Clonostachin, a novel peptaibol that inhibits platelet aggregation

Journal of Antibiotics

Volumn 50, Issue 2, 1997, Pages 105-110

  Chikanishi, Toshihiro ^a   Hasumi, Keiji ^a   Harada, Tomotaka ^a   Kawasaki, Nobuhide ^a   Endo, Akira ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; CLONOSTACHIN; SILICA GEL; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; FERMENTATION; GEL CHROMATOGRAPHY; HUMAN; HUMAN CELL; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TAXONOMY; THROMBOCYTE; THROMBOCYTE AGGREGATION INHIBITION;

EID: 0030973663     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.105     Document Type: Article

References (8)

1. PANDEY, R. C.; J. C. COOK & K. L. RINEHART, Jr.: High resolution and field desorption mass spectrometry studies and revised structures of alamethicins I and II. J. Am. Chem. Soc. 99: 8469-8483, 1977
2. ANDO, S.; T. ARIGA & T. YAMAKAWA: Identification of stereoisomers of methyl hexopyranosides by mass spectrometry of their trifluoroacetates. Bull. Chem. Soc. Jpn. 49: 1335-1339, 1976
3. ZUCKER, M. B.: Platelet aggregation measured by the photometric method. Methods Enzymol. 169: 117-133, 1989
4. BORN, G. V. R.: Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 169: 927-929, 1962
5. TUBAKI, K.: Notes on the Japanese hyphomycetes. I. Chloridium, Clonostachys, Ishmospora, Psuedobotrytis, Stachybotrys and Stephanoma. Trans. Mycol. Soc. Japan 4: 83-90, 1963
6. SAMANEN, J.; F. ALI, T. ROMOFF, R. CALVO, E. SORENSON, J. VASKO, B. STORER, D. POWERS, J. STADEL & A. NICHOLS: Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro. J. Med. Chem. 34: 3114-3125, 1991
7. NICHOLSON, N. S.; S. G. PANZER-KNODLE, A. K. SALYERS, B. B. TAITE, L. W. KING, M. MIYANO, R. J. GORCZYNSKI, M. H. WILLIAMS, M. E. ZUPEC, F. S. TJOENG, S. P. ADAMS & L. P. FEIGEN: In vitro and in vivo effects of a peptide mimetic (SC-47643) of RGD as an antiplatelet and antithrombotic agent. Thromb. Res. 62: 567-578, 1991
8. 3, the fibrinogen receptor. Proc. Soc. Exp. Biol. Med. 208: 346-360, 1995