Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 12, 2010, Pages 5471-5476

  Chagpar, Ryaz B ^a   Links, Philip H ^b   Pastor, M Chris ^a   Furber, Levi A ^a   Hawrysh, Andrea D ^b   Chamberlain, M Dean ^a   Anderson, Deborah H ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b SASKATCHEWAN CANCER AGENCY   (Canada)

Author keywords

Explains mouse phenotypes; Insulin signaling; Lipid phosphatase; Protein:protein interactions; PTEN tumor suppressor

Indexed keywords

EPIDERMAL GROWTH FACTOR; INSULIN; ISOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P110; PROTEIN P50; PROTEIN P55; PROTEIN P85; PROTEIN P85 ALPHA; PROTEIN SH3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE DELETION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INSULIN SENSITIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; EPIDERMAL GROWTH FACTOR; HELA CELLS; HUMANS; INSULIN; MICE; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; PHENOTYPE; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN SUBUNITS; PTEN PHOSPHOHYDROLASE; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; SIGNAL TRANSDUCTION;

MUS;

EID: 77950440345     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908899107     Document Type: Article

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