Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 9, 2003, Pages 5187-5192

  Olsen, Hervør L ^a   Høy, Marianne ^a   Zhang, Wei ^b   Bertorello, Alejandro M ^b   Bokvist, Krister ^a,e   Capito, Kirsten ^c   Efanov, Alexander M ^b,e   Meister, Björn ^b   Thams, Peter ^c   Yang, Shao Nian ^b   Rorsman, Patrik ^d   Berggren, Per Olof ^b   Gromada, Jesper ^a,e  

^a NOVO NORDISK A S   (Denmark)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d LUND UNIVERSITY   (Sweden)

^e Lilly Research Laboratories   (Germany)

Author keywords

Ca2+ dependent activator protein for secretion (CAPS); Exocytosis; Insulin; Phosphoinositides

Indexed keywords

ADENOSINE TRIPHOSPHATE; INSULIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL KINASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXOCYTOSIS; INSULIN RELEASE; MEMBRANE POTENTIAL; METABOLISM; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SECRETORY GRANULE;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANIMALS; BIOSENSING TECHNIQUES; EXOCYTOSIS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; MICE;

ANIMALIA;

EID: 0038303159     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0931282100     Document Type: Article

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