Nodulisporic acid B, B1, and B2: A series of 1′-deoxy-nodulisporic acids from Nodulisporium sp.

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 20, 2002, Pages 2941-2944

  Ondeyka, John G ^a   Dahl Roshak, Arlene M ^a   Tkacz, Jan S ^a   Zink, Deborah L ^a   Zakson Aiken, Michelle ^a   Shoop, Wesley L ^a   Goetz, Michael A ^a   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1' DEOXYNODULISPORIC ACID; ESTER DERIVATIVE; INSECTICIDE; LEAD; METHYL ESTER; NODULISPORIC ACID A; NODULISPORIC ACID B; SODIUM; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG ISOLATION; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG TARGETING; FLEA; FUNGUS; NODULISPORIUM; STRUCTURE ANALYSIS;

ANIMALS; ASCOMYCOTA; CHROMATOGRAPHY, ION EXCHANGE; FLEAS; INDOLES; INSECTICIDES; IVERMECTIN; MAGNETIC RESONANCE SPECTROSCOPY; MUTATION; STEREOISOMERISM;

NODULISPORIUM; SIPHONAPTERA (FLEAS);

EID: 0037152533     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00621-2     Document Type: Article

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11. -1.
12. 3), 47.3 (C-8), 45.3 (C-13), 45.0 (C-4), 44.2 (C-9), 42.9 (C-12), 31.7 (C-32), 30.8 (C-5), 30.1 (C-34), 29.9 (C-1′), 29.6 (C-31), 27.5 (C-11), 26.4 (C-6), 23.1 (C-10), 22.9 (C-33), 19.5 (C-5′), 19.3 (C-29), 15.9 (C-28), 12.9 (C-6″), 11.7 (C-30).
13. 2, 500 MHz) δ 7.4 (1H, s, H-16), 7.22 (1H, d, J=11.1 Hz, H-3″), 6.43 (1H, dd, 1.1, 15.5 Hz, H-2″), 6.35 (1H, s, H-19), 5.92 (1H, d, 15.5 Hz, H-1″), 5.3 (1H, m, H-2′), 6.52 (1H, s, H-24), 4.85 (1H, s, H-4′), 4.75 (1H, s, H-4′), 3.75 (3H, s, OCH3), 3.6 (1H, m, H-13), 3.4 (1H, m, H-7), 4.05 (1H, dd J=8.2, 16.4 Hz, H-1′), 3.52 (1H, d J=16.4 Hz, H-1′), 2.7 (1H, m, H-12), 2.25 (1H, dd J=10.5, 13.2 Hz, H-13), 2.6 (1H, dd J=6.6, 13.2 Hz, H-13), 1.2 (2H, m, H-5), 1.95 (3H, s, H-6″), 1.29 (3H, s, H-5′), 1.6 (2H, m, H-11), 1.7 (1H, m, H-6), 1.9 (1H, m, H-6), 1.62 (1H, m, H-9), 1.68 (3H, s, H-29), 1.40 (1H, m, H-10), 1.52 (3H, s, H-34), 1.40 (3H, s, H-31), 1.40 (3H, s, H-32), 1.4 (3H, s, H-33), 1.00 (3H, s, H-28) and 1.05 (3H, s, H-30).
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