TMC-205 a new transcriptional up-regulator of SV40 promoter produced by an unidentified fungus. Fermentation, isolation, physico-chemical properties, structure determination and biological activities

Journal of Antibiotics

Volumn 54, Issue 8, 2001, Pages 628-634

  Sakurai, M ^a   Kohno, J ^a   Nishio, M ^a   Yamamoto, K ^a   Okuda, T ^a   Kawano, K ^a   Nakanishi, N ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; LUCIFERASE; TMC 205; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; ENHANCER REGION; ENZYME ACTIVATION; FERMENTATION; FUNGUS; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTON NUCLEAR MAGNETIC RESONANCE; REPORTER GENE; SIMIAN VIRUS 40; TRANSCRIPTION REGULATION; TUMOR CELL LINE;

EID: 0034831029     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.628     Document Type: Article

References (12)

1. Activation of the AP-1 transcription factor by arabinofuranosyl- cytosine in myeloid leukemia cells
2. Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites
3. FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor
4. Trans-acting protein factors and the regulation of eukaryotic transcription: Lessons from studies on DNA tumor virus
5. Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions
6. Tumor selectivity and transcriptional activation by Azelaic bishydroxamic acid in human melanocytic cells
7. FR901228, A novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity
8. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination
9. FR901228, A novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice
10. New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
11. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action
12. A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet