Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member

Molecular Biology of the Cell

Volumn 13, Issue 4, 2002, Pages 1238-1251

  Gary, Jonathan D ^a   Sato, Trey K ^a   Stefan, Christopher J ^a   Bonangelino, Cecilia J ^a   Weisman, Lois S ^a   Emr, Scott D ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAB1 PHOSPHATIDYLINOSITOL 3 PHOSPHATE 5 KINASE; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL KINASE; POLYPHOSPHOINOSITIDE; PROTEIN FIG4; PROTEIN SAC1; PROTEIN VAC7; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ENZYME REGULATION; FUNGAL GENE; GENE DELETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVITY;

ALLELES; AMINO ACID SEQUENCE; CELL MEMBRANE; CLONING, MOLECULAR; ESCHERICHIA COLI; FLAVOPROTEINS; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS;

FUNGI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036231465     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.01-10-0498     Document Type: Article

References (53)

1. Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics
2. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function
3. Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology
4. Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment
5. Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes
6. The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae
7. Phosphoinositides as regulators in membrane traffic
8. 2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes
9. Sac1 lipid phosphatase and Stt4 PtdIns 4-kinase regulate a pool of PtdIns(4)P that functions in the control of the actin cytoskeleton and vacuole morphology
10. Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis
11. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
12. SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
13. Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae
14. Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase
15. SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases
16. Subcellular targeting by membrane lipids
17. Transformation of intact yeast cells treated with alkali cations
18. Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis
19. Membrane fusion and exocytosis
20. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
21. Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body
22. Phosphoinositide signaling and the regulation of membrane trafficking in yeast
23. Structure, function, and control of phosphoinositide-specific phospholipase C
24. Protein sorting in Saccharomyces cerevisiae: Isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases
25. Cloning genes by complementation in yeast
26. Location, location, location: Membrane targeting directed by PX domains
27. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
28. SMART: A web-based tool for the study of genetically mobile domains
29. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
30. Disruption of three phosphatidylinositol-polyphosphate 5-phosphatase genes from Saccharomyces cerevisiae results in pleiotropic abnormalities of vacuole morphology, cell shape, and osmohomeostasis
31. Vesicle-mediated protein transport: Regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast
32. A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole
33. INP51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype
34. Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae
35. Inaugural article: Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
36. Signaling through the lipid products of phosphoinositide-3-OH kinase
37. A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast
38. Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants
39. The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi
40. Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly
41. Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation
42. A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15
43. D-3 phosphoinositide metabolism in cells treated with platelet-derived growth factor
44. Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts
45. SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast
46. The yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail: Regulation of secretion from the endoplasmic reticulum
47. Phoxy lipids. Revealing px domains as phosphoinositide binding modules
48. Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities
49. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways
50. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P
51. Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast
52. All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate