The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin

Nature

Volumn 422, Issue 6932, 2003, Pages 629-633

  Inoue, Mayumi ^a   Chang, Louise ^a   Hwang, Joseph ^a   Chiang, Shian Huey ^a   Saltiel, Alan R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; PROTEINS; SIGNAL PROCESSING;

GLUCOSE TRANSPORT;

PLASMAS;

GLUCOSE TRANSPORTER 4; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; PROTEIN; PROTEIN EXO70; UNCLASSIFIED DRUG;

MEDICINE;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; EMBRYO; EXOCYTOSIS; GENE OVEREXPRESSION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

3T3 CELLS; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD GLUCOSE; CARRIER PROTEINS; CELL LINE; CELL MEMBRANE; EXOCYTOSIS; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; MEMBRANE PROTEINS; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PROTEIN BINDING; PROTEIN TRANSPORT; RHO GTP-BINDING PROTEINS;

EID: 0037431329     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01533     Document Type: Article

References (29)

1. Saltiel, A. R. & Kahn, C. R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806 (2001).
2. Bryant, N. J., Govers, R. & James, D. E. Regulated transport of the glucose transporter GLUT4. Nature Rev. Mol. Cell Biol. 3, 267-277 (2002).
3. Chiang, S. H. et al. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature 410, 944-948 (2001).
4. Liu, J., Kimura, A., Baumann, C. A. & Saltiel, A. R. APS facilitates c-Cb1 tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol. Cell. Biol. 22, 3599-3609 (2002).
5. Neudauer, C. L., Joberty, G., Tatsis, N. & Macara, I. G. Distinct cellular effects and interactions of the Rho-family GTPase TC10. Curr. Biol. 8, 1151-1160 (1998).
6. TerBush, D. R., Maurice, T., Roth, D. & Novick, P. The exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J. 15, 6483-6494 (1996).
7. Kee, Y. et al. Subunit structure of the mammalian exocyst complex. Proc. Natl Acad. Sci. USA 94, 14438-14443 (1997).
8. Symons, M. Rho family GTPases: the cytoskeleton and beyond. Trends Biochem. Sci. 21, 178-181 (1996).
9. Tapon, N. & Hall, A. Rho, Rac, and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr. Opin. Cell Biol. 9, 86-92 (1997).
10. Van Aelst, L. & D'Souza-Schorey, C. Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322 (1997).
11. Chiang, S. H., Hou, J. C., Hwang, J., Pessin, J. E. & Saltiel, A. R. Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport. J. Biol. Chem. 277, 13067-13073 (2002).
12. Hsu, S. C., Hazuka, C. D., Foletti, D. L. & Scheller, R. H. Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex. Trends Cell. Biol. 9, 150-153 (1999).
13. Guo, W., Sacher, M., Barrowman, J., Ferro-Novick, S. & Novick, P. Protein complexes in transport vesicle targeting. Trends Cell Biol. 10, 251-255 (2000).
14. Lipschutz, J. H. & Mostov, K. E. Exocytosis: the many masters of the exocyst. Curr. Biol. 12, R212-R214 (2002).
15. Ting, A. E. et al. rSec6 and rSec8, mammalian homologs of yeast proteins essential for secretion. Proc. Natl Acad. Sci. USA 92, 9613-9617 (1995).
16. Yeaman, C., Grindstaff, K. K., Wright, J. R. & Nelson, W. J. Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells. J. Cell Biol. 155, 593-604 (2001).
17. Kimura, A., Baumann, C. A., Chiang, S. H. & Saltiel, A. R. The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. Proc. Natl Acad. Sci. USA 98, 9098-9103 (2001).
18. Dawson, K., Aviles-Hernandez, A., Cushman, S. W. & Malide, D. Insulin-regulated trafficking of dual-labelled glucose transporter 4 in primary rat adipose cells. Biochem. Biophys. Res. Commun. 287, 445-454 (2001).
19. Novick, P. & Guo, W. Ras family therapy: Rab, Rho and Ral talk to the exocyst. Trends Cell Biol. 12, 247-249 (2002).
20. Cheatham, B. GLUT4 and company: SNAREing roles in insulin-regulated glucose uptake. Trends Endocrinol. Metab. 11, 356-361 (2000).
21. Chamberlain, L. H. & Gould, G. W. The v-and t-SNARE proteins that mediate Glut4 vesicle fusion are localised in detergent-insoluble lipid rafts present on distinct intracellular membranes. J. Biol. Chem. 277, 49750-49754 (2002).
22. Sherman, L. A., Hirshman, M. F., Cormont, M., Le Marchand-Brustel, Y. & Goodyear, L. J. Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle. Endocrinology 137, 266-273 (1996).
23. Cormont, M. et al. Potential role of Rab4 in the regulation of subcellular localizAtion of Glut4 in adipocytes. Mol. Cell. Biol. 16, 6879-6886 (1996).
24. Shisheva, A. & Czech, M. P. Association of cytosolic Rab4 with GDI isoforms in insulin-sensitive 3T3-L1 adipocytes. Biochemistry 36, 6564-6570 (1997).
25. Millar, C. A., Shewan, A., Hickson, G. R., James, D. E. & Gould, G. W. Differential regulation of secretory compartments containing the insulin-responsive glucose transporter 4 in 3T3-L1 adipocytes. Mol. Biol. Cell 10, 3675-3688 (1999).
26. Chang, L., Adams, R. D. & Saltiel, A. R. The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Proc. Natl Acad. Sci. USA 99, 12835-12840 (2002).
27. Lin, D. et al. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nature Cell Biol. 2, 540-547 (2000).
28. Thurmond, D. C. et al. Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes. J. Biol. Chem. 273, 33876-33883 (1998).
29. Hwang, J. B. & Frost, S. C. Effect of alternative glycosylation on insulin receptor processing. J. Biol. Chem. 274, 22813-22820 (1999).