-
1
-
-
0035825643
-
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
-
DOI 10.1038/35055575
-
Abel ED, Peroni O, Kim JK et al (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409:729-733. doi:10.1038/35055575 (Pubitemid 32144519)
-
(2001)
Nature
, vol.409
, Issue.6821
, pp. 729-733
-
-
Abel, E.D.1
Peroni, O.2
Kim, J.K.3
Kim, Y.-B.4
Boss, O.5
Hadro, E.6
Minnemann, T.7
Shulman, G.I.8
Kahn, B.B.9
-
2
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B et al (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541-6551 (Pubitemid 26413787)
-
(1996)
EMBO Journal
, vol.15
, Issue.23
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
3
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP et al (1997) Characterization of a 3-phosphoinositidedependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7:261-269. doi:S0960-9822 (06) 00122-9 [pii] (Pubitemid 27176852)
-
(1997)
Current Biology
, vol.7
, Issue.4
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.J.5
Reese, C.B.6
Cohen, P.7
-
4
-
-
0024601010
-
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
-
DOI 10.1016/0092-8674(89)90182-7
-
Auger KR, Serunian LA, Soltoff SP et al (1989) PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57:167-175 (Pubitemid 19098878)
-
(1989)
Cell
, vol.57
, Issue.1
, pp. 167-175
-
-
Auger, K.R.1
Serunian, L.A.2
Soltoff, S.P.3
Libby, P.4
Cantley, L.C.5
-
5
-
-
39749141485
-
The regulation and function of Class III PI3Ks: Novel roles for Vps34
-
DOI 10.1042/BJ20071427
-
Backer JM (2008) The regulation and function of class III PI3Ks: novel roles for Vps34. Biochem J 410:1-17. doi:10.1042/BJ20071427 (Pubitemid 351300321)
-
(2008)
Biochemical Journal
, vol.410
, Issue.1
, pp. 1-17
-
-
Backer, J.M.1
-
6
-
-
33745933535
-
Phosphatidylinositol 4-kinases: old enzymes with emerging functions
-
DOI 10.1016/j.tcb.2006.05.003, PII S0962892406001383
-
Balla A, Balla T (2006) Phosphatidylinositol 4-kinases: old enzymes with emerging functions. Trends Cell Biol 16:351-361. doi:10.1016/j.tcb.2006.05.003 (Pubitemid 44062315)
-
(2006)
Trends in Cell Biology
, vol.16
, Issue.7
, pp. 351-361
-
-
Balla, A.1
Balla, T.2
-
8
-
-
27944470541
-
The structure and regulation of myotubularin phosphatases
-
DOI 10.1016/j.sbi.2005.10.016, PII S0959440X05001995, Catalysis and Regulation/Proteins
-
Begley M, Dixon J (2005) The structure and regulation of myotubularin phosphatases. Curr Opin Struct Biol 15:614-620 (Pubitemid 41668516)
-
(2005)
Current Opinion in Structural Biology
, vol.15
, Issue.6
, pp. 614-620
-
-
Begley, M.J.1
Dixon, J.E.2
-
9
-
-
12344290720
-
Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles
-
DOI 10.1242/jcs.01517
-
Berwick DC, Dell G, Welsh G et al (2004) Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles. J Cell Sci 117:5985-5993 (Pubitemid 40123965)
-
(2004)
Journal of Cell Science
, vol.117
, Issue.25
, pp. 5985-5993
-
-
Berwick, D.C.1
Dell, G.C.2
Welsh, G.I.3
Heesom, K.J.4
Hers, I.5
Fletcher, L.M.6
Cooke, F.T.7
Tavare, J.M.8
-
10
-
-
0033574429
-
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110 subunit of phosphoinositide 3-kinase
-
Bi L, Okabe I, Bernard DJ et al (1999) Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110 subunit of phosphoinositide 3-kinase. J Biol Chem 274:10963-10968
-
(1999)
J Biol Chem
, vol.274
, pp. 10963-10968
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
-
11
-
-
0036185944
-
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
-
DOI 10.1007/s00335-001-2123-x
-
Bi L, Okabe I, Bernard DJ, Nussbaum RL (2002) Early embryonic lethality in mice deficient in the p110 catalytic subunit of PI 3-kinase. New York 172:169-172. doi:10.1007/s00335-001-2123-x (Pubitemid 34185317)
-
(2002)
Mammalian Genome
, vol.13
, Issue.3
, pp. 169-172
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Nussbaum, R.L.4
-
12
-
-
69749113579
-
The Vam6 GEF controls TORC1 by activating the EGO complex
-
doi:10.1016/j.molcel.2009.06.033
-
Binda M, Péli-Gulli M-P, Bonfils G et al (2009) The Vam6 GEF controls TORC1 by activating the EGO complex. Mol Cell 35:563-573. doi:10.1016/j.molcel.2009.06.033
-
(2009)
Mol Cell
, vol.35
, pp. 563-573
-
-
Binda, M.1
Péli-Gulli, M.-P.2
Bonfils, G.3
-
13
-
-
84855407584
-
Recruitment of OCRL and Inpp 5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling
-
doi:10.1091/mbc. E11-06-0489
-
Bohdanowicz M, Balkin DM, De Camilli P, Grinstein S (2011) Recruitment of OCRL and Inpp 5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling. Mol Biol Cell 23:176-187 doi:10.1091/mbc. E11-06-0489
-
(2011)
Mol Biol Cell
, vol.23
, pp. 176-187
-
-
Bohdanowicz, M.1
Balkin, D.M.2
De Camilli, P.3
Grinstein, S.4
-
14
-
-
0030692711
-
Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology
-
Bonangelino C, Catlett NL, Weisman LS (1997) Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology. Mol Cell Biol 17:6847-6858 (Pubitemid 27505914)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.12
, pp. 6847-6858
-
-
Bonangelino, C.J.1
Catlett, N.L.2
Weisman, L.S.3
-
15
-
-
0028812255
-
The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases
-
Boronenkov IV, Anderson RA (1995) The sequence of phosphatidylinositol-4- phosphate 5-kinase defines a novel family of lipid kinases. J Biol Chem 270:2881-2884
-
(1995)
J Biol Chem
, vol.270
, pp. 2881-2884
-
-
Boronenkov, I.V.1
Anderson, R.A.2
-
16
-
-
53149141824
-
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase
-
Botelho RJ, Efe JA, Teis D, Emr SD (2008) Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase. Mol Biol Cell 19:4273-4286
-
(2008)
Mol Biol Cell
, vol.19
, pp. 4273-4286
-
-
Botelho, R.J.1
Efe, J.A.2
Teis, D.3
Emr, S.D.4
-
17
-
-
14144250240
-
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice
-
DOI 10.1128/MCB.25.5.1596-1607.2005
-
Brachmann SM, Ueki K, Engelman JA et al (2005) Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Society 25:1596-1607. doi:10.1128/MCB.25.5.1596 (Pubitemid 40282598)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.5
, pp. 1596-1607
-
-
Brachmann, S.M.1
Ueki, K.2
Engelman, J.A.3
Kahn, R.C.4
Cantley, L.C.5
-
18
-
-
0032993885
-
Transdermally delivered peroxovanadium can lower blood glucose levels in diabetic rats
-
DOI 10.1016/S0378-5173(99)00071-X, PII S037851739900071X
-
Brand RM, Hamel FG (1999) Transdermally delivered peroxovanadium can lower blood glucose levels in diabetic rats. Int J Pharm 183:117-123 (Pubitemid 29257957)
-
(1999)
International Journal of Pharmaceutics
, vol.183
, Issue.2
, pp. 117-123
-
-
Brand, R.M.1
Hamel, F.G.2
-
19
-
-
77956677775
-
PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha
-
doi:10.1042/BJ20100341
-
Bultsma Y, Keune W-J, Divecha N (2010) PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha. Biochem J 430:223-235. doi:10.1042/BJ20100341
-
(2010)
Biochem J
, vol.430
, pp. 223-235
-
-
Bultsma, Y.1
Keune, W.-J.2
Divecha, N.3
-
20
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
doi:10.1038/376599a0
-
Burgering BM, Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602. doi:10.1038/376599a0
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
21
-
-
0036231778
-
Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice
-
Butler M, McKay RA, Popoff IJ et al (2002) Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes 51:1028-1034 (Pubitemid 34438346)
-
(2002)
Diabetes
, vol.51
, Issue.4
, pp. 1028-1034
-
-
Butler, M.1
McKay, R.A.2
Popoff, I.J.3
Gaarde, W.A.4
Witchell, D.5
Murray, S.F.6
Dean, N.M.7
Bhanot, S.8
Monia, B.P.9
-
22
-
-
25444457577
-
HVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
DOI 10.1074/jbc.M507201200
-
Byfield MP, Murray JT, Backer JM (2005) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 280:33076-33082. doi:10.1074/jbc. M507201200 M507201200 [pii] (Pubitemid 41368357)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.38
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
23
-
-
77950440345
-
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase
-
doi:10.1073/pnas.0908899107
-
Chagpar RB, Links PH, Pastor MC et al (2010) Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 107:5471-5476. doi:10.1073/pnas.0908899107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 5471-5476
-
-
Chagpar, R.B.1
Links, P.H.2
Pastor, M.C.3
-
24
-
-
10344232033
-
The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins
-
DOI 10.1074/jbc.M409769200
-
Chamberlain M, Berry T, Pastor M, Anderson DH (2004) The p85{alpha} subunit of phosphatidylinositol 30-kinase binds to and stimulates the GTPase activity of Rab proteins. J Biol Chem 279:48607-48614 (Pubitemid 39625735)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.47
, pp. 48607-48614
-
-
Chamberlain, M.D.1
Berry, T.R.2
Pastor, M.C.3
Anderson, D.H.4
-
25
-
-
79959446484
-
Ablation of PI3K p110-A prevents high-fat diet-induced liver steatosis
-
doi:10.2337/db10-0869
-
Chattopadhyay M, Selinger ES, Ballou LM, Lin RZ (2011) Ablation of PI3K p110-a prevents high-fat diet-induced liver steatosis. Liver. doi:10.2337/db10-0869
-
(2011)
Liver
-
-
Chattopadhyay, M.1
Selinger, E.S.2
Ballou, L.M.3
Lin, R.Z.4
-
26
-
-
0347480266
-
Expression of Myotubularin by an Adenoviral Vector Demonstrates Its Function as a Phosphatidylinositol 3-Phosphate [Ptdlns(3)P] Phosphatase in Muscle Cell Lines: Involvement of Ptdlns(3)P in Insulin-Stimulated Glucose Transport
-
DOI 10.1210/me.2003-0261
-
Chaussade C, Pirola L, Bonnafous S et al (2003) Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns (3) P] phosphatase in muscle cell lines: involvement of PtdIns (3) P in insulin-stimulated glucose transport. Mol Endocrinol (Baltimore, Md) 17:2448-2460. doi:10.1210/me.2003-0261 (Pubitemid 37542209)
-
(2003)
Molecular Endocrinology
, vol.17
, Issue.12
, pp. 2448-2460
-
-
Chaussade, C.1
Pirola, L.2
Bonnafous, S.3
Blondeau, F.4
Brenz-Verca, S.5
Tronchere, H.6
Portis, F.7
Rusconi, S.8
Payrastre, B.9
Laporte, J.10
Van Obberghen, E.11
-
27
-
-
34548188298
-
Activation of RalA Is Required for Insulin-Stimulated Glut4 Trafficking to the Plasma Membrane via the Exocyst and the Motor Protein Myo1c
-
DOI 10.1016/j.devcel.2007.07.007, PII S1534580707002687
-
Chen XW, Leto D, Chiang SH et al (2007) Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell 13:391-404. doi:10.1016/j.devcel.2007.07. 007 S1534-5807 (07) 00268-7 [pii] (Pubitemid 47308676)
-
(2007)
Developmental Cell
, vol.13
, Issue.3
, pp. 391-404
-
-
Chen, X.-W.1
Leto, D.2
Chiang, S.-H.3
Wang, Q.4
Saltiel, A.R.5
-
28
-
-
78651085682
-
A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
-
doi:10.1091/mbc. E10-08-0665
-
Chen X-W, Leto D, Xiong T et al (2011) A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell 22:141-152. doi:10.1091/mbc. E10-08-0665
-
(2011)
Mol Biol Cell
, vol.22
, pp. 141-152
-
-
Chen, X.-W.1
Leto, D.2
Xiong, T.3
-
29
-
-
34447133038
-
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
-
DOI 10.1038/nature05876, PII NATURE05876
-
Chow C, Zhang Y, Dowling JJ et al (2007) Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature 448:68-72 (Pubitemid 47036999)
-
(2007)
Nature
, vol.448
, Issue.7149
, pp. 68-72
-
-
Chow, C.Y.1
Zhang, Y.2
Dowling, J.J.3
Jin, N.4
Adamska, M.5
Shiga, K.6
Szigeti, K.7
Shy, M.E.8
Li, J.9
Zhang, X.10
Lupski, J.R.11
Weisman, L.S.12
Meisler, M.H.13
-
30
-
-
0033174034
-
Phosphatidylinositol-3-OH kinases are Rab5 effectors
-
Christoforidis S, Miaczynska M, Ashman K et al (1999) Phosphatidylinositol-3-OH kinases are Rab5 effectors. Nat Cell Biol 1:249-252 (Pubitemid 129500945)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.4
, pp. 249-252
-
-
Christoforidis, S.1
Miaczynska, M.2
Ashman, K.3
Wilm, M.4
Zhao, L.5
Yip, S.-C.6
Waterfield, M.D.7
Backer, J.M.8
Zerial, M.9
-
31
-
-
55649084906
-
Phosphoinositide 3-kinase p110beta activity: Key role in metabolism and mammary gland cancer but not development
-
doi:10.1126/scisignal.1161577
-
Ciraolo E, Iezzi M, Marone R et al (2008) Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Science Signal 1: ra3. doi:10.1126/scisignal.1161577
-
(2008)
Science Signal
, vol.1
-
-
Ciraolo, E.1
Iezzi, M.2
Marone, R.3
-
32
-
-
0022369636
-
Selectivity of the insulin-like actions of vanadate on glucose and protein metabolism in skeletal muscle
-
Clark AS, Fagan JM, Mitch WE (1985) Selectivity of the insulin-like actions of vanadate on glucose and protein metabolism in skeletal muscle. Biochem J 232:273-276 (Pubitemid 16199010)
-
(1985)
Biochemical Journal
, vol.232
, Issue.1
, pp. 273-276
-
-
Clark, A.S.1
Fagan, J.M.2
Mitch, W.E.3
-
33
-
-
0028260280
-
Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin
-
Clarke JF, Young PW, Yonezawa K et al (1994) Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Biochem J 300(Pt 3):631-635 (Pubitemid 24180574)
-
(1994)
Biochemical Journal
, vol.300
, Issue.3
, pp. 631-635
-
-
Clarke, J.F.1
Young, P.W.2
Yonezawa, K.3
Kasuga, M.4
Holman, G.D.5
-
34
-
-
0035804251
-
The lipid phosphatase SHIP2 controls insulin sensitivity
-
DOI 10.1038/35051094
-
Clément S, Krause U, Desmedt F et al (2001) The lipid phosphatase SHIP2 controls insulin sensitivity. Nature 409:92-97. doi:10.1038/35051094 (Pubitemid 32098631)
-
(2001)
Nature
, vol.409
, Issue.6816
, pp. 92-97
-
-
Clement, S.1
Krause, U.2
Desmedt, F.3
Tanti, J.-F.4
Behrends, J.5
Pesesse, X.6
Sasaki, T.7
Penninger, J.8
Doherty, M.9
Malaisse, W.10
Dumont, J.E.11
Le Marchand-Brustel, Y.12
Erneux, C.13
Hue, L.14
Schurmans, S.15
-
35
-
-
0024828304
-
Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function
-
DOI 10.1083/jcb.109.6.2939
-
Cleves AE, Novick PJ, Bankaitis VA (1989) Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function. J Cell Biol 109:2939-2950. doi:10.1016/0168-9525 (90) 90063-C (Pubitemid 20011920)
-
(1989)
Journal of Cell Biology
, vol.109
, Issue.6
, pp. 2939-2950
-
-
Cleves, A.E.1
Novick, P.J.2
Bankaitis, V.A.3
-
36
-
-
0033084143
-
Role of phosphatidylinositol 3, 4, 5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
-
Currie RA, Walker KS, Gray A et al (1999) Role of phosphatidylinositol 3, 4, 5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem J 337(Pt 3):575-583
-
(1999)
Biochem J
, vol.337
, Issue.PART 3
, pp. 575-583
-
-
Currie, R.A.1
Walker, K.S.2
Gray, A.3
-
37
-
-
18544375193
-
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
-
doi:10.1074/jbc. M205838200
-
Dan HC, Sun M, Yang L et al (2002) Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 277:35364-35370. doi:10.1074/jbc. M205838200
-
(2002)
J Biol Chem
, vol.277
, pp. 35364-35370
-
-
Dan, H.C.1
Sun, M.2
Yang, L.3
-
38
-
-
33749836234
-
Phosphoinositides in cell regulation and membrane dynamics
-
DOI 10.1038/nature05185, PII NATURE05185
-
Di Paolo G, De Camilli P (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443:651-657. doi:10.1038/nature05185 (Pubitemid 44564702)
-
(2006)
Nature
, vol.443
, Issue.7112
, pp. 651-657
-
-
Di Paolo, G.1
De Camilli, P.2
-
39
-
-
0029089452
-
The cloning and sequence of the C isoform of PtdIns4P 5-kinase
-
Divecha N, Truong O, Hsuan JJ et al (1995) The cloning and sequence of the C isoform of PtdIns4P 5-kinase. Biochem J 309(Pt 3):715-719
-
(1995)
Biochem J
, vol.309
, Issue.PART 3
, pp. 715-719
-
-
Divecha, N.1
Truong, O.2
Hsuan, J.J.3
-
40
-
-
0034697119
-
The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles
-
DOI 10.1074/jbc.275.16.11943
-
Domin J, Gaidarov I, Smith ME et al (2000) The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles. J Biol Chem 275:11943-11950 (Pubitemid 30237765)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.16
, pp. 11943-11950
-
-
Domin, J.1
Gaidarov, I.2
Smith, M.E.K.3
Keen, J.H.4
Waterfield, M.D.5
-
41
-
-
79952997159
-
Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells
-
doi:10.1074/jbc. M110.200295
-
Dominguez V, Raimondi C, Somanath S et al (2010) Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem 1-22. doi:10.1074/jbc. M110.200295
-
(2010)
J Biol Chem
, pp. 1-22
-
-
Dominguez, V.1
Raimondi, C.2
Somanath, S.3
-
42
-
-
3142583199
-
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors
-
DOI 10.1038/sj.emboj.7600203
-
Dove SK, Piper RC, McEwen RK et al (2004) Svp1p defines a family of phosphatidylinositol 3, 5-bisphosphate effectors. EMBO J 23:1922-1933. doi:10.1038/sj.emboj.7600203 7600203 [pii] (Pubitemid 38902070)
-
(2004)
EMBO Journal
, vol.23
, Issue.9
, pp. 1922-1933
-
-
Dove, S.K.1
Piper, R.C.2
McEwen, R.K.3
Yu, J.W.4
King, N.C.5
Hughes, D.C.6
Thuring, J.7
Holmes, A.B.8
Cooke, F.T.9
Michell, R.H.10
Parker, P.J.11
Lemmon, M.A.12
-
43
-
-
18044364473
-
Probing phosphoinositide functions in signaling and membrane trafficking
-
DOI 10.1016/j.tcb.2005.03.008
-
Downes CP, Gray A, Lucocq JM (2005) Probing phosphoinositide functions in signaling and membrane trafficking. Trends Cell Biol 15:259-268. doi:10.1016/j.tcb.2005.03.008 (Pubitemid 40603895)
-
(2005)
Trends in Cell Biology
, vol.15
, Issue.5
, pp. 259-268
-
-
Downes, C.P.1
Gray, A.2
Lucocq, J.M.3
-
44
-
-
0023921326
-
Insulin-like effects of vanadate in isolated rat adipocytes
-
Duckworth WC, Solomon SS, Liepnieks J et al (1988) Insulin-like effects of vanadate in isolated rat adipocytes. Endocrinology 122:2285-2289
-
(1988)
Endocrinology
, vol.122
, pp. 2285-2289
-
-
Duckworth, W.C.1
Solomon, S.S.2
Liepnieks, J.3
-
45
-
-
33646247181
-
Phosphoinositide 5-phosphatase Fig4p Is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3, 5-bisphosphate levels
-
Duex JE, Nau J, Kauffman E, Weisman LS (2006a) Phosphoinositide 5-phosphatase Fig4p Is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3, 5-bisphosphate levels. Eukaryot Cell 5:723-731
-
(2006)
Eukaryot Cell
, vol.5
, pp. 723-731
-
-
Duex, J.E.1
Nau, J.2
Kauffman, E.3
Weisman, L.S.4
-
46
-
-
33644499479
-
The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3, 5P2 synthesis and turnover
-
Duex JE, Tang F, Weisman LS (2006b) The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3, 5P2 synthesis and turnover. J Cell Biol 172:693-704
-
(2006)
J Cell Biol
, vol.172
, pp. 693-704
-
-
Duex, J.E.1
Tang, F.2
Weisman, L.S.3
-
47
-
-
35848929068
-
Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate
-
DOI 10.1091/mbc.E07-04-0301
-
Efe J, Botelho RJ, Emr SD (2007) Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3, 5-bisphosphate. Mol Biol Cell 18:4232-4244 (Pubitemid 350060155)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.11
, pp. 4232-4244
-
-
Efe, J.A.1
Botelho, R.J.2
Emr, S.D.3
-
48
-
-
28544435205
-
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein
-
doi:10.1016/j.cmet.2005.09.005
-
Eguez L, Lee A, Chavez JA et al (2005) Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein. Cell Metab 2:263-272. doi:10.1016/j.cmet.2005.09.005
-
(2005)
Cell Metab
, vol.2
, pp. 263-272
-
-
Eguez, L.1
Lee, A.2
Chavez, J.A.3
-
49
-
-
84860390458
-
SHIP2 multiple functions: A balance between a negative control of PtdIns (3, 4, 5) P (3) level, a positive control of PtdIns (3, 4) P (2) production, and intrinsic docking properties
-
doi:10.1002/jcb.23146
-
Erneux C, Edimo WE, Deneubourg L, Pirson I (2011) SHIP2 multiple functions: a balance between a negative control of PtdIns (3, 4, 5) P (3) level, a positive control of PtdIns (3, 4) P (2) production, and intrinsic docking properties. J Cell Biochem 112:2203-2209. doi:10.1002/jcb.23146
-
(2011)
J Cell Biochem
, vol.112
, pp. 2203-2209
-
-
Erneux, C.1
Edimo, W.E.2
Deneubourg, L.3
Pirson, I.4
-
50
-
-
34948866354
-
The role of phosphoinositide 3-kinase C2alpha in insulin signaling
-
DOI 10.1074/jbc.M704357200
-
Falasca M, Hughes WE, Dominguez V et al (2007) The role of phosphoinositide 3-kinase C2alpha in insulin signaling. J Biol Chem 282:28226-28236. doi:10.1074/jbc. M704357200 (Pubitemid 47529549)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.38
, pp. 28226-28236
-
-
Falasca, M.1
Hughes, W.E.2
Dominguez, V.3
Sala, G.4
Fostira, F.5
Fang, M.Q.6
Cazzolli, R.7
Shepherd, P.R.8
James, D.E.9
Maffucci, T.10
-
51
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
DOI 10.1126/science.1066015
-
Fang Y, Vilella-Bach M, Bachmann R et al (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science (New York, NY) 294:1942-1945. doi:10.1126/science.1066015 (Pubitemid 33101594)
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Bach, M.2
Bachmann, R.3
Flanigan, A.4
Chen, J.5
-
52
-
-
0344663973
-
PLD1 Regulates mTOR Signaling and Mediates Cdc42 Activation of S6K1
-
DOI 10.1016/j.cub.2003.11.021
-
Fang Y, Park I-H, Wu A-L et al (2003) PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1. Curr Biol 13:2037-2044. doi:10.1016/j.cub. 2003.11.021 (Pubitemid 37502519)
-
(2003)
Current Biology
, vol.13
, Issue.23
, pp. 2037-2044
-
-
Fang, Y.1
Park, I.-H.2
Wu, A.-L.3
Du, G.4
Huang, P.5
Frohman, M.A.6
Walker, S.J.7
Brown, H.A.8
Chen, J.9
-
53
-
-
78650675585
-
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
-
doi:10.1073/pnas.1015245107
-
Fedele CG, Ooms LM, Ho M et al (2010) Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci U S A 107:22231-22236. doi:10.1073/pnas. 1015245107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 22231-22236
-
-
Fedele, C.G.1
Ooms, L.M.2
Ho, M.3
-
54
-
-
0036081022
-
Glucose transport rate and glycogen synthase activity both limit skeletal muscle glycogen accumulation
-
Fisher JS, Nolte LA, Kawanaka K et al (2002) Glucose transport rate and glycogen synthase activity both limit skeletal muscle glycogen accumulation. Am J Physiol Endocrinol Metab 282:E1214-E1221. doi:10.1152/ajpendo.00254.2001 (Pubitemid 34654689)
-
(2002)
American Journal of Physiology - Endocrinology and Metabolism
, vol.282
, Issue.6
-
-
Fisher, J.S.1
Nolte, L.A.2
Kawanaka, K.3
Han, D.-H.4
Jones, T.E.5
Holloszy, J.O.6
-
55
-
-
79953841907
-
Endocytosis, recycling and regulated exocytosis of glucose transporter 4 (GLUT4)
-
doi:10.1021/bi2000356
-
Foley K, Boguslavsky S, Klip A (2011) Endocytosis, recycling and regulated exocytosis of glucose transporter 4 (GLUT4). Biochemistry. doi:10.1021/bi2000356
-
(2011)
Biochemistry
-
-
Foley, K.1
Boguslavsky, S.2
Klip, A.3
-
56
-
-
0035172107
-
Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology
-
Foti M, Audhya A, Emr SD (2001) Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell 12:2396-2411 (Pubitemid 33051964)
-
(2001)
Molecular Biology of the Cell
, vol.12
, Issue.8
, pp. 2396-2411
-
-
Foti, M.1
Audhya, A.2
Emr, S.D.3
-
57
-
-
33744990592
-
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation
-
DOI 10.1038/nature04694, PII NATURE04694
-
Foukas LC, Claret M, Pearce W et al (2006) Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 441:366-370. doi:10.1038/nature04694 (Pubitemid 44050203)
-
(2006)
Nature
, vol.441
, Issue.7091
, pp. 366-370
-
-
Foukas, L.C.1
Claret, M.2
Pearce, W.3
Okkenhaug, K.4
Meek, S.5
Peskett, E.6
Sancho, S.7
Smith, A.J.H.8
Withers, D.J.9
Vanhaesebroeck, B.10
-
58
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke TF, Yang SI, Chan TO et al (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
-
59
-
-
0035103107
-
The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking
-
DOI 10.1016/S1097-2765(01)00191-5
-
Gaidarov I, Smith ME, Domin J, Keen JH (2001) The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol Cell 7:443-449 (Pubitemid 32206511)
-
(2001)
Molecular Cell
, vol.7
, Issue.2
, pp. 443-449
-
-
Gaidarov, I.1
Smith, M.E.K.2
Domin, J.3
Keen, J.H.4
-
60
-
-
0032487577
-
Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis
-
DOI 10.1083/jcb.143.1.65
-
Gary JD, Wurmser AE, Bonangelino C et al (1998) Fab1p is essential for PtdIns (3) P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. J Cell Biol 143:65-79 (Pubitemid 28480518)
-
(1998)
Journal of Cell Biology
, vol.143
, Issue.1
, pp. 65-79
-
-
Gary, J.D.1
Wurmser, A.E.2
Bonangelino, C.J.3
Weisman, L.S.4
Emr, S.D.5
-
61
-
-
0036231465
-
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member
-
DOI 10.1091/mbc.01-10-0498
-
Gary J, Sato T, Stefan C et al (2002) Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell 13:1238-1251 (Pubitemid 34309619)
-
(2002)
Molecular Biology of the Cell
, vol.13
, Issue.4
, pp. 1238-1251
-
-
Gary, J.D.1
Sato, T.K.2
Stefan, C.J.3
Bonangelino, C.J.4
Weisman, L.S.5
Emr, S.D.6
-
62
-
-
67651148274
-
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
-
doi:10.1016/j.ccr.2009.06.006
-
Gewinner C, Wang ZC, Richardson A et al (2009) Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16:115-125. doi:10.1016/j.ccr.2009.06.006
-
(2009)
Cancer Cell
, vol.16
, pp. 115-125
-
-
Gewinner, C.1
Wang, Z.C.2
Richardson, A.3
-
63
-
-
66349098674
-
Insulin-modulated Akt subcellular localization determines Akt isoformspecific signaling
-
doi:10.1073/pnas.0901933106
-
Gonzalez E, McGraw TE (2009) Insulin-modulated Akt subcellular localization determines Akt isoformspecific signaling. Proc Natl Acad Sci U S A 106:7004-7009. doi:10.1073/pnas.0901933106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 7004-7009
-
-
Gonzalez, E.1
McGraw, T.E.2
-
64
-
-
55549088220
-
Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake
-
doi:10.1074/jbc. M802623200
-
Green CJ, Göransson O, Kular GS et al (2008) Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake. J Biol Chem 283:27653-27667. doi:10.1074/jbc. M802623200
-
(2008)
J Biol Chem
, vol.283
, pp. 27653-27667
-
-
Green, C.J.1
Göransson, O.2
Kular, G.S.3
-
65
-
-
33747078270
-
Adipocytes contain a novel complex similar to the tuberous sclerosis complex
-
DOI 10.1016/j.cellsig.2006.01.002, PII S0898656806000179
-
Gridley S, Chavez JA, Lane WS, Lienhard GE (2006) Adipocytes contain anovel complex similar to the tuberous sclerosis complex. Cell Signal 18:1626-1632. doi:10.1016/j.cellsig.2006.01.002 (Pubitemid 44216120)
-
(2006)
Cellular Signalling
, vol.18
, Issue.10
, pp. 1626-1632
-
-
Gridley, S.1
Chavez, J.A.2
Lane, W.S.3
Lienhard, G.E.4
-
66
-
-
80054804471
-
IKBKE activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and PH domain to sustain malignant transformation
-
doi:10.1074/jbc. M111.287433
-
Guo J-P, Coppola D, Cheng JQ (2011) IKBKE activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and PH domain to sustain malignant transformation. J Biol Chem. doi:10.1074/jbc. M111.287433
-
(2011)
J Biol Chem.
-
-
Guo, J.-P.1
Coppola, D.2
Cheng, J.Q.3
-
67
-
-
0037837872
-
Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization: The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation
-
DOI 10.1074/jbc.M209991200
-
Gurung R, Tan A, Ooms LM et al (2003) Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epide. J Biol Chem 278:11376-11385. doi:10.1074/jbc. M209991200 (Pubitemid 36792695)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.13
, pp. 11376-11385
-
-
Gurung, R.1
Tan, A.2
Ooms, L.M.3
McGrath, M.J.4
Huysmans, R.D.5
Munday, A.D.6
Prescott, M.7
Whisstock, J.C.8
Mitchell, C.A.9
-
68
-
-
0032541135
-
Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein
-
DOI 10.1074/jbc.273.29.18605
-
Habib T, Hejna JA, Moses RE, Decker SJ (1998) Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein. J Biol Chem 273:18605-18609 (Pubitemid 28334792)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.29
, pp. 18605-18609
-
-
Habib, T.1
Hejna, J.A.2
Moses, R.E.3
Decker, S.J.4
-
69
-
-
34648823113
-
Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane
-
DOI 10.1038/sj.emboj.7601834, PII 7601834
-
He B, Xi F, Zhang X et al (2007) Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. EMBO J 26:4053-4065. doi:10.1038/sj.emboj.7601834 (Pubitemid 47462093)
-
(2007)
EMBO Journal
, vol.26
, Issue.18
, pp. 4053-4065
-
-
He, B.1
Xi, F.2
Zhang, X.3
Zhang, J.4
Guo, W.5
-
70
-
-
85047694402
-
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
-
doi:10.1172/JCI200420513.1774
-
Horie Y, Suzuki A, Kataoka E et al (2004) Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Investig. doi:10.1172/JCI200420513.1774
-
(2004)
J Clin Investig.
-
-
Horie, Y.1
Suzuki, A.2
Kataoka, E.3
-
72
-
-
0037312905
-
SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation
-
DOI 10.1128/MCB.23.4.1209-1220.2003
-
Ijuin T, Takenawa T (2003) SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. Mol Cell Biol 23:1209-1220. doi:10.1128/MCB.23.4.1209 (Pubitemid 36177031)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.4
, pp. 1209-1220
-
-
Ijuin, T.1
Takenawa, T.2
-
73
-
-
84857695184
-
Regulation of insulin signalling and glucose transporter 4 (GLUT4) exocytosis by the phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) phosphatase, SKIP
-
doi:10.1074/jbc. M111.335539
-
Ijuin T, Takenawa T (2012) Regulation of insulin signalling and glucose transporter 4 (GLUT4) exocytosis by the phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) phosphatase, SKIP. J Biol Chem. doi:10.1074/jbc. M111.335539
-
(2012)
J Biol Chem.
-
-
Ijuin, T.1
Takenawa, T.2
-
74
-
-
50249182374
-
Increased insulin action in SKIP heterozygous knockout mice
-
doi:10.1128/MCB.01990-06
-
Ijuin T, Yu YE, Mizutani K et al (2008) Increased insulin action in SKIP heterozygous knockout mice. Mol Cell Biol 28:5184-5195. doi:10.1128/MCB.01990-06
-
(2008)
Mol Cell Biol
, vol.28
, pp. 5184-5195
-
-
Ijuin, T.1
Yu, Y.E.2
Mizutani, K.3
-
75
-
-
0036892149
-
Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects
-
DOI 10.1210/en.2002-220615
-
Ikonomov OC, Sbrissa D, Mlak K, Shisheva A (2002) Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects. Endocrinology 143:4742-4754 (Pubitemid 35397616)
-
(2002)
Endocrinology
, vol.143
, Issue.12
, pp. 4742-4754
-
-
Ikonomov, O.C.1
Sbrissa, D.2
Mlak, K.3
Shisheva, A.4
-
76
-
-
34250006277
-
ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes
-
DOI 10.1016/j.yexcr.2007.03.024, PII S0014482707001139
-
Ikonomov OC, Sbrissa D, Dondapati R, Shisheva A (2007) ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes. Exp Cell Res 313:2404-2416. doi:10.1016/j.yexcr. 2007.03.024 S0014-4827 (07) 00113-9 [pii] (Pubitemid 46891465)
-
(2007)
Experimental Cell Research
, vol.313
, Issue.11
, pp. 2404-2416
-
-
Ikonomov, O.C.1
Sbrissa, D.2
Dondapati, R.3
Shisheva, A.4
-
77
-
-
69949143770
-
Sac3 is an Insulin-regulated PtdIns (3, 5) P2 phosphatase: Gain in insulin responsiveness through Sac3 downregulation in adipocytes
-
doi:10.1074/jbc. M109.025361. M109.025361 pii
-
Ikonomov OC, Sbrissa D, Ijuin T et al (2009) Sac3 is an Insulin-regulated PtdIns (3, 5) P2 phosphatase: gain in insulin responsiveness through Sac3 downregulation in adipocytes. J Biol Chem. doi:10.1074/jbc. M109.025361. M109.025361 [pii]
-
(2009)
J Biol Chem.
-
-
Ikonomov, O.C.1
Sbrissa, D.2
Ijuin, T.3
-
78
-
-
77956243411
-
ArPIKfyve regulates Sac3 protein abundance and turnover: Disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder
-
doi:10.1074/jbc. C110.154658
-
Ikonomov OC, Sbrissa D, Fligger J et al (2010) ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder. J Biol Chem. doi:10.1074/jbc. C110.154658
-
(2010)
J Biol Chem.
-
-
Ikonomov, O.C.1
Sbrissa, D.2
Fligger, J.3
-
79
-
-
79953854419
-
The phosphoinositide kinase PIKfyve is vital in early embryonic development: Preimplantation lethality of PIKfyve-/-embryos but normality of PIKfyve+/-mice
-
doi:10.1074/jbc. M111.222364
-
Ikonomov OC, Sbrissa D, Delvecchio K et al (2011) The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/-embryos but normality of PIKfyve+/-mice. J Biol Chem 286:13404-13413. doi:10.1074/jbc. M111.222364
-
(2011)
J Biol Chem
, vol.286
, pp. 13404-13413
-
-
Ikonomov, O.C.1
Sbrissa, D.2
Delvecchio, K.3
-
80
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
DOI 10.1038/ncb839
-
Inoki K, Li Y, Zhu T et al (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4:648-657. doi:10.1038/ncb839 ncb839 [pii] (Pubitemid 34993700)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.9
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
81
-
-
0043127125
-
Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
DOI 10.1101/gad.1110003
-
Inoki K, Li Y, Xu T, Guan K-L (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17:1829-1834. doi:10.1101/gad.1110003 (Pubitemid 36944560)
-
(2003)
Genes and Development
, vol.17
, Issue.15
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.-L.4
-
82
-
-
0037431329
-
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
-
DOI 10.1038/nature01533
-
Inoue M, Chang L, Hwang J et al (2003) The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Nature 422:629-633. doi:10.1038/nature01533 nature01533 [pii] (Pubitemid 36460418)
-
(2003)
Nature
, vol.422
, Issue.6932
, pp. 629-633
-
-
Inoue, M.1
Chang, L.2
Hwang, J.3
Chiang, S.-H.4
Saltiel, A.R.5
-
83
-
-
33745746188
-
Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering
-
DOI 10.1091/mbc.E06-01-0030
-
Inoue M, Chiang SH, Chang L et al (2006) Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering. Mol Biol Cell 17:2303-2311. doi:10.1091/mbc. E06-01-0030 E06-01-0030 [pii] (Pubitemid 44011745)
-
(2006)
Molecular Biology of the Cell
, vol.17
, Issue.5
, pp. 2303-2311
-
-
Inoue, M.1
Chiang, S.-H.2
Chang, L.3
Chen, X.-W.4
Saltiel, A.R.5
-
84
-
-
23344431984
-
Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides
-
DOI 10.1074/jbc.M500501200
-
Ishiki M, Randhawa VK, Poon V et al (2005) Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides. J Biol Chem 280:28792-28802. doi:10.1074/jbc. M500501200 (Pubitemid 41105781)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.31
, pp. 28792-28802
-
-
Ishiki, M.1
Randhawa, V.K.2
Poon, V.3
JeBailey, L.4
Klip, A.5
-
85
-
-
0029993517
-
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation
-
James SR, Downes CP, Gigg R et al (1996) Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3, 4, 5-trisphosphate without subsequent activation. Biochem J 315(Pt 3):709-713 (Pubitemid 26147592)
-
(1996)
Biochemical Journal
, vol.315
, Issue.3
, pp. 709-713
-
-
James, S.R.1
Downes, C.P.2
Gigg, R.3
Grove, S.J.A.4
Holmes, A.B.5
Alessi, D.R.6
-
86
-
-
48249119533
-
Phosphatidylinositol 4, 5-bisphosphate regulates SNARE-dependent membrane fusion
-
doi:10.1083/jcb.200801056
-
James DJ, Khodthong C, Kowalchyk JA, Martin T F J (2008) Phosphatidylinositol 4, 5-bisphosphate regulates SNARE-dependent membrane fusion. J Cell Biol 182:355-366. doi:10.1083/jcb.200801056
-
(2008)
J Cell Biol
, vol.182
, pp. 355-366
-
-
James, D.J.1
Khodthong, C.2
Kowalchyk, J.A.3
Martin, T.F.J.4
-
87
-
-
49649087385
-
Essential roles of PI (3) K-p110b in cell growth, metabolism and tumorigenesis
-
doi:10.1038/nature07091
-
Jia S, Liu Z, Zhang S et al (2008) Essential roles of PI (3) K-p110b in cell growth, metabolism and tumorigenesis. Nature. doi:10.1038/nature07091
-
(2008)
Nature
-
-
Jia, S.1
Liu, Z.2
Zhang, S.3
-
88
-
-
0037934650
-
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
-
DOI 10.1073/pnas.1332633100
-
Jiang ZY, Zhou QL, Coleman KA et al (2003) Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A 100:7569-7574. doi:10.1073/pnas.1332633100 (Pubitemid 36760010)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.13
, pp. 7569-7574
-
-
Jiang, Z.Y.1
Zhou, Q.L.2
Coleman, K.A.3
Chouinard, M.4
Boese, Q.5
Czech, M.P.6
-
89
-
-
58049198294
-
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI (3, 5) P (2) in yeast and mouse
-
doi:10.1038/emboj.2008.248 emboj2008248 pii
-
Jin N, Chow CY, Liu L et al (2008) VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI (3, 5) P (2) in yeast and mouse. EMBO J 27:3221-3234. doi:10.1038/emboj.2008.248 emboj2008248 [pii]
-
(2008)
EMBO J
, vol.27
, pp. 3221-3234
-
-
Jin, N.1
Chow, C.Y.2
Liu, L.3
-
90
-
-
33748193467
-
Nuclear PtdIns5P as a Transducer of Stress Signaling: An In Vivo Role for PIP4Kbeta
-
DOI 10.1016/j.molcel.2006.07.014, PII S1097276506004953
-
Jones DR, Bultsma Y, Keune W-J et al (2006) Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Mol Cell 23:685-695. doi:10.1016/j.molcel.2006.07.014 (Pubitemid 44308589)
-
(2006)
Molecular Cell
, vol.23
, Issue.5
, pp. 685-695
-
-
Jones, D.R.1
Bultsma, Y.2
Keune, W.-J.3
Halstead, J.R.4
Elouarrat, D.5
Mohammed, S.6
Heck, A.J.7
D'Santos, CliveS.8
Divecha, N.9
-
91
-
-
0027249346
-
Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of P13-kinase
-
DOI 10.1006/bbrc.1993.2111
-
Kanai F, Ito K, Todaka M et al (1993) Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase. Biochem Biophys Res Commun 195:762-768. doi:10.1006/bbrc.1993.2111 (Pubitemid 23280482)
-
(1993)
Biochemical and Biophysical Research Communications
, vol.195
, Issue.2
, pp. 762-768
-
-
Kanai, F.1
Ito, K.2
Todaka, M.3
Hayashi, H.4
Kamohara, S.5
Ishii, K.6
Okada, T.7
Hazeki, O.8
Ui, M.9
Ebina, Y.10
-
92
-
-
0030913673
-
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
-
DOI 10.1093/emboj/16.10.2783
-
Khwaja A, Rodriguez-Viciana P, Wennström S et al (1997) Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 16:2783-2793. doi:10.1093/emboj/16.10.2783 (Pubitemid 27226215)
-
(1997)
EMBO Journal
, vol.16
, Issue.10
, pp. 2783-2793
-
-
Khwaja, A.1
Rodriguez-Viciana, P.2
Wennstrom, S.3
Warne, P.H.4
Downward, J.5
-
93
-
-
0035809160
-
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase y sorting in Saccharomyces cerevisiae
-
Kihara A, Noda T, Ishihara N, Ohsumi Y (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152:519-530 (Pubitemid 34280235)
-
(2001)
Journal of Cell Biology
, vol.153
, Issue.3
, pp. 519-530
-
-
Kihara, A.1
Noda, T.2
Ishihara, N.3
Ohsumi, Y.4
-
94
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
doi:10.1038/ncb1753 ncb1753 pii
-
Kim E, Goraksha-Hicks P, Li L et al (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 10:935-945. doi:10.1038/ncb1753 ncb1753 [pii]
-
(2008)
Nat Cell Biol
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
-
95
-
-
51849096491
-
The roles of PTEN in development, physiology and tumorigenesis in mouse models: A tissue-by-tissue survey
-
doi:10.1038/onc.2008.238
-
Knobbe CB, Lapin V, Suzuki A, Mak TW (2008) The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey. Oncogene 27:5398-5415. doi:10.1038/onc.2008.238
-
(2008)
Oncogene
, vol.27
, pp. 5398-5415
-
-
Knobbe, C.B.1
Lapin, V.2
Suzuki, A.3
Mak, T.W.4
-
96
-
-
33746975370
-
Phosphatidylinositol 3-phosphate [PtdIns(3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: Endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane
-
DOI 10.1128/MCB.00203-06
-
Kong AM, Horan KA, Sriratana A et al (2006) Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane. Mol Cell Biol 26:6065-6081. doi:10.1128/MCB.00203-06 (Pubitemid 44204526)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.16
, pp. 6065-6081
-
-
Kong, A.M.1
Horan, K.A.2
Sriratana, A.3
Bailey, C.G.4
Collyer, L.J.5
Nandurkar, H.H.6
Shisheva, A.7
Layton, M.J.8
Rasko, J.E.J.9
Rowe, T.10
Mitchell, C.A.11
-
97
-
-
14844340146
-
Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue
-
DOI 10.1128/MCB.25.6.2498-2510.2005
-
Kurlawalla-Martinez C, Stiles B, Wang Y et al (2005) Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol 25:2498-2510. doi:10.1128/MCB.25. 6.2498-2510.2005 (Pubitemid 40354642)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.6
, pp. 2498-2510
-
-
Kurlawalla-Martinez, C.1
Stiles, B.2
Wang, Y.3
Devaskar, S.U.4
Kahn, B.B.5
Wu, H.6
-
98
-
-
0034912213
-
Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5
-
Kurosu H, Katada T (2001) Association of phosphatidylinositol 3-kinase composed of p110betacatalytic and p85-regulatory subunits with the small GTPase Rab5. J Biochem 130:73-78 (Pubitemid 32674567)
-
(2001)
Journal of Biochemistry
, vol.130
, Issue.1
, pp. 73-78
-
-
Kurosu, H.1
Katada, T.2
-
99
-
-
77649251207
-
MTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
-
doi:10.1073/pnas.1000323107
-
Laplante M, Sabatini DM (2010) mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. Proc Natl Acad Sci U S A 107:3281-3282. doi:10.1073/pnas.1000323107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 3281-3282
-
-
Laplante, M.1
Sabatini, D.M.2
-
100
-
-
0345687169
-
ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate
-
DOI 10.1073/pnas.2232129100
-
Lawrence J T R, Birnbaum MJ (2003) ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4, 5-bisphosphate. Proc Natl Acad Sci U S A 100:13320-13325. doi:10.1073/pnas. 2232129100 (Pubitemid 37444740)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.23
, pp. 13320-13325
-
-
Lawrence, J.T.R.1
Birnbaum, M.J.2
-
101
-
-
0029149712
-
Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: Comparison with fat cells
-
Le Marchand-Brustel Y, Gautier N, Cormont M, Van Obberghen E (1995) Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells. Endocrinology 136:3564-3570
-
(1995)
Endocrinology
, vol.136
, pp. 3564-3570
-
-
Le Marchand-Brustel, Y.1
Gautier, N.2
Cormont, M.3
Van Obberghen, E.4
-
102
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
DOI 10.1126/science.275.5308.1943
-
Li J, Yen C, Liaw D et al (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (New York, NY) 275:1943-1947 (Pubitemid 27148818)
-
(1997)
Science
, vol.275
, Issue.5308
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
103
-
-
35848947444
-
Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells
-
DOI 10.1091/mbc.E07-05-0461
-
Liu J, Zuo X, Yue P, Guo W (2007) Phosphatidylinositol 4, 5-bisphosphate mediates the targeting of the Exocyst to the plasma membrane for exocytosis in mammalian cells. Mol Biol Cell 18:4483-4492. doi:10.1091/mbc. E07 (Pubitemid 350060175)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.11
, pp. 4483-4492
-
-
Liu, J.1
Zuo, X.2
Yue, P.3
Guo, W.4
-
104
-
-
51349091876
-
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5
-
doi:10.1091/mbc. E08-01-0105
-
Lodhi I, Bridges D, Chiang S-H et al (2008) Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol Biol Cell. doi:10.1091/mbc. E08-01-0105
-
(2008)
Mol Biol Cell.
-
-
Lodhi, I.1
Bridges, D.2
Chiang, S.-H.3
-
105
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
DOI 10.1074/jbc.273.22.13375
-
Maehama T, Dixon J (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 273:13375-13378 (Pubitemid 28268370)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.22
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
106
-
-
0042466604
-
Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation
-
DOI 10.1093/emboj/cdg402
-
Maffucci T, Brancaccio A, Piccolo E et al (2003) Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. EMBO J 22:4178-4189. doi:10.1093/emboj/cdg402 (Pubitemid 37021746)
-
(2003)
EMBO Journal
, vol.22
, Issue.16
, pp. 4178-4189
-
-
Maffucci, T.1
Brancaccio, A.2
Piccolo, E.3
Stein, R.C.4
Falasca, M.5
-
107
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
-
DOI 10.1016/S1097-2765(02)00568-3
-
Manning BD, Tee AR, Logsdon MN et al (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10:151-162 (Pubitemid 34876569)
-
(2002)
Molecular Cell
, vol.10
, Issue.1
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon M.Nicole3
Blenis, J.4
Cantley, L.C.5
-
108
-
-
67650373163
-
A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
-
doi:10.1038/emboj.2009.155
-
Mao Y, Balkin DM, Zoncu R et al (2009) A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J 28:1831-1842. doi:10.1038/emboj.2009.155
-
(2009)
EMBO J
, vol.28
, pp. 1831-1842
-
-
Mao, Y.1
Balkin, D.M.2
Zoncu, R.3
-
109
-
-
79958047958
-
Class II phosphoinositide 3-kinase C2alpha: What we learned so far
-
Mazza S, Maffucci T (2011) Class II phosphoinositide 3-kinase C2alpha: what we learned so far. J Biochem Mol Biol 2:168-182
-
(2011)
J Biochem Mol Biol
, vol.2
, pp. 168-182
-
-
Mazza, S.1
Maffucci, T.2
-
110
-
-
2942563750
-
3 binding to PDK1 PH domain defined by knockin mutation
-
DOI 10.1038/sj.emboj.7600218
-
McManus EJ, Collins BJ, Ashby PR et al (2004) The in vivo role of PtdIns (3, 4, 5) P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J 23:2071-2082. doi:10.1038/sj.emboj.7600218 (Pubitemid 38737734)
-
(2004)
EMBO Journal
, vol.23
, Issue.10
, pp. 2071-2082
-
-
McManus, E.J.1
Collins, B.J.2
Ashby, P.R.3
Prescott, A.R.4
Murray-Tait, V.5
Armit, L.J.6
Arthur, J.S.C.7
Alessi, D.R.8
-
111
-
-
84055214006
-
Multiple roles for the p85a isoform in the regulation and function of PI3K signalling and receptor trafficking
-
doi:10.1042/BJ20111164
-
Mellor P, Furber LA, Nyarko J N K, Anderson DH (2012) Multiple roles for the p85a isoform in the regulation and function of PI3K signalling and receptor trafficking. Biochem J 441:23-37. doi:10.1042/BJ20111164
-
(2012)
Biochem J
, vol.441
, pp. 23-37
-
-
Mellor, P.1
Furber, L.A.2
Nyarko, J.N.K.3
Anderson, D.H.4
-
112
-
-
23044500717
-
Mutant kinesin-2 motor subunits increase chromosome loss
-
DOI 10.1091/mbc.
-
Meunier FA, Osborne SL, Hammond G R V et al (2005) Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol Biol Cell 16:4841-4851. doi:10.1091/mbc. E05-02-0171 (Pubitemid 41077089)
-
(2005)
Molecular Biology of the Cell
, vol.16
, Issue.8
, pp. 3810-3820
-
-
Miller, M.S.1
Esparza, J.M.2
Lippa, A.M.3
Lux III, F.G.4
Cole, D.G.5
Dutcher, S.K.6
-
113
-
-
1642417606
-
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment
-
DOI 10.1016/S0092-8674(04)00117-5, PII S0092867404001175
-
Miaczynska M, Christoforidis S, Giner A et al (2004) APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 116:445-456 (Pubitemid 38366320)
-
(2004)
Cell
, vol.116
, Issue.3
, pp. 445-456
-
-
Miaczynska, M.1
Christoforidis, S.2
Giner, A.3
Shevchenko, A.4
Uttenweiler-Joseph, S.5
Habermann, B.6
Wilm, M.7
Parton, R.G.8
Zerial, M.9
-
114
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
Michael MD, Kulkarni RN, Postic C et al (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6:87-97
-
(2000)
Mol Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
-
115
-
-
70349499329
-
Phosphoinositides and SNARE chaperones synergistically assemble and remodel SNARE complexes for membrane fusion
-
Mima J, Wickner W (2009) Phosphoinositides and SNARE chaperones synergistically assemble and remodel SNARE complexes for membrane fusion. Proc Natl Acad Sci U S A 106:16191-16196
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 16191-16196
-
-
Mima, J.1
Wickner, W.2
-
116
-
-
41449087811
-
Rapid Activation of Akt2 Is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes
-
DOI 10.1016/j.cmet.2008.02.008, PII S1550413108000429
-
Ng Y, Ramm G, Lopez JA, James DE (2008) Rapidactivation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes. Cell Metab 7:348-356. doi:10.1016/j.cmet.2008.02.008 (Pubitemid 351455217)
-
(2008)
Cell Metabolism
, vol.7
, Issue.4
, pp. 348-356
-
-
Ng, Y.1
Ramm, G.2
Lopez, J.A.3
James, D.E.4
-
117
-
-
33745030531
-
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo
-
DOI 10.1128/MCB.00238-06
-
Nguyen K-TT, Tajmir P, Lin CH et al (2006) Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Mol Cell Biol 26:4511-4518. doi:10.1128/MCB.00238-06 (Pubitemid 43877571)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.12
, pp. 4511-4518
-
-
Nguyen, K.-T.T.1
Tajmir, P.2
Lin, C.H.3
Liadis, N.4
Zhu, X.-D.5
Eweida, M.6
Tolasa-Karaman, G.7
Cai, F.8
Wang, R.9
Kitamura, T.10
Belsham, D.D.11
Wheeler, M.B.12
Suzuki, A.13
Mak, T.W.14
Woo, M.15
-
118
-
-
47649106149
-
Endosomal phosphoinositides and human diseases
-
DOI 10.1111/j.1600-0854.2008.00754.x
-
Nicot A-S, Laporte J (2008) Endosomal phosphoinositides and human diseases. Traffic (Copenhagen, Denmark) 9:1240-1249 (Pubitemid 352016284)
-
(2008)
Traffic
, vol.9
, Issue.8
, pp. 1240-1249
-
-
Nicot, A.-S.1
Laporte, J.2
-
119
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
DOI 10.1073/pnas.0506925102
-
Nobukuni T, Joaquin M, Roccio M et al (2005) Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 102:14238-14243. doi:10.1073/pnas. 0506925102 (Pubitemid 41429682)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.40
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
Zwartkruis, F.J.T.11
Thomas, G.12
-
120
-
-
0042266341
-
A peroxovanadium compound stimulates muscle glucose transport as powerfully as insulin and contractions combined
-
DOI 10.2337/diabetes.52.8.1918
-
Nolte LA, Han D-H, Hansen PA et al (2003) A peroxovanadium compound stimulates muscle glucose transport as powerfully as insulin and contractions combined. Diabetes 52:1918-1925 (Pubitemid 36919782)
-
(2003)
Diabetes
, vol.52
, Issue.8
, pp. 1918-1925
-
-
Nolte, L.A.1
Han, D.-H.2
Hansen, P.A.3
Hucker, K.A.4
Holloszy, J.O.5
-
121
-
-
0029000258
-
The isolation and characterizationofcDNA encoding human and rat brain inositol polyphosphate 4-phosphatase
-
Norris FA, Auethavekiat V, Majerus PW (1995) The isolation and characterizationofcDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. J Biol Chem 270:16128-16133
-
(1995)
J Biol Chem
, vol.270
, pp. 16128-16133
-
-
Norris, F.A.1
Auethavekiat, V.2
Majerus, P.W.3
-
122
-
-
0030863996
-
The cDNA cloning and characterization of inositol polyphosphate 4- phosphatase type II. Evidence for conserved alternative splicing in the 4- phosphatase family
-
DOI 10.1074/jbc.272.38.23859
-
Norris FA, Atkins RC, Majerus PW (1997) The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem 272:23859-23864 (Pubitemid 27410966)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.38
, pp. 23859-23864
-
-
Norris, F.A.1
Atkins, R.C.2
Majerus, P.W.3
-
123
-
-
0028124189
-
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
-
Okada T, Kawano Y, Sakakibara T et al (1994) Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J Biol Chem 269:3568-3573
-
(1994)
J Biol Chem
, vol.269
, pp. 3568-3573
-
-
Okada, T.1
Kawano, Y.2
Sakakibara, T.3
-
124
-
-
33947128563
-
Synip phosphorylation is required for insulin-stimulated Glut4 translocation
-
DOI 10.1016/j.bbrc.2007.02.095, PII S0006291X07003828
-
Okada S, Ohshima K, Uehara Y et al (2007) Synip phosphorylation is required for insulinstimulated Glut4 translocation. Biochem Biophys Res Commun 356:102-106. doi:10.1016/j.bbrc.2007.02.095 (Pubitemid 46413135)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.356
, Issue.1
, pp. 102-106
-
-
Okada, S.1
Ohshima, K.2
Uehara, Y.3
Shimizu, H.4
Hashimoto, K.5
Yamada, M.6
Mori, M.7
-
125
-
-
0038303159
-
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells
-
DOI 10.1073/pnas.0931282100
-
Olsen HL, Hoy M, Zhang W et al (2003) Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Proc Natl Acad Sci U S A 100:5187-5192. doi:10.1073/pnas.0931282100 (Pubitemid 36542680)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.9
, pp. 5187-5192
-
-
Olsen, H.L.1
Hoy, M.2
Zhang, W.3
Bertorello, A.M.4
Bokvist, K.5
Capito, K.6
Efanov, A.M.7
Meister, B.8
Thams, P.9
Yang, S.-N.10
Rorsman, P.11
Berggren, P.-O.12
Gromada, J.13
-
126
-
-
62749155738
-
The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
-
doi:10.1042/BJ20081673
-
Ooms LM, Horan KA, Rahman P et al (2009) The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem J 419:29-49. doi:10.1042/BJ20081673
-
(2009)
Biochem J
, vol.419
, pp. 29-49
-
-
Ooms, L.M.1
Horan, K.A.2
Rahman, P.3
-
127
-
-
79951494608
-
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation
-
doi:10.1016/j.molcel.2011.01.019
-
Ou Y-H, Torres M, Ram R et al (2011) TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell 41:458-470. doi:10.1016/j.molcel.2011.01.019
-
(2011)
Mol Cell
, vol.41
, pp. 458-470
-
-
Ou, Y.-H.1
Torres, M.2
Ram, R.3
-
128
-
-
0020025201
-
Separation of phospholipids and individual molecular species of phospholipids by high-performance liquid chromatography
-
Patton GM, Fasulo JM, Robins SJ (1982) Separation of phospholipids and individual molecular species of phospholipids by high-performance liquid chromatography. J Lipid Res 23:190-196 (Pubitemid 12112627)
-
(1982)
Journal of Lipid Research
, vol.23
, Issue.1
, pp. 190-196
-
-
Patton, G.M.1
Fasulo, J.M.2
Robins, S.J.3
-
129
-
-
79961165137
-
MTOR complex 1 regulates Lipin 1 localization to control the SREBP pathway
-
doi:10.1016/j.cell.2011.06.034
-
Peterson T R R, Sengupta S S S, Harris T E E et al (2011) mTOR complex 1 regulates Lipin 1 localization to control the SREBP pathway. Cell 146:408-420. doi:10.1016/j.cell.2011.06.034
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.R.1
Sengupta, S.S.S.2
Harris, T.E.E.3
-
130
-
-
0029078130
-
Selective inhibition of p70 S6 kinase activation by phosphatidylinositol 3-kinase inhibitors
-
Petritsch C, Woscholski R, Edelmann HM et al (1995) Selective inhibition of p70 S6 kinase activation by phosphatidylinositol 3-kinase inhibitors. Eur J Biochem/FEBS 230:431-438
-
(1995)
Eur J Biochem/FEBS
, vol.230
, pp. 431-438
-
-
Petritsch, C.1
Woscholski, R.2
Edelmann, H.M.3
-
131
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
DOI 10.1073/pnas.96.4.1563
-
Podsypanina K, Ellenson LH, Nemes A et al (1999) Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A 96:1563-1568 (Pubitemid 29098491)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.4
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
Gu, J.4
Tamura, M.5
Yamada, K.M.6
Cordon-Cardo, C.7
Catoretti, G.8
Fisher, P.E.9
Parsons, R.10
-
132
-
-
67650034408
-
Specific tyrosine phosphorylations mediate signaldependent stimulation of SHIP2 inositol phosphatase activity, while the SH2 domain confers an inhibitory effect to maintain the basal activity
-
doi:10.1021/bi900492d
-
Prasad NK, Werner ME, Decker SJ (2009) Specific tyrosine phosphorylations mediate signaldependent stimulation of SHIP2 inositol phosphatase activity, while the SH2 domain confers an inhibitory effect to maintain the basal activity. Biochemistry 48:6285-6287. doi:10.1021/bi900492d
-
(2009)
Biochemistry
, vol.48
, pp. 6285-6287
-
-
Prasad, N.K.1
Werner, M.E.2
Decker, S.J.3
-
133
-
-
70349311460
-
P85 Associates with unphosphorylated PTEN and the PTEN-associated complex
-
doi:10.1128/MCB.01649-08
-
Rabinovsky R, Pochanard P, McNear C et al (2009) p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol 29:5377-5388. doi:10.1128/MCB.01649-08
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5377-5388
-
-
Rabinovsky, R.1
Pochanard, P.2
McNear, C.3
-
134
-
-
0030721527
-
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
-
DOI 10.1038/36621
-
Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997) A new pathway for synthesis of phosphatidylinositol-4, 5-bisphosphate. Nature 390:192-196. doi:10.1038/36621 (Pubitemid 27507991)
-
(1997)
Nature
, vol.390
, Issue.6656
, pp. 192-196
-
-
Rameh, L.E.1
Tolias, K.F.2
Duckworth, B.C.3
Cantley, L.C.4
-
135
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
DOI 10.1038/370527a0
-
Rodriguez-Viciana P, Warne PH, Dhand R et al (1994) Phosphatidylinositol- 3-OH kinase as a direct target of Ras. Nature 370:527-532. doi:10.1038/370527a0 (Pubitemid 24264918)
-
(1994)
Nature
, vol.370
, Issue.6490
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
Fry, M.J.6
Waterfield, M.D.7
Downward, J.8
-
136
-
-
0035735902
-
Mediation of IGF-1-induced skeletal myotube hypertrophy by Pl(3)K/Alt/mTOR and Pl(3)K/Akt/GSK3 pathways
-
DOI 10.1038/ncb1101-1009
-
Rommel C, Bodine SC, Clarke BA et al (2001) Mediation of IGF-1-induced skeletal myotube hypertrophy by PI (3) K/Akt/mTOR and PI (3) K/Akt/GSK3 pathways. Nat Cell Biol 3:1009-1013. doi:10.1038/ncb1101-1009 (Pubitemid 34428746)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.11
, pp. 1009-1013
-
-
Rommel, C.1
Bodine, S.C.2
Clarke, B.A.3
Rossman, R.4
Nunez, L.5
Stitt, T.N.6
Yancopoulos, G.D.7
Glass, D.J.8
-
137
-
-
33947496373
-
A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)
-
doi:10.1021/cb600352f
-
Rosivatz E, Matthews JG, McDonald NQ et al (2006) A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol 1:780-790. doi:10.1021/cb600352f
-
(2006)
ACS Chem Biol
, vol.1
, pp. 780-790
-
-
Rosivatz, E.1
Matthews, J.G.2
McDonald, N.Q.3
-
139
-
-
0346729925
-
2-specific Phosphatase
-
DOI 10.1091/mbc.E03-05-0297
-
Rudge S, Anderson DH, Emr SD (2004) Vacuole size control: regulation of PtdIns (3, 5) P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns (3, 5) P2-specific phosphatase. Mol Biol Cell 15:24-36 (Pubitemid 38044940)
-
(2004)
Molecular Biology of the Cell
, vol.15
, Issue.1
, pp. 24-36
-
-
Rudge, S.A.1
Anderson, D.M.2
Emr, S.D.3
-
140
-
-
36148932174
-
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
-
DOI 10.1074/jbc.M704150200
-
Saito T, Jones CC, Huang S et al (2007) The interaction of Akt with APPL1 is required for insulinstimulated Glut4 translocation. J Biol Chem 282:32280-32287. doi:10.1074/jbc. M704150200 (Pubitemid 350106472)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.44
, pp. 32280-32287
-
-
Saito, T.1
Jones, C.C.2
Huang, S.3
Czech, M.P.4
Pilch, P.F.5
-
141
-
-
45849105156
-
The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
DOI 10.1126/science.1157535
-
Sancak Y, Peterson TR, Shaul YD et al (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (New York, NY) 320:1496-1501 (Pubitemid 351929429)
-
(2008)
Science
, vol.320
, Issue.5882
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
142
-
-
77951768486
-
Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak Y, Bar-Peled L, Zoncu R et al (2010) Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141:290-303
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
-
143
-
-
0037677096
-
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
-
DOI 10.1074/jbc.C300063200
-
Sano H, Kane S, Sano E et al (2003) Insulin-stimulated phosphorylation of a Rab GTPaseactivating protein regulates GLUT4 translocation. J Biol Chem 278:14599-14602. doi:10.1074/jbc. C300063200 (Pubitemid 36799780)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.17
, pp. 14599-14602
-
-
Sano, H.1
Kane, S.2
Sano, E.3
Miinea, C.P.4
Asara, J.M.5
Lane, W.S.6
Garner, C.W.7
Lienhard, G.E.8
-
144
-
-
19744378802
-
Synip phosphorylation does not regulate insulin-stimulated GLUT4 translocation
-
DOI 10.1016/j.bbrc.2005.05.027, PII S0006291X05010004
-
Sano H, Kane S, Sano E, Lienhard GE (2005) Synip phosphorylation does not regulate insulinstimulated GLUT4 translocation. Biochem Biophys Res Commun 332:880-884. doi:10.1016/j.bbrc.2005.05.027 (Pubitemid 40745195)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.332
, Issue.3
, pp. 880-884
-
-
Sano, H.1
Kane, S.2
Sano, E.3
Lienhard, G.E.4
-
145
-
-
33947578085
-
Rab10, a Target of the AS160 Rab GAP, Is Required for Insulin-Stimulated Translocation of GLUT4 to the Adipocyte Plasma Membrane
-
DOI 10.1016/j.cmet.2007.03.001, PII S1550413107000629
-
Sano H, Eguez L, Teruel MN et al (2007) Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell Metab 5:293-303. doi:10.1016/j.cmet.2007.03.001 (Pubitemid 46477855)
-
(2007)
Cell Metabolism
, vol.5
, Issue.4
, pp. 293-303
-
-
Sano, H.1
Eguez, L.2
Teruel, M.N.3
Fukuda, M.4
Chuang, T.D.5
Chavez, J.A.6
Lienhard, G.E.7
McGraw, T.E.8
-
146
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
DOI 10.1126/science.1106148
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (New York, NY) 307:1098-1101. doi:10.1126/science.1106148 (Pubitemid 40262113)
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
147
-
-
77954930785
-
A novel HPLC-based approach makes possible the spacial characterization of cellular PtdIns5P and other phosphoinositides
-
doi:10.1042/BJ20100129
-
Sarkes D, Rameh LE (2010) A novel HPLC-based approach makes possible the spacial characterization of cellular PtdIns5P and other phosphoinositides. Biochem J 384:375-384. doi:10.1042/BJ20100129
-
(2010)
Biochem J
, vol.384
, pp. 375-384
-
-
Sarkes, D.1
Rameh, L.E.2
-
148
-
-
14844328642
-
Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway
-
DOI 10.1074/jbc.M412729200
-
Sbrissa D, Shisheva A (2005) Acquisition of unprecedented phosphatidylinositol 3, 5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway. J Biol Chem 280:7883-7889. doi:10.1074/jbc. M412729200 M412729200 [pii] (Pubitemid 40349685)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.9
, pp. 7883-7889
-
-
Sbrissa, D.1
Shisheva, A.2
-
149
-
-
0033618375
-
PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes
-
Sbrissa D, Ikonomov OC, Shisheva A (1999) PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. J Biol Chem 274:21589-21597
-
(1999)
J Biol Chem
, vol.274
, pp. 21589-21597
-
-
Sbrissa, D.1
Ikonomov, O.C.2
Shisheva, A.3
-
150
-
-
8644279885
-
Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation
-
DOI 10.1210/en.2004-0489
-
Sbrissa D, Ikonomov OC, Strakova J, Shisheva A (2004) Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation. Endocrinology 145:4853-4865. doi:10.1210/en. 2004-0489 (Pubitemid 39551102)
-
(2004)
Endocrinology
, vol.145
, Issue.11
, pp. 4853-4865
-
-
Sbrissa, D.1
Ikonomov, O.C.2
Strakova, J.3
Shisheva, A.4
-
151
-
-
34548221502
-
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport: Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex
-
DOI 10.1074/jbc.M611678200
-
Sbrissa D, Ikonomov OC, Fu Z et al (2007) Core protein machinery for mammalian phosphatidylinositol 3, 5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. J Biol Chem 282:23878-23891. doi:10.1074/jbc. M611678200 M611678200 [pii] (Pubitemid 47328041)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.33
, pp. 23878-23891
-
-
Sbrissa, D.1
Ikonomov, O.C.2
Fu, Z.3
Ijuin, T.4
Gruenberg, J.5
Takenawa, T.6
Shisheva, A.7
-
152
-
-
56249092073
-
ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality
-
Sbrissa D, Ikonomov OC, Fenner H, Shisheva A (2008) ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. J Mol Biol 384:766-779
-
(2008)
J Mol Biol
, vol.384
, pp. 766-779
-
-
Sbrissa, D.1
Ikonomov, O.C.2
Fenner, H.3
Shisheva, A.4
-
153
-
-
42949092018
-
The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development
-
DOI 10.1016/j.cell.2008.02.044, PII S0092867408003942
-
Schenck A, Goto-Silva L, Collinet C et al (2008) The endosomal protein App l1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 133:486-497. doi:10.1016/j.cell.2008.02.044 (Pubitemid 351608689)
-
(2008)
Cell
, vol.133
, Issue.3
, pp. 486-497
-
-
Schenck, A.1
Goto-Silva, L.2
Collinet, C.3
Rhinn, M.4
Giner, A.5
Habermann, B.6
Brand, M.7
Zerial, M.8
-
154
-
-
2442601508
-
Bisperoxovanadium compounds are potent PTEN inhibitors
-
DOI 10.1016/j.febslet.2004.03.102, PII S0014579304004351
-
Schmid AC, Byrne RD, Vilar R, Woscholski R (2004) Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett 566:35-38. doi:10.1016/j. febslet.2004.03.102 (Pubitemid 38625928)
-
(2004)
FEBS Letters
, vol.566
, Issue.1-3
, pp. 35-38
-
-
Schmid, A.C.1
Byrne, R.D.2
Vilar, R.3
Woscholski, R.4
-
155
-
-
0027905021
-
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
-
Schu PV, Takegawa K, Fry MJ et al (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science (New York, NY) 260:88-91 (Pubitemid 23122750)
-
(1993)
Science
, vol.259
, Issue.5104
, pp. 88-91
-
-
Schu, P.V.1
Takegawa, K.2
Fry, M.J.3
Stack, J.H.4
Waterfield, M.D.5
Emr, S.D.6
-
156
-
-
0028797745
-
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: Evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase
-
Shepherd PR, Navé BT, Siddle K (1995) Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase. Biochem J 305(Pt 1):25-28
-
(1995)
Biochem J
, vol.305
, Issue.PART 1
, pp. 25-28
-
-
Shepherd, P.R.1
Navé, B.T.2
Siddle, K.3
-
157
-
-
23944437499
-
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
-
DOI 10.1083/jcb.200505128
-
Shin HW, Hayashi M, Christoforidis S et al (2005) An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol 170:607-618. doi:10.1083/jcb.200505128 jcb.200505128 [pii] (Pubitemid 41186935)
-
(2005)
Journal of Cell Biology
, vol.170
, Issue.4
, pp. 607-618
-
-
Shin, H.-W.1
Hayashi, M.2
Christoforidis, S.3
Lacas-Gervais, S.4
Hoepfner, S.5
Wenk, M.R.6
Modregger, J.7
Uttenweiler-Joseph, S.8
Wilm, M.9
Nystuen, A.10
Frankel, W.N.11
Solimena, M.12
De Camilli, P.13
Zerial, M.14
-
158
-
-
20044364159
-
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
-
DOI 10.1038/nm1178
-
Sleeman MW, Wortley KE, Lai K-MV et al (2005) Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med 11:199-205. doi:10.1038/nm1178 (Pubitemid 40321356)
-
(2005)
Nature Medicine
, vol.11
, Issue.2
, pp. 199-205
-
-
Sleeman, M.W.1
Wortley, K.E.2
Lai, K.-M.V.3
Gowen, L.C.4
Kintner, J.5
Kline, W.O.6
Garcia, K.7
Stitt, T.N.8
Yancopoulos, G.D.9
Wiegand, S.J.10
Glass, D.J.11
-
159
-
-
77249100829
-
Specific roles of the p110a isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation
-
doi:10.1016/j.cmet.2010.02.002
-
Sopasakis VR, Liu P, Suzuki R et al (2010) Specific roles of the p110a isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metab 11:220-230. doi:10.1016/j.cmet.2010.02.002
-
(2010)
Cell Metab
, vol.11
, pp. 220-230
-
-
Sopasakis, V.R.1
Liu, P.2
Suzuki, R.3
-
160
-
-
0023945139
-
Thymic lymphoma induction by the AKT8 murine retrovirus
-
Staal SP, Hartley JW (1988) Thymic lymphoma induction by the AKT8 murine retrovirus. J Exp Med 167:1259-1264
-
(1988)
J Exp Med
, vol.167
, pp. 1259-1264
-
-
Staal, S.P.1
Hartley, J.W.2
-
161
-
-
11144237619
-
Mechanism of membrane binding of the phospholipase D1 PX domain
-
DOI 10.1074/jbc.M407798200
-
Stahelin R, Ananthanarayanan B, Blatner N et al (2004) Mechanism of membrane binding of the phospholipase D1 PX domain. J Biol Chem 279:54918-54926 (Pubitemid 40053238)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.52
, pp. 54918-54926
-
-
Stahelin, R.V.1
Ananthanarayanan, B.2
Blatner, N.E.3
Singh, S.4
Bruzik, K.S.5
Murray, D.6
Cho, W.7
-
162
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
DOI 10.1038/ng0497-356
-
Steck PA, Pershouse MA, Jasser SA et al (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15:356-362. doi:10.1038/ng0497-356 (Pubitemid 27147102)
-
(1997)
Nature Genetics
, vol.15
, Issue.4
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.A.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
Frye, C.11
Hu, R.12
Swedlund, B.13
Teng, D.H.F.14
Tavtigian, S.V.15
-
163
-
-
10744222107
-
Live-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity
-
DOI 10.1073/pnas.0308617100
-
Stiles B, Wang Y, Stahl A et al (2004) Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A 101:2082-2087. doi:10.1073/pnas.0308617100 (Pubitemid 38229018)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.7
, pp. 2082-2087
-
-
Stiles, B.1
Wang, Y.2
Stahl, A.3
Bassilian, S.4
Lee, W.P.5
Kim, Y.-J.6
Sherwin, R.7
Devaskar, S.8
Lesche, R.9
Magnuson, M.A.10
Wu, H.11
-
164
-
-
33645217126
-
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes
-
doi:10.1128/MCB.26.7.2772
-
Stiles BL, Kuralwalla-Martinez C, Guo W et al (2006) Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol 26:2772. doi:10.1128/MCB.26.7.2772
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2772
-
-
Stiles, B.L.1
Kuralwalla-Martinez, C.2
Guo, W.3
-
165
-
-
78650549552
-
Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells
-
doi:10.1073/pnas.1009523107
-
Sun Y, Bilan PJ, Liu Z, Klip A (2010) Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells. Proc Natl Acad Sci U S A 2010:6-11. doi:10.1073/pnas.1009523107
-
(2010)
Proc Natl Acad Sci U S A
, vol.2010
, pp. 6-11
-
-
Sun, Y.1
Bilan, P.J.2
Liu, Z.3
Klip, A.4
-
166
-
-
70350057467
-
Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2
-
doi:10.1111/j.1476-5381.2009.00358.x
-
Suwa A, Yamamoto T, Sawada A et al (2009) Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br J Pharmacol 158:879-887. doi:10.1111/j.1476-5381.2009. 00358.x
-
(2009)
Br J Pharmacol
, vol.158
, pp. 879-887
-
-
Suwa, A.1
Yamamoto, T.2
Sawada, A.3
-
167
-
-
13144249184
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
-
Suzuki A, De La Pompa JL, Stambolic V et al (1998) High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol CB 8:1169-1178 (Pubitemid 28494715)
-
(1998)
Current Biology
, vol.8
, Issue.21
, pp. 1169-1178
-
-
Suzuki, A.1
De La Pompa, J.L.2
Stambolic, V.3
Elia, A.J.4
Sasaki, T.5
Del Barco Barrantes, I.6
Ho, A.7
Wakeham, A.8
Itie, A.9
Khoo, W.10
Fukumoto, M.11
Mak, T.W.12
-
168
-
-
77949900267
-
App l1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts
-
doi:10.1074/jbc. M109.068452
-
Tan Y, You H, Wu C et al (2010) App l1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem 285:6377-6389. doi:10.1074/jbc. M109.068452
-
(2010)
J Biol Chem
, vol.285
, pp. 6377-6389
-
-
Tan, Y.1
You, H.2
Wu, C.3
-
169
-
-
79953186071
-
Next generation Akt inhibitors provide greater specificityeffects on glucose metabolism in adipocytes
-
doi:10.1042/BJ20110040
-
Tan S-X, Ng Y, James DE (2011) Next generation Akt inhibitors provide greater specificityeffects on glucose metabolism in adipocytes. Biochem J. doi:10.1042/BJ20110040
-
(2011)
Biochem J.
-
-
Tan, S.-X.1
Ng, Y.2
James, D.E.3
-
170
-
-
0042701991
-
Tuberous Sclerosis Complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
DOI 10.1016/S0960-9822(03)00506-2
-
Tee AR, Manning BD, Roux PP et al (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13:1259-1268 (Pubitemid 36953298)
-
(2003)
Current Biology
, vol.13
, Issue.15
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
171
-
-
84857406235
-
PI3K signalling: The path to discovery and understanding
-
doi:10.1038/nrm3290
-
Vanhaesebroeck B, Stephens L, Hawkins P (2012) PI3K signalling: the path to discovery and understanding. Nat Rev Mol Cell Biol 13:195-203. doi:10.1038/nrm3290
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 195-203
-
-
Vanhaesebroeck, B.1
Stephens, L.2
Hawkins, P.3
-
172
-
-
83555163852
-
OCRL controls trafficking through early regulation of endosomal actin
-
doi:10.1038/emboj.2011.354
-
Vicinanza M, Campli AD, Polishchuk E et al (2011) OCRL controls trafficking through early regulation of endosomal actin. EMBO J 1-16. doi:10.1038/emboj.2011.354
-
(2011)
EMBO J
, pp. 1-16
-
-
Vicinanza, M.1
Campli, A.D.2
Polishchuk, E.3
-
173
-
-
33749527232
-
Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion
-
DOI 10.1073/pnas.0606881103
-
Vicogne J, Vollenweider D, Smith JR et al (2006) Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion. Proc Natl Acad Sci U S A 103:14761-14766. doi:10.1073/pnas.0606881103 (Pubitemid 44527802)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.40
, pp. 14761-14766
-
-
Vicogne, J.1
Vollenweider, D.2
Smith, J.R.3
Huang, P.4
Frohman, M.A.5
Pessin, J.E.6
-
174
-
-
0035135318
-
Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity
-
DOI 10.1128/MCB.21.5.1633-1646.2001
-
Wada T, Sasaoka T, Funaki M et al (2001) Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 50-phosphatase catalytic activity. Mol Cell Biol 21:1633-1646. doi:10.1128/MCB.21.5.1633-1646.2001 (Pubitemid 32156383)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.5
, pp. 1633-1646
-
-
Wada, T.1
Sasaoka, T.2
Funaki, M.3
Hori, H.4
Murakami, S.5
Ishiki, M.6
Haruta, T.7
Asano, T.8
Ogawa, W.9
Ishihara, H.10
Kobayashi, M.11
-
175
-
-
28144450659
-
Role of phosphoinositide signaling in the control of insulin exocytosis
-
DOI 10.1210/me.2004-0530
-
Waselle L, Gerona R R L, Vitale N et al (2005) Role of phosphoinositide signaling in the control of insulin exocytosis. Mol Endocrinol (Baltimore, Md) 19:3097-3106. doi:10.1210/me.2004-0530 (Pubitemid 41697724)
-
(2005)
Molecular Endocrinology
, vol.19
, Issue.12
, pp. 3097-3106
-
-
Waselle, L.1
Gerona, R.R.L.2
Vitale, N.3
Martin, T.F.J.4
Bader, M.-F.5
Regazzi, R.6
-
176
-
-
59449105295
-
Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2alpha on neurosecretory vesicles
-
doi:10.1091/mbc. E08-06-0595
-
Wen PJ, Osborne SL, Morrow IC et al (2008) Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2alpha on neurosecretory vesicles. Mol Biol Cell 19:5593-5603. doi:10.1091/mbc. E08-06-0595
-
(2008)
Mol Biol Cell
, vol.19
, pp. 5593-5603
-
-
Wen, P.J.1
Osborne, S.L.2
Morrow, I.C.3
-
177
-
-
0028939115
-
Multiple independent inputs are required for activation of the p70 S6 kinase
-
Weng QP, Andrabi K, Kozlowski MT et al (1995) Multiple independent inputs are required for activation of the p70 S6 kinase. Mol Cell Biol 15:2333-2340
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2333-2340
-
-
Weng, Q.P.1
Andrabi, K.2
Kozlowski, M.T.3
-
178
-
-
0033150718
-
Peroxyvanadium compounds inhibit glucose-6-phosphatase activity and glucagon-stimulated hepatic glucose output in the rat in vivo
-
DOI 10.1006/abbi.1999.1181
-
Westergaard N, Brand CL, Lewinsky RH et al (1999) Peroxyvanadium compounds inhibit glucose-6-phosphatase activity and glucagon-stimulated hepatic glucose output in the rat in vivo. Arch Biochem Biophys 366:55-60. doi:10.1006/abbi.1999.1181 (Pubitemid 29394228)
-
(1999)
Archives of Biochemistry and Biophysics
, vol.366
, Issue.1
, pp. 55-60
-
-
Westergaard, N.1
Brand, C.L.2
Lewinsky, R.H.3
Andersen, H.S.4
Carr, R.D.5
Burchell, A.6
Lundgren, K.7
-
179
-
-
19944430614
-
Muscle-specific Pten deletion protects against insulin resistance and diabetes
-
DOI 10.1128/MCB.25.3.1135-1145.2005
-
Wijesekara N, Konrad D, Eweida M et al (2005) Muscle-specific Pten deletion protects against insulin resistance and diabetes. Society 25:1135-1145. doi:10.1128/MCB.25.3.1135 (Pubitemid 40165819)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.3
, pp. 1135-1145
-
-
Wijesekara, N.1
Konrad, D.2
Eweida, M.3
Jefferies, C.4
Liadis, N.5
Giacca, A.6
Crackower, M.7
Suzuki, A.8
Mak, T.W.9
Kahn, C.R.10
Klip, A.11
Woo, M.12
-
180
-
-
37248998974
-
Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway
-
DOI 10.1242/jcs.014423
-
Williams C, Choudhury R, McKenzie E, Lowe M (2007) Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway. J Cell Sci 120:3941-3951. doi:10.1242/jcs.014423 (Pubitemid 350269400)
-
(2007)
Journal of Cell Science
, vol.120
, Issue.22
, pp. 3941-3951
-
-
Williams, C.1
Choudhury, R.2
McKenzie, E.3
Lowe, M.4
-
181
-
-
33846493564
-
Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity
-
DOI 10.1007/s00125-006-0531-x
-
Wong JT, Kim P T W, Peacock JW et al (2007) Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity. Diabetologia 50:395-403. doi:10.1007/s00125-006-0531-x (Pubitemid 46169771)
-
(2007)
Diabetologia
, vol.50
, Issue.2
, pp. 395-403
-
-
Wong, J.T.1
Kim, P.T.W.2
Peacock, J.W.3
Yau, T.Y.4
Mui, A.L.-F.5
Chung, S.W.6
Sossi, V.7
Doudet, D.8
Green, D.9
Ruth, T.J.10
Parsons, R.11
Verchere, C.B.12
Ong, C.J.13
-
182
-
-
75849118878
-
Targeting the PI3K signaling pathway in cancer
-
doi:10.1016/j.gde.2009.11.002
-
Wong K-K, Engelman JA, Cantley LC (2010) Targeting the PI3K signaling pathway in cancer. Curr Opin Genet Dev 20:87-90. doi:10.1016/j.gde.2009.11.002
-
(2010)
Curr Opin Genet Dev
, vol.20
, pp. 87-90
-
-
Wong, K.-K.1
Engelman, J.A.2
Cantley, L.C.3
-
183
-
-
0037323892
-
Phosphoinositide 3-kinase gamma: A key modulator in inflammation and allergy
-
Wymann MP, Björklöf K, Calvez R et al (2003) Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy. Biochem Soc Trans 31:275-280. doi:10.1042 (Pubitemid 36241444)
-
(2003)
Biochemical Society Transactions
, vol.31
, Issue.1
, pp. 275-280
-
-
Wymann, M.P.1
Bjorklof, K.2
Calvez, R.3
Finan, P.4
Thomas, M.5
Trifilieff, A.6
Barbier, M.7
Altruda, F.8
Hirsch, E.9
Laffargue, M.10
-
184
-
-
80052770295
-
C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane
-
doi:10.1016/j.cmet.2011.06.015
-
Xie X, Gong Z, Mansuy-Aubert V et al (2011a) C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab 14:378-389. doi:10.1016/j.cmet.2011.06.015
-
(2011)
Cell Metab
, vol.14
, pp. 378-389
-
-
Xie, X.1
Gong, Z.2
Mansuy-Aubert, V.3
-
185
-
-
79955615939
-
I{kappa}B kinase varepsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation
-
doi:10.1073/pnas.1016132108
-
Xie X, Zhang D, Zhao B et al (2011b) I{kappa}B kinase varepsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1016132108
-
(2011)
Proc Natl Acad Sci U S A
-
-
Xie, X.1
Zhang, D.2
Zhao, B.3
-
186
-
-
63049093727
-
Knockdown of endogenous SKIP gene enhanced insulininduced glycogen synthesis signaling in differentiating C2C12 myoblasts
-
Xiong Q, Deng C-Y, Chai J et al (2009) Knockdown of endogenous SKIP gene enhanced insulininduced glycogen synthesis signaling in differentiating C2C12 myoblasts. BMB Rep 42:119-124
-
(2009)
BMB Rep
, vol.42
, pp. 119-124
-
-
Xiong, Q.1
Deng, C.-Y.2
Chai, J.3
-
187
-
-
79960387847
-
Phospholipase D mediates nutrient input to mTORC1
-
doi:10.1074/jbc. M111.249631
-
Xu L, Salloum D, Medlin PS et al (2011) Phospholipase D mediates nutrient input to mTORC1. J Biol Chem 286:25477-25486. doi:10.1074/jbc. M111.249631
-
(2011)
J Biol Chem
, vol.286
, pp. 25477-25486
-
-
Xu, L.1
Salloum, D.2
Medlin, P.S.3
-
188
-
-
15444374951
-
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
-
DOI 10.1083/jcb.200408182
-
Yamada E, Okada S, Saito T et al (2005) Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles. J Cell Biol 168:921-928. doi:10.1083/jcb.200408182 (Pubitemid 40397006)
-
(2005)
Journal of Cell Biology
, vol.168
, Issue.6
, pp. 921-928
-
-
Yamada, E.1
Okada, S.2
Saito, T.3
Ohshima, K.4
Sato, M.5
Tsuchiya, T.6
Uehara, Y.7
Shimizu, H.8
Mori, M.9
-
189
-
-
76349093365
-
Structural basis for the Rho-and phosphoinositide-dependent localization of the exocyst subunit Sec3
-
doi:10.1038/nsmb.1722
-
Yamashita M, Kurokawa K, Sato Y et al (2010) Structural basis for the Rho-and phosphoinositide-dependent localization of the exocyst subunit Sec3. Nat Struct Mol Biol 17:180-186. doi:10.1038/nsmb.1722
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 180-186
-
-
Yamashita, M.1
Kurokawa, K.2
Sato, Y.3
-
190
-
-
79960960007
-
Akt stimulates hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
-
doi:10.1016/j.cmet.2011.06.002
-
Yecies JL, Zhang HH, Menon S et al (2011) Akt stimulates hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways. Cell Metab 14:21-32. doi:10.1016/j.cmet.2011.06.002
-
(2011)
Cell Metab
, vol.14
, pp. 21-32
-
-
Yecies, J.L.1
Zhang, H.H.2
Menon, S.3
-
191
-
-
84855731134
-
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
-
doi:10.1083/jcb.201107033
-
Yoon M-S, Du G, Backer JM et al (2011) Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol. doi:10.1083/jcb.201107033
-
(2011)
J Cell Biol.
-
-
Yoon, M.-S.1
Du, G.2
Backer, J.M.3
-
192
-
-
0035941208
-
All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate
-
doi:10.1074/jbc. M108811200
-
Yu JW, Lemmon MA (2001) All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. J Biol Chem 276:44179-44184. doi:10.1074/jbc. M108811200
-
(2001)
J Biol Chem
, vol.276
, pp. 44179-44184
-
-
Yu, J.W.1
Lemmon, M.A.2
-
193
-
-
0030874014
-
Peroxovanadate and insulin action in adipocytes from NIDDM patients. Evidence against a primary defect in tyrosine phosphorylation
-
DOI 10.1007/s001250050807
-
Yu ZW, Jansson PA, Posner BI et al (1997) Peroxovanadate and insulin action in adipocytes from NIDDM patients. Evidence against a primary defect in tyrosine phosphorylation. Diabetologia 40:1197-1203. doi:10.1007/s001250050807 (Pubitemid 27421892)
-
(1997)
Diabetologia
, vol.40
, Issue.10
, pp. 1197-1203
-
-
Yu, Z.-W.1
Jansson, P.-A.2
Posner, B.I.3
Smith, U.4
Eriksson, J.W.5
-
194
-
-
36248949658
-
RSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells
-
DOI 10.1038/cr.2007.82, PII CR200782
-
Yuan Y, Gao X, Guo N et al (2007) rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells. Cell Res 17:919-932. doi:10.1038/cr.2007.82 (Pubitemid 350126863)
-
(2007)
Cell Research
, vol.17
, Issue.11
, pp. 919-932
-
-
Yuan, Y.1
Gao, X.2
Guo, N.3
Zhang, H.4
Xie, Z.5
Jin, M.6
Li, B.7
Yu, L.8
Jing, N.9
-
195
-
-
15444351150
-
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules
-
DOI 10.1074/jbc.272.28.17756
-
Zhang X, Loijens JC, Boronenkov IV et al (1997) Phosphatidylinositol-4- phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem 272:17756-17761 (Pubitemid 27311215)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.28
, pp. 17756-17761
-
-
Zhang, X.1
Loijens, J.C.2
Boronenkov, I.V.3
Parker, G.J.4
Norris, F.A.5
Chen, J.6
Thum, O.7
Prestwich, G.D.8
Majerus, P.W.9
Anderson, R.A.10
-
196
-
-
36349018627
-
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
-
DOI 10.1073/pnas.0702275104
-
Zhang Y, Zolov SN, Chow C et al (2007) Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3, 5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci 104:17518-17523 (Pubitemid 350219870)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.44
, pp. 17518-17523
-
-
Zhang, Y.1
Zolov, S.N.2
Chow, C.Y.3
Slutsky, S.G.4
Richardson, S.C.5
Piper, R.C.6
Yang, B.7
Nau, J.J.8
Westrick, R.J.9
Morrison, S.J.10
Meisler, M.H.11
Weisman, L.S.12
-
197
-
-
0033834248
-
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
-
DOI 10.1038/78693
-
Zisman A, Peroni OD, Abel ED et al (2000) Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 6:924-928. doi:10.1038/78693 (Pubitemid 30644753)
-
(2000)
Nature Medicine
, vol.6
, Issue.8
, pp. 924-928
-
-
Zisman, A.1
Peroni, O.D.2
Abel, E.D.3
Michael, M.D.4
Mauvais-Jarvis, F.5
Lowell, B.B.6
Wojtaszewski, J.F.P.7
Hirshman, M.F.8
Virkamaki, A.9
Goodyear, L.J.10
Kahn, C.R.11
Kahn, B.B.12
-
198
-
-
62549151303
-
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes
-
doi:10.1016/j.cell.2009.01.032 S0092-8674 09 00080-4 pii
-
Zoncu R, Perera RM, Balkin DM et al (2009) A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell 136:1110-1121. doi:10.1016/j.cell.2009.01.032 S0092-8674 (09) 00080-4 [pii]
-
(2009)
Cell
, vol.136
, pp. 1110-1121
-
-
Zoncu, R.1
Perera, R.M.2
Balkin, D.M.3
-
199
-
-
80555143078
-
MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase
-
doi:10.1126/science.1207056
-
Zoncu R, Bar-Peled L, Efeyan A et al (2011) mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase. Science (New York, NY) 334:678-683. doi:10.1126/science.1207056
-
(2011)
Science (New York, NY)
, vol.334
, pp. 678-683
-
-
Zoncu, R.1
Bar-Peled, L.2
Efeyan, A.3
-
200
-
-
34548421080
-
Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae
-
DOI 10.1534/genetics.107.072835
-
Zurita-Martinez SA, Puria R, Pan X et al (2007) Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics 176:2139-2150 (Pubitemid 47360648)
-
(2007)
Genetics
, vol.176
, Issue.4
, pp. 2139-2150
-
-
Zurita-Martinez, S.A.1
Puria, R.2
Pan, X.3
Boeke, J.D.4
Cardenas, M.E.5
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