Bisperoxovanadium compounds are potent PTEN inhibitors

FEBS Letters

Volumn 566, Issue 1-3, 2004, Pages 35-38

  Schmid, Annette C ^a   Byrne, Richard D ^a,b   Vilar, Ramón ^a   Woscholski, Rüdiger ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

bpV; bpV(bipy), potassium bisperoxo(bipyridine)oxovanadate; bpV(HOpic), dipotassium bisperoxo(5 hydroxypyridine 2 carboxyl)oxovanadate; bpV, bisperoxovanadate; Insulin mimetic; PI 3 kinase; PKB Akt; PTEN; Small molecule inhibitor

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SERINE; VANADIUM DERIVATIVE;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; ENZYME PHOSPHORYLATION; IN VIVO CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; INHIBITORY CONCENTRATION 50; INSULIN; MICE; MORPHOLINES; NIH 3T3 CELLS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECOMBINANT PROTEINS; TUMOR SUPPRESSOR PROTEINS; TYROSINE; VANADIUM COMPOUNDS;

EID: 2442601508     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.03.102     Document Type: Article

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