Isolation of SMTP-3, 4, 5 and -6, novel analogs of staplabin, and their effects on plasminogen activation and fibrinolysis

Journal of Antibiotics

Volumn 51, Issue 12, 1998, Pages 1059-1068

  Hasumi, Keiji ^a   Ohyama, Shigeki ^a   Kohyama, Tomoo ^a   Ohsaki, Yuko ^a   Takayasu, Ritsuko ^a   Endo, Akira ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; FIBRIN; FIBRINOLYTIC AGENT; IODINE 125; LEUCINE; PHENYLALANINE; PLASMINOGEN; PLASMINOGEN ACTIVATOR; SERINE; SMTP 3; SMTP 4; SMTP 5; SMTP 6; STAPLABIN ANALOG; TRYPTOPHAN; UNCLASSIFIED DRUG; UROKINASE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; EXTRACTION; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; FERMENTATION; FIBRINOLYSIS; FRACTIONATION; HYPHOMYCETES; INFRARED SPECTROMETRY; NONHUMAN; OPTICAL ROTATION; PHYSICAL CHEMISTRY; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0032410568     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.51.1059     Document Type: Article

References (19)

1. OSSOWSKI, L.; D. BIEGEL & E. REICH: Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplasmic tissue. Cell 16: 929-940, 1979
2. OPDENAKKER, G. & J. VAN DAMME: Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer. Cytokine 4: 251-258, 1992
3. CARMELIET, P. & D. COLLEN: Role of the plasminogen/plasmin system in thrombosis, hemostasis, restenosis, and atherosclerosis. Evaluation in transgenic animals. Trends Cardiovasc. Med. 5: 117-122, 1995
4. TRYGGVASON, K.; M. HÖYHTYÄ & T. SALO: Proteolytic degradation of extracellular matrix in tumor invasion. Biochim. Biophys. Acta 907: 191-217, 1987
5. BOYLE, M. D. & R. LOTTENBERG: Plasminogen activation by invasive human pathogens. Thromb. Haemost. 77: 1-10, 1997
6. SOTTRUP-JENSEN, L.; H. CLAEYS, M. ZAJDEL, T. E. PETERSEN & S. MAGNUSSEN: The primary structure of human plasminogen: isolation of two lysine-binding fragments and one "mini-" plasminogen (MW, 38,000) by elastase-catalyzed-specific limited proteolysis. Prog. Chem. Fibrinolysis Thrombolysis 3: 191-209, 1978
7. FORSGREN, M.; B. RADEN, M. ISRAELSSON, K. LARSSON & L.-O. HEDEN: Molecular cloning and characterization of a full-length cDNA clone for human plasminogen. FEBS Lett. 213: 254-260, 1987
8. CHRISTENSEN, U. : The AH-site of plasminogen and two C-terminal fragments. A weak lysine-binding site preferring ligands not carrying a free carboxylate function. Biochem. J. 223: 413-421, 1984
9. MARSHALL, J. M.; A. J. BROWN & C. P. PONTING: Conformational studies of human plasminogen and plasminogen fragments: evidence for a novel third conformation of plasminogen. Biochemistry 33: 3599-3606, 1994
10. LUCAS, M. A.; L. J. FRETTO & P. A. MCKEE: The binding of human plasminogen to fibrin and fibrinogen. J. Biol. Chem. 258: 4249-4256, 1983
11. NESHEIM, M. E.; J. C. FREDENBURGH & G. R. LARSEN: The dissociation constants and stoichiometries of the interactions of Lys-plasminogen and chloromethyl ketone derivatives of tissue plasminogen activator and the variant ΔFEIX with intact fibrin. J. Biol. Chem. 265: 21541-21548, 1990
12. HAJJAR, K. A. & R. L. NACMAN: Endothelial cell-mediated conversion of Glu-plasminogen to Lys-plasminogen. Further evidence for assembly of the fibrinolytic system on the endothelial cell surface. J. Clin. Invest. 82: 1769-1778, 1988
13. VIOLAND, B. N. & F. J. CASTELLINO: Mechanism of the urokinase-catalyzed activation of human plasminogen. J. Biol. Chem. 251: 3906-3912, 1976
14. FREDENBURGH, J. C. & M. E. NESHEIM: Lys-plasminogen is a significant intermediate in the activation of Gluplasminogen during fibrinolysis in vitro. J. Biol. Chem. 267: 26150-26156, 1992
15. RAMAKRISHNAN, V.; L. PATTHY & W. F. MANGEL: Conformation of Lys-plasminogen and the kringle 1-3 fragment of plasminogen analyzed by small-angle neutron scattering. Biochemistry 30: 3963-3969, 1991
16. PLOW, E. F.; T. HERREN, A. REDLITZ, L. A. MILES & J. L. HOOVER-PLOW: The cell biology of the plasminogen system. FASEB J. 9: 939-945, 1995
17. SHINOHARA, C.; K. HASUMI, W. HATSUMI & A. ENDO: Staplabin, a novel fungal triprenyl phenol which stimulates the binding of plasminogen to fibrin and U937 cells. J. Antibiotics 49: 961-966, 1996
18. TAKAYASU, R.; K. HASUMI, C. SHINOHARA & A. ENDO: Enhancement of fibrin binding and activation of plasminogen by staplabin through induction of a conformational change in plasminogen. FEBS Lett. 418: 58-62, 1997
19. KOHYAMA, T.; K. HASUMI, A. HAMANAKA & A. ENDO: SMTP-1 and -2, novel analogs of staplabin produced by Stachybotrys microspora IFO30018. J. Antibiotics 50: 172-174, 1997