Production, isolation and biological properties of TMC-120A, B and C, novel inhibitors of eosinophil survival from Aspergillus ustus TC 1118

Journal of Antibiotics

Volumn 52, Issue 10, 1999, Pages 913-916

  Kohno, Jun ^a   Sakurai, Masaaki ^a   Kameda, Noriaki ^a   Nishio, Maki ^a   Kawano, Kimio ^a   Kishi, Noboru ^a   Okuda, Toru ^a   Komatsubara, Saburo ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; DRUG DERIVATIVE; TMC 120A; TMC 120B; TMC 120C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASPERGILLUS; CELL SURVIVAL; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EOSINOPHIL; GUINEA PIG; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL;

ASPERGILLUS USTUS;

EID: 0032712036     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.52.913     Document Type: Article

References (6)

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4. ROTHENBERG, M. E.; W. F. OWEN, Jr., D. S. SILBERSTEIN, J. WOODS, R. J. SOBERMAN, K. F. AUSTEN & R. L. STEVENS: Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J. Clin. Invest. 81: 1986-1992, 1988
5. YAMAGUCHI, Y.; T. SUDA, S. OHTA, K. TOMINAGA, Y. MIURA & T. KASAHARA: Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. Blood 78: 2542-2547, 1991
6. KOHNO, J.; H. HIRAMATSU, M. NISHIO, M. SAKURAI, T. OKUDA & S. KOMATSUBARA: Structures of TMC-120A, B and C, novel isoquinoline alkaloids from Aspergillus ustus TC 1118. Tetrahedron 55: 11247-11252, 1999