goulard, C.; Prigent, Y.; Bodo, B.; Wroblewski, H.; Rebuffat, S. Sequences and antimycoplasmic properties of longibrachins LGB II and LGB III, two novel 20-residue peptaibols from Trichoderma longibrachiatum. Journal of Natural Products 2001, 64, 164-170.
217. Ritzau, M.; Heinze, S.; Dornberger, K.; Berg, A.; Fleck, W.; Schlegel, B.; Hartl, A.; Grafe, U. Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI- 0053 with neuroleptic activity in mice. Journal of Antibiotics 1997, 50, 722-728.
218. Hulsmann, H.; Heinze, S.; Ritzau, M.; Schlegel, B.; Grafe, U. Isolation and structure of peptaibolin, a new peptaibol from Sepedonium strains. Journal of Antibiotics 1998, 51, 1055-1058.
219. Berg, A.; Schlegel, B.; Ihn, W.; Demuth, U.; Grafe, U. Isolation and structural elucidation of new peptaibols, bergofungins B, C and D, from Emericellopsis donezkii HKI 0059. Journal of Antibiotics 1999, 52, 666-669.
220. Lee, S.J.; Yun, B.S.; Cho, D.H.; Yoo, I.D. Tylopeptins A and B, new antibiotic peptides from Tylopilus neofelleus. Journal of Antibiotics 1999, 52, 998-1006.
221. Schiell, M.; Hofmann, J.; Kurz, M.; Schmidt, F.R.; Vertesy, L.; Vogel, M.; Wink, J.; Seibert, G. Cephaibols, new peptaibol antibiotics with anthelmintic properties from Acremonium tubakii DSM 12774. Journal of Antibiotics 2001, 54, 220-233.
222. Oh, S.U.; Yun, B.S.; Lee, S.J.; Kim, J.H.; Yoo, I.D. Atroviridins A approximate to C and neoatroviridins A approximate to D, novel peptaibol antibiotics—Produced by Trichoderma atroviride F80317 - I. Taxonomy, fermentation, isolation and biological activities. Journal of Antibiotics 2002, 55, 557-564.
223. Komatsu, K.; Shigemori, H.; Kobayashi, J.i. Dictyonamides A and B, New Peptides from Marine-Derived Fungus. Journal of Organic Chemistry 2001, 66, 6189-6192.
224. Koguchi, Y.; Kohno, J.; Nishio, M.; Takahashi, K.; Okuda, T.; Ohnuki, T.; Komatsubara, S. TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, production, isolation, and biological activities. Journal of Antibiotics 2000, 53, 105-109.
225. Hegde, V.R.; Silver, J.; Patel, M.; Gullo, V.P.; Yarborough, R.; Huang, E.; Das, P.R.; Puar, M.S.; DiDomenico, B.J.; Loebenberg, D. Novel fungal metabolites as cell wall active antifungals: fermentation, isolation, physico-chemical properties, structure and biological activity. Journal of Antibiotics 2001, 54, 74-83.
226. Asai, Y.; Nonaka, N.; Nishio, M.; Okamura, K.; Date, T.; Sugita, T.; Ohnuki, T.; Komatsubara, S. TMC-2A, -2B and -2C, new dipeptidyl peptidase IV inhibitors produced by Aspergillus oryzae A374. II. Isolation and structure determination. Journal of Antibiotics 1997, 50, 653-658.
227. Inokoshi, J.; Shiomi, K.; Masuma, R.; Tanaka, H.; Yamada, H.; Omura, S. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. Journal of Antibiotics 1999, 52, 1095-1100.
228. Komatsu, R.; Shigemori, H.; Mikami, Y.; Kobayashi, J. Sculezonones A and B, two metabolites possessing a phenalenone skeleton from a marine-derived fungus Penicillium species. Journal of Natural Products 2000, 63, 408-409.
229. Laurent, D.; Guella, G.; Mancini, I.; Roquebert, M.F.; Farinole, F.; Pietra, F. A new cytotoxic tetralone derivative from Humicola grisea, a filamentous fungus from wood in the southeastern lagoon of New Caledonia. Tetrahedron 2002, 58, 9163-9167.
230. Soman, A.G.; Gloer, J.B.; Angawi, R.F.; Wicklow, D.T.; Dowd, P.F. Vertilecanins: New phenopicolinic acid analogues from Verticillium lecanii. Journal of Natural Products 2001, 64, 189-192.
231. Dekker, K.A.; Inagaki, T.; Gootz, T.D.; Kaneda, K.; Nomura, E.; Sakakibara, T.; Sakemi, S.; Sugie, Y.; Yamauchi, Y.; Yoshikawa, N.; Kojima, N. CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: fermentation, isolation, structural elucidation and biological activities. Journal of Antibiotics 1997, 50, 833-839.
232. Tsuge, N.; Mori, T.; Hamano, T.; Tanaka, H.; Shin-Ya, K.; Seto, H. Cinnatriacetins A and B, new antibacterial triacetylene derivatives from the fruiting bodies of Fistulina hepatica. Journal of Antibiotics 1999, 52, 578-581.
233. Schlingmann, G.; Milne, L.; Carter, G.T. Isolation and identification of antifungal polyesters from the marine fungus Hypoxylon oceanicum LL-15G256. Tetrahedron 2002, 58, 6825-6835.
234. Hegde, V.R.; Dai, P.; Chu, M.; Patel, M.; Bryant, R.; Terracciano, J.; Das, P.R.; Puar, M.S. Neurokinin receptor inhibitors: Fermentation, isolation, physicochemical properties, structure and biological activity. Journal of Antibiotics 1997, 50, 983-991.
235. Oh, H.; Swenson, D.C.; Gloer, J.B.; Shearer, C.A. Massarilactones A and B: novel secondary metabolites from the freshwater aquatic fungus Massarina tunicata. Tetrahedron Letters 2001, 42, 975-977.
236. Nishihara, Y.; Tsujii, E.; Takase, S.; Tsurumi, Y.; Kino, T.; Hino, M.; Yamashita, M.; Hashimoto, S. FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415: I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation. Journal of Antibiotics 2000, 53, 1333-1340.
237. Tanaka, M.; Nara, F.; Yamasato, Y.; Ono, Y.; Ogita, T. F-11334s, new inhibitors of membrane- bound neutral sphingomyelinase. Journal of Antibiotics 1999, 52, 827-830.
238. Levy, L.M.; Cabrera, G.M.; Wright, J.E.; Seldes, A.M. Indole alkaloids from a culture of the fungus Aporpium caryae. Phytochemistry 2000, 54, 941-943.
239. Nozawa, Y.; Yamamoto, K.; Ito, M.; Sakai, N.; Mizoue, K.; Mizobe, F.; Hanada, K. Stachybotrin C and parvisporin, novel neuritogenic compounds. I. Taxonomy, isolation, physico-chemical and biological properties. Journal of Antibiotics 1997, 50, 635-640.
240. Hasumi, K.; Ohyama, S.; Kohyama, T.; Ohsaki, Y.; Takayasu, R.; Endo, A. Isolation of SMTP-3, 4, 5 and -6, novel analogs of staplabin, and their effects on plasminogen activation and fibrinolysis. Journal of Antibiotics 1998, 51, 1059-1068.
241. Merlini, L.; Nasini, G.; Scaglioni, L.; Cassinelli, G.; Lanzi, C. Secondary mold metabolites: Structure elucidation of clavilactone D: an inhibitor of protein tyrosine kinases. Phytochemistry 2000, 53, 1039-1041.
242. Krohn, K.; Florke, U.; John, M.; Root, N.; Steingrover, K.; Aust, H.J.; Draeger, S.; Schulz, B.; Antus, S.; Simonyi, M.; Zsila, F. Biologically active metabolites from fungi. Part 16: New preussomerins J, K and L from an endophytic fungus: structure elucidation, crystal structure analysis and determination of absolute configuration by CD calculations. Tetrahedron 2001, 57, 4343-4348.
243. Yun, B.-S.; Lee, I.-K.; Kim, J.-P.; Yoo, I.-D. Curtisians A.apprx.D, new free radical scavengers from the mushroom Paxillus curtisii. Journal of Antibiotics 2000, 53, 114-122.
244. Yun, B.S.; Lee, I.K.; Kim, J.P.; Yoo, I.D. Leucomentin-5 and-6, two new Leucomentin derivatives from the mushroom Paxillus panuoides. Journal of Antibiotics 2000, 53, 711-713.
245. Lee, H.J.; Rhee, I.K.; Lee, K.B.; Yoo, I.D.; Song, K.S. Kynapcin-12, a new p-terphenyl derivative from polyozellus multiplex, inhibits prolyl endopeptidase. Journal of Antibiotics 2000, 53, 714-719.
246. Ichikawa, K.; Hirai, H.; Ishiguro, M.; Kambara, T.; Kato, Y.; Kim, Y.J.; Kojima, Y.; Matsunaga, Y.; Nishida, H.; Shiomi, Y.; Yoshikawa, N.; Kojima, N. Novel cytokine production inhibitors produced by a basidiomycete, Marasmiellus sp. Journal of Antibiotics 2001, 54, 703-709.
247. Wagenaar, M.M.; Gibson, D.M.; Clardy, J. Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis. Organic Letters 2002, 4, 671-673.
248. Schmidt, K.; Gunther, W.; Stoyanova, S.; Schubert, B.; Li, Z.Z.; Hamburger, M. Militarinone A, a neurotrophic pyridone alkaloid from Paecilomyces militaris. Organic Letters 2002, 4, 197-199.
249. Stierle, A.A.; Stierle, D.B.; Bugni, T. Sequoiatones C-F, constituents of the redwood endophyte Aspergillus parasiticus. Journal of Natural Products 2001, 64, 1350-1353.
250. Erkel, G.; Rether, J.; Anke, T.; Sterner, O. Trichodion, a new bioactive pyrone from a Trichosporiella species. Journal of Antibiotics 2000, 53, 1401-1404.
251. Arai, M.; Tomoda, H.; Okuda, T.; Wang, H.Y.; Tabata, N.; Masuma, R.; Yamaguchi, Y.; Omura, S. Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromyces flavus FKI-0076. Journal of Antibiotics 2002, 55, 172-180.
252. Amagata, T.; Minoura, K.; Numata, A. Cytotoxic metabolites produced by a fungal strain from a Sargassum alga. Journal of Antibiotics 1998, 51, 432-434.
253. Daferner, M.; Anke, T.; Sterner, O. Zopfiellamides A and B, antimicrobial pyrrolidinone derivatives from the marine fungus Zopfiella latipes. Tetrahedron 2002, 58, 7781-7784.
254. Nakai, R.; Ogawa, H.; Asai, A.; Ando, K.; Agatsuma, T.; Matsumiya, S.; Akinaga, S.; Yamashita, Y.; Mizukami, T. UCS 1025A, a novel antibiotic produced by Acremonium sp. Journal of Antibiotics 2000, 53, 294-296.
255. Sugie, Y.; Hirai, H.; Kachi-Tonai, H.; Kim, Y.-J.; Kojima, Y.; Shiomi, Y.; Sugiura, A.; Sugiura, A.; Suzuki, Y.; Yoshikawa, N.; Brennan, L.; Duignan, J.; Huang, L.H.; Sutcliffe, J.; Kojima, N. New pyrrolizidinone antibiotics CJ-16,264 and CJ-16,367. Journal of Antibiotics 2001, 54, 917-925.
256. Kim, W.-G.; Song, N.-K.; Yoo, I.-D. Quinolactacins A1 and A2, new acetylcholinesterase inhibitors from Penicillium citrinum. Journal of Antibiotics 2001, 54, 831-835.
257. Lee, I.K.; Yun, B.S.; Han, G.; Cho, D.H.; Kim, Y.H.; Yoo, I.D. Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata. Journal of Natural Products 2002, 65, 1769-1772.
258. Kakinuma, N.; Iwai, H.; Takahashi, S.; Hamano, K.; Yanagisawa, T.; Nagai, K.; Tanaka, K.; Suzuki, K.; Kirikae, F.; Kirikae, T.; Nakagawa, A. Quinolactacins A, B and C: novel quinolone compounds from Penicillium sp. EPF-6. I. Taxonomy, production, isolation and biological properties. Journal of Antibiotics 2000, 53, 1247-1251.
259. Lin, Y.; Shao, Z.; Jiang, G.; Zhou, S.; Cai, J.; Vrijmoed, L.L.P.; Gareth Jones, E.B. Penicillazine, a unique quinolone derivative with 4H-5,6-dihydro-1,2- oxazine ring system from the marine fungus Penicillium sp. (Strain 386) from the South China Sea. Tetrahedron 2000, 56, 9607-9609.
260. Uchida, R.; Tomoda, H.; Arai, M.; Omura, S. Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus. Journal of Antibiotics 2001, 54, 882-889.
261. Isaka, M.; Suyarnsestakorn, C.; Tanticharoen, M.; Kongsaeree, P.; ThebtarAnonth, Y. Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus. Journal of Organic Chemistry 2002, 67, 1561-1566.
262. Zhao, A.; Lee, S.H.; Mojena, M.; Jenkins, R.G.; Patrick, D.R.; Huber, H.E.; Goetz, M.A.; Hensens, O.D.; Zink, D.L.; Vilella, D.; Dombrowski, A.W.; Lingham, R.B.; Huang, L. Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK. Journal of Antibiotics 1999, 52, 1086-1094.
263. Hirotani, M.; Sai, K.; Nagai, R.; Hirotani, S.; Takayanagi, H.; Yoshikawa, T. Blazeispirane and protoblazeispirane derivatives from the cultured mycelia of the fungus Agaricus blazei. Phytochemistry 2002, 61, 589-595.
264. Kim, Y.J.; Nishida, H.; Pang, C.H.; Saito, T.; Sakemi, S.; Tonai Kachi, H.; Yoshikawa, N.; VanVolkenburg, M.A.; Parker, J.C.; Kojima, Y. CJ-21,164, a new D-glucose-6-phosphate phosphohydrolase inhibitor produced by a fungus Chloridium sp. Journal of Antibiotics 2002, 55, 121-127.
265. Smith, C.J.; Morin, N.R.; Bills, G.F.; Dombrowski, A.W.; Salituro, G.M.; Smith, S.K.; Zhao, A.; MacNeil, D.J. Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPYY5 receptor. Journal of Organic Chemistry 2002, 67, 5001-5004.
266. McMorris, T.C.; Lira, R.; Gantzel, P.K.; Kelner, M.J.; Dawe, R. Sesquiterpenes from the basidiomycete Omphalotus illudens. Journal of Natural Products 2000, 63, 1557-1559.
267. Che, Y.S.; Gloer, J.B.; Wicklow, D.T. Phomadecalins A-D and phomapentenone A: New bioactive metabolites from Phoma sp NRRL 25697, a fungal colonist of Hypoxylon stromata. Journal of Natural Products 2002, 65, 399-402.
268. Momose, I.; Sekizawa, R.; Hosokawa, N.; Iinuma, H.; Matsui, S.; Nakamura, H.; Naganawa, H.; Hamada, M.; Takeuchi, T. Melleolides K, L and M, new melleolides from Armillariella mellea. Journal of Antibiotics 2000, 53, 137-143.
269. Dorfelt, H.; Schlegel, B.; Grafe, U. Dictyopanines A, B and C, new bicyclic sesquiterpene esters from Dictyopanus sp. HKI 0181. Journal of Antibiotics 2000, 53, 839-843.
270. Cabrera, G.M.; Roberti, M.J.; Wright, J.E.; Seldes, A.M. Cryptoporic and isocryptoporic acids from the fungal cultures of Polyporus arcularius and P-ciliatus. Phytochemistry 2002, 61, 189-193.
271. Eilbert, F.; Engler Lohr, M.; Anke, H.; Sterner, O. Bioactive sesquiterpenes from the basidiomycete Resupinatus leightonii. Journal of Natural Products 2000, 63, 1286-1287.
272. Castronovo, F.; Clericuzio, M.; Toma, L.; Vidari, G. Fungal metabolites. Part 45: The sesquiterpenes of Collybia maculata and Collybia peronata. Tetrahedron 2001, 57, 2791-2798.
273. Cueto, M.; Jensen, P.R.; Fenical, W. Aspergilloxide, a novel sesterterpene epoxide from a marine-derived fungus of the genus Aspergillus. Organic Letters 2002, 4, 1583-1585.
274. Renner, M.K.; Jensen, P.R.; Fenical, W. Mangicols: Structures and biosynthesis of a new class of sesterterpene polyols from a marine fungus of the genus Fusarium. Journal of Organic Chemistry 2000, 65, 4843-4852.
275. Wang, Y.; Dreyfuss, M.; Ponelle, M.; Oberer, L.; Riezman, H. A glycosylphosphatidylinositol- anchoring inhibitor with an unusual tetracarbocyclic sesterterpene skeleton from the fungus Codinaea simplex. Tetrahedron 1998, 54, 6415-6426.
276. Alvi, K.A.; Nair, B.G.; Rabenstein, J.; Davis, G.; Baker, D.D. CD45 tyrosine phosphatase inhibitory components from Aspergillus niger. Journal of Antibiotics 2000, 53, 110-113.
277. Masuoka, Y.; Shin-Ya, K.; Furihata, K.; Hayakawa, Y.; Seto, H. A novel substance with TGF-.beta. like activity, diheteropeptin, produced by a fungus, Diheterospora sp. Journal of Antibiotics 1997, 50, 1058-1060.
278. Amagata, T.; Usami, Y.; Minoura, K.; Ito, T.; Numata, A. Cytotoxic substances produced by a fungal strain from a sponge: physico-chemical properties and structures. Journal of Antibiotics 1998, 51, 33-40.
279. Otsuka, T.; Muramatsu, Y.; Higaki, T.; Nakanishi, T.; Takase, S.; Hatanaka, H.; Okamoto, M.; Hino, M.; Hashimoto, S. WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp. I. Taxonomy, production, purification and structure elucidation. Journal of Antibiotics 1999, 52, 536-541.
280. Anon, CRM-51005, a new phospholipase C inhibitor produced by unidentified fungal strain MT51005. Journal of Antibiotics 1997, 50, 1083-1085.
281. Otsuka, T.; Muramatsu, Y.; Nakanishi, T.; Hatanaka, H.; Okamoto, M.; Hino, M.; Hashimoto, S. WF14865A and B, new cathepsins B and L inhibitors produced by Aphanoascus fulvescens. I. Taxonomy, production, purification and biological properties. Journal of Antibiotics 2000, 53, 449-458.
282. Lateff, A.; Konig, G.M.; Fisch, K.M.; Holler, U.; Jones, P.G.; Wright, A.D. New antioxidant hydroquinone derivatives from the algicolous marine fungus Acremonium sp. Journal of Natural Products 2002, 65, 1605-1611.
283. Kinsman, O.S.; Chalk, P.A.; Jackson, H.C.; Middleton, R.F.; Shuttleworth, A.; Rudd, B.A.M.; Jones, C.A.; Noble, H.M.; Wildman, H.G.; Dawson, M.J.; Stylli, C.; Sidebottom, P.J.; Lamont, B.; Lynn, S.; Hayes, M.V. Isolation and characterization of an antifungal antibiotic (GR 135402) with protein synthesis inhibition. Journal of Antibiotics 1998, 51, 41-49.
284. Okada, H.; Kamiya, S.; Shina, Y.; Suwa, H.; Nagashima, M.; Nakajima, S.; Shimokawa, H.; Sugiyama, E.; Kondo, H.; Kojiri, K.; Suda, H. BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum I. Description of producing organism, fermentation, isolation, physicochemical and biological properties. Journal of Antibiotics 1998, 51, 1081-1086.
285. Quang, D.N.; Hashimoto, T.; Tanaka, M.; Baumgartner, M.; Stadler, M.; Asakawa, Y. Concentriols B, C and D, three squalene-type triterpenoids from the ascomycete Daldinia concentrica. Phytochemistry 2002, 61, 345-353.
286. Daferner, M.; Anke, T.; Hellwig, V.; Steglich, W.; Sterner, O. Strobilurin M, tetrachloropyrocatechol and tetrachloropyrocatechol methyl ether: new antibiotics from a Mycena species. Journal of Antibiotics 1998, 51, 816-822.
287. Hosokawa, N.; Momose, I.; Sekizawa, R.; Naganawa, H.; Iinuma, H.; Takeuchi, T.; Matsui, S. New strobilurins O and P from a mushroom. Journal of Antibiotics 2000, 53, 297-300.
288. Mizushina, Y.; Takahashi, N.; Hanashima, L.; Koshino, H.; Esumi, Y.; Uzawa, J.; Sugawara, F.; Sakaguchi, K. Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. Bioorganic and Medicinal Chemistry 1999, 7, 2047-2052.
289. Brady, S.F.; Singh, M.P.; Janso, J.E.; Clardy, S. Guanacastepene, a fungal-derived diterpene antibiotic with a new carbon skeleton. Journal of the American Chemical Society 2000, 122, 2116-2117.
290. Vertesy, L.; Kogler, H.; Markus, A.; Schiell, M.; Vogel, M.; Wink, J. Memnopeptide A, a novel terpene peptide from Memnoniella with an activating effect on SERCA2. Journal of Antibiotics 2001, 54, 771-782.
291. Kamigauchi, T.; Sakazaki, R.; Nagashima, K.; Kawamura, Y.; Yasuda, Y.; Matsushima, K.; Tani, H.; Takahashi, Y.; Ishii, K.; Suzuki, R.; Koizumi, K.; Nakai, H.; Ikenishi, Y.; Terui, Y. Terprenins, novel immunosuppressants produced by Aspergillus candidus. Journal of Antibiotics 1998, 51, 445-450.
292. Stead, P.; Affleck, K.; Sidebottom, P.J.; Taylor, N.L.; Drake, C.S.; Todd, M.; Jowett, A.; Webb, G. Isolation and characterization of a prenylated p-terphenyl metabolite of Aspergillus candidus possessing potent and selective cytotoxic activity; studies on mechanism of action. Journal of Antibiotics 1999, 52, 89-95.
293. Lee, H.J.; Lee, J.H.; Hwang, B.Y.; Kim, H.S.; Lee, J.J. Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. Journal of Antibiotics 2002, 55, 552-556.
294. Geraci, C.; Neri, P.; Paterno, C.; Rocco, C.; Tringali, C. An unusual nitrogenous terphenyl derivative from fruiting bodies of the basidiomycete Sarcodon leucopus. Journal of Natural Products 2000, 63, 347-351.
295. Wagenaar, M.M.; Clardy, J. Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint. Journal of Natural Products 2001, 64, 1006-1009.
296. Li, J.Y.; Strobel, G.; Harper, J.; Lobkovsky, E.; Clardy, J. Cryptocin, a potent tetramic acid antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Organic Letters 2000, 2, 767-770.
297. Osterhage, C.; Kaminsky, R.; Konig, G.M.; Wright, A.D. Ascosalipyrrolidinone A, an antimicrobial alkaloid, from the obligate marine fungus Ascochyta salicorniae. Journal of Organic Chemistry 2000, 65, 6412-6417.
298. Suzuki, S.; Hosoe, T.; Nozawa, K.; Kawai, K.; Yaguchi, T.; Udagawa, S. Antifungal substances against pathogenic fungi, talaroconvolutins, from Talaromyces convolutus. Journal of Natural Products 2000, 63, 768-772.
299. Kakeya, H.; Kageyama, S.-I.; Nie, L.; Onose, R.; Okada, G.; Beppu, T.; Norbury, C.J.; Osada, H. Lucilactaene, a new cell cycle inhibition in p53-transfected cancer cells, produced by a Fusarium sp. Journal of Antibiotics 2001, 54, 850-854.
300. Michael, A.P.; Grace, E.J.; Kotiw, M.; Barrow, R.A. Ravenic acid, a new tetramic acid isolated from a cultured microfungus, Penicillium sp. Journal of Natural Products 2002, 65, 1360-1362.
301. Eilbert, F.; Thines, E.; Arendholz, W.R.; Sterner, O.; Anke, H. Fusarin C, (7Z)-fusarin C and (5Z)-fusarin C; inhibitors of dihydroxynaphthalene-melanin biosynthesis from Nectria coccinea (Cylindrocarpon sp.). Journal of Antibiotics 1997, 50, 443-445.
302. Sugawara, T.; Tanaka, A.; Nagai, K.; Suzuki, K.; Okada, G. New members of the trichothecene family. Journal of Antibiotics 1997, 50, 778-780.
303. Wagenaar, M.M.; Clardy, J. Two new roridins isolated from Myrothecium sp. Journal of Antibiotics 2001, 54, 517-520.
304. Murakamo, Y.; Okuda, T.; Shindo, K. Roridin L, M and verrucarin M, new macrocyclic trichothecene group antitumor antibiotics, from Myrothecium verrucaria. Journal of Antibiotics 2001, 54, 980-983.
305. Honda, Y.; Ueki, M.; Okada, G.; Onose, R.; Usami, R.; Horikoshi, K.; Osada, H. Isolation, and biological properties of a new cell cycle inhibitor, curvularol, isolated from Curvularia sp. RK97-F166. Journal of Antibiotics 2001, 54, 10-16.
306. Guo, B.Y.; Dai, J.R.; Ng, S.; Huang, Y.C.; Leong, C.Y.; Ong, W.; Carte, B.K. Cytonic acids A and B: Novel tridepside inhibitors of hCMV protease from the endophytic fungus Cytonaema species. Journal of Natural Products 2000, 63, 602-604.
307. Zou, W.X.; Meng, J.C.; Lu, H.; Chen, G.X.; Shi, G.X.; Zhang, T.Y.; Tan, R.X. Metabolites of Colletotrichum gloesporioides, an endophytic fungus in Artemisia mongolica. Journal of Natural Products 2000, 63, 1529-1530.
308. Toske, S.G.; Jensen, P.R.; Kauffman, C.A.; Fenical, W. Aspergillamides A and B: modified cytotoxic tripeptides produced by a marine fungus of the genus Aspergillus. Tetrahedron 1998, 54, 13459-13466.
309. Kohyama, T.; Hasumi, K.; Hamanaka, A.; Endo, A. SMTP-1 and -2, novel analogs of staplabin produced by Stachybotrys microspora IFO30018. Journal of Antibiotics 1997, 50, 172-174.
310. Suzuki, K.; Kuwahara, A.; Yoshida, H.; Fujita, S.; Nishikiori, T.; Nakagawa, T. NF00659A1, A2, A3, B1 and B2, novel antitumor antibiotics produced by Aspergillus sp. NF 00659. I. Taxonomy, fermentation, isolation and biological activities. Journal of Antibiotics 1997, 50, 314-317.
311. Sato, T.; Hanada, T.; Arioka, M.; Ando, K.; Sugiyama, J.; Uramoto, M.; Yamasaki, M.; Kitamoto, K. S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans. I. Producing strain, fermentation, isolation and biological activity. Journal of Antibiotics 1998, 51, 897-901.
312. Sato, T.; Hanada, T.; Arioka, M.; Morita, T.-I.; Koshino, H.; Uramoto, M.; Yamasaki, M.; Kitamoto, K. S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans. II. Structure elucidation. Journal of Antibiotics 1998, 51, 1047-1050.
313. Rosecke, J.; Konig, W.A. Constituents of the fungi Daedalea quercina and Daedaleopsis confragosa var. tricolor. Phytochemistry 2000, 54, 757-762.
314. Igarashi, Y.; Sekine, A.; Fukazawa, H.; Uehara, Y.; Yamaguchi, K.; Endo, Y.; Okudo, T.; Furumai, T.; Oki, T. Anicequol, a novel inhibitor for anchorage-independent growth of tumor cells from Penicillium aurantiogriseum Dierckx TP-F0213. Journal of Antibiotics 2002, 55, 371-376.
315. Joshi, B.K.; Gloer, J.B.; Wicklow, D.T. Bioactive natural products from a sclerotium-colonizing isolate of Humicola fuscoatra. Journal of Natural Products 2002, 65, 1734-1737.
316. Seephonkai, P.; Isaka, M.; Kittakoop, P.; Trakulnaleamsai, S.; Rattanajak, R.; Tanticharoen, M.; ThebtarAnonth, Y. A new tropolone from the insect pathogenic fungus Cordyceps sp BCC 1681. Journal of Antibiotics 2001, 54, 751-752.
317. Nose, H.; Seki, A.; Yaguchi, T.; Hosoya, A.; Sasaki, T.; Hoshiko, S.; Shomura, T. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities. Journal of Antibiotics 2000, 53, 33-37.
318. Isaka, M.; Jaturapat, A.; Rukseree, K.; Danwisetkanjana, K.; Tanticharoen, M.; ThebtarAnonth, Y. Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. Journal of Natural Products 2001, 64, 1015-1018.