UCS1025A and B, New Antitumor Antibiotics from the Fungus Acremonium Species

Organic Letters

Volumn 4, Issue 25, 2002, Pages 4387-4390

  Agatsuma, Tsutomu ^a   Akama, Tsutomu ^a   Nara, Shinji ^a   Matsumiya, Shigeki ^a   Nakai, Ryuichiro ^a   Ogawa, Harumi ^a   Otaki, Shizuo ^a   Ikeda, Shun Ichi ^a   Saitoh, Yutaka ^a   Kanda, Yutaka ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; PYRROLIZIDINE ALKALOID; UCS 1025A; UCS1025B;

ACREMONIUM; ARTICLE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

ACREMONIUM; ANTINEOPLASTIC AGENTS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLIZIDINE ALKALOIDS;

EID: 18744382434     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol026923b     Document Type: Article

References (16)

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2. Recently, UCS1025A (1) was identified as a novel telomerase inhibitor. Telomeres, the repetitive sequences of six base pairs TTAGGG in the chromosome ends, are essential for stable chromosome maintenance and are maintained by the ribonucleoprotein enzyme telornerase. Since telomerase activity appears to be necessary for the proliferation of most tumor cells antitumor agents based on telomerase inhibition may potentially provide an effective chemotherapy. Details of full accounts of the inhibitory activity of UCS1025A (1) against telomerase will be reported elsewhere.
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