TMC-2A, -2B and -2C, new dipeptidyl peptidase IV inhibitors produced by Aspergillus oryzae A374. II. Isolation and structure determination

Journal of Antibiotics

Volumn 50, Issue 8, 1997, Pages 653-658

  Asai, Yasuyuki ^a   Nonaka, Nobuaki ^a   Nishio, Maki ^a   Okamura, Kimio ^a,b   Date, Tadamasa ^a,b   Sugita, Takahisa ^a,b   Ohnuki, Tetsuo ^a   Komatsubara, Saburo ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; ENZYME INHIBITOR; TMC 2A; TMC 2B; TMC 2C; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS ORYZAE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL ANALYSIS; DRUG ISOLATION; DRUG STRUCTURE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

EID: 0030806176     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.653     Document Type: Article

References (12)

1. NONAKA, N.; Y. ASAI, M. NISHIO, K. TAKAHASHI, T. OKUDA, S. TANAKA, T. SUGITA, T. OHNUKI & S. KOMATSUBARA: TMC-2A, -2B and -2C, novel dipeptidyl peptidase IV inhibitors produced by Aspergillus oryzae A374. I. Taxonomy of producing strain, fermentation, and biochemical properties. J. Antibiotics 50: 646-652, 1997
2. UMEZAWA, H.; T. AOYAGI, K. OGAWA, H. NAGANAWA, M. HAMADA & T. TAKEUCHI: Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria. J. Antibiotics 37: 422-425, 1984
3. RAHFELD, J.; M. SCHIERHORN, B. HARTRODT, K. NEUBERT & J. HEINS: Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV? Biochim. Biophys. Acta 1076: 314-316, 1991
4. ARAI, T.; Y. MIKAMI, K. FUKUSHIMA, T. UTSUMI & K. YAZAWA: A new antibiotic leucinosatin, derived from Penicillium lilacinum. J. Antibiotics 16: 157-161, 1973
5. BORY, S.; M. GAUDRY & A. MARQUET: Synthesis of DL-5-5′-dihydroxyleucine the reduction product of γ carboxy glutamic acid. Biochem. Biophys. Res. Commun. 87: 85-91, 1979
6. 14 into mescaline and anhalonidine. J. Am. Chem. Soc. 88: 4218-4221, 1966
7. BHAKUNI, D. S.; A. N. SINGH, S. TEWARI & R. S. KAPIL: Biosynthesis of reticuline. J. C. S. Perkin I: 1662, 1977
8. KAMETANI, T. & T. KIKUCHI: Studies on the syntheses of heterocyclic compounds. CLXXXII. A modified synthesis of so-called corpaverine. Chem. Pharm. Bull. 15: 879-883, 1967
9. SCHÖN, E.; S. JAHN, S. T. KIESSIG, H.-U. DEMUTH, K. NEUBERT, A. BARTH, R. V. BAEHR & S. ANSORGE: The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro. Eur. J. Immunol. 17: 1821-1826, 1987
10. YAN, T.; H. SHIN & C. HOU: Catalytic properties of X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. ceremoris nTR. Biosci. Biotech. Biochem. 56: 704-707, 1992
11. SHELDRICK, G. M.: SHELXS-86: A program for the solution of crystal structures. University of Goettingen, Germany, 1986
12. SHELDRICK, G. M.: SHELXS-93: A program for crystal structure refinement. University of Goettingen, Germany, 1993