CJ-21,058, a new SecA inhibitor isolated from a fungus

Journal of Antibiotics

Volumn 55, Issue 1, 2002, Pages 25-29

  Sugie, Yutaka ^a   Inagaki, Sae ^a   Kato, Yoshinao ^a   Nishida, Hiroyuki ^a   Pang, Chang Hong ^a   Saito, Toshiyuki ^a   Sakemi, Shinichi ^a   Dib Hajj, Fadia ^a   Mueller, John P ^a   Sutcliffe, Joyce ^a   Kojima, Yasuhiro ^a  

^a Nagoya Laboratories   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CJ 21058; PROTEIN INHIBITOR; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION MEDIUM; FUNGUS; GRAM POSITIVE BACTERIUM; INHIBITION KINETICS; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

EID: 0036173056     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.55.25     Document Type: Article

References (15)

1. Sec-dependent preprotein translocation in bacteria
2. Biogenesis of the Gram-negative bacterial envelope
3. SecA, an essential component of the secondary machinery of Escherichia coli, exists as a homodimer
4. Characterization of membrane-associated and soluble states of SecA protein from wild-type and SecA52 (Ts) mutant strains of Escherichia coli
5. The SecA protein hydrolyzes ATP and is an essential component of the protein translocation ATPase of E. coli
6. Regulation of a membrane component required for protein secretion in Escherichia coli
7. The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins
8. SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion
9. Azide-resistant mutants of Escherichia coli alter the SecA protein, an azide-sensitive component of the protein export machinery
10. Inhibition of preprotein translocation and reversion of the membrane inserted state of SecA by a carboxy terminus binding mAb
11. Characterization of the Fusarium toxin equisetin: The use of phenylboronates in structure assignment
12. A novel antibiotic CJ-17,572 from a fungus, Pezicula sp.
13. Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase
14. The tetramic acids-An overview of their biological properties
15. LL-49F233α, a novel antibiotic produced by an unknown fungus: Biological and mechanistic activities