Cytotoxic substances produced by a fungal strain from a sponge: Physico-chemical properties and structures

Journal of Antibiotics

Volumn 51, Issue 1, 1998, Pages 33-40

  Amagata, Taro ^a   Usami, Yoshihide ^a   Minoura, Katsuhiko ^a   Ito, Tadayoshi ^b   Numata, Atsushi ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b Institute for Fermentation Osaka   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC AGENT; HARZIALACTONE A; HARZIALACTONE B; MEVALONOLACTONE; TRICHODENONE A; TRICHODENONE B; TRICHODENONE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; FUNGUS; FUNGUS CULTURE; LEUKEMIA P 388; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SPONGE; TRICHODERMA;

EID: 0031891808     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.51.33     Document Type: Article

References (21)

1. NUMATA, A.; C. TAKAHASHI, T. MATSUSHITA, T. MIYAMOTO, K. KAWAI, Y. USAMI, M. INOUE, H. OHISHI & T. SHINGU: Fumiquinazolines, novel metabolites of a fungus isolated from a saltfish. Tetrahedron Lett. 33: 1621-1624, 1992
2. TAKAHASHI, C.; T. MATSUSHITA, M. DOI, K. MINOURA, T. SHINGU, Y. KUMEDA & A. NUMATA: Fumiquinazolines A-G, novel metabolites of a fungus separated from a Pseudolabrus marine fish. J. Chem. Soc., Perkin Trans. 1: 2345-2353, 1995
3. TAKAHASHI, C.; T. TAKADA, T. YAMADA, K. MINOURA, K. UCHIDA, E. MATSUMURA & A. NUMATA: Halichomycin, a new class of potent cytotoxic macrolide produced by an actinomycete from a marine fish. Tetrahedron Lett. 35: 5013-5014, 1994
4. NUMATA, A.; C. TAKAHASHI, Y. ITO, T. TAKADA, K. KAWAI, Y. USAMI, E. MATSUMURA, M. IMACHI, T. ITO & T. HASEGAWA: Communesins, cytotoxic metabolites of a fungus isolated from a marine alga. Tetrahedron Lett. 34: 2355-2358, 1993
5. NUMATA, A.; C. TAKAHASHI, Y. ITO, K. MINOURA, T. YAMADA, C. MATSUDA & K. NOMOTO: Penochalasins, a novel class of cytotoxic cytochalasans from a Penicillium species separated from a marine alga: Structure determination and solution conformation. J. Chem. Soc., Perkin Trans 1: 239-245, 1996
6. TAKAHASHI, C.; A. NUMATA, T. YAMADA, K. MINOURA, S. ENOMOTO, K. KONISHI, M. NAKAI, C. MATSUDA & K. NOMOTO: Penostatins, novel cytotoxic metabolites from a Penicillium species separated from a green alga. Tetrahedron Lett. 37: 655-658, 1996
7. TAKAHASHI, C.; A. NUMATA, Y. ITO, E. MATSUMURA, H. ARAKI, H. IWAKI & K. KUSHIDA: Leptosins, antitumour metabolites of a fungus isolated from a marine alga. J. Chem. Soc., Perkin Trans. 1: 1859-1864, 1994
8. TAKAHASHI, C.; A. NUMATA, E. MATSUMURA, K. MINOURA, H. ETO, T. SHINGU, T. ITO & T. HASEGAWA: Leptosins I and J, cytotoxic substances produced by a Leptoshaeria sp. J. Antibiot. 47: 1242-1249, 1994
9. TAKAHASHI, C.; K. MINOLIRA, T. YAMADA, A. NUMATA, K. KUSHIDA, T. SHINGU, S. HAGISHITA, H. NAKAI, T. SATO & H. HARADA: Potent cytotoxic metabolites from a Leptosphaeria species. Structure determination and conformational analysis. Tetrahedron 51: 3483-3498, 1995
10. TAKAHASHI, C.; Y. TAKAI, Y. KIMURA, A. NUMATA, N. SHIGEMATSU & H. TANAKA: Cytotoxic metabolites from a fungal adherent of a marine alga. Phytochemistry 38: 155-158, 1995
11. NUMATA, A.; P. YANG, C. TAKAHASHI, R. FUJIKI, M. NABAE & E. FUJITA: Cytotoxic triterpenes from a Chinese medicine, goreishi. Chem. Pharm. Bull. 37: 648-651, 1989
12. MORI, K. & K. OKADA: Synthesis of mevalonolactone (hiochic acid lactone) employing asymmetric epoxidation as the key-step. Tetrahedron 41: 557-559, 1985
13. MASH, E. A. & J. B. ARTERBURN: Enatiomerically pure \ acetals in organic synthesis. 3. A synthesis of (R)-mevalonic acid lactone. J. Org. Chem. 56: 885-888, 1991
14. PRETSCH, E.; T. CLERC, J. SEIBL & W. SIMON: In Tabellen zur Strukturaufklarung organischer Verbindungen mit spectroskopischen Methoden. Japanese version (Transl. K. NAKANISHI et al.), p. 146, KS, Tokyo, 1982
15. 1H FTNMR Spectra, Edition 1, Vol. 1, pp. 666-669, 673, 713, 715, Aldrich Chemical Company, 1993
16. NUMATA, A.; T. AMAGATA, K. MINOURA & T. ITO: Gymnastatins, novel cytotoxic metabolites produced by a fungal strain from a sponge. Tetrahedron Lett. 32: 5675-5678, 1997
17. HIGA, T.: 2-(1-Chloro-2-hydroxyethyl)-4,4-dimethylcyclohexa-2,5-dione: A precursor of 4,5-dimethylbenzo[b]-furan from the red alga Desmia hornemanni. Tetrahedron Lett. 26: 2335-2336, 1985
18. FUJIMOTO, Y.; K. OKAMURA, T. UKITA, H. MIYAGAWA, K. NISHIMURA, T. UENO, T. TSURUSHIMA & H. IRIE : Structure and synthesis of antafumicins A and B, novel antifungal substances produced by Aspergillus niger NH-401. 35th Symposium on the Chemistry of Natural Products, Symposium Papers, pp. 662-669, 1993
19. FUJIMOTO, Y.; H. MIYAGAWA, T. TSURUSHIMA, H. IRIE, K. OKAMURA & T. UENO: Structures of antafumicins A and B, novel antifungal substances produced by the fungus Aspergillus niger NH-401. Biosci. Biotech. Biochem. 57: 1222-1224, 1993
20. OHTANI, I.; T. KUSUMI, Y. KASHMAN & H. KAKISAWA: High-field FT NMR application of Mosher's method. Absolute configurations of marine terpenoids. J. Am. Chem. Soc. 113: 4092-4096, 1991
21. DUH, C.-Y.; J. M. PEZZUTO, A. D. KINGHORN, S. L. LEUNG & N. R. FARNSWORTH: Plant anticancer agents XLIV. Cytotoxic constituents from Stizophyllum riparium. J. Nat. Prod. 50: 63-74, 1987