Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts

Journal of Biological Chemistry

Volumn 285, Issue 9, 2010, Pages 6377-6389

  Tan, Yinfei ^a   You, Huihong ^a,c   Wu, Chao ^b   Altomare, Deborah A ^a,d   Testa, Joseph R ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEINS; AKT ACTIVATION; BINDING PROTEINS; CELL SURVIVAL; CULTURE CONDITIONS; EPIDERMAL GROWTH FACTORS; FETAL BOVINE SERUM; GROWTH FACTOR; IN-VIVO; KNOCK OUTS; LEUCINE ZIPPERS; MEMBRANE-BOUND RECEPTORS; MURINE EMBRYONIC FIBROBLASTS; PHENOTYPIC ABNORMALITIES; PHOSPHOTYROSINE BINDINGS; PLECKSTRIN HOMOLOGY; WILD TYPES; YEAST TWO HYBRID;

ACTIVATION ANALYSIS; AMINO ACIDS; BIOACTIVITY; FIBROBLASTS; PEPTIDES; PLANTS (BOTANY); SIGNAL TRANSDUCTION; SIGNALING; TRANSCRIPTION FACTORS;

CELL CULTURE;

ADAPTOR PROTEIN; ADAPTOR PROTEIN CONTAINING PLECKSTRIN HOMOLOGY PHOSPHOTYROSINE BINDING AND LEUCINE ZIPPER MOTIF; EPIDERMAL GROWTH FACTOR; INSULIN; PROTEIN KINASE B; PROTEIN KINASE B BETA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CARRIER PROTEIN; DIP13ALPHA PROTEIN, HUMAN; SCATTER FACTOR; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; EXON; FEMALE; FETUS; FIBROBLAST; GENOTYPE; LOXP SITE; MALE; MOUSE; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL MOTION; DRUG EFFECT; EMBRYO DEVELOPMENT; GENETICS; METABOLISM; MOUSE MUTANT; NEWBORN; PHYSIOLOGY;

BOVINAE; MURINAE; MUS;

ANIMALS; ANIMALS, NEWBORN; CARRIER PROTEINS; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; EMBRYONIC DEVELOPMENT; FIBROBLASTS; HEPATOCYTE GROWTH FACTOR; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 77949900267     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.068452     Document Type: Article

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