Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation

Journal of Antibiotics

Volumn 51, Issue 3, 1998, Pages 296-302

  Abbanat, D ^a   Leighton, M ^a   Maiese, W ^a   Jones, E B G ^b   Pearce, C ^a,c   Greenstein, M ^a  

^a PFIZER INC   (United States)

^b CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^c OSI Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15G256ALPHA; 15G256BETA; 15G256GAMMA; ANTIFUNGAL AGENT; DEPSIPEPTIDE; LIPODEPSIPEPTIDE; MACROLIDE; SEA WATER; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CELL WALL; FERMENTATION; FUNGUS; NONHUMAN; PRIORITY JOURNAL; TAXONOMY; TEMPERATURE;

HYPOXYLON OCEANICUM;

EID: 0031900772     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.51.296     Document Type: Article

References (22)

1. KIRSCH, D. & M. LAI: A modified screen for the detection of cell wall acting antifungal compounds. J. Antibiotics 39(11): 1620-1622, 1986
2. SCHLINGMANN, G.; L. MILNE, D. R. WILLIAMS & G. T. CARTER: Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. II. Isolation and structure determination. J. Antibiotics 51: 303-316, 1998
3. EDWARDS, R. L.; D. J. MAITLAND & A. J. WHALLEY: Metabolites of the higher fungi. Part 24. Cytochalasin N, O, P, Q, and R. New cytochalasins from the fungus Hypoxylon terricola Mill. J. Chem. Soc., Perkin Trans. 1(1): 57-65, 1989
4. EDWARDS, R. L & A. J. WHALLEY: Metabolites of the higher fungi. Part 18. 3-Butyl-4-methylfuran-2(5H)-one and 3-butyl-4-methylenefuran-2(5H)-one. New γ-buty-rolactones from the fungus Hypoxylon serpens (Persoon ex Fries) Kickx. J. Chem. Soc., Perkin Trans. 1(3): 803-806, 1979
5. ANDERSON, J. R.; E. L. RAYMOND & A. J. WHALLEY: Metabolites of the higher fungi. Part 19. Serpenone, 3-methoxy-4-methyl-5-prop-1-enylfuran-2(5H)-one, a new γ-butyrolactone from the fungus Hypoxylon serpens (Barrons strain) (Persoon ex Fries) Kickx. J. Chem. Soc., Perkin Trans. 1(1): 215-221, 1982
6. ANDERSON, J. R.; E. L. RAYMOND & A. J. WHALLEY: Metabolites of the higher fungi. Part 21. 3-Methyl-3,4-dihydroisocoumarins and related compounds from the ascomycete family Xylariaceae. J. Chem. Soc., Perkin Trans. 1(9): 2185-2192, 1983
7. BORGSCHULTE, K.; S. REBUFFAT, W. TROWITZSCHKIENAST, D. SCHOMBURG, J. PINON & B. BODO: Isolation and structure elucidation of hymatoxins B∼E and other phytotoxins from Hypoxylon mammalian fungal pathogen of leuce poplars. Tetrahedron 47(39): 8351-8360, 1991
8. BODO, B.; R. G. TIH, D. DAVOUST & H. JACQUEMIN: Hypoxylone, a naphthylnaphthoquinone pigment from the fungus Hypoxylon sclerophaeum. Phytochemistry 22(11): 2579-2581, 1983
9. URAMOTO, M.; Y. ITOH, R. SEKIGUCHI, K. SHIN-YA, H. KUSAKABE & K. ISONO: A new antifungal antibiotic, cystargin: Fermentation, isolation, and characterization. J. Antibiotics 41(12): 1763-1768, 1988
10. DEBONO, M.: The echinocandins: Fungicides targeted to the fungal cell wall. Expert Opin. Invest. Drugs 3(8): 821-829, 1994
11. ISONO, K. & S. SABURO: The polyoxins: pyrimidine nucleoside peptide antibiotics inhibiting fungal cell wall biosynthesis. Heterocycles 13: 333-351, 1979
12. DAEHN, U.; H. HOEHNE, W. A. KOENIG, G. WOLF & H. ZAEHNER: Metabolic products of microorganisms. Part 154. Nikkomycin, a new inhibitor of fungal chitin synthesis. Arch. Microbiol. 107(2): 143-160, 1976
13. ALBAUGH, D.; G. ALBERT, P. BRADFORD, V. COTTER, J. FROYD, J. GAUGHRAN, D. KIRSCH, M. LAI, A. REHNIG, E. SIEVERDING & S. SILVERMAN: Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. III. Biological Properties of 15G256γ. J. Antibiotics 51: 317-322, 1998
14. SCHATZ, S.; Hypoxylon oceanicum, new species from mangroves: Mycotaxon 33: 413-418, 1988
15. JU, YU-MING: Studies of Xylariaceae from Taiwan. M. S. Thesis, Washington State University. Pullman, Washington, U.S.A. 1990
16. BREINHOLT, J.; G. W. JENSEN, R. I. NIELSEN, C. E. OLSEN & J. C. FRISVAD: Antifungal macrocyclic polylactones from Penicillium verruculosum. J. Antibiotics 46(7): 1101-1108, 1993
17. SCHLINGMANN, G.; L. MILNE, C. J. PEARCE, E. B. G. JONES & D. A. ALBAUGH: Novel fungicidal agents 15G256γ, δ and ε produced by LL-15G256 (Hypoxylon oceanicum). Patent application; US 460331 (June 02, 1995), EP 0 745 680 (April 12, 1996)
18. VIJAYAKUMAR, E. K.; K. ROY, S. CHATTERJEE, S. K. DESHMUNKH, B. N. GANULI, H. W. FEHLABER & H. KOGLER: Arthrichitin. A new cell wall active metabolite from Arthrinium phaeospermum. J. Org. Chem. 61(19): 6591-6593, 1996
19. JONES, E. B. G.: Tropical Marine Fungi. In Aspects of Tropical Mycology. Ed., S. ISAAC et al., pp. 73-89. Cambridge University Press, Cambridge, UK., 1993
20. TAN, T. K.; C. L. TENG & E. B. G. JONES: Substrate type and microbiological interactions as factors affecting ascocarp formation by mangrove fungi. Hydrobiologia 295: 127-134, 1994
21. POINTING, S. B.; L. L. P. VRIJMOED & E. B. G. JONES: Screening of mangrove fungi for Lignocellulose degrading enzymes with biotechnology potential. J. Marine Biotechnology 1997. In press
22. POINTING, S. B.; L. L. P. VRIJMOED & E. B. G. JONES: A quantitative assessment of lignocellulose degrading enzymes in selected marine fungi. Biotanica Marina 1997. In press