ArPIKfyve regulates Sac3 protein abundance and turnover disruption of the mechanism by Sac3I41T mutation causing charcot-marie-tooth 4J disorder

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 26760-26764

  Ikonomov, Ognian C ^a   Sbrissa, Diego ^a   Fligger, Jason ^a   Delvecchio, Khortnal ^a   Shisheva, Assia ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINARY COMPLEXES; BISPHOSPHATES; CO-EXPRESSION; COEXPRESSED; CYCLOHEXIMIDES; HYDROLYZING ACTIVITY; MAMMALIAN CELLS; MOLECULAR DEFECTS; MRNA LEVEL; PHOSPHATIDYLINOSITOL; PROTEASOMES; PROTEIN DEGRADATION; PROTEIN LEVEL; PROTEIN STABILITY; PROTEIN SYNTHESIS; REGULATORY MECHANISM; TERNARY COMPLEX; TRANSIENT EXPRESSION;

DEGRADATION; HYDROLYSIS; MAMMALS;

PROTEINS;

ASSOCIATED REGULATOR OF PHOSPHOINOSITIDE KINASE FOR POSITION FIVE CONTAINING A FYVE FINGER DOMAIN; CYCLOHEXIMIDE; ISOLEUCINE; MESSENGER RNA; MUTANT PROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,5 BIPHOSPHATE; PROTEASOME; PROTEIN ARPIKFYVE; PROTEIN SAC3; REGULATOR PROTEIN; SAC DOMAIN CONTAINING PHOSPHATASE 3; THREONINE; TRIPHOSPHOINOSITIDE; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LEVEL; CELL STRAIN 3T3; CELL STRAIN COS1; CONTROLLED STUDY; GENE MUTATION; HALF LIFE TIME; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTEIN METABOLISM; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; STEADY STATE; TRANSIENT EXPRESSION; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3-L1 CELLS; AMINO ACID SUBSTITUTION; ANIMALS; CARRIER PROTEINS; CERCOPITHECUS AETHIOPS; CHARCOT-MARIE-TOOTH DISEASE; COS CELLS; FLAVOPROTEINS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HALF-LIFE; HUMANS; HYDROLYSIS; MEMBRANE PROTEINS; MICE; MULTIPROTEIN COMPLEXES; MUTATION, MISSENSE; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING;

MAMMALIA;

EID: 77956243411     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C110.154658     Document Type: Article

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