LL-49F233α, a novel antibiotic produced by an unknown fungus: Biological and mechanistic activities

Journal of Antibiotics

Volumn 51, Issue 12, 1998, Pages 1109-1112

  Singh, M P ^a   Zaccardi, J ^a   Greenstein, M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CHLORAMPHENICOL; CIPROFLOXACIN; LL 49F233 ALPHA; METICILLIN; PIPERACILLIN; RIFAMPICIN; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; BACTERIAL DNA; BACTERIAL PROTEIN; BACTERIAL RNA; LL 49F233ALPHA; NAPHTHALENE DERIVATIVE; POTASSIUM; PYRROLE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MEMBRANE; CELL STRUCTURE; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ESCHERICHIA COLI; FERMENTATION; FUNGUS; MEMBRANE DAMAGE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RNA SYNTHESIS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; METABOLISM; MICROBIOLOGICAL EXAMINATION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; FUNGI; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NAPHTHALENES; POTASSIUM; PYRROLES; RNA, BACTERIAL;

EID: 0032241167     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.51.1109     Document Type: Article

References (14)

1. ZACCARDI, J. & G. ELLESTAD: LL-49F233*, a novel antibiotic produced by an unknown fungus: Isolation and structure elucidation. J. Antibiotics (Manuscript under revision)
2. TODA, S.; S. NAKAGAWA, T. NAITO & H. KAWAGUCHI: Bu-2313, a new antibiotic complex active against anaerobes. III. Semisynthesis of Bu-2313 and their analogs. J. Antibiotics 33: 173-181, 1980
3. BRILL, G. M.; J. B. MCALPINE & D. WHITTERN: Tirandalydigin, a novel tetramic acid of the tirandamycinstreptolydigin type. II. Isolation and structure characterization. J. Antibiotics 41: 36-44, 1988
4. PHILLIPS, N. J.; J. T. GOODWIN, A. FRAIMAN, R. J. COLE & D. J. LYNN: Characterization of the Fusarium toxin equisetin: the use of phenylboronates in structure assignment. J. Am. Chem. Soc. 111: 8223-8231, 1989
5. FURUI, M.; J. TAKASHIMA, T. MIKAWA, T. YOSHIKAWA & H. OKISHI (Mitsubishi Chemicam Company, Ltd.): MBP049, a new biologically active substance and its production. JP Appl. No. H2-185843, July 13, 1990
6. SASAKI, T.; M. TAKAGI, M. YAGUCHI, K. NISHIYAMA, T. YAGUCHI & M. KOYAMA (Meiji Seika Kaisha, Ltd.): Novel antibiotic PF1052 and its manufacture with Phoma species. Jpn. Tokkyo Koho JP 04,316578, April 15, 1991
7. ROSEN, T.; P. B. FERNANDES, M. A. MAROVICH, L. SHEN, J. MAO, & A. G. PERNET: Aromatic dienoyl tetramic acids. Novel antibacterial agents with activity against anaerobes and staphylococci. J. Med. Chem. 32: 1062-1069, 1989
8. HAYAKAWA, Y.; N. KANAMARU, A. SHIMAZU & H. SETO: Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity. J. Antibiotics 44: 282-287, 1991
9. KARWOWSKI, J. P.; M. JACKSON, R. J. THERIAULT, G. J. BARLOW, L. COEN, D. M. HENSEY & P. E. HUMPHREY: Tirandalydigin, a novel tetramic acid of the tirandamycinstreptolydigin type. I. Taxonomy of the producing organism, fermentation and biological activity. J. Antibiotics 45: 1125-1132, 1992
10. HAYAKAWA, Y.; N. KANAMARU, N. MORISAKI, K. FURIHATA & H. SETO: Lydicamycin, a new antibiotic of a novel skeletal type. II. Physicochemical properties and structure elucidation. J. Antibiotics 44: 288-292, 1991
11. RADL, S.: Structure activity relationship in DNA gyrase inhibitors. Pharmacol. Ther. 48: 1-17, 1990
12. National Committee for Clincal Laboratory Standards. 1991. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A. National Committee for Clincal Laboratory Standards, Villanova, Pa.
13. 2, a novel antibiotic produced by S. viridodiastaticus subsp. "litoralis" LL-31F508. Antimicrob. Agents Chemother. 38: 1808-1812, 1994
14. SINGH, M. P.; P. J. PETERSEN, N. V. JACOBUS, M. J. MROCZENSKI-WILDEY, W. M. MAIESE, M. GREENSTEIN & D. A. STEINBERG: Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus LL-42D005: II. Biological activities. J. Antibiotics 47: 1258-1265, 1994