Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

Journal of Biological Chemistry

Volumn 283, Issue 41, 2008, Pages 27653-27667

  Green, Charlotte J ^a   Göransson, Olga ^b   Kular, Gursant S ^a   Leslie, Nick R ^a   Gray, Alexander ^a   Alessi, Dario R ^a   Sakamoto, Kei ^a   Hundal, Harinder S ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINES; BIOCHEMISTRY; CHEMICAL REACTIONS; GLUCOSE; HORMONES; INSULIN; MUSCLE; ORGANIC ACIDS; PHOSPHORYLATION;

ADIPOCYTES; ALLOSTERIC INHIBITORS; AMINO ACID UPTAKES; CELLULAR EXPRESSIONS; DO-MAINS; GLUCOSE TRANSPORTS; GLYCOGEN SYNTHASE KINASES; GLYCOGEN SYNTHESIS; HORMONAL REGULATIONS; ISOFORMS; MECHANISM OF ACTIONS; MUSCLE CELLS; MYOTUBES; PHOSPHATIDYLINOSITOL; PHOSPHOINOSITIDE BINDINGS; PLECKSTRIN HOMOLOGY DOMAINS; PROTEIN KINASES; RESISTANT MUTANTS; S6 KINASES; SKELETAL MUSCLES; SUBMICROMOLAR CONCENTRATIONS; TRYPTOPHAN RESIDUES; TYROSINE PHOSPHORYLATIONS;

AMINO ACIDS;

AMINO ACID; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLECKSTRIN; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE C; S6 KINASE; AMINO ACID TRANSPORTER; ANTIDIABETIC AGENT; GLUCOSE TRANSPORTER 4; GLYCOGEN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; ISOENZYME; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SLC2A4 PROTEIN, MOUSE; SLC2A4 PROTEIN, RAT; TBC1D4 PROTEIN, MOUSE;

ADIPOCYTE; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLUCOSE TRANSPORT; MOUSE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; CELL STRAIN 3T3; CYTOLOGY; DRUG ANTAGONISM; DRUG RESISTANCE; GENETICS; METABOLISM; MISSENSE MUTATION; SKELETAL MUSCLE; TRANSPORT AT THE CELLULAR LEVEL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3-L1 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOCYTES; AMINO ACID TRANSPORT SYSTEM A; AMINO ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; DRUG RESISTANCE; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; GTPASE-ACTIVATING PROTEINS; HYPOGLYCEMIC AGENTS; INSULIN; ISOENZYMES; MICE; MUSCLE, SKELETAL; MUTATION, MISSENSE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RIBOSOMAL PROTEIN S6 KINASES;

EID: 55549088220     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802623200     Document Type: Article

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