A family of depsi-peptide fungal metabolites, as selective and competitive human tachykinin receptor (NK2) antagonists: Fermentation, isolation, physico-chemical properties, and biological activity

Journal of Antibiotics

Volumn 54, Issue 2, 2001, Pages 125-135

  Hegde, V R ^a   Puar, M S ^a   Dai, P ^a   Pu, H ^a   Patel, M ^a   Anthes, J C ^a   Richard, C ^a   Terracciano, J ^a   Das, P R ^a   Gullo, V ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID ETHYL ESTER; AMINO ACID DERIVATIVE; CALCIUM ION; DEPSIPEPTIDE; GLYCEROL; GLYCINE DERIVATIVE; HYDROXYACID; LEUCINE; METHANOL; METHIONINE DERIVATIVE; NATURAL PRODUCT; NEUROKININ A; NEUROKININ B; ORGANIC COMPOUND; PEPTONE; PHENYLALANINE DERIVATIVE; PIPECOLIC ACID; POTASSIUM DIHYDROGEN PHOSPHATE; PROLINE; SCH 217048; SCH 378161; SCH 378167; SCH 378199; SODIUM CHLORIDE; SODIUM SULFATE; SUBSTANCE P; TACHYKININ; TACHYKININ RECEPTOR; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHO CELL; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVITY; DRUG DEGRADATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; FERMENTATION; FRACTIONATION; FUNGUS CULTURE; FUNGUS IDENTIFICATION; GEL FILTRATION CHROMATOGRAPHY; METABOLITE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPECTROSCOPY; STRUCTURE ANALYSIS; TAXONOMY;

EID: 0035079996     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.125     Document Type: Article

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