Novel human topoisomerase I inhibitors, topopyrones A, B, C and D. I. Producing strain, fermentation, isolation, physico-chemical properties and biological activity

Journal of Antibiotics

Volumn 53, Issue 9, 2000, Pages 863-872

  Kanai, Y ^a   Ishiyama, D ^a   Senda, H ^a   Iwatani, W ^a   Takahashi, H ^a   Konno, H ^a   Tokumasu, S ^a   Kanazawa, S ^a  

^a Inst Biotech Appl Soil Eumycetes   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETONITRILE; ACICLOVIR; AMPHOTERICIN B; AMSACRINE; ANTHRAQUINONE DERIVATIVE; BUTANOL; CAMPTOTHECIN; DACTINOMYCIN; DIMETHYL SULFOXIDE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; EDETIC ACID; ETOPOSIDE; FLUCYTOSINE; FUNGAL DNA; GYRASE INHIBITOR; METHANOL; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEINASE K; SODIUM BROMIDE; SODIUM HYDROXIDE; TENIPOSIDE; TOPOPYRONE A; TOPOPYRONE B; TOPOPYRONE C; TOPOPYRONE D; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA STRUCTURE; DRUG ACTIVITY; DRUG ISOLATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; FERMENTATION; FUNGUS CULTURE; FUNGUS GROWTH; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; HERPES VIRUS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; PENICILLIUM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL LINE; VARICELLA ZOSTER VIRUS; VIROGENESIS; YEAST;

PENICILLIUM; PHOMA;

EID: 0033778305     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.863     Document Type: Article

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