The structure and regulation of myotubularin phosphatases

Current Opinion in Structural Biology

Volumn 15, Issue 6, 2005, Pages 614-620

  Begley, Michael J ^a   Dixon, Jack E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYOTUBULARIN; PHOSPHATASE; PHOSPHATIDYLINOSITIDE; PHOSPHOPROTEIN; PROTEIN; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME REGULATION; ENZYME STRUCTURE; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW;

CHARCOT-MARIE-TOOTH DISEASE; HUMANS; MODELS, MOLECULAR; MUTATION; MYOPATHIES, STRUCTURAL, CONGENITAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE;

EID: 27944470541     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sbi.2005.10.016     Document Type: Review

References (37)

1. J. Laporte, L.J. Hu, C. Kretz, J.-L. Mandel, P. Kioschis, J.F. Coy, S.M. Kluack, A. Poustka, and N. Dahl A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast Nat Genet 13 1996 175 182
2. J. Denu, and J.E. Dixon Protein tyrosine phosphatases: mechanisms of catalysis and regulation Curr Opin Chem Biol 2 1998 633 641
3. J. Laporte, F. Bedez, A. Bolino, and J-L. Mandel Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositide phosphatases Hum Mol Genet 12 2003 R285 R292
4. A. Bolino, M. Muglia, F.L. Conforti, E. LeGuern, M.A.M. Salih, D.-M. Georgiou, K. Christodoulou, I. Hausmanowa-Petrusewicz, P. Mandich, and A. Schenone Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2 Nat Genet 25 2000 17 19
5. J. Senderek, C. Bergmann, S. Weber, U. Ketelsen, H. Schorle, S. Rudnik-Shoneborn, R. Buttner, E. Buchheim, and K. Zerres Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15 Hum Mol Genet 12 2003 349 356 This study combined genetic linkage analysis and bioinformatics to identify MTMR13/SBF2, an inactive myotubularin, as mutated in CMT4B. This highlighted the biological significance of the inactive myotubularins, and suggested that active MTMR2 and inactive MTMR13/SBF2 function in the same pathway.
6. G.S. Taylor, T. Maehama, and J.E. Dixon Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate Proc Natl Acad Sci USA 97 2000 8910 8915
7. S-A. Kim, G.S. Taylor, K.M. Torgersen, and J.E. Dixon Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease J Biol Chem 277 2002 4526 4531
8. F. Blondeau, J. Laporte, S. Bodin, G. Superti-Furga, B. Payrastre, and J-L. Mandel Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphatase pathway Hum Mol Genet 9 2000 2223 2229
9. R. Zhao, Y. Qi, J. Chen, and Z.J. Zhao FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphatidylinositol 3-phosphate Exp Cell Res 265 2001 329 338
10. D.M. Walker, S. Urbe, S.K. Dove, D. Tenza, G. Raposo, and M.J. Clague Characterization of MTMR3, an inositol lipid 3-phosphatase with novel substrate specificity Curr Biol 11 2001 1600 1605
11. P. Berger, S. Bonneick, S. Willi, M. Wymann, and U. Suter Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1 Hum Mol Genet 11 2002 1569 1579
12. J. Schaletzky, S.K. Dove, B. Short, O. Lorenzo, M.J. Clague, and F.A. Barr Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases Curr Biol 13 2003 504 509 This paper provides evidence that PtdIns(5)P, the product of the hydrolytic activity of myotubularin phosphatases, is an allosteric activator, suggesting that a positive feedback loop controls activity.
13. M.A. Lemmon Phosphoinositide recognition domains Traffic 4 2003 201 213
14. Y. Xue, H. Fares, B. Grant, Z. Li, A.M. Rose, S.G. Clark, and E.Y. Skolnik Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans J Biol Chem 278 2003 34380 34386
15. H. Dang, Z. Li, EY. Skolnik, and H. Fares Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans Mol Biol Cell 15 2004 189 196
16. K. Tsujita, T. Itoh, T. Ijuin, A. Yamamoto, A. Shisheva, J. Laporte, and T. Takenawa Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction J Biol Chem 279 2004 13817 13824
17. M.J. Begley, G.S. Taylor, S-A. Kim, D.M. Veine, J.E. Dixon, and J.A. Stuckey Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome Mol Cell 12 2003 1391 1402 This paper reports the crystal structure of a fragment of MTMR2 that includes the PH-GRAM and PTP domains. Unexpectedly, the structure revealed that the GRAM domain has a PH domain fold. Several of the structural determinants of PI substrate specificity were accurately inferred based on the structure of the PTP domain. All missense disease mutations in MTM1 and MTMR2 reported at the time were mapped to the structure.
18. 2, and identifies several conserved structural features that underlie the substrate specificity of the family.
19. T. Doerks, M. Strauss, M. Brendel, and P. Bork GRAM, a novel domain in glucosyltransferases, myotubularins, and other putative membrane-associated proteins Trends Biochem Sci 25 2000 483 485
20. M.A. Lemmon Pleckstrin homology domains: not just for phosphoinositides Biochem Soc Trans 32 2004 707 711
21. O. Lorenzo, S. Urbe, and M.J. Clague Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3 J Cell Sci 118 2005 2005 2012 This biochemical study demonstrates that the PH-GRAM domain selectively binds PtdIns(5)P in vitro and provides evidence that this interaction occurs in vivo.
22. P. Berger, C. Schaffitzel, I. Berger, N. Ban, and U. Suter Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module Proc Natl Acad Sci USA 100 2003 12177 12182
23. M.J. Clague, S.K. Dove, and F.A. Barr I-proteins - a proposed switch in myotubularin function Trends Biochem Sci 29 2004 58 61
24. J. Yuvaniyama, J.M. Denu, J.E. Dixon, and M.A. Saper Crystal structure of the dual specificity protein phosphatase VHR Science 272 1996 1328 1331
25. X. Cui, I. De Vivo, R. Slany, A. Miyamoto, R. Firestein, and M.L. Cleary Association of SET domain and myotubularin-related proteins modulates growth control Nat Genet 18 1998 331 337
26. 3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles J Cell Sci 115 2002 3105 3117
27. J.M. Gaullier, A. Simonsen, A. D'Arrigo, B. Bremnes, and H. Stenmark FYVE fingers bind PI(3)P Nature 394 1998 432 433
28. V. Patki, D.C. Lawe, S. Corvera, J.V. Virbasius, and A. Chawla A functional PtdIns(3)P-binding motif Nature 394 1998 433 434
29. E. Levivier, B. Goud, M. Souchet, T.P.G. Calmels, J.-P. Mornon, and I. Callebaut uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways Biochem Biophys Res Commun 287 2001 688 695
30. S.J. Isakoff, T. Cardozo, J. Andreev, Z. Li, K.M. Ferguson, R. Abagyan, M.A. Lemmon, A. Aronheim, and E.Y. Skolnik Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay system in yeast EMBO J 17 1998 5374 5387
31. T. Hunter Anti-phosphatases take the stage Nat Genet 18 1998 303 305
32. S-A. Kim, P.O. Vacratsis, R. Firestein, M.L. Cleary, and J.E. Dixon Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase Proc Natl Acad Sci USA 100 2003 4492 4497 This paper provides the first biochemical evidence that active and inactive myotubularins directly interact, and demonstrates that MTMR5 affects the localization and catalytic activity of MTMR2.
33. H.H. Nandurkar, M. Layton, J. Laporte, C. Selan, L. Corcoran, K.K. Caldwell, Y. Mochizuki, P.W. Majerus, and C.A. Mitchell Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP Proc Natl Acad Sci USA 100 2003 8660 8665 This study demonstrates that endogenous 3-PAP/MTMR12 and MTM1 interact, and shows that MTMR12 affects the localization of MTM1.
34. Y. Mochizuki, and P.W. Majerus Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 Proc Natl Acad Sci USA 100 2003 9768 9773 This study demonstrates that endogenous MTMR9 and MTMR7 interact; the association enhances the catalytic activity of MTMR7.
35. F.L. Robinson, and J.E. Dixon The phosphoinositide 3-phosphatase MTMR2 associates with MTMR13, a novel, membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease J Biol Chem 280 2005 31699 31707 This study demonstrates that MTMR13/SBF2 and MTMR2, both of which are mutated in CMT4B, directly interact.
36. A. Lupas Prediction and analysis of coiled-coil structures Methods Enzymol 266 1996 513 525
37. J. Schultz, F. Milpetz, P. Bork, and C.P. Ponting SMART, a simple modular architecture research tool: identification of signaling domains Proc Natl Acad Sci USA 95 1998 5857 5864