The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

EMBO Journal

Volumn 23, Issue 10, 2004, Pages 2071-2082

  McManus, Edward J ^a   Collins, Barry J ^a   Ashby, Peter R ^a   Prescott, Alan R ^a   Murray Tait, Victoria ^a   Armit, Laura J ^a   Arthur, J Simon C ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

mTOR; PI 3 kinase; PKB Akt; PKC; RSK

Indexed keywords

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE; PROTEIN KINASE B; S6 KINASE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; EMBRYO; EMBRYO LOSS; ENZYME ACTIVATION; ISOENZYMES; MICE; MUTATION; PHENOTYPE; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; STEM CELLS;

EID: 2942563750     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600218     Document Type: Article

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